甘利欣注射液联合雷公藤多苷片治疗寻常型银屑病疗效观察

目的：探讨甘利欣注射液联合雷公藤多苷片治疗寻常型银屑病的疗效。方法：将24例寻常型银屑病患者分为治疗组和对照组，每组各12例。两组均给与雷公藤多苷20mg，每日3次，维生素C200mg，每日3次口服，局部外涂0．05％氯倍他索霜（本院自制）。治疗组同时用甘利欣注射液150mg加入10％葡萄糖250ml中静脉滴注，每日1次，每周连续3日，两组患者均治疗1个月为1个疗程，连用2个疗程。结果：治疗组痊愈3例，显效6例，有效2例，无效1例，总有效率为75％（9／12）；对照组痊愈1例，显效3例，有效5例，无效3例，总有效率33．3％（4／12）。结论：甘利欣注射液与雷公藤多苷联合应用对寻常型银屑病起到较好的控制作用，有明显的近期疗效。     

雷公藤、雷尼替丁或加氨苯砜治疗银屑病35例疗效观察

雷公藤、雷尼替丁或加氨苯砜治疗银屑病３５例疗效观察吕俊元，何弘，高效贤我科用雷公藤、雷尼替丁或加氨苯砜联合治疗寻常型银屑病３５例，现小结如下：一般资料：男性３２例，女性３例，年龄１８～５６岁，病期１０天～１５年。进行期２２例，静止期１２例，退行期１例...     

迪银片治疗寻常型银屑病30例疗效观察

迪银片治疗寻常型银屑病３０例疗效观察何成雄①采用重庆华邦制药有限公司研制的迪银片治疗３０例进行期寻常型银屑病，收到较为满意的效果，现总结报告如下。１病例选择１．１入选标准：年满１５岁；发病前１周未经治疗的新发或复发的银屑病患者；既往无高血压、心血管疾...     

复方青黛胶囊治疗银屑病疗效观察

用复方青黛胶囊治疗寻常型银屑病１５４例，痊愈率为３２．５％显效率为３４．４％，总有效率为８９．６％，部分病例在治疗前扣进行血、尿常规及肝功能检查，均未有异常发迹５４例中有６例出现肠道反应。占３．９％，一般不需停药。和该药第一代产品复方青黛丸治疗寻常型银屑病１２１例对比，疗铲相当，在该药剂型改良后减轻了副作用而疗效仍然满意。     

昆仙胶囊治疗进行期寻常型银屑病的单中心随机双盲安慰剂对照临床试验研究

目的：评价昆仙胶囊治疗进行期寻常型银屑病的疗效及安全性。方法：按照入选和排除标准将进行期寻常型银屑病患者随机分成昆仙胶囊治疗组及安慰剂对照组，治疗周期为4周，采用PASI评分评价药物疗效。结果：共纳入病例60例，每组30例，治疗组脱落3例，对照组脱落1例。治疗组达到PASI 50、PASI 75、PASI 90的患者比例分别为74.1%、29.6%和14.8%，对照组各组患者均为0%，两组各PASI组均存在显著差异（P值分别为0.001，0.002，0.048）。治疗组和对照组中分别出现不良事件6例和1例。结论：昆仙胶囊治疗进行期寻常型银屑病疗效优于安慰剂。     

烟酸肌醇酯软膏治疗寻常痤疮50例

烟酸肌醇酯软膏治疗寻常痤疮５０例镇江市第一人民医院皮肤科徐家森治疗方法：外用江苏启东化工厂生产的１０％烟酸肌醇酯软膏，每日３次，１个月为一疗程。疗效判定标准：基本痊愈为皮损消退或遗留轻度色素沉着；显效为皮疹消退７０％以上；有效为皮疹消退４０％以上；无...     

