胸骨病变CT引导下经皮穿刺活检

目的 评价CT引导下经皮穿刺活检在胸骨病变中的诊断价值.方法 CT引导下经皮穿刺活检胸骨病变36例,局麻下操作,经病变前方进针.结果 36例穿刺活检成功,35例(97.2%)获得病理诊断;1例穿刺获取组织不足病理检查所需.36例中30例有手术病理结果,29例手术结果和穿刺结果相符,1例不相符,另6例转移瘤找到原发病灶而未手术.CT引导下经皮穿刺活检胸骨病变其组织学定性的符合率为97.2%,均未见严重并发症.结论 CT引导下经皮穿刺活检在胸骨病变的应用中安全可靠,并发症少,可得到明确的病理诊断,为临床制订治疗方案提供依据.     

骨骼肌肉恶性肿瘤病变CT引导下经皮穿刺活检正确性分析

目的 探讨CT导引下经皮穿刺活检对骨骼肌肉恶性肿瘤性疾病的诊断价值.方法 106例骨骼肌肉病变行CT导引下经皮穿刺活检,对比穿刺病理结果与临床诊断最终结果.结果 106例CT导引下经皮骨骼肌肉穿刺活检病例,经临床手术及切开活检病理结果全部为恶性肿瘤病变,其中89例病理结果与CT导引下经皮穿刺活枪结果相符,17例CT导引下穿刺活检病理结果为"阴性".活检正确率84.0%;结论CT导引下经皮穿刺对骨骼肌肉恶性肿瘤性病变是安全、简便、有效的诊断手段,对于活检结果为"阴性"的病例适时的切开活检可能是必要的.     

超声引导穿刺活检和增强CT对AFP阴性肝脏占位性病变的诊断分析

目的探讨超声引导下经皮穿刺活检和增强CT对甲胎蛋白(AFP)阴性肝脏占位性病变的诊断价值。方法选取本院诊治的AFP阴性肝脏占位性病变患者108例为研究对象,在超声引导下穿刺活组织检查,比较CT增强对AFP阴性肝脏占位性病变的诊断结果与病理学检查标准之间的差异,分析其诊断价值。结果 108例患者行经皮穿刺活检病理学检查结果发现,恶性病变的有74例,良性病变的有34例。超声引导下穿刺活检病理学检查的灵敏度、特异度均为100%,增强CT为89.19%、82.35%。结论超声引导下经皮肝脏穿刺活组织检查对AFP阴性肝占位性病变具有操作简单、安全性高,适宜临床应用。     

CT引导胸壁病变穿刺活检的临床应用研究

目的探讨CT引导经皮胸壁穿刺活检对不明原因胸壁病变的诊断价值和并发症。方法选择2013年3月至2014年12月,我院收治的19例不明原因胸壁病变的患者进行CT引导下经皮穿刺活检的临床资料进行分析总结,并结合文献进行复习。结果 19例患者全部穿刺成功并明确诊断,穿刺成功率100%。其中胸壁恶性肿瘤16例(84%),良性病变3例(16%)。在13例胸壁软组织病变中,转移性肺癌4例,浆细胞性骨髓瘤3例,转移性乳腺癌2例,肉瘤1例,恶性神经鞘瘤1例,良性神经鞘瘤1例,结核1例。在6例肋骨病变中,转移性肺癌2例,浆细胞性骨髓瘤2例,侵袭性骨母细胞瘤1例,肋骨结核1例。总的并发症发生率为11%(2/19),其中胸壁出血1例,气胸1例,症状均较轻微。结论 CT引导经皮胸壁穿刺活检对不明原因胸壁病变确诊率高、安全、并发症少而轻微,是临床上一种比较实用的微创检查技术。     

CT引导下经皮穿刺活检对肝部恶性肿瘤的诊断价值分析

目的探讨分析CT引导下经皮穿刺活检对肝部恶性肿瘤的诊断价值。方法收集接受CT引导下经皮穿刺活检,且经病理证实的120例肝脏恶性肿瘤患者的临床资料,统计穿刺成功率、穿刺并发症发生情况及与病理诊断符合情况。结果 120例患者1次定位成功率98.33%,1次穿刺活检成功率为95.83%;穿刺后穿刺部位出现轻度疼痛41例,2例低热,2例肝包膜少量出血;120例中经皮穿刺活检确诊为肝脏恶性病变108例,病理阴性12例,但经术后证实1例为肝细胞肝癌,3例为腺癌,2例为未分化癌,1例为神经内分泌癌,1例为鳞癌,1例为小细胞癌,3例为未分类癌,经皮穿刺活检与手术病理及随访结果符合度为90.00%。结论 CT引导下经皮穿刺活检诊断肝部恶性肿瘤与手术病理符合度高,定位及穿刺成功率高。     

