2 419例17 530颗胆囊息肉内镜微创保胆手术后病理结果分析

目的 通过对胆囊息肉保胆手术后病理结果分析,评估内镜微创保胆手术对胆囊息肉的治疗价值。方法 收集2007年1月－2020年12月行内镜微创保胆手术的2 419例17 530颗胆囊息肉患者的病理资料,纳入回顾性研究,以内镜微创保胆手术的手术适应证作为入组标准,分析其术后病理结果。结果 胆囊良性息肉占99.68%,均行保胆取息肉手术,0.20%的患者息肉为恶性,且为早期,均行胆囊癌根治术,0.12%的患者为腺瘤高级别上皮内瘤变,行胆囊切除术。结论 胆囊息肉中恶性肿瘤占比较低,内镜微创保胆手术是治疗胆囊息肉的首选手术方法,既可以去除胆囊良性病变,又能保留胆囊功能,还可以早期发现胆囊癌。因此,胆囊息肉应早期行微创保胆手术以明确诊断,防止恶变。     

高帧频超声造影在鉴别诊断胆囊腺瘤性息肉与胆固醇性息肉中的临床应用

目的比较常规超声造影（CEUS）与高帧频超声造影（H-CEUS）在鉴别腺瘤性息肉与胆固醇性息肉中的诊断价值。 方法收集2019年8月至2020年2月解放军总医院第一医学中心因胆囊息肉样病变（GPL）行腹腔镜胆囊切除术的患者65例。术前先行CEUS和H-CEUS,根据术后病理结果分为腺瘤性息肉组（16例）和胆固醇性息肉组（49例）,比较2种检查方法对病变的灌注特征的显示和最终诊断。采用χ²检验比较2组之间以及CEUS和H-CEUS下的血管形态、增强强度和胆囊壁完整性的差异。 结果CEUS对胆囊腺瘤性息肉和胆固醇性息肉的血管形态判断,差异无统计学意义（P>0.05）。CEUS观察到85.71%（42/49）的胆固醇性息肉和68.75%（11/16）的胆囊腺瘤性息肉血管形态表现为均匀点状。H-CEUS判断胆囊腺瘤性息肉和胆固醇性息肉之间的血管形态,差异具有统计学意义（χ²=26.527,P<0.001）。H-CEUS可观察到75.51%（37/49）的胆固醇性息肉和25.00%（4/16）的腺瘤性息肉血管形态表现为均匀点状。胆固醇性息肉组在CEUS和H-CEUS下的血管形态比较,差异无统计学意义（P>0.05）,而腺瘤性息肉组,在CEUS和H-CEUS下的血管形态比较,差异具有统计学意义（χ²=7.878,P=0.019）。腺瘤性息肉组中CEUS仅能检测到6.25%（1/16）的分支血管形态,而H-CEUS能检测到43.75%（7/16）的分支血管形态。 结论H-CEUS通过提高帧频来提高时间分辨率,有助于准确反映GPL微循环的差异,并提高胆固醇性息肉和腺瘤性息肉的鉴别诊断能力。在选择治疗方案时,H-CEUS可作为GPL诊断的有效影像学检查手段。     

Port-site metastasis of unsuspected gallbladder carcinoma with ossification after laparoscopic cholecystectomy: A case report

BACKGROUNDUnsuspected gallbladder carcinoma (UGC) refers to cholecystectomy due to benign gallbladder disease, which is pathologically confirmed as gallbladder cancer during or after surgery. Port-site metastasis (PSM) of UGC following laparoscopic cholecystectomy is rare, especially after several years.CASE SUMMARYA 55-year-old man presenting with acute cholecystitis and gallstones was treated by laparoscopic cholecystectomy in July 2008. Histological analysis revealed unexpected papillary adenocarcinoma of the gallbladder with gallstones, which indicated that the tumor had spread to the muscular space (pT1b). Radical resection of gallbladder carcinoma was performed 10 d later. In January 2018, the patient was admitted to our hospital for a mass in the upper abdominal wall after surgery for gallbladder cancer 10 years ago. Laparoscopic exploration and complete resection of the abdominal wall tumor were successfully performed. Pathological diagnosis showed metastatic or invasive, moderately differentiated adenocarcinoma in fibrous tissue with massive ossification. Immuno-histochemistry and medical history were consistent with invasion or metastasis of gallbladder carcinoma. His general condition was well at follow-up of 31 mo. No recurrence was found by ultrasound and epigastric enhanced computed tomography.CONCLUSIONPSM of gallbladder cancer is often accompanied by peritoneal metastasis, which indicates poor prognosis. Once PSM occurs after surgery, laparoscopic exploration is recommended to rule out abdominal metastasis to avoid unnecessary surgery.     

