青岛地区MSM中HIV/梅毒及尖锐湿疣的感染情况

目的了解青岛地区男男性行为人群（MSM）艾滋病病毒（HIV）/梅毒及尖锐湿疣的感染情况。方法利用中盖项目支持平台,对前来接受干预检测的MSM进行相关查体及实验室检查。结果 687名MSM共检出尖锐湿疣41例,检出率为5.97%;梅毒89例,检出率为12.95%;HIV 8例,检出率1.16%。8例HIV阳性患者中,3例合并CA,4例合并梅毒;2例CA患者同时伴有HIV、梅毒阳性;89例梅毒阳性患者中,19例合并CA。结论 MSM中HIV、梅毒及尖锐湿疣感染情况严重,提示临床医生在对MSM的梅毒、尖锐湿疣患者诊治的同时,应注重HIV的检测。     

2011-2012年南宁市三类人群梅毒感染情况分析

目的通过对南宁市三类人群进行梅毒血清学检测,了解南宁市不同人群中梅毒感染情况,为今后加强梅毒的防控工作提供依据。方法采用甲苯胺红不加热血清试验(TRUST)、梅毒螺旋体明胶颗粒凝集试验(TPPA),检测南宁市性病门诊就诊者、艾滋病病毒(HIV)感染门诊抗病毒治疗者、从业人员健康体检者的梅毒感染情况。结果 2011-2012年,南宁市性病门诊就诊者、HIV感染门诊抗病毒治疗者、从业人员健康体检者的梅毒感染率分别为27.33%(85/311)、3.37%(15/445)、0.11%(27/23 684),性病门诊就诊者梅毒感染率明显高于其他人群。梅毒感染者在性病高危人群和一般人群中检出率无性别差异。结论南宁市检测的三个人群梅毒感染率不同,应针对不同人群采取不同的干预措施,防范HIV及梅毒等性病从高危人群向一般人群传播。     

MSM人群尖锐湿疣合并HIV感染治疗的临床分析

目的通过分析男男性行为人群(MSM)中是否合并艾滋病病毒(HIV)感染,探讨治疗尖锐湿疣的不同预后。方法对佑安医院2009年1月至2010年12月确诊的MSM人群中尖锐湿疣患者进行回顾性分析。皮损给予外用咪喹莫特、γ-干扰素及自制外用药外涂,观察疗效。结果 MSM人群中发生尖锐湿疣的258例中,单一性伴者30例,多性伴者228例;单纯感染尖锐湿疣者180例,尖锐湿疣合并HIV感染78例。治疗结束后,合并HIV感染的尖锐湿疣患者复发率为44.9%(35/78),单纯尖锐湿疣患者复发率为13.9%(25/180),两组进行χ2检验,差异有统计学意义(P<0.005)。结论 MSM人群中尖锐湿疣发生率较高,但复发率不高;如合并HIV感染,则复发率较高。因此对于反复出现尖锐湿疣的患者,要增加HIV检查。     

常德市性病门诊男性就诊者梅毒感染的危险因素分析

目的了解常德市性病门诊男性就诊人群梅毒感染状况及梅毒感染的危险因素。方法采用方便抽样,对性病门诊男性就诊人群进行匿名问卷调查,拟合多因素Logistic回归模型探讨梅毒感染的危险因素。结果此次共调查性病门诊男性就诊者1250例,年龄中位数39岁,梅毒感染率11.9%(149例)。多因素Logistic回归分析结果表明,最近3个月与暗娼、临时性伴发生性行为是性病门诊男性就诊者感染梅毒的主要危险因素。结论常德市性病门诊男性就诊人群梅毒感染率呈上升趋势,危险行为在此类人群中普遍存在。     

汕头市性病门诊2004-2011年梅毒及HIV感染状况调查

目的了解汕头地区性病门诊患者梅毒及艾滋病感染情况。方法对皮肤性病防治院2004年1月至2011年12月性病门诊患者进行梅毒、艾滋病血清学检测,并对检测结果及临床资料进行统计分析。结果 14 491例性病门诊患者中,共确认梅毒阳性666例,阳性率4.60%。其中男性患者感染率为3.76%(384/10 214),女性患者感染率为6.59%(282/4 277),两者差异有统计学意义(P<0.01)。确认HIV阳性者20例,阳性率0.14%。其中男性患者HIV阳性率0.14%(14/10 214),女性患者阳性率0.14%(6/4 277),两者差异无统计学意义(P>0.05)。有6例HIV阳性者合并感染梅毒。结论汕头地区性病门诊就诊患者梅毒及HIV感染率近年虽未见明显增长,但还应继续做好性病高危人群HIV及梅毒的防治工作,争取早发现、早治疗,防范HIV及梅毒向一般人群的传播。     

