类风湿关节炎患者焦虑及抑郁情绪与 疾病活动度的相关性

目的 分析类风湿关节炎患者焦虑及抑郁情绪与疾病活动度的相关性。方法 选取2017年1月~2018年3月在我院收治的类风湿关节炎患者105例作为研究对象,采用问卷调查的方式,调查患者焦虑、抑郁情绪评分以及疾病活动度程度,进一步分析患者焦虑及抑郁情绪与疾病活动度的相关性。结果 105例患者中存在焦虑情绪者43例,占40.95%,平均焦虑评分（42.94±3.88）分;抑郁情绪者33例,占31.42%,平均抑郁评分（46.83±3.91）分。患者平均疾病活动度指数得分（3.72±1.44）分,其中缓解期25例,占28.31%;轻度活动期16例,占15.23%;中度活动期44例,占 41.90%;重度活动期20例,占19.04%。不同疾病活动度患者焦虑、抑郁评分比较,差异有统计学意义（P＜0.05）;类风湿关节炎患者焦虑、抑郁情绪与疾病活动度评分呈正相关（r=0.273、0.322,P＜0.05）。结论 类风湿关节炎患者焦虑、抑郁情绪与疾病活动度存在一定的相关性,临床治疗过程中应重视对焦虑、抑郁情绪的疏导和环节,以促进患者的早日康复。     

类风湿关节炎患者外周血单个核细胞中PADI4 mRNA的表达及其意义

目的检测类风湿关节炎(RA)患者外周血单个核细胞(PBMCs)肽酰基精氨酸脱亚氨酶4(PADI4)mRNA的表达,分析其与RA患者的临床指标的相关性,探讨PADI4在RA发病机制中的作用及意义。方法实时定量PCR检测RA组(60例)、正常对照组(40例)PBMCs中PADI4 mRNA表达,并分析其与抗环瓜氨酸肽(CCP)抗体、疾病活动指数DAS28评分、C反应蛋白(CRP)、红细胞沉降率(ESR)、类风湿因子(RF)及病程等指标的关系。结果 RA组PADI4 mRNA相对表达[34.6(16.7,70.8)],明显高于正常对照组[20.6(11.1,51.8)](P<0.05)。RA组中PADl4 mRNA表达与抗CCP抗体、DAS28评分水平、ESR、RF呈正相关(r=0.527,P<0.001;r=0.416,P=0.001;r=0.371,P=0.004;r=0.287,P=0.030),与CRP、病程无相关性(r=0.015,P=0.919;r=0.064,P=0.625)。结论 RA病人外周血PBMCs PADI4 mRNA表达显著增高,并与抗CCP抗体水平、DAS28评分、ESR、RF呈正相关,可能是RA病情活动的一个有用的指标,PADI4可能在RA的发病和病理过程中起重要作用。     

类风湿关节炎患者外周血单个核细胞Sonic Hedgehog信号通路表达的初步研究

目的: 初步探讨类风湿关节炎(RA)患者外周血单个核细胞(PBMCs)和滑膜组织中Sonic Hedgehog(Shh)信号通路相关因子表达及意义。方法: 收集符合1987年美国风湿病学会(ACR)RA分类标准、28个关节疾病活动度评分(DAS28)≥3.2,病情活动RA患者(35例)及年龄、性别相匹配的健康志愿者(35例)外周血2 mL,分离PBMCs,提取总RNA,采用实时荧光定量PCR(real-time PCR)检测Shh信号通路中信号肽Shh、膜受体Ptch1和核转录因子Gli1 mRNA的表达。收集10例病情中度活动(DAS28≥3.2)RA患者的滑膜组织,同时收集5例外伤或半月板损伤(无关节炎)者滑膜组织作为对照组,免疫组化检测Shh、Ptch1和Gli1的蛋白表达情况。结果: RA患者PBMCs中Shh和Gli1 mRNA的相对表达量分别为1.36±1.48和1.15±0.68,对照组上述信号分子的mRNA表达量分别为0.47±0.25和0.49±0.05,2组差异有统计学意义(P<0.05),Ptch1 mRNA表达在2组间的差异无统计学意义(P>0.05);免疫组化示Shh和Gli1蛋白表达的阳性细胞百分率均高于对照组(P<0.05),Ptch1蛋白表达阳性细胞百分率2组无显著差异(P>0.05)。结论: RA患者PBMCs与滑膜组织中检测到Shh通路相关信号分子Shh和Gli1的表达上调,提示RA患者中可能存在Shh信号通路的激活,其在RA发病机制中的作用值得进一步研究。     