囊肿型胆道闭锁MRI和MRCP特征

目的 分析囊肿型胆道闭锁（CBA）的MRI和MR胰胆管造影（MRCP）表现。方法 回顾性分析24例经手术病理证实的CBA患儿术前MRCP及MRI资料,结合术中造影及病理结果,分析CBA的影像学特点。结果 24例CBA,MRI均显示肝门区囊状结构,11例出现肝门区门静脉周围T2WI高信号,23例显示胆囊宽径明显小于长径,1例胆囊未显示;5例显示肝门区纤维斑块。24例CBA患儿MRCP均可见肝外胆总管区囊性结构,位于肝门区22例,位于左右肝管区2例;18例肝门区囊肿与胆囊管相通。结论 肝门区囊肿及纤维斑块、胆囊大小、形态及MRCP显示的肝外胆管情况是诊断CBA的重要征象。MRCP对于早期诊断CBA具有一定价值。     

无痛内镜下冷切除术在老年患者5～9 mm扁平无蒂结直肠息肉治疗中的临床应用价值

目的 探讨无痛内镜下冷切除术在老年患者5～9 mm扁平无蒂结直肠息肉治疗中的临床应用价值。方法 选取在开封市人民医院内镜中心行无痛肠镜检查,发现扁平无蒂结直肠息肉且直径在5～9 mm的124例老年患者为研究对象,按照随机数表法分为研究组（n=64）和对照组（n=60）。研究组应用圈套器对息肉行冷切除治疗,对照组给予黏膜下注射使息肉抬举后,应用圈套器行高频电切除治疗。比较两组患者手术时间、术中出血量、一次性完整切除率、标本回收率、息肉病理类型、术后并发症及手术费用。结果研究组手术时间较对照组短,手术费用较对照组少,术后并发腹胀的情况较对照组少,差异均有统计学意义（P <0.05）;两组患者术中出血例数、一次性完整切除率、标本回收率、术后并发腹痛和出血比较,差异均无统计学意义（P> 0.05）。结论 无痛内镜下应用圈套器对5～9 mm扁平无蒂结直肠息肉行冷切除术,手术时间短,安全性高,并发症少,费用低,且避免了高频电对周围正常黏膜的损伤。     

超声检查在急性胆囊炎腹腔镜胆囊切除术前的应用价值

目的 评价术前超声检查对预测腹腔镜胆囊切除术(LC)治疗急性胆囊炎难度的价值。方法 对180例因急性胆囊炎接受LC的患者,术前超声检查综合分析胆囊轮廓、胆囊颈部、囊壁厚度、囊壁回声、囊内回声情况,评估胆囊周围、Calot三角区的粘连程度,并与手术病理进行对照。结果 超声检查综合性评估胆囊与周围组织粘连程度的敏感度为92.78%(90/97),特异度为93.98%(78/83),准确率为93.33%(168/180)。结论 术前超声检查对预测LC治疗急性胆囊炎的难度有重要价值。     

Failed or difficult laparoscopic cholecystectomy: Can preoperative ultrasonography identify potential problems?

A prospective study was performed to assess the role of preoperative ultrasonography in predicting failed or difficult laparoscopic cholecystectomy. Fifty patients underwent detailed preoperative ultrasound examinations. The number and size of calculi, evidence of acute or chronic cholecystitis, gallbladder morphology, and the presence or absence of aberrant anatomy were documented. A comparison was made of the surgical outcome and the ultrasound findings in each patient. Six patients were converted to open cholecystectomy because of inflammatory changes in the gallbladder. The preoperative ultrasound studies in 5 of these patients demonstrated evidence of cholecystitis and cholelithiasis. Gallbladder wall thickening and contraction were also seen. Five gallbladder resections had intraoperative difficulties; preoperative ultrasonography demonstrated a thickened gallbladder wall in 2. Of 31 uneventful cases, 7 had evidence of gallbladder wall thickening and/or contraction. There were no ultrasound features that identified between the unsuccessful, difficult, or uneventful laparoscopic cholecystectomies. We conclude that detailed preoperative ultrasound evaluation of the gallbladder in patients destined for laparoscopic cholecystectomy is of little value in screening for difficult or unsuitable cases. © 1994 John Wiley & Sons, Inc.     