2012年天津市性病门诊男性就诊者HIV/梅毒感染现状及影响因素分析

目的了解性病门诊男性就诊者中,艾滋病病毒（HIV）、梅毒（SP）的感染状况及危险因素,为在该人群中开展相关防控措施提供依据。方法对天津市2家性病门诊中符合条件的男性就诊者开展问卷调查,同时抽取血样检测梅毒和HIV抗体。结果800例性病门诊男性就诊者中,HIV抗体阳性16例,阳性率为2．0％。多因素分析表明,最近3个月有同性性行为[比值比（OR）=21．642,95％可信区间（CI）：7．211～64．946]、感染梅毒（OR=3．097,95％CI：1．059～9．055）与HIV感染关系有统计学意义。梅毒阳性129例,阳性率为16．1％。多因素分析表明,最近3个月有商业性行为（OR=6．306,95％CI：3．930～10．118）、最近3个月有同性性行为（OR=5．948,95％CI：3．017～11．725）与梅毒感染关系有统计学意义。结论性病门诊男性就诊者HIV、梅毒感染率较高,危险行为普遍存在,急需采取有效措施来控制性病艾滋病的传播蔓延。     

北京地区2001-2010年MSM人群HIV感染状况及综合干预模式的探讨

目的了解北京地区男男性行为人群(MSM)近年来艾滋病病毒(HIV)感染状况,探索控制MSM人群HIV传播的有效干预模式。方法 2001-2010年间,每隔3年对MSM人群进行HIV筛查,调查HIV感染危险因素。通过队列研究方法,在MSM人群中建立3年期随访队列,探讨该人群HIV干预模式。结果北京地区MSM人群HIV感染率从2001年的1.33%递增为2010年的15.33%。同性性经历时间较短、性伴数量多、性伴HIV阳性、性行为中以被动方为主、合并感染梅毒等性病以及合并肛周疾病,是MSM人群感染HIV的高危因素。经干预后,队列人群中HIV检出率为3.2%,同期社会MSM人群HIV检出率为8.7%~15.33%。结论以HIV传染源干预为主的综合干预措施,可能有助于减少该人群HIV的传播。     

新疆乌鲁木齐市男性同性恋人群检测结果分析

目的 了解乌鲁木齐市男性同性恋人群(MSM)中HIV、HCV、梅毒感染情况,并应用HIV-1 BED-CEIA新近感染检测方法估计乌鲁木齐市男性同性恋人群的发病率.方法 利用网络招募方式获得求询者145名,采集血清样品143份进行HIV,HCV的ELISA初筛,对HIV阳性反应标本进行WB确证及HIV-1 BED-CEIA新近感染检测;143名求询者的样品进行梅毒RPR初筛和梅毒TPPA确认.结果 网络招募男性同性恋人群(MSM)中HIV阳性8名,检出率5.6%(8/143);HIV-1 BED-CEIA方法检出4名新近感染估计发病率6.74% (CI 0.13%～13.35%);梅毒阳性14名检出率9.8%;HCV均为阴性.结论 (1)男性同性恋人群(MSM)HIV感染率与HIV-1 BED-CEIA估计发病率较接近;(2)网络招募男性同性恋人群(MSM)梅毒的检出率比较高,其中有2名招募者HIV与梅毒合并感染;性病是HIV和HCV传播的协同因素,相对危险度均大于1(RR＞1).     

