共查询到20条相似文献,搜索用时 15 毫秒
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Fiona C. Malcomson BSc MRes PhD Christopher Wiggins BSc MRes Solange Parra-Soto BSc MSc Frederick K. Ho BSc PhD Carlos Celis-Morales BSc PhD Linda Sharp BSc MSc PhD John C. Mathers BSc Dip. Nutr. PhD 《Cancer》2023,129(17):2655-2670
Background
The World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations are lifestyle-based guidelines that aim to reduce cancer risk. A systematic review and meta-analysis of studies investigating associations between a score for adherence to the 2018 Cancer Prevention Recommendations and cancer risk was conducted.Methods
MEDLINE, Embase, Web of Science, and Scopus were searched for studies published to November 28, 2022. In meta-analysis, the estimated risk ratios and 95% CIs for adherence score as a continuous (per 1-point increment) and categorical (highest vs. lowest score category) variable using random-effects models were estimated.Results
Eighteen studies (11 cohort; seven case-control) were included investigating incidence of breast (n = 7), colorectal (n = 5), prostate (n = 2), lung (n = 2), pancreatic (n = 1), endometrial (n = 1), unknown primary cancer (n = 1), chronic lymphocytic leukemia (n = 1), and overall (any) cancer (n = 1). The summary risk ratio per 1-point increment in adherence score was 0.89 (95% CI, 0.85–0.93; I2 = 76.5%; n = 7) for breast cancer, 0.88 (95% CI, 0.84–0.91; I2 = 26.2%; n = 4) for colorectal cancer, and 0.92 (95% CI, 0.86–0.98, I2 = 66.0%; n = 2) for lung cancer. There were no significant associations with prostate or other cancers. Meta-analysis results using categorical adherence score variables were consistent with these findings.Conclusions
Greater adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations was associated with lower risk of breast, colorectal, and lung cancers. Future studies investigating associations with risk of other forms of cancer are warranted.PROSPERO registration number
CRD42022313327. 相似文献4.
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《Psycho-oncology》2018,27(7):1735-1741
Objective
Depression is common among patients diagnosed with cancer. Patients with cancer and depression use more health care services compared with nondepressed cancer patients. The current study seeks to estimate the added cost of depression in cancer patients in the first year after cancer diagnosis.Methods
Health care charges were obtained for 2051 depressed and 11 182 nondepressed patients with an International Classification of Diseases, Ninth Revision, diagnosis of cancer in the 2014 calendar year from the University of California San Diego Healthcare System. The annual health care charges for cancer patients with and without depression were analyzed using generalized linear models with a log‐link function and gamma distribution, covarying for age, sex, race/ethnicity, comorbid diseases, and presence of metastatic disease. Total cost data were broken down into several categories including ambulatory care, emergency department visits, and hospital visits.Results
Depressed cancer patients had total annual health care charges that were 113% higher than nondepressed cancer patients (B = 0.76; P < .001). The estimated mean charges for depressed patients were $235 337 compared with $110 650 for nondepressed patients. Depressed cancer patients incurred greater charges than nondepressed patients in ambulatory care (B = 0.70; P < .001), emergency department charges (B = 0.31; P < .001), and hospital charges (B = 0.39; P < .001).Conclusions
Depressed cancer patients incur significantly higher health care charges across multiple cost categories including ambulatory care, emergency department visits, and hospital visits. Future research should investigate if interventions for detecting and treating depression are effective for reducing health care use and costs in cancer patients.6.
Objective
To observe anti-tumor eff ects of PVAX-PSMA gene vaccine. 相似文献7.
Takahiro Nakajima Makoto Suzuki Soichiro Ando Tomohiko Iida Akinobu Araki Takehiko Fujisawa Hideki Kimura 《BMC cancer》2006,6(1):11-5
Background
Spontaneous regression of metastatic renal cell carcinoma is rarely observed. 相似文献8.
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Trinh XB van Dam PA Vermeulen PB Van Laere SJ Van den Eynden GG Tjalma WA Dirix LY 《Clinical & translational oncology》2011,13(11):805-808
Background
The mechanisms of tumour progression during anti-VEGF-A treatment are poorly understood. 相似文献10.
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Marnita L Benford Tiva T VanCleave Nicole A Lavender Rick A Kittles LaCreis R Kidd 《BMC cancer》2010,10(1):334
Background
Human chromosome 8q24 has been implicated in prostate tumorigenesis. 相似文献12.
