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Nanomaterials are being used in cosmetic products for various effects. However, their use also raises potential safety concerns. Some of these concerns can be addressed by determining the type of nanomaterials used, as well as stability, potential for skin absorption, route of exposure, and how they are formulated in cosmetic products. There has been considerable effort internationally to harmonize approaches in order to address definitional issues and safety concerns related to the use of nanomaterials in cosmetic products. 相似文献
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Meng-Hsuan Chung Wei-Sheng Huang Yu-Chang Chang Yu-Hsuan Chen Ming-Shin Lee Shou-Chieh Huang Yu-Pen Chen Daniel Yang-Chih Shih Hwei-Fang Cheng 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2014,22(4):399-406
The Food and Drug Administration in Taiwan is responsible for the quality regulation and control of cosmetics. In order to have a clear understanding of the trends in the product quality monitoring outcomes and the regulatory control measures over the past years, this study has put together the reports of nine cosmetic surveillance projects conducted between 1982 and 2012. The findings can be used as a reference in developing a more solid quality monitoring plan and management system for cosmetic products. Results show that permanent wave products, hair dye products, and phthalate esters in cosmetic products have the highest average noncompliance rates at 39.2%, 14.2%, and 11.2%, respectively. These are followed by the average noncompliance rates of mercury in products, sunscreen products, and microorganisms in products, at 8.5%, 7.1%, and 5.5%, respectively, and the remaining three projects averaging below 4.1%. Since 1997, when new standards were announced and assistance to manufacturers was reinforced, the noncompliance rates of permanent wave products decreased annually, until 2007, when it was fully qualified for the standards. Overall, the study showed that the noncompliance rates of permanent wave products and for levels of phthalate esters, mercury, and hydroquinone in cosmetic products have all decreased in the previous years. The results of surveillance projects conducted after 2005 revealed only one noncompliance sample with lead, arsenic, and cadmium, whereas the surveillance projects on permanent wave products and chloroform- and 1,4-dioxane-containing products revealed full compliance with regulation standards. However, the noncompliance rates for microorganisms in cosmetics and the ingredients in hair dye products and sunscreen products were still high. These high-risk products must be monitored. These surveillance projects are conducted to ensure the safety of cosmetics in the market. 相似文献
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《Toxicology mechanisms and methods》2013,23(3):112-118
The new EU legislations for cosmetics (Seventh Amendment) have laid down deadlines for the replacement of animal tests in cosmetics. This policy stimulates the acceptance of in vitro approaches to test embryotoxic potentials of compounds in cosmetics products. The embryonic stem cell test (EST) designed by The European Centre for the Validation of Alternative Methods (ECVAM) is currently the most promising in vitro assay to predict the embryotoxic potential of compounds. In this study, six selected compounds (hydroquinone, eugenol, dibutyl phthalate, antimony (III) oxide, neodymium (III) nitrate hydrate, melamine) formerly involved in cosmetic products were selected to test their embryotoxic potentials by the EST. 5-Fluorouracil and penicillin G were separately set as positive and negative control. The embryotoxic potential was determined by the prediction model (PM), which was calculated from three endpoints, the IC50 3T3, IC50 ES, and ID50. Hydroquinone, eugenol, and antimony (III) oxide indicated with strong embryotoxicity, while dibutyl phthalate, neodymium (III) nitrate hydrate, and melamine exhibited a weak embryotoxicity. These results may provide a valuable attempt to expand the application of EST to the cosmetics field. 相似文献
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《Regulatory toxicology and pharmacology : RTP》2014,68(3):447-467