郑州市467名男男性行为者HIV和性病感染状况与流行病学特征

目的分析郑州市男男性行为者(MSM)艾滋病病毒(HIV)及性病(STD)感染状况与流行病学特征,为MSM艾滋病流行控制提供科学依据。方法采用横断面调查方法,对郑州市MSM社会人口学特征、性行为特征及HIV/STD感染状况进行调查。结果共调查467名MSM,其中21~40岁占77.5%(362人),大专及以上文化程度占58.2%(272人),39.8%已婚或与女性同居。HIV抗体阳性率13.3%(62例),梅毒和2型单纯疱疹病毒(HSV-2)感染率分别为6.4%(30例)和11.3%(53例)。寻找性伴场所为浴池的MSM的HIV感染率为20.0%(27/135),显著高于其他类型MSM(χ2=7.46,P=0.006);梅毒感染者和HSV-2感染者HIV阳性率高于非梅毒感染者和非HSV-2感染者(χ2=7.79,P=0.005;χ2=6.57,P=0.01)。结论郑州市MSM的HIV感染率高,同时高危性行为普遍存在,性病患者是HIV感染的高危人群,应作为艾滋病预防控制的重点人群。     

深圳市男男性行为人群HIV感染分布特征及影响因素

目的了解深圳市男男性行为人群(Men who have sex with men,MSM)艾滋病病毒(Human immunodeficiency virus,HIV)感染分布特征及其影响因素。方法对2005-2011年深圳市MSM的HIV感染监测资料进行单因素和多因素Logistic回归分析。结果共有5 232人接受了自愿咨询检测,HIV感染率为6.46%,HIV合并梅毒感染率3.56%。多因素Logistic回归分析结果表明,MSM人群感染HIV和年龄、文化程度、性角色及合并梅毒感染有关。年龄≥40岁者感染HIV的危险性是年龄<40岁者的1.508倍;大专及以上文化程度者感染HIV的危险性是高中及以下者的0.703倍;性角色以主动为主者和主动被动两者兼有者感染HIV的危险性分别是被动为主者的0.428倍和0.624倍;合并梅毒感染者感染HIV的危险性是梅毒阴性者的4.887倍。结论 2005-2011年,深圳市MSM人群HIV感染率上升趋势明显,在该人群中开展艾滋病预防控制工作迫在眉睫。     

204例MSM人群HIV／梅毒感染状况及行为学特征分析

目的了解天津市部分男男同性性行为人群（MSM）艾滋病相关危险行为,以及艾滋病病毒（HIV）、梅毒（SP）感染状况,为预防性病、艾滋病传播提供依据。方法采用横断面调查,对进入酒吧的男同性恋者进行问卷调查,同时抽取血样进行梅毒和HIV的实验室检测。结果调查的204人中,HIV感染率为5．9％,梅毒感染率为18．7％。艾滋病知识知晓率为81．4％,近6个月每次性行为均使用安全套的比例为47．9％,HIv感染者安全套使用率低,仅为11．1％,71．4％的HIV感染者最近6个月存在多性伴现象。结论天津市MSM人群危险性行为普遍存在,安全套使用率低,HIV、梅毒感染率较高,应加强对该人群艾滋病性病相关的宣传教育及干预工作,控制HIv的传播。     

82例男性肛周尖锐湿疣病人合并其他STD/HIV感染状况

目的了解男性肛周尖锐湿疣病人合并其他性传播疾病（STD）/艾滋病病毒（HIV）感染状况,对其性行为进行调查分析,为制定有效的防治措施提供信息和依据。方法 2008年9月-2010年2月,对江西省皮肤病专科医院性病科门诊及南昌市疾病预防控制中心介绍的共82例男性肛周尖锐湿疣病人进行问卷调查,并采集血液、分泌物进行检测。结果 82例男性肛周尖锐湿疣病人中,HIV感染9例,占10.98%;合并感染梅毒6例,占7.32%;4例合并感染衣原体,占4.88%。男性肛周尖锐湿疣病人合并HIV/其他STD呈低龄化趋势;过去一年内同性性伴人数与男性肛周尖锐湿疣病人合并HIV和其他STD的感染率差异有统计学意义,（χ2=11.86,0.01〈P〈0.05）;与同性认识到发生性行为的时间与男性肛周尖锐湿疣病人合并HIV和其他STD的感染率差异有统计学意义（χ2=41.61,0.01〈P〈0.05）;无保护性行为的肛周尖锐湿疣病人合并HIV（χ2=8.45,P〈0.05）或/及梅毒（χ2=13.47,P〈0.05）的感染率较高。结论无保护的危险性行为导致STD/HIV的传播,需要采取有针对性且易为该人群接受的防治措施加以干预,并通过对性病的控制来遏制艾滋病向青少年人群蔓延。     