Application of near-infrared fluorescent cholangiography using indocyanine green in laparoscopic cholecystectomy

ObjectiveNear-infrared fluorescence cholangiography (NIRF-C) can help to identify the bile duct during laparoscopic cholecystectomy. This retrospective study was performed to investigate the effect of NIRF-C in laparoscopic cholecystectomy.MethodsConsecutive patients who underwent NIRF-C-assisted laparoscopic cholecystectomy (n = 34) or conventional laparoscopic cholecystectomy (n = 36) were enrolled in this study. Identification of biliary structures, the operation time, intraoperative blood loss, and postoperative complications were analyzed.ResultsLaparoscopic cholecystectomy was completed in all patients without conversion to laparotomy. The median operation time and intraoperative blood loss were not significantly different between the two groups. No intraoperative injuries or postoperative complications occurred in either group. In the NIRF-C group, the visualization rate of the cystic duct, common bile duct, and common hepatic duct prior to dissection was 91%, 79%, and 53%, respectively. The success rate of cholangiography was 100% in the NIRF-C group. NIRF-C was more effective for visualizing biliary structures in patients with a BMI of <25 than >25 kg/m².ConclusionsNIRF-C is a safe and effective technique that enables real-time identification of the biliary anatomy during laparoscopic cholecystectomy. NIRF-C helps to improve the efficiency of dissection.     

Enlargement of umbilical incision in standard laparoscopic cholecystectomy is frequently necessary: An argument for the single incision approach?

Objective: Cosmetic result after cholecystectomy is up for debate. The aim of this study was to investigate the incidence and extent of enlargement of initial skin and fascia incision in standard laparoscopic cholecystectomy and to detect predictive factors for such an enlargement. Material and methods: The size of the umbilical incision was measured before and after standard laparoscopic gallbladder removal in 391 patients from August 2009 to October 2012. Predisposing factors for the need of enlargement of the umbilical incision were analysed. Results: Additional enlargement of the umbilical incision for gallbladder removal was required in 35.8% of the patients at skin level, and in 40.4% at fascia level. The median enlargement of the umbilical skin incision was 11 mm, from 25 mm to 36 mm. Gallbladder weight, total stone weight, maximum diameter of largest stone and shorter initial length of incision were independent predisposing factors for enlargement of the incision. Conclusions: In standard laparoscopic cholecystectomy the umbilical incision frequently requires secondary enlargement, especially if a large stone mass is involved. Therefore, the cosmetic result after laparoscopic cholecystectomy depends on more than only the technique used for access and the surgical technique for cholecystectomy should be chosen individually for each patient according to the stone mass.     

内镜黏膜冷切除术和热切除术在结直肠6~10 mm无蒂息肉治疗中的疗效对比

目的：探讨黏膜下注射后内镜黏膜冷切除术和黏膜热切除术在治疗结直肠直径6~10 mm无蒂息肉中的疗效。方法：选取2016年1月至2017年6月江阴市中医院收治的因结直肠无蒂息肉（6~10 mm）拟行内镜切除的110例患者，共131枚息肉，随机分为冷切除组和热切除组。所有患者均于术中采用靛胭脂、生理盐水混合液进行黏膜下注射。分析2组患者病变完整切除率、手术时间、手术相关并发症发生率（包括术中出血或穿孔及术后1个月内迟发性出血或穿孔）及术后半年内息肉残留或复发率。结果：冷切除组55例患者，共62枚息肉，热切除组55例，共69枚息肉。2组息肉大小、位置、内镜形态和病理类型差异无统计学意义。冷切除组平均手术时间较热切除组明显缩短[（2.2±1.1）min vs（3.6±1.4）min，P<0.001]。冷切除组息肉完整切除率为95.2%，热切除组息肉完整切除率为91.3%，差异无统计学意义（P=0.599）。冷切除组术中出血1例，术后出血1例；热切除组术中出血2例，术中穿孔1例，术后出血1例，2组并发症差别无统计学意义（P=0.675）。术后半年复查肠镜，无息肉残留或复发。结论：黏膜下注射后内镜黏膜冷切除术是传统冷切除术的有效改良，可作为结直肠6~10 mm无蒂息肉的有效切除方式。     