The persistence of metals in the environment and their natural occurrence in rocks, soil and water cause them to be present in the manufacture of pigments and other raw materials used in the cosmetic industry. Thus, people can be exposed to metals as trace contaminants in cosmetic products they daily use. Cosmetics may have multiple forms, uses and exposure scenarios, and metals contained in them can cause skin local problems but also systemic effects after their absorption via the skin or ingestion. Even this, cosmetics companies are not obliged to report on this kind of impurities and so consumers have no way of knowing about their own risk. This paper reviewed both the concentration of metals in different types of cosmetics manufactured and sold worldwide and the data on metals’ dermal penetration and systemic toxicology. The eight metals of concern for this review were antimony (Sb), arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), mercury (Hg), nickel (Ni) and lead (Pb). This was because they are banned as intentional ingredients in cosmetics, have draft limits as potential impurities in cosmetics and are known as toxic. 相似文献
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Context: Mercury is one of the skin-lightening ingredients in cosmetics as mercury ions are thought to inhibit the synthesis of the skin pigment melanin in melanocyte cells.Objective: The objective of this study was to evaluate the mercury levels of cosmetics currently marketed in Shijiazhuang, a northern city in China.Methods: We collected 146 random cosmetic samples and analyzed for mercury concentrations or levels by cold vapor atomic absorption spectrometry.Results: Among the 146 samples, 134 (91.8%) were positive for mercury, and the concentrations of mercury ranged from not detectable to 592?ng/g. Cosmetic samples for children and babies had the highest detection rate (100%), followed by shampoo and hair conditioner (92.3%) and skin-lightening cream (92.0%). All of them were lower than the acceptable limit (1?μg/g) in China.Discussion and conclusions: Cosmetics for skin had the highest mean mercury content (45?ng/g), followed by hair products (42.1?ng/g). The concentrations of mercury detected in samples were lower than the current legal limit in China, indicating it may not pose a risk to consumers. 相似文献
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Pauline McNamee Jalila Hibatallah Margit Costabel-Farkas Carsten Goebel Daisuke Araki Eric Dufour Nicola J. Hewitt Penny Jones Annette Kirst Béatrice Le Varlet Martin Macfarlane Monique Marrec-Fairley Joanna Rowland Florian Schellauf Julia Scheel 《Regulatory toxicology and pharmacology : RTP》2009
The need for alternative approaches to replace the in vivo rabbit Draize eye test for evaluation of eye irritation of cosmetic ingredients has been recognised by the cosmetics industry for many years. Extensive research has lead to the development of several assays, some of which have undergone formal validation. Even though, to date, no single in vitro assay has been validated as a full replacement for the rabbit Draize eye test, organotypic assays are accepted for specific and limited regulatory purposes. Although not formally validated, several other in vitro models have been used for over a decade by the cosmetics industry as valuable tools in a weight of evidence approach for the safety assessment of ingredients and finished products. In light of the deadlines established in the EU Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision-tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. Furthermore, recommendations are given on how remaining data gaps and research needs can be addressed. 相似文献
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目的:探讨综合护理干预在皮肤激光美容治疗中的应用效果。方法选取2012年6月~2014年6月在本院接受激光美容手术的96例患者作为研究对象,随机分为两组。对照组给予常规护理,观察组给予综合护理干预。比较两组的焦虑评分、不良反应发生率、患者满意度评分、半年复发率。结果两组护理后的焦虑评分显著低于护理前,差异有统计学意义(P<0.05)。观察组护理后的焦虑评分显著低于对照组护理后,差异有统计学意义(P<0.05)。观察组的患者满意度评分显著高于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率、半年复发率显著低于对照组,差异有统计学意义(P<0.05)。结论综合护理干预在激光美容治疗中的应用效果显著,可显著缓解患者的焦虑情绪,降低不良反应发生率及复发率,提高护理满意度。 相似文献
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As stated in the European legislation, cosmetic products present on the European market must be safe for the consumer. Safety evaluation of the products is carried out by a qualified safety assessor who needs to consider potential exposure scenarios next to the physicochemical and toxicological profiles of all composing ingredients. Whereas, until recently, the tools to determine the toxicological profile of cosmetic ingredients mainly consisted of animal experiments, they have now been narrowed down substantially by the legally imposed animal testing ban on cosmetic ingredients, taken up in the Cosmetic Products Directive (76/768/EEC). This Directive, however, is not a stand-alone piece of European legislation, since as well directly as indirectly it is influenced by a complex web of related legislations. Vertical legislations deal with different categories of chemicals, including