Investigating HIV Infection and HIV Incidence Among Chinese Men Who Have Sex with Men with Recent Sexual Debut,Chongqing, China, 2011

HIV among men who have sex with men (MSM) with recent male–male sexual debut, such as within the past 5 years, may be a proxy for recent HIV infection. Using this definition, we explored factors associated with HIV infection in this group to understand the evolving HIV epidemic among MSM in Chongqing. We conducted a cross-sectional respondent-driven sampling survey among Chongqing MSM in 2011. Computer-assisted, self-administered questionnaires were used and blood specimens were collected for HIV and syphilis testing. Three hundred and ninety-one unique MSM were recruited of which 65.7 % (257) had their sexual debut with another man in the past 5 years. HIV prevalence among men with recent sexual debut was 18.7 % suggesting a possible HIV incidence of 3.7 %. Multivariable analysis among men with recent sexual debut suggests that lower education, having more than one male partner, and currently being infected with syphilis are associated with HIV among men with recent sexual debut. HIV prevalence is high among MSM with recent sexual debut in Chongqing, which may be a proxy a high incidence rate. HIV prevention efforts should focus on STD reduction among those MSM with lower educational attainment.     

长沙市男男性行为者HIV和梅毒感染现状及影响因素分析

目的 了解长沙地区男男性行为者(MSM)艾滋病病毒(HIV)和梅毒感染状况及其影响因素.方法 2018年10月至2019年6月期间,委托非政府组织(NGOs)应用滚雪球的方法招募MSM,开展问卷调查和HIV及梅毒检测.采用多因素Logistic回归模型分析HIV和梅毒感染的影响因素.结果 共招募1 220名MSM,其中...     

The association of syphilis with risk of human immunodeficiency virus infection in patients attending sexually transmitted disease clinics

A serologic survey of 4863 patients attending two inner-city sexually transmitted disease clinics was conducted in 1988 1 year after an initial survey to reassess the prevalence and associated risk factors for human immunodeficiency virus (HIV) infection. The HIV seroprevalence rates had not changed significantly (5.2% in 1987, 4.9% in 1988), and remained higher among men (5.6%) than among women (3.6%). The HIV seroprevalence increased steadily with age, to 34 years in women and to 39 years in men. Of patients with a reactive syphilis serologic test result, 24.3% were HIV infected compared with 3.5% of patients with a nonreactive test for syphilis. In multivariate analysis, a reactive serologic test for syphilis was significantly associated with HIV infection in all major risk behavior categories. Among heterosexuals who denied parenteral drug abuse, HIV infection rates were 6.8 and 8.7 times greater for women and men, respectively, who had a reactive serologic test for syphilis. Evidence of heterosexual transmission of HIV was further suggested by a change in HIV seroprevalence in women from 3.0% in 1987 to 3.6% in 1988, a male to female HIV infection ratio of 1.6, and 3.0% prevalence of infection among patients who denied established risk factors. This was most evident among those younger than 25 years, in whom 72% of infected women and 46.2% of infected men denied high-risk behaviors. These data demonstrate the strong association between syphilis and HIV infection and the importance of heterosexual HIV transmission in patients attending sexually transmitted disease clinics. This study underscores the need for a more comprehensive control program for sexually transmitted diseases, including syphilis and HIV infection.     

Incidence of HTLV-I in high-risk population in Delhi

Human infection due to HTLV-I occurs by transmission of infected T-cells via sexual intercourse, blood transfusion or breastfeeding. The present investigation was carried out to find the incidence of HTLV-I in high risk population and its relationship with syphilis and HIV infection. The study group comprised 124 antenatal cases, 9 patients attending Sexually Transmitted Disease (STD) clinics and 144 blood donors. Passive particle agglutination test was performed on all the test sera for anti HTLV-I antibodies. VDRL and Treponema pallidum haemagglutination tests were carried out on sera from antenatal and STD cases. Sera from blood donors were tested for HIV antibodies by ELISA and confirmed by Western Blot. Anti HTLV-I antibodies were found in 10.6% of the cases studied. There was no association between the presence of anti HTLV-I antibodies and syphilis in expectant mothers and STD cases. However, significant association was found between the former and HIV infection in blood donors.     