Laparoendoscopic single-site cholecystectomy: A randomized controlled study

Abstract

This study reports the initial experience with laparoendoscopic single-site (LESS) cholecystectomy and compares it with laparoscopic cholecystectomy (LC) through a randomized controlled trial. Sixty selective patients diagnosed with cholelithiasis or polyp lesion of the gallbladder (PLG) were randomly divided into two groups undergoing either LESS cholecystectomy or LC separately. The clinical data about operations and recovery of the two groups were compared. In the LESS group 28 of 30 patients underwent LESS cholecystectomy successfully and the remaining two (6.7%) were converted to standard laparoscopic surgery. LC was successfully performed in all patients in the control group. Mean operative time of LESS cholecystectomy group and LC group was 55.6 ± 25.7 versus 42.7 ± 18.6 (p < 0.05). Mean postoperative hospital stay was 3.7 ± 1.3 versus 3.8 ± 0.8 days (p < 0.05). Mean pain index was 2.8 ± 0.6 versus 3.7 ± 1.1 (p < 0.05). A questionnaire revealed that the mean scores of satisfaction with the operation were 8.9 ± 0.7 versus 8.1 ± 1.5 (p < 0.05). LESS cholecystectomy is safe, feasible, minimally invasive, and cosmetic. It is a reasonable alternative to selective patients with uncomplicated cholelithiasis and PLG. But larger controlled studies are still needed.     

Minimally invasive surgical approach for radicalization of incidental post-cholecystectomy gallbladder carcinoma: safety,feasibility and outcomes

Background and aims: Gallbladder carcinoma is a rare but aggressive malignant neoplasm. The incidence of intra- or post-operative incidental gallbladder carcinoma diagnosis following laparoscopic cholecystectomy is estimated to be 1–2%. Aggressive re-resection is warranted as the majority of patients have residual disease either in the liver or the lymph nodes. However the use of a minimally invasive surgical approach (MISA) to perform a radicalization in these patients has not been investigated yet. We retrospectively analyzed surgical and oncologic outcome of a small selected cohort of patients with incidental gallbladder carcinoma whom underwent redo radicalization surgery by MISA.

Material and methods: From April 2012 to June 2014 at our department six patients (three females and three males) with incidental findings of gallbladder carcinoma pT1b (stage I) following laparoscopic cholecystectomy, and referred to our center from other secondary-level referral hospitals, underwent a redo surgery for radicalization by means of laparoscopic (n. 3) or robotic approach (n. 3). A retrospective analysis of prospective collected data was performed.

Results: The redo procedure consisted of a liver resection (segments IVb?+?V) and lymph nodes clearance of hepatoduodenal hilum and common hepatic artery. Conversion rate was zero. Median operative time was 290 (250–310) min. Estimate blood loss was 175 (100–350) ml. Total hospital stay was 6 (5–10) days. All liver resections were performed without inflow vascular clamping. One patient was re-operated for hemoperitoneum while peri-operative mortality was zero. Oncologically, an R0 resection was always achieved with a mean number of lymph nodes retrieved of 17,5 (14–22). The stage of the neoplasm was confirmed in all cases but one, who was found to have a pN1 status (stage IIIb). At 21 (6–32) months follow-up all patients are alive and no recurrence has been observed.

Conclusions: Our data suggest that radicalization of patients with stage I incidental postoperative gallbladder carcinoma can be done by a MISA without compromising the oncologic outcome. Larger studies are needed to validate these results.     

结肠息肉与幽门螺杆菌感染及胃息肉的关系

目的 研究结肠息肉与幽门螺杆菌（Hp）感染及胃息肉的关系。方法 选取2014年10月-2019年8月该院接受胃镜和结肠镜检查的患者235例。依据结肠镜结果,将患者分为结肠息肉组（119例）和对照组（116例）。统计分析各组Hp感染率。结果 左半结肠息肉组的Hp感染率高于对照组,腺瘤性息肉组和增生性息肉组的Hp感染率高于对照组,差异均有统计学意义（P <0.05）。各亚组组内Hp感染率比较,差异无统计学意义（P> 0.05）。两组患者胃息肉发生率比较,差异无统计学意义（P> 0.05）。结论 Hp感染可促进结肠息肉的发生和发展。结肠腺瘤性息肉和增生性息肉与Hp感染相关。对于感染Hp的结肠腺瘤性息肉和增生性息肉患者,建议立即进行息肉切除术。结肠息肉的存在与胃息肉的存在没有直接关系。     