CT引导下经皮肺穿刺活检对肺部病变的诊断价值

目的 探讨CT引导下经皮肺穿刺活检的效果及临床价值.方法 回顾性分析60例行CT引导下经皮肺穿刺活检术患者的临床与影像资料.结果 60例患者中,57例经病理明确诊断,其中原发性肺癌47例(腺癌21例,鳞癌18例,小细胞癌3例,肺泡癌5例),转移性肺癌7例,结核3例.3例病理报告为慢性炎症,未做出明确诊断, 术后病理证实干酪性肺炎2例,真菌感染1例.60例患者穿刺成功率100.0%,诊断准确率95.0%,并发症发生率21.7%(气胸7例,占11.7%,出血5例,占8.3%,针道出血1例,占1.7%).结论 CT引导下经皮肺穿刺活检术是一种安全、准确、有较高临床应用价值的诊断和鉴别肺内病变的方法.     

CT引导下经皮穿刺同轴活检术对肺部空洞性病变的诊断价值

目的 评价CT引导下经皮穿刺同轴活检术对肺部空洞性病变的诊断价值.方法 回顾性分析因肺部空洞性病变而于本院行CT引导下经皮穿刺同轴活检术患者的相关临床资料(n=48).根据病变大小(A1 ＜20 mm,n=12;B1≥20 mm,n=36),针道距离(A2＜5 cm,n=33;B2≥5 cm,n=15),空洞壁厚度(A3＜5 mm,n=18;B3≥5 mm,n=30)将其分为A、B2组.分别计算A、B2组的敏感性、特异性及准确性,并采用Fisher's确切概率法比较其差异是否有统计学意义.结果 病理诊断恶性病变38例,良性病变7例.CT引导下经皮穿刺同轴活检术对肺部空洞性病变的敏感性、特异性及准确性分别为95％、87.5％、93.8％.对于不同大小、不同针道距离以及空洞壁厚度不同的病变,其诊断准确性差异均无统计学意义(P＞0.05).结论 对于肺部空洞性病变的诊断,CT引导下经皮穿刺同轴活检术具有较高的灵敏度、特异度和准确率,其准确性与病变大小、针道的距离以及空洞壁厚度无关.     

CT引导下经皮椎体病变穿刺活检的临床研究

目的评价CT引导下经皮椎体病变穿刺活检的成功率、诊断正确性及临床应用价值。方法85例椎体病变患者经皮穿刺活检,病变位于颈椎3例,胸椎26例,腰椎37例和骶椎19例。影像学上表现57例为溶骨性病变,19例成骨性病变,9例溶骨性与成骨性病变共存。穿刺标本行细胞学及组织学检查。临床怀疑感染性病变时行细菌学检查。对穿刺标本进行诊断的正确性分析。结果CT证实85例穿刺活检针均位于病灶内,81例取得病变组织,活检成功率95%。活检标本包括29例骨组织标本,5例软组织标本,47例骨组织与软组织混合标本,4例未取得标本;病理结果包括44例转移瘤,17例原发性骨肿瘤,18例感染性病变,2例正常椎体组织。79例诊断正确,诊断正确性97.5%。结论CT引导下经皮椎体病变穿刺活检是对椎体病变作出正确诊断的重要手段,为临床提供了可靠的组织学依据,且穿刺部位正确、三维定向好、损伤小,可以作为诊断不明确的溶骨性及溶骨与成骨混合性椎体病变拟行椎体成形术术前常规。     

CT导引下3 cm以下肺结节切割针活检的价值

目的评价多排螺旋CT引导下经皮肺切割针活检直径≤3 cm肺结节的价值.方法 CT引导下经皮肺穿刺活检肺部病灶直径≤3 cm结节81例,用意大利或美国20 G活检针对病灶至少穿刺取材2次.结果肺结节穿刺准确率达100%,病理证实恶性病灶56例,良性病灶24例;其中结节太小取材少不能定性1例,诊断准确率为98.76%.并发症中发生气胸12例(14.81%)、咯血15例(18.52%),穿刺针通过肺大泡而没有引起气胸1例,无严重并发症发生.结论 CT引导经皮穿刺直径≤3 cm肺部结节活检的准确性高且发生并发症较低,可作为肺内3 cm以下孤立性结节灶在临床治疗前病理诊断的首选方法.     