Zeynep Eroglu MD Shifra Krinshpun MS LCGC Ekaterina Kalashnikova PhD Sumedha Sudhaman PhD Turkan Ozturk Topcu MD Matt Nichols BS Justin Martin MS Katherine M. Bui MD Charuta C. Palsuledesai PhD Meenakshi Malhotra PhD Perry Olshan MA PhD Joseph Markowitz MD PhD Nikhil I. Khushalani MD Ahmad A. Tarhini MD PhD Jane L. Messina MD Alexey Aleshin MD MBA 《Cancer》2023,129(11):1723-1734
Background
Immune checkpoint inhibitors (ICIs) have substantially improved overall survival in patients with advanced melanoma; however, the lack of biomarkers to monitor treatment response and relapse remains an important clinical challenge. Thus, a reliable biomarker is needed that can risk-stratify patients for disease recurrence and predict response to treatment.Methods
A retrospective analysis using a personalized, tumor-informed circulating tumor DNA (ctDNA) assay on prospectively collected plasma samples (n = 555) from 69 patients with advanced melanoma was performed. Patients were divided into three cohorts: cohort A (N = 30), stage III patients receiving adjuvant ICI/observation; cohort B (N = 29), unresectable stage III/IV patients receiving ICI therapy; and cohort C (N = 10), stage III/IV patients on surveillance after planned completion of ICI therapy for metastatic disease.Results
In cohort A, compared to molecular residual disease (MRD)-negative patients, MRD-positivity was associated with significantly shorter distant metastasis-free survival (DMFS; hazard ratio [HR], 10.77; p = .01). Increasing ctDNA levels from the post-surgical or pre-treatment time point to after 6 weeks of ICI were predictive of shorter DMFS in cohort A (HR, 34.54; p < .0001) and shorter progression-free survival (PFS) in cohort B (HR, 22; p = .006). In cohort C, all ctDNA-negative patients remained progression-free for a median follow-up of 14.67 months, whereas ctDNA-positive patients experienced disease progression.Conclusion
Personalized and tumor-informed longitudinal ctDNA monitoring is a valuable prognostic and predictive tool that may be used throughout the clinical course of patients with advanced melanoma. 相似文献13.
Infante JR Jones SF Bendell JC Greco FA Yardley DA Lane CM Spigel DR Hainsworth JD Burris HA 《Cancer chemotherapy and pharmacology》2012,69(1):137-144
Purpose
To address tolerability and a possible pharmacologic interaction of capecitabine with sorafenib. 相似文献14.
Khaled Kasim Kenneth C. Johnson Patrick Levallois Belkacem Abdous Pierre Auger 《Cancer causes & control : CCC》2009,20(8):1377-1386
Objective
To examine the association between adult onset leukemia and recreational physical activity. 相似文献15.
Lebedinsky C Gómez J Park YC Nieto A Soto-Matos A Parekh T Alfaro V Roy E Lardelli P Kahatt C 《Cancer chemotherapy and pharmacology》2011,68(5):1223-1231
Purpose
This analysis provides a cross-study evaluation of the cardiac safety of trabectedin. 相似文献16.
Michael F. Leitzmann Andrew Flood Leah M. Ferrucci Philip Schoenfeld Brooks Cash Arthur Schatzkin Amanda J. Cross 《Cancer causes & control : CCC》2009,20(8):1497-1507
Objective
To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps. 相似文献17.
Jo Taylor Elizabeth A. Fradgley Tara Clinton-McHarg Alix Hall Christine L. Paul 《Asia-Pacific Journal of Clinical Oncology》2023,19(6):681-689
Introduction
Emotional support provided by health care professionals (HCPs) for people diagnosed with cancer is associated with improved outcomes. Support via social networks may also be important.Aims
To report among a sample of distressed patients and caregivers, (1) the importance attributed to different sources of emotional support (HCPs and social networks) by distressed cancer patients and caregivers; (2) the proportion who indicate they did not receive sufficient levels of emotional support; and (3) potential associations between respondents’ demographic and clinical characteristics and reported lack of emotional support.Methods
This study utilised cross-sectional data from telephone interviews collected during the usual-care phase of the Structured Triage and Referral by Telephone (START) trial. Participants completed a telephone interview 6 months after their initial call to the Cancer Council Information and Support service and included recall of importance and sufficiency of emotional support.Results
More than two-thirds of patients (n = 234) and caregivers (n = 152) reported that family and friends were very important sources of emotional support. Nurses (69% and 42%) and doctors (68% and 47%) were reported very important, while a lower proportion reported that psychologists and psychiatrists were very important (39%, and 43%). Insufficient levels of support were reported by 36% of participants. Perceptions of insufficient support were significantly associated with distress levels (p < .0001) and not having a partner (p = .0115).Conclusion
Social networks, particularly family, are an important source of emotional support. Higher levels of distress, those without partners, and caregivers may require targeted interventions to increase their access to emotional support. 相似文献18.
Renaud Sabatier Corinne Bouvier Gonzague de Pinieux Anthony Sarran Isabelle Brenot-Rossi Florence Pedeutour Bruno Chetaille Patrice Viens Pierre-Jean Weiller François Bertucci 《BMC cancer》2010,10(1):645
Background
Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare. 相似文献19.
OBJECTIVE To evaluate the MR imaging features of solitary plasmacytomas of the spine. METHODS The MR images of 7 patients with histologically proven solitary plasmacytomas of the spine were reviewed. RESULTS All tumors showed predominantly isoto hypointensity relative to muscle on Tl-weighted MR images and intermediate signal intensity between muscle and fat on T2- weighted images. Curvilinear low signal intensity structures were seen within the lesions on T1 and T2-weighted images in five tumors. Moderate to strong enhancement was seen in all 6 tumors that underwent contrast enhanced MR examination. All tumors showed areas of high signal intensity on T2-weighted images and heterogeneous enhancement, except the 2 largest tumors without pathologic fracture in the sacrum. Intervertebral discs were preserved in all tumors. CONCLUSION The MR imaging features that suggest plasmacytorna of the spine include predominant intermediate signal intensity on T2-weighted images, curvilinear low signal intensity structures, moderate to strong enhancement, relatively homogeneous appearance if there are no pathologic fracture and preservation of the intervertebral discs. 相似文献
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