结直肠息肉经内镜摘除术后并发出血的危险因素分析

目的分析结直肠息肉经内镜摘除术后并发出血的危险因素。方法以该院收治的342例行内镜摘除术治疗的结直肠息肉患者为研究对象,统计该组患者经内镜摘除术后并发出血的发生率。并将该组患者分为并发出血组和未并发出血组,以术后并发出血为因变量,以可能诱发患者术后出血的相关因素(性别、年龄、合并糖尿病、合并高血压、高血脂史、饮酒史、息肉发生位置、息肉病理分型、息肉大小、息肉形态和息肉数量)为自变量,先进行单因素回归分析,再运用Logistic回归分析工具进行多因素分析。结果该组342例患者术后并发出血的发生率为7.60%(26/342)。单因素分析结果显示,并发出血组患者合并高血压者比例高于未并发者(P0.05),合并高血脂史者比例高于未并发者(P0.05),息肉直径2.0 cm者比例高于未并发者(P0.05),息肉形态有蒂息肉者比例高于未并发者(P0.05)。多因素分析结果显示,高血压、合并高血脂、息肉直径2.0 cm、息肉形态有蒂息肉均为结直肠息肉经内镜摘除术后并发出血的危险因素(P0.05)。结论结直肠息肉经内镜摘除术后并发出血的危险因素包括高血压、合并高血脂、息肉直径2.0 cm、息肉形态为有蒂息肉。     

CT differentiation of 1–2-cm gallbladder polyps: benign vs malignant

Purpose

To evaluate MDCT findings of 1–2-cm sized gallbladder (GB) polyps for differentiation between benign and malignant polyps.

Methods

Institutional review board approval was obtained, and informed consent was waived. Portal venous phase CT scans of 1–2-cm sized GB polyps caused by various pathologic conditions were retrospectively reviewed by two blinded observers. Among the 36 patients identified, 21 had benign polyps with the remaining 15 having malignant polyps. Size, margin, and shape of GB polyps were evaluated. Attenuation values of the polyps, including mean attenuation, maximum attenuation, and standard deviation, were recorded. As determined by visual inspection, the degree of polyp enhancement was evaluated. Using these CT findings, each of the two radiologists assessed and recorded individual diagnostic confidence for differentiating benign versus malignant polyps on a 5-point scale. The diagnostic performance of CT was evaluated using a receiver operating characteristic curve analysis.

Results

There was no significant difference in size between benign and malignant GB polyps. Ill-defined margin and sessile morphology were significantly associated with malignant polyp. There was a significant difference in mean and maximum attenuation values between benign and malignant GB polyps. Mean standard deviation value of malignant polyps was significantly higher than that of benign polyps. All malignant polyps showed either hyperenhancement or marked hyperenhancement. A _z value for the diagnosis of malignant GB polyps was 0.905.

Conclusion

Margin, shape, and enhancement degree are helpful in differentiating between benign and malignant polyps of 1–2-cm sizes.     

Internal retraction in single-port laparoscopic cholecystectomy: Initial experience and learning curve

Abstract

Introduction: We report our experience and learning curve in single-port laparoscopic cholecystectomy (SPLC) using an internal anchored retraction system. Methods: Usefulness of the retraction system was analysed in 18 SPLC. The first eight, the following ten SPLC and 20 consecutive four-port laparoscopic cholecystectomies (4PLC) were compared. Duration of operation, burns on nontarget tissue and gallbladder perforations were assessed by reviewing videotapes recorded during the procedures. Results: Use of the retraction system failed in three out of five patients (60%) with intraoperative signs of chronic inflammation and in one out of 13 (7.1%) without such signs (p = 0.0441). Median operation time was 90 (45–120) in the first eight and 55 (40–180) minutes in the following ten SPLC (p = 0.0361). Whereas the first eight SPLC lasted longer compared to 4PLC (70 (40–140) minutes, p = 0.0435) the difference disappeared after eight procedures (p = 0.2076). Median number of burns to nontarget tissue was seven (1–16) in the first eight and one (0–8) in the following ten SPLC (p = 0.0049). There was no difference in perforation of the gallbladder. Discussion: Internal retraction enables a safe exposure of the Calot triangle avoiding bile spillage in cholecystectomies without intraoperative signs of inflammation. Familiarisation with SPLC was rapidly achieved. Operation time and dexterity were equal to 4PLC after eight SPLC.     