骨肿瘤及肿瘤样病变CT引导下穿刺活检与手术病理对照研究

目的CT引导下经皮穿刺活检骨肿瘤及肿瘤样病变与手术病理对照研究,评价CT引导下穿刺活检术的诊断价值。方法CT引导下经皮穿刺活检骨骼病变,选择其中经手术病理诊断为骨肿瘤或肿瘤样病变的病例362例,将2种方法进行对照。结果362例穿刺针均在位,穿刺均获成功,并获得穿刺病理诊断及手术病理诊断,其中285例穿刺结果与手术病理相符,77例不相符,其组织学定性的准确率为78.7%（285/362）。结论CT引导下经皮穿刺活检对于骨肿瘤及肿瘤样病变的诊断具有重要临床应用价值,是安全有效的检查方法。但是实际工作中应该采取临床、影像和病理相结合的科学分析。     

直径3cm以下肺孤立性病灶的CT引导下经皮肺穿刺活检

目的:评价直径3cm以下肺孤立性病灶的CT引导下经皮肺穿刺活检的价值。方法:68例直径3cm以下肺孤立性病灶在CT引导下,采用抽吸式活检针,选择最佳穿刺层面及穿刺点获取标本。结果:本组病例共行84次穿刺活检,获得细胞学涂片检查者68例,获得组织学检查59例。总的诊断准确度为89.7%,其中细胞学和组织学标本诊断准确度分别为662%(45/68)和81.4%(48/59)。阳性预告值和阴性预告值分别为100%(51/51)和58.8%(10/17)。并发症:气胸16例(23.5%),出血5例(7.4%),咯血4例(5.9%)。结论:CT引导下经皮肺穿刺活检是一种创伤小而实用的定性诊断方法,对直径3cm以下肺孤立性病灶的诊断具有较高的临床应用价值。     

CT导引四肢骨活检的价值(附50例报告)

目的　报告应用CT导引活检在四肢骨病变诊断中的方法和作用。方法　对 5 0例四肢骨病变行CT导引下活检。每例常规取样 2～ 3次。对 13例灶区或灶周硬化明显者应用了Ackmann骨钻针 ,对 42例应用了Temno核心切割针 ,12例囊性或有明显液化区的病灶则加用了细抽吸针。结果　活检的诊断准确率 88%( 4 4/5 0 )。 6例假阴性者的病灶特征包括 3例增生硬化性病灶 ,2例液化性及 1例混合性病灶。 5 0例可以分为原发恶性骨肿瘤 (n =2 3) ,原发良性骨肿瘤及肿瘤样病变 (n =12 ) ,骨转移 (n =8)及骨感染 (n =7)四类 ,其活检准确率分别为 91%、83%、10 0 %和 71%。Ackmann骨钻针、Temno核心切割针及细抽吸针的活检准确率分别为6 2 %、83%和 5 8%。未发生严重并发症。结论　CT导引下四肢骨活检是一种安全、准确而有效的方法。根据病变类型选用骨钻针、核心切割针或细抽吸针 ,并注意避开坏死区及多靶点取样 ,三种活检针的取样结果有互补性 ,合理联合使用可以提高诊断准确率。     

CT-guided needle biopsy of the lung: factors affecting risk of complications

PURPOSE: To analyze factors influencing the risk of complications associated with CT-guided percutaneous needle biopsy for lung lesions. MATERIALS AND METHODS: Sixty patients, aged 24-85 years (37 men and 23 women), underwent CT-guided needle biopsy. A definite diagnosis was made in 49 of 60 cases (81.7%), including 38 of 43 malignant lesions (88.4%) and 11 of 17 benign lesions (64.7%). Complications associated with biopsy were observed in 35 patients (58.3%). Major complications included pneumothorax (n = 26) and pulmonary hemorrhage (n = 20). Chest tube placement was needed in 5 (19.2%) of 26 pneumothorax cases (8.3% of all biopsies). RESULTS: The high frequency of pneumothorax (43.3%) in this series had several contributing factors, including the presence of pulmonary emphysema, lesion size, and traversal of aerated lung. Chest tube replacement was necessary more frequently in patients with pulmonary emphysema. The number of pleural passes, location of lesions, and size of needles were not correlated with the incidence of pneumothorax. CONCLUSION: The presence of pulmonary emphysema, lesion size, and traversal of aerated lung are the predominant risk factors for pneumothorax in patients with CT-guided lung biopsy.     