外周血单个核细胞CCL5表达水平作为类风湿关节炎与骨性关节炎潜在鉴别诊断标志物的研究

目的 探讨类风湿关节炎(RA)与骨性关节炎(OA)患者外周血单个核细胞(PMBC)中C-C模式趋化因子配体5(CCL5)表达水平差异,以及其作为类风湿关节炎与骨性关节炎潜在鉴别诊断标志物的可能性。方法 收集临床RA与OA患者外周血样本,以健康人做对照,提取PMBC中mRNA,利用Q-PCR方法检测CCL5表达水平。比较RA、OA患者PMBC中CCL5表达差异,并对比类风湿因子(RF)与抗环瓜氨酸肽抗体(ACPA)在RA与OA鉴别诊断中的作用,利用ROC曲线明确CCL5表达水平对RA与OA的区分情况,对CCL5表达水平与RA严重程度进行相关性分析。结果 收集RA与OA患者外周血样本各30例,RA患者PMBC中CCL5表达水平显著高于OA患者(P<0.05),其在RA与OA鉴别诊断中的灵敏度、特异性、阳性预测值、阴性预测均高于RF,ROC曲线表明,CCL5表达水平可以有效区分RA与OA患者(AUC=0.823),RA患者CCL5表达水平与TJC(关节压痛指数)、SJC(肿胀关节指数)、DAS28评分呈显著正相关(P<0.05),其相关系数分别为0.60、0.75、0.79。结论...     

类风湿关节炎患者外周血单个核细胞Notch及其配体表达

为研究Notch信号途径在类风湿关节炎(RA)发病机制中的作用,选取活动期RA患者,采用流式细胞术结合细胞表面及细胞内染色技术检测外周血单个核细胞Notch受体及配体表达情况,并与正常对照进行比较。结果发现,活动期RA患者外周血T细胞Notch2、Notch3及Notch4表达较正常人明显增加,Notch1分子表达均较少,二者未见差异。其中表达Notch分子的细胞以CD4+T细胞为主。二者B细胞Notch1、Notch2、Notch3及Notch4的表达均较低,之间未见明显差异。RA患者单核细胞Jagged1分子表达明显增加,而Delta1表达降低。结果提示活动期RA患者外周血单个核细胞中不同群体细胞存在Notch及其配体表达水平的改变。     

尿酸、黄嘌呤氧化酶与类风湿关节炎疾病活动度的关系

目的 探究血清尿酸(UA)、黄嘌呤氧化酶(XOD)表达水平与类风湿关节炎(RA)患者疾病活动度的关系。方法分析本院2019年3月至2021年1月接收的180例RA患者(RA组)的临床资料,根据28个关节的疾病活动度评分(DAS28)将患者分为缓解期组(86例)(DAS28评分<2.6分)和活动期组(94例)(DAS28评分≥2.6分),同时依据X线检查将患者分为骨损伤组(60例)和无骨损伤组(120例);对照组(176例)为健康体检者。血清UA水平的检测采用全自动生化分析仪,血清XOD水平的检测采用双抗体夹心酶联免疫吸附(ELISA)法;采用Pearson进行RA患者血清UA、XOD与疾病活动度的相关性分析;采用Logistic回归法分析UA、XOD对RA患者疾病活动度的影响。结果 RA组血清UA、XOD表达水平明显高于对照组(P<0.05)。活动期组血清UA、XOD表达水平明显高于缓解期组(P<0.05)。活动期RA患者UA与XOD、UA与DAS28评分、XOD与DAS28评分均呈正相关(r=0.721、0.622、0.571,P均<0.05)。缓解期RA患者...     

类风湿关节炎患者外周血单个核细胞中TRAIL、c-FLIP 等表达水平及临床意义

目的:分析类风湿关节炎(RA)患者外周血单个核细胞中肿瘤坏死因子相关凋亡诱导配体TRAIL、c-FLIP、Caspase-8等基因表达情况,探讨其在RA中的临床意义,为RA的临床诊治寻找更有效的途径和方法提供实验基础。方法:采用实时荧光定量PCR的方法检测外周血单个核细胞肿瘤坏死因子相关凋亡诱导配体TRAIL、c-FLIP、caspase-8 mRNA 表达水平;采用蛋白免疫印迹法检测PBMC 中TRAIL、c-FLIP、caspase-8 蛋白表达水平。结果:各组RA 患者PBMC 的TRAIL、c-FLIP、Caspase-8 的mRNA 表达水平:中活动组(M)中TRAIL的mRNA为(3.26±0.78),高于健康对照(N)(1.30±0.20,P=0.028)。低活动组(L)和高活动组(H)(1.56±0.37、1.83±0.26),略高于健康对照(N)(P=0.048、0.043);L、M、H 组c-FLIP mRNA相对表达量分别为1.27±0.28,1.32±.34,1.93±0.40,均高于N组1.08±0.12(P 分别为0.035、0.034、0.030),差异有统计学意义;caspase-8 mRNA L、M、H 组中分别为(2.77±0.97)、(4.52±0.85)、(2.13±0.44),均高于N 组(1.04±0.13,P=0.023,0.012,0.032)。RA 患者PBMC 中TRAIL、c-FLIP、caspase-8 蛋白表达:M 组TRAIL 蛋白表达明显高于N 组(P=0.013 ),H 组稍高于N 组(P=0.043),L组与N组无明显统计学差异(P=0.058),M 组明显高于L、H 组(P=0.011,0.021);c=FLIP 蛋白表达中M组明显高于N 组(P<0.01),而L、H 组与N 组无显著差异(P =0.062,0.053);L 组表达与N 组无显著差异(P>0.05),而M、H组caspase-8 蛋白表达明显高于N 组(P=0.003,0.001)。结论:在RA 的不同活动期中,外周血单个核细胞TRAIL、c-FLIP 和Caspase-8 等表达水平总体趋势增加,可为RA 的临床诊治及后续研究提供实验参考。     