术前超声对腹腔镜胆囊切除术难度的预测

目的评估术前腹部超声对腹腔镜胆囊切除术(LC)难度预测的价值。方法对1980例LC的难度和术前腹部超声进行临床研究。术前超声检查包括胆囊壁厚度,胆囊周围有无积液、胆囊大小、胆总管直径和胆囊结石。结果超声诊断与LC的符合率98.8%。超声正确诊断提供了手术适应证和手术方式的选择。结论超声诊断胆囊疾病准确,对选择LC适应证具有重要价值。     

黄色肉芽肿性胆囊炎的临床诊断及治疗分析

目的探讨黄色肉芽肿性胆囊炎的诊断与治疗,提高对该疾病的认识及诊治水平。方法对2004年9月2009年10月确诊为黄色肉芽肿性胆囊炎的15例患者资料进行回顾性分析。结果确诊为黄色肉芽肿性胆囊炎3例,慢性胆囊炎8例,胆囊癌4例。10例行胆囊切除术,2例行胆囊切除加胆总管探查T管引流术,1例行胆囊大部切除加十二指肠瘘修补术,1例行胆囊大部切除加胃瘘修补术,1例行胆囊切除加胆囊床部肝组织切除。术后并发胆瘘1例,切口感染2例。无死亡病例。结论黄色肉芽肿性胆囊炎术前难诊断,术中冷冻切片检查和术后病理检查是诊断的关键,手术切除胆囊是主要治疗方法。     

肠镜与多层螺旋CT小肠造影对炎症性肠病的诊断价值评估

目的探讨肠镜与多层螺旋CT小肠造影(MSCTE)对炎症性肠病(IBD)的诊断效能。方法回顾性分析2018年5月13日-2019年6月13日该院消化科76例经病理确诊为IBD患者的肠镜和MSCTE影像学检查资料,观察分析肠黏膜溃疡、多节段性病变、鹅卵石征、肠息肉、肠壁强化、肠壁增厚、结肠带消失、瘘管形成与腹腔脓肿的情况,并利用统计学方法对两项检查进行诊断效能的评估和分析。结果肠镜对IBD的诊断敏感性、特异性分别为98.68%和90.00%,肠镜和病理诊断结果的一致性较好(Kappa=0.77);MSCTE对IBD的诊断敏感性、特异性分别为88.16%和25.00%,MSCTE和病理诊断结果的一致性一般(Kappa=0.50)。MSCTE对IBD的诊断敏感性、特异性均明显低于肠镜,差异均有统计学意义(P 0.05)。肠镜+MSCTE对IBD的诊断敏感性、特异性分别为100.00%和95.00%,其与病理诊断结果的一致性较好(Kappa=0.84)。肠镜对于诊断IBD患者中肠壁溃疡、肠息肉、瘘管形成、鹅卵石征和结肠带消失有较高的诊断敏感性,但对瘘管形成的诊断特异性极低,MSCTE对肠壁增厚、肠壁强化和瘘管形成的敏感性均为100.00%,但对肠息肉、多节段病变的诊断特异性极低。结论肠镜仍是目前临床上诊断IBD的首选方式,对于身体状况不耐受和合并肠壁増厚、瘘管形成和腹腔脓肿等并发症的患者,则需要MSCTE才能获得全面、准确的诊断。肠镜和MSCTE的联合检查方式,对于IBD的诊断具有更高的临床价值。     

Laparoscopic cholecystectomy for gangrenous cholecystitis in around nineties: Two case reports

BACKGROUNDGangrenous cholecystitis is a form of acute cholecystitis which involves gangrenous alterations in the gallbladder wall and it often follows an acute and serious course. We herein report on two cases of very elderly people diagnosed early with gangrenous cholecystitis, who safely underwent laparoscopic cholecystectomy (LC) and both demonstrated a good outcome.CASE SUMMARYCase 1: An 89-year-old female. She underwent abdominal contrast-enhanced computed tomography (CECT) due to abdominal pain and diarrhea. Her gallbladder wall indicated the absence of contrast enhancement, thus leading to diagnosis of gangrenous cholecystitis and she therefore underwent LC. Although her gallbladder demonstrated diffuse necrosis and it was also partly perforated, she was able to be discharged without any serious complications. Case 2: A 91-year-old female. She made an emergency visit with a chief complaint of abdominal pain. Abdominal CECT revealed swelling of the gallbladder and an ambiguous continuity of the gallbladder wall. She was diagnosed with gangrenous cholecystitis and underwent LC. Her gallbladder had swelling and diffuse necrosis. Although her preoperative blood culture was positive, she showed a good outcome following surgery.CONCLUSIONAlthough a definite diagnosis of gangrenous cholecystitis is difficult to make prior to surgery, if an early diagnosis can be made and appropriate treatment can be carried out, then even very elderly individuals may be discharged without major complications.