膈顶部肝脏病变CT引导下切割针活检的准确性和安全性

目的评价膈顶部肝脏病变CT引导下切割针活检的准确性和安全性。方法25例患者在CT引导下用16 G或18 G切割针进行穿刺活检。结果组织学检查恶性病变17例,良性病变8例。总体检查假阴性2例(8%),未发现假阳性,恶性病变和良性病变诊断特异度分别为100%和75%,诊断总准确率92%。并发气胸者2例(8%);1例出现针道出血(4%),1例出现肝包膜下出血(4%)。结论CT引导下膈顶部肝脏病变切割针活检是一种可靠和相对安全的诊断方法。     

CT引导下经皮穿刺活检在骨骼病变中的应用价值

目的：评价CT引导下经皮穿刺活检在骨骼病变中的诊断价值。方法：对108例骨骼病变行CT引导下活检,每例常规取材2～3次,其中62例病灶区域灶周硬化明显者采用Ackermann骨钻针,35例破坏灶或有明显骨皮质薄弱区者采用切割式活检针,11例有明显灶区液化者采用抽吸式活橙针。结果：108例中102例获得病理诊断,穿刺活检取材阳性率为94．3％,其中97例穿刺结果与手术病理结果相符、5例不相符,其组织学定性诊断符合率为95．0％。6例假阴性者包括4例增生硬化性病灶、2例为液化灶。结论：CT引导下经皮穿刺活检在骨骼病变中的应用安全可靠,并发症少,可得到准确的病理诊断。     

Freehand Two-Step CT-Guided Brain Tumor Biopsy: A Fast and Effective Interventional Procedure in Selected Patients

Purpose To evaluate the efficacy and safety of CT-guided needle biopsy of brain lesions without a stereotactic device, and to determine the best possible indications for this technique. Methods From February 2001 to February 2004, 20 patients (12 men, 8 women; age 61–82 years) underwent CT-guided brain lesion biopsy. The procedure started with a brain CT scan for lesion localization and for selection of the inlet for needle insertion. The patient was then transported to the operating room where cranioanatrisis was performed. Subsequently, the biopsy was performed under CT guidance using a 14G brain biopsy needle with a blind smooth end and lateral holes. At the end of the biopsy, the field was checked for possible complications with a CT scan. Results Histopathologic results were: brain tumor in 16 patients (80%), inflammatory process in 3 (15%), and no conclusive diagnosis in 1 (5%). A repeat of the process was required in 2 patients. A minor complication of local hematoma was found in 1 patient (5%). There were no deaths or other serious complications. Conclusion CT-guided biopsy is a reliable method for histopathologic diagnosis of brain lesions in selected cases. It is a simple, fast, effective, low-cost procedure with minimal complications, indicated especially for superficial and large tumors.     

Clinical Value of CT-Guided Needle Biopsy for Retroperitoneal Lesions

Objective

The purpose of this study was to investigate retrospectively the clinical procedural performance of CT-guided needle biopsy for retroperitoneal lesions.

Materials and Methods

CT-guided needle biopsy was performed in 74 consecutive patients (M:F = 44:30; mean age, 59.7 years) with retroperitoneal lesions between April 1998 and June 2009. The target lesion ranged from 1.5 to 12.5 cm in size. The biopsy access path ranged from 3.5 to 11.5 cm in depth. A biopsy specimen was obtained using an 18-gauge core needle under a CT or CT-fluoroscopy guidance and with the patient under local anesthesia. The histopathological diagnoses from the biopsies were obtained. The diagnostic confirmation of the subtype of lymphoma was evaluated.

Results

Satisfactory biopsy samples were obtained in 73 (99%) of 74 patients and a pathological diagnosis was made in 70 (95%) of 74 patients. Sixty three lesions were malignant (45 lymphomas, nine primary tumors, nine lymph node metastases) and seven were benign. The subtype of lymphoma was specified in 43 (96%) of 45 patients who were diagnosed with lymphoma. Analysis of the value of CT-guided biopsy in this series indicated 63 true positives, zero false positive, six true negatives and five false negatives. This test had a sensitivity of 93%, a specificity of 100% and an accuracy of 93%. No major complications were seen and minor complications were noted in seven patients (five with local hematomas, two with transient pain at the puncture site).