复方甘草酸苷辅助治疗寻常型银屑病疗效观察

目的:探讨复方甘草酸苷辅助治疗进行期寻常型银屑病的临床疗效。方法:将进行期寻常型银屑病患者96例随机分为治疗组与对照组各48例,对照组口服复方氨肽素片、转移因子胶囊,同时外搽艾洛松软膏;治疗组在对照组治疗的基础上,同时静脉注射复方甘草酸苷20 mL,每日1次,共四周。结果:治疗组治愈10例,显效24例,有效率为70.83%;对照组治愈4例,显效16例,有效率为41.67%,两组差异有统计学意义(χ2=5.83,P<0.05)。结论:复方甘草酸苷辅助治疗进行期寻常型银屑病效果确切。     

维特明治疗寻常型银屑病的临床疗效观察

23例寻常型银屑病，每日早、晚两次将0．05％维特明凝胶[（中美）山东德美克制药有限公司生产]涂于皮损处，头皮部损害配合外用泽它洗剂。对照组20例，每日2次外用维胺脂乳膏，头皮部损害外用乐肤液。两组均以治疗4周为1个疗程，间歇1周后再进行第2疗程。结果：治疗组痊愈11例，显效8例，好转3例，无效1例，总有效率96％。对照组痊愈3例，显效3例，好转9例，无效5例，总有效率75％。两组的总有效率有显著性差异（P＜0.05）。维特明治疗寻常型银屑病的临床疗效观察@陈可$江苏省淮安市人民医院皮肤科     

寻常型银屑病患者皮损类型、面积与sICAM—1的关系探讨

银屑病是以表皮角质形成细胞过度增殖,白细胞局部浸润为特征的慢性炎症性皮肤病。已有报道,寻常型银屑病皮损处的表皮角质形成细胞及血管内皮细胞上的细胞间粘连分子１ＩＣＡＭ１表达增强,血清可溶性细胞间粘连分子１ｓＩＣＡＭ１浓度增高１～３,但寻常型银屑病患者皮损类型、面积与血清ｓＩＣＡＭ１浓度的关系,国内少见报道,为此,我们做了这方面的研究,现报告如下。１材料与方法寻常型银屑病患者９０例,均处进行期或稳定期,其中点滴状２１例,男１２例,女９例,年龄１３～４７岁,病程０．５～６月。斑块型６９例,男３９例,女…     

绞股蓝总甙胶囊治疗寻常型银屑病

绞股蓝总甙胶囊治疗寻常型银屑病马百芳，宋执敬，曹兰芝我们应用绞股蓝总甙胶囊（中外合资深圳海滨制药有限公司生产）治疗寻常型银屑病，现报告如下。临床资料：１８２例进行期寻常型银屑病患者，男１０１例，女８１例；年龄１４～６９岁；病程１周～３４年，１年以上者...     

Efficiency of acitretin in combination with UV-B in the treatment of severe psoriasis

Compared with the antipsoriatic retinoid etretinate, the new aromatic retinoid acitretin represents an important advance due to its rapid elimination kinetics. Since in psoriasis vulgaris retinoids are used predominantly in combination regimens, we investigated the therapeutic efficacy of acitretin and UV-B compared with placebo and UV-B in a double-blind, randomized multicenter trial in 82 patients with severe psoriasis. They were treated with 35 mg of the study medication during the first 4 weeks of therapy and 25 mg thereafter, concomitantly with UV-B irradiation in increasing energy doses. Forty patients who underwent therapy with acitretin and UV-B and 38 patients who underwent therapy with placebo and UV-B were evaluated for efficacy. The target variables--psoriasis severity index and total UV-B dose--were reported at intervals of 2 weeks over a maximum period of 8 weeks. At the end of treatment, the psoriasis severity index decrease was 79% in the acitretin and UV-B group and 35% in the placebo and UV-B group. The response rate, defined as greater than or equal to a 75% decrease of the psoriasis severity index, was 60% for the combination treatment and only 24% for the control treatment. This treatment response was achieved with markedly lower cumulative UV-B energy. The median cumulative UV-B energy applied to reach 75% clinical improvement was 11.8 J/cm2 vs 6.9 J/cm2. Side effects showed a similar pattern in both groups. Our data show that the acitretin dramatically improves the results of UV-B treatment in patients with severe psoriasis. In addition, it markedly decreases the effective cumulative UV-B dose, thereby reducing the potential long-term hazards of UV irradiation. We conclude that the acitretin plus UV-B combination treatment represents a highly effective therapeutic regimen in severe psoriasis.     