秦皇岛市MSM的HIV、TP、HCV感染状况及影响因素

目的了解秦皇岛市男男性行为人群（MSM）的艾滋病病毒（HIV）、梅毒螺旋体（TP）、丙型肝炎病毒（HCV）感染状况和相关影响因素,提出有针对性的防控性病艾滋病的干预建议。方法 2009-2012年连续4年采用自愿招募和滚雪球的方法,通过自愿咨询检测（VCT）门诊和开展外展干预活动,对第一次接受艾滋病咨询检测的MSM进行问卷调查和血清学检测。结果 4年共招募MSM 1043人。70.76%（738/1043）的人通过网络寻找性伴,4年间,艾滋病知识知晓率、接受艾滋病干预服务和接受HIV检测人数均逐年上升（P〈0.01）。近6个月,898人（86.10%）有过同性肛交行为,其中坚持使用安全套率为42.76%;34.63%（311/898）有过异性性行为,安全套坚持使用率为36.98%;9.02%（81/898）有过商业性性行为,安全套坚持使用率为53.09%。HIV、TP、HCV平均感染率分别为5.75%（60/1043）、7.19%（75/1043）、0.19%（2/1043）,HIV、TP感染率呈逐年上升趋势（P〈0.05）。多因素分析结果显示：文化程度相对低、在当地居住时间短、曾感染过性病是HIV、TP感染率的危险因素;年龄较大的MSM,TP感染的风险更大。结论秦皇岛市MSM HIV、TP感染率较高,应重点加强对年轻MSM的宣传干预力度,切实提高安全意识和安全行为,同时推广网络宣传干预;而在年龄大、已婚的MSM,则应加强TP筛查并提供方便、可及的诊疗服务。在开展性病艾滋病防治宣传的同时不应忽视丙型肝炎防治知识的宣传。     

HIV Incidence and Care Linkage among MSM First-Time-Testers in Shenyang,China 2012–2014

HIV testing is the first step to the fulfillment of Treat as Prevention (TasP) and reaching the 90-90-90 goal in HIV control. However, there are still a large number of Men who have Sex with Men (MSM) have never been tested for HIV before, and little is known about the HIV incidence and care linkage among this population. A Mixed method was used to recruit MSM who had never tested for HIV before from January 2012 to December 2014 in Shenyang, China. Potential MSM participants were invited to attend the enrollment for HIV and syphilis testing at a general hospital-based voluntary counseling and test (VCT). HIV confirmed positive subjects were further tested by BED HIV-1 capture enzyme immunoassay (BED-CEIA) to determine the HIV incidence. Syphilis was screened by the rapid plasma reagent test (RPR) and confirmed by Treponema pallidum particle assay (TPPA). All the HIV positive subjects were referred to the local Center for Disease Control and Prevention (CDC) and clinics for HIV primary care and follow-ups. In total 646 HIV first-time-testers of MSM (FMSM) attended this study, 73.4% (474/646) were aged under 31-year-old and 57.3% (370/646) and used the Internet as their major cruising avenue for seeking male sexual partners. The average prevalence of HIV and current syphilis infection was 10.8% (70/646) and 11.0% (71/646), respectively. The HIV incidence was 10.3 (95% confidence interval [CI] 6.1–14.5)/100PY. Multivariate logistic analysis showed that factors such as use of the Internet as the major cruising avenue (adjusted OR [AOR] 2.7, 95% CI 0.9–7.6) and having a current syphilis infection (AOR 4.2, 95% CI 1.8–12.2) were independent correlates of a recent HIV infection. Of the 95 HIV screening test positive FMSM, 73.7% (70/95) returned and be confirmed positive, 92.9% (65/70) of confirmed patients were linked to care. Among those retained and underwent CD4+ T cell test, 76.3% (42/55) started HIV antiretroviral therapy. Among the unconfirmed, 84.0% (21/25) were non-local migrants. The HIV incidence of FMSM in Shenyang was high. Future HIV testing program needs to keep on expanding among the MSM who have never been tested for HIV yet. The Internet-based campaigns and syphilis testing and treatment could represent an opportunity to get access to this hard-to-reach population and link them to HIV care. Future linkage to HIV care of this population should underscore the usage of HIV rapid diagnostic tests to prevent lost at early steps of linkage.