Conclusion

CT-guided needle biopsy for retroperitoneal lesions is highly practical and useful, and particularly for determining the subtypes in patients with lymphoma.     

CT-guided aspiration core needle biopsy of gastrointestinal wall lesions

PURPOSE: The purpose of this work was to examine the accuracy and safety of CT-guided core biopsy of gastrointestinal wall lesions. METHOD: We reviewed over 1,200 CT-guided abdominal core biopsy results from 1989 through 1998. Forty-five were from gastrointestinal wall lesions (16 gastric, 3 duodenal, 7 small intestine, and 19 colon). RESULTS: A definitive histologic diagnosis was obtained from the core biopsy in 41 patients (91%) without complication. The gastric lesion diagnoses were mesenchymal tumor of smooth muscle origin (eight), lymphoma (one), adenocarcinoma (three), and normal (one). Duodenal core biopsy diagnoses were inflammation (one) and normal (one). Small intestinal core biopsy diagnoses were non-Hodgkin lymphoma (four), metastatic leiomyosarcoma (one), carcinoma (one), and tuberculosis (one). Colon core biopsy diagnoses were carcinoma (11), lymphoma (2), actinomycosis (2), granulomatous inflammation (1), metastatic squamous cell carcinoma (1), chronic abscess (1), and mesenchymal tumor of smooth muscle origin (1). CONCLUSION: Percutaneous CT-guided core needle biopsy from gastrointestinal wall lesions is safe and accurate, especially in submucosal lesions, and should be considered in selected cases with negative endoscopic biopsy or in which endoscopic biopsy is not possible.     

CT引导下肺内孤立性病变经皮穿刺活检并发症的分析

目的分析肺外围型孤立病变CT引导下经皮穿刺活检并发症的原因。方法选取2002-10～2004-10连续2年内的所有肺内外围型孤立病变行CT引导下肺穿刺活检的患者71例,回顾性研究总结穿刺活检的并发症发生率与年龄、性别、穿刺针所经肺组织深度、肿块周围有无肺气肿表现、穿刺的次数、穿刺针的粗细等几个方面的关系。结果并发症共26例次,气胸3例(4.23%),肺内出血9例(12.67%),出现血痰或血痰加重13例(18.3%),胸膜反应1例(1.41%)。经统计学分析,并发症的发生与穿刺针所经肺组织深度、病变周围肺气肿及穿刺次数和穿刺针的粗细有明显的相关性。结论CT引导下肺内病变经皮穿刺活检并发症以血痰最常见。病灶离胸膜的间距、病灶周围肺气肿、穿刺次数及穿刺针粗细是经皮穿刺肺活检并发症的危险因素。     

Factors affecting diagnostic accuracy of CT-guided coaxial cutting needle lung biopsy: retrospective analysis of 631 procedures

PURPOSE: To analyze variables affecting diagnostic accuracy of computed tomography (CT)-guided percutaneous coaxial cutting needle biopsy of lung lesions. MATERIALS AND METHODS: A retrospective analysis of factors affecting diagnostic accuracy of CT-guided percutaneous coaxial cutting needle lung biopsy was performed in 631 consecutive procedures with confirmed final diagnoses. Benign and malignant needle biopsy results were cross-examined with correct and incorrect final outcomes to determine diagnostic accuracy. Factors affecting diagnostic accuracy were determined by multivariate logistic regression analysis of variables thought to affect diagnostic accuracy. A P value less than 0.05 was interpreted as statistically significant. RESULTS: The overall diagnostic accuracy of CT-guided percutaneous coaxial cutting needle biopsy of lung lesions was 95% (95% CI: 92.7%-96.2%). Sensitivity was 93%, specificity 98%, negative predictive value 6%, positive predictive value 99%, false-positive rate 0.7%, and false-negative rate 15%. The factors affecting diagnostic accuracy were final diagnoses (benign, 86%; malignant, 99%; chi(2) test, P < 0.001) and lesion size (lesions <1.5 cm, 84%; lesions 1.5-5.0 cm, 96%; lesions >5 cm, 93%; chi(2) test, P = 0.06). CONCLUSION: Benign lung lesions, lung lesions smaller than 1.5 cm (which pose technical difficulty), and lung lesions larger than 5 cm (which are associated with a higher necrosis rate) affect diagnostic accuracy of CT-guided percutaneous coaxial cutting needle biopsy of lung lesions.