dangerous substances, biocides, plant protection products, food additives, medicinal products, and of course also cosmetics. Horizontal legislative texts, on the contrary, cover more general fields such as protection of experimental animals, consumer product safety, misleading of consumers, specific provisions for aerosols, and others. Experience has learnt that having a general overview of these related legislations is necessary to understand their impact on the cosmetic world in general terms and on cosmetic safety evaluation in particular. This goes for a variety of concerned parties, including national and European regulators/agencies, contract laboratories, raw material suppliers, cosmetic companies, research and educational centers. They all deal with a number of aspects important for the quality and toxicity of cosmetics and their ingredients.This review summarises the most relevant points of the legislative texts of different types of product categories and emphasises their impact on the safety evaluation of cosmetics. 相似文献
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We present a simple eco-friendly extraction-release strategy for enhancing the assessment of salicylic acid (SA) in cosmetic samples. Given that the extraction and the formation of mixed metal hydroxides (MMHs) acting as sorbent occurred at the same time, the in situ solid phase extraction (is-SPE) of SA was achieved by mixing magnesium and aluminium ions in an alkaline sample solution. After the is-SPE, the MMHs precipitates were isolated by centrifugation and dissolved completely in sulfuric acid. Subsequently, the released SA was quantified by spectrophotometry at 237 nm. The is-SPE parameters including the amount of hydroxide ions, amount of metal ions, extraction time, and centrifugation time were studied thoroughly. Under the optimized conditions, this method provided the linear range of 0.15–2 mg L?1 with the relative standard deviations of less than 7.20% and the limit of detection of 45 μg L?1. In addition, the proposed method was successfully applied for SA analysis in toner, foam, and serum samples with reasonable relative recoveries in the range of 76.3–100.3%. This method eliminated the use of organic solvents and avoided the synthesis step of sorbents as well as their characterization, thus saving time, chemicals, and energy. 相似文献
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Natural substances are frequently used ingredients in personal care products. As the discharge of rinse-off products, like shampoos or soap, is mainly via the aquatic environment, the question is, whether these natural substances pose an environmental risk. More than a quarter of the natural substances which are listed in the “Inventory …… of ingredients employed in cosmetic products” (INCI list) are classified as dangerous for the environment with long lasting effects according to the European regulation on classification and labelling, e.g. various Citrus preparations, Cupressus sempervirens extract, Picea excelsa extract or Pinus sylvestris leaf extract. Some of the components responsible for the classification of natural substances as dangerous for the environment are e.g. limonene, pinenes or benzyl benzoate. Classification and labelling is a trigger for the registration requirements for natural substances according to the European regulation on chemicals (REACH), but so far only 5% of natural substances classified are registered. It must be assumed that there are more substances that should undergo the REACH process among the 703 natural substances that do not yet turn up in the data base of substances classified and labelled as hazardous (C&L inventory). Natural substances and personal care products receive special treatments in the European chemical legislation. The compilation of the classifications might question whether this special treatment is justified. 相似文献
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目的 探索《化妆品分类规范》中的分层分类方法在化妆品检验结果分析中的提示作用。方法 按《化妆品分类规范》对2012年至2017年企业委托的行政许可检验化妆品进行分层分类,并对不同类别化妆品检验结果进行分析。结果 滋养类和膏霜剂型产品送检量最多,宣称修复功能、油剂类产品的不合格率最高,膏霜剂型、保湿功能产品不合格批次最多。微生物不合格产品水剂较多,毒理学不合格主要是油剂类和膏霜乳液类产品。结论 新分层分类方法更利于追溯化妆品的安全风险点,在化妆品监管过程中,可根据不同剂型、功能宣称、使用部位、适用人群化妆品的不合格风险差别,指导监管重点以及监督检验项目的制定。 相似文献