Treatment of psoriasis by the topical application of the novel cholecalciferol analogue calcipotriol (MC 903)

Calcipotriol (the synthetic compound MC 903) is a structural analogue of naturally occurring, biologically active calcitriol. Calcipotriol and calcitriol (1,25-dihydroxy vitamin D3) show similar receptor binding and comparable effects on cell differentiation. However, calcipotriol seems to be at least 100 times less potent in its effects on calcium metabolism. In a double-masked study involving 50 patients with psoriasis vulgaris, the efficacy and tolerability of ointments containing various calcipotriol concentrations (25, 50, or 100 micrograms/g) or the vehicle alone were compared in a study involving a right-left, within-patient randomized design. Patients were treated twice daily for 8 weeks. Marked improvement was seen in 40% of the patients treated with the 25-micrograms/g concentration of calcipotriol in 63% of patients treated with the 50-micrograms/g concentration, and in 88% treated with the 100-micrograms/g concentration. No patient treated with placebo had more than slight improvement. Five patients developed facial dermatitis during the study. The serum levels of ionized calcium were unchanged. This study demonstrates that calcipotriol ointment provides an effective and well-tolerated treatment of psoriasis vulgaris.     

复方氟米松软膏治疗寻常性银屑病临床观察

目的观察复方氟米松软膏治疗寻常性银屑病的疗效和安全性。方法72例寻常性银屑病患者随机分为治疗组和对照组各36例。治疗组外用复方氟米松软膏,对照组外用他扎罗汀乳膏,两组疗程均为6周。结果治疗组有效率88.89%,对照组为66.67%,两组疗效差异有显著性(P<0.05);治疗组的不良反应发生率为5.56%,对照组为22.22%,两者差异有显著性(P<0.05)。结论复方氟米松软膏治疗寻常性银屑病疗效好,安全性高。     

UVA与UVB治疗寻常型银屑病临床对照研究

目的：评价煤焦油软膏外用联合UVA＋UVB照射治疗寻常型银屑病的疗效及安全性。方法：91例寻常型银屑病患者外用煤焦油软膏联合UVA＋UVB照射，并与53例寻常型银屑病患者外用煤焦油软膏联合UVA、51例联合UVB照射进行对比观察。结果：治疗8周后UVA＋UVB组痊愈率为63．74％，总有效率为98．90％，明显高于UVA组和UVB组；治疗2周、4周、6周和8周后PASI评分均较治疗前明显下降，UVA＋UVB组与UVA组、UVB组对比有显著性差异；1年内复发率UVA＋UVB组27．66％，明显低于UVA组或UVB组。结论：外用煤焦油软膏联合UVA＋UVB照射治疗寻常型银屑病较单纯联合UVA或UVB照射疗效高、复发率低。     

Evaluation of 308-nm monochromatic excimer light in the treatment of psoriasis vulgaris and palmoplantar psoriasis

Background: The purpose of this study is to evaluate the efficacy and safety of 308‐nm monochromatic excimer light (MEL) in the treatment of psoriasis vulgaris and palmoplantar psoriasis. Methods: Thirty‐five patients with psoriasis vulgaris and 15 patients with palmoplantar psoriasis were recruited for this study. Thirty patients with psoriasis vulgaris completed a total of 16 treatments with 308‐nm MEL twice a week, and 15 patients palmoplantar psoriasis completed 25 treatments administered once weekly. The clinical response to therapy and adverse effects were recorded. Results: Patients with psoriasis vulgaris (n=30) showed a 74.6% improvement in the mean psoriasis area and severity index score after a total of 16 MEL treatments (2 ×/week) with 36.7% of the patients (n=11) achieving clearance. Patients with palmoplantar psoriasis (n=15) showed a 52.5% improvement in the mean severity index score after a total of 25 MEL treatments (1 ×/week) with only one patient (6.7%) achieving clearance. The MEL therapy was well tolerated with a low incidence of side effects, which included pruritus, erythema and blister formation. Conclusion: The 308‐nm MEL can be utilized as an effective and safe treatment modality for patients with mild‐to‐moderate psoriasis vulgaris and palmoplantar psoriasis.     

银屑胶囊联合阿维A胶囊治疗寻常性银屑病的临床观察

目的观察银屑胶囊联合阿维A胶囊治疗寻常性银屑病的疗效和安全性。方法将患者随机分为试验组和对照组,各40例。两组均口服阿维A胶囊20mg,1次/d,试验组加用银屑胶囊3粒,3次/d。两组均治疗8周判效。结果试验组、对照组的有效率分别为87.18%和63.16%,二者差异有统计学意义(P<0.05);试验组、对照组的不良反应发生率分别为47.50%和50.00%,二者差异无统计学意义(P>0.05),两组的不良反应均轻微,可耐受。结论银屑胶囊联合阿维A胶囊治疗寻常性银屑病安全、有效。     