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We have introduced the 3T3 NRU cytotoxicity test for methodological, economical and ethical reasons as a regular part of tier pre-marketing testing to assess local tolerance of raw materials for cosmetics, household chemicals and final cosmetic products. Using the 3T3 cell line according to the standard INVITTOX protocol No.64 (NRU Assay) the borderline concentration, relevant to the highest tolerated dose, is determined for each material. The toxic effect is reached at different concentration levels specific for individual cosmetics categories, depending on their chemical characteristics. Typical ranges of cytotoxicity for specific categories of cosmetics were established after testing of hundreds of materials. The range lies between 1 μg/ml (anti-dandruff shampoos), up to 2000 μg/ml (toothpastes and mouthwashes). The 3T3 NRU cytotoxicity test is a sensitive tool able to identify more agressive products, that are also more likely to evoke irritation in human skin. It was even possible to detect protective effects of one natural herbal ingredient. The comparative study of cytotoxicity test results and human patch test results from a group of essential oils is presented. Cytotoxicity tests represent a highly ethical approach for estimation of irritancy. On the basis of in vitro test results suggesting low risk we can proceed to confirmatory tests in human volunteers. 相似文献
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Martin Macfarlane Penny Jones Carsten Goebel Eric Dufour Joanna Rowland Daisuke Araki Margit Costabel-Farkas Nicola J. Hewitt Jalila Hibatallah Annette Kirst Pauline McNamee Florian Schellauf Julia Scheel 《Regulatory toxicology and pharmacology : RTP》2009
Evaluation of the skin irritancy and corrosivity potential of an ingredient is a necessity in the safety assessment of cosmetic ingredients. To date, there are two formally validated alternatives to the rabbit Draize test for skin corrosivity in place, namely the rat skin transcutaneous electrical resistance (TER) assay and the Human Skin Model Test using EpiSkin™, EpiDerm™ and SkinEthic™ reconstructed human epidermal equivalents. For skin irritation, EpiSkin™, EpiDerm™ and SkinEthic™ are validated as stand-alone test replacements for the rabbit Draize test. Data from these tests are rarely considered in isolation and are evaluated in combination with other factors to establish the overall irritating or corrosive potential of an ingredient. In light of the deadlines established in the Cosmetics Directive for cessation of animal testing for cosmetic ingredients, a COLIPA scientific meeting was held in Brussels on 30th January, 2008 to review the use of alternative approaches and to set up a decision tree approach for their integration into tiered testing strategies for hazard and safety assessment of cosmetic ingredients and their use in products. In conclusion, the safety assessments for skin irritation/corrosion of new chemicals for use in cosmetics can be confidently accomplished using exclusively alternative methods. 相似文献
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Chia-Hui Lu Ming-Chih Fang Yu-Zi Chen Shou-Chieh Huang Der-Yuan Wang 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2021,29(4):700
Fragrances are the most common chemicals in cosmetics to which people expose every day. However, the unwanted allergic reactions such as contact dermatitis caused by direct contact with fragrances may happen. In Directive 2003/15/EC of the EU, cosmetic product containing one or more of 26 fragrance allergens must be declared on the package label. In addition, commission regulation (EU) 2017/1410 amending Annexes II and III of cosmetic regulation 1223/2009 restricted fragrance chemical of methyl eugenol, and prohibited Lyral, atranol, chloroatranol to be used in cosmetic. In this study, an efficient and sensitive GC–MS method for 3 banned fragrances, 26 fragrance allergens along with restricted methyl eugenol in cosmetics was established. Sample preparation by liquid–liquid extraction was developed by testing various solvent systems to simplify traditional complex extraction methodologies. Validation of the proposed method showed good linearities in a wide concentration ranges of 0.1–10 μg/mL. The intra-day and inter-day recoveries were between 84.4 and 119% with coefficient of variation (CV) below 13.5%. The limit of quantifications (LOQs) of 27 fragrance allergens were in the range of 2–20 μg/g. A surveillance study consisted with 82 cosmetics was conducted, among which 31 products claimed fragrance-free. The results showed some fragrance-free claims were false. In the other hand, there were seven cosmetics labeled containing Lyral, but only four were detected. The top fragrance allergens detected in the samples were linalool, limonene, and geraniol. The analysis of fragrance allergens in cosmetics indicated that potential contact allergy related to these products should be considered, even though some fragrance allergens were from natural extracts, such as oak moss absolute. 相似文献