活血解毒汤治疗银屑病血瘀证的临床疗效观察

目的观察活血解毒汤治疗银屑病血瘀证的临床疗效和安全性。方法 80例银屑病患者随机分为试验组和对照组,试验组给予活血解毒汤治疗,对照组给予安慰剂治疗,治疗12周后,进行银屑病面积与严重性指数(PASI)评分、中医主要临床症状、皮肤病生活质量指数(DLQI)、临床疗效及安全性评价。结果试验组总有效率为86.84%,对照组总有效率为50.00%,两组总有效率相比差异有统计学意义(P0.05);治疗后试验组与对照组相比,PASI评分、DLQI评分明显降低,差异具有统计学意义(P0.05);治疗后试验组在红斑、浸润改善方面优于对照组,差异具有统计学意义(P0.05)。两组患者均无明显不良反应。结论活血解毒汤对寻常性银屑病血瘀证安全有效。     

Management of Psoriasis Vulgaris with Methotrexate 0.25% In a Hydrophilic Gel: A Placebo-Controlled, Double-Blind Study

Background: Methotrexate has been used as one of the first and systemic therapies for psoriasis. In general, 70% of patients with psoriasis prefer topical therapy as the treatment of choice. Objective: The purpose of this placebo-controlled double-blind study was to evaluate the clinical efficacy and tolerability of methotrexate 0.25% incorporated in a hydrophilic gel (hydroxyethylcellulose 1%) to treat patients afflicted with psoriasis vulgaris. Methods: Sixty patients (37M/23F) ranging between 18 and 70 years of age, with slight to moderate chronic plaque-type psoriasis and PASI (Psoriasis Area and Severity Index) scores between 5.3 and 17.5 joined the study. The mean duration of the disease at entry was 9.6 years (range 1-24 years). The diagnosis of psoriasis was established by clinical and histopathologic methods. Patients were sequentially randomized into two parallel groups. Each patient was allocated a precoded 100-g tube (active or placebo) with instructions on how to self-administer the trial medication topically (without occlusion) to their lesions two times daily for 5 consecutive days per week. The study lasted for 12 weeks with 4 weeks of active treatment. Patients were examined on a weekly basis and those showing total clearing or remission of lesions were considered effectively treated. Results: By the end of the treatment, breaking the code disclosed that methotrexate 0.25% gel had significantly treated more patients than placebo (83.3% vs. 6.7%; p < 0.0001), reduced the PASI score to a mean of 2.2, and cleared more plaques (82.2% vs. 4.3%; p < 0.0001). Laboratory evaluations, including CBC with differential and platelet count, renal function, liver chemistry [SGOT (aspartate transaminase) and SGPT (alanine transaminase)], and serum creatinine, were within the normal limits. The treatment was well-tolerated by all the patients, with no adverse drug-related symptoms and no dropouts. The study was followed up for 12 months from the first day of the treatment; two cured patients had relapsed after 8 months. Conclusion: The findings of this study demonstrate that methotrexate 0.25% in a hydrophilic gel is well tolerated and significantly more effective than placebo as a patient-applied topical medication to treat psoriasis vulgaris.     

心理治疗寻常性银屑病疗效观察

目的 观察心理治疗银屑病的疗效。方法 将277例寻常性银屑病患者随机分为试验组和对照组，试验组患者进行心理咨询治疗，应用PASI评分法判定疗效，比较两组的治疗情况及显效者的复发率。结果 试验组和对照组的显效、有效、无效例数分别为71、50；66、59；11、20，两组总有效率比较差异有显著性（P＜0．05）。对两组显效者随访1年，复发率分别为46．5％（33／71）和68．0％（34／50）,两组复发率比较差异有显著性（P＜0．05）。结论 心理咨询是控制银屑病的重要手段。     

阿维A联合窄谱中波紫外线照射治疗寻常型银屑病临床疗效分析

目的观察阿维A联合窄谱中波紫外线照射治疗寻常型银屑病临床疗效。方法治疗组口服阿维A胶囊10mg,3次/d同时窄谱中波紫外线全身照射,3次/周;对照组口服阿维A胶囊,疗程均为8周。结果治疗组有效率90.00%,对照组有效率64.28%,两组有效率差异有显著性(P<0.05)。结论阿维A联合窄谱中波紫外线照射治疗寻常型银屑病疗效好,不良反应少。