胶原三螺旋重复蛋白-1与类风湿关节炎疾病活动度的相关性分析

目的：探究类风湿关节炎（RA）患者血清胶原三螺旋重复蛋白-1(CTHRC1)水平与疾病活动度的关系。方法：ELISA检测122例RA患者和61例健康体检者的血清CTHRC1水平。应用DAS28-ESR将RA患者分为非活动性RA组和活动性RA组,Spearman相关系数和二元Logistic回归分析CTHRC1浓度与RA疾病活动度的相关性。结果：(1)活动性RA组CTHRC1浓度明显高于非活动性RA组（P<0.001）,且与复合疾病活动度评分及大多数指标呈正相关;(2)血清CTHRC1水平诊断活动性RA组和非活动性RA组的曲线下面积（AUC）为0.843;(3)二元Logistic回归分析显示CTHRC1是与RA病情严重程度相关的独立危险因素,OR(95%CI)为1.010(1.001～1.012)。结论：RA患者CTHRC1水平显著升高并与疾病活动度相关。因此,CTHRC1可能成为评估RA疾病活动性的一种新型生物标志物。     

类风湿关节炎患者单个核细胞IL-23的表达及意义

目的:通过分析比较类风湿关节炎(Rheumatoid Arthritis,RA)患者血清和外周血单个核细胞(Peripheral bloodmononuclear cell,PBMC)IL-23的表达,探讨其在RA发病过程中的作用,以期为治疗开辟新途径。方法:应用ELISA方法检测RA、骨性关节炎(Osteoarthritis,OA)及正常对照组血清中IL-23和TNFα-蛋白水平,采用RT-PCR法测定各组PBMC中IL-23p19mRNA的表达,并作血清IL-23含量、PBMC IL-23p19mRNA的表达与血清TNFα-水平的相关分析。结果:RA组血清IL-23水平高于正常对照组(P=0.001),其他组间无统计学差异(分别为P=0.122,P=0.127);而各组血清TNFα-的水平均具有统计学差异,RA和OA组均高于对照组(P=0.000,P=0.042),RA组也高于OA组(P=0.013);RA组IL-23p19mRNA的表达高于OA和正常对照组(P=0.000,P=0.000),而OA组与正常对照组差异无统计学意义(P=0.628);血清中IL-23和TNFα-的相关性无统计学差异(r=0.212,P=0.262),而PBMC中IL-23p19mRNA的表达与血清TNFα-呈正相关关系(r=0.392,P=0.032)。结论:IL-23在RA患者PBMC中高表达,在RA的炎性发展过程起到了重要作用。     

痛风性关节炎肌骨超声表现与疾病活动度的相关性分析

目的 对痛风性关节炎肌骨超声表现及其与疾病活动度的相关性进行分析,探讨肌骨超声在痛风性关节炎疾病活动度中的价值.方法 选择2019年5月至10月在西安交通大学医学院附属红会医院接受治疗的痛风性关节炎患者80例(观察组),其中男性42例,女性38例;年龄27～58岁,平均年龄41.86岁.选取同时期在医院进行治疗的其他类...     

Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity

Tim-3 has been reported as an important regulatory molecule and plays a pivotal role in several autoimmunity diseases. Here, we demonstrated the increased expression of Tim-3 on peripheral CD4⁺ T, CD8⁺ T, NKT cells and monocytes from RA patients compared to those from healthy controls. Percentage of Tim-3⁺ cells in peripheral blood mononuclear cells (PBMCs) showed an inverse correlation with disease activity score 28 (DAS28) and plasma TNF-α level. Similar negative correlations were found between disease activity and Tim-3 levels on CD4⁺ T, CD8⁺ T and NKT cells. Consistently, Tim-3 expression on CD3⁺ T cells was further increased in patients with disease remission after treatment. Tim-3 expression on CD8⁺ T and NKT cells negatively correlates with plasma TNF-α. Our results suggest that Tim-3 might participate in the proceeding of RA by its negative regulation on various T cell subsets. Tim-3 might be a potential new marker for assessing severity of RA.     

CD123+CD11c-pDC在初发类风湿关节炎患者外周血及关节液中的表达

目的:探讨外周血及关节液中浆细胞样树突状细胞(Plasmaetoid dendritic cell,pDC)的数量在初发类风湿关节炎(RA)患者中的表达,进一步明确pDC在类风湿关节炎发病机制中的作用.方法:采集RA组患者(30人),骨关节炎(0A)组(25人),健康对照组(25人)抗凝外周血及关节液,流式细胞术检测CD123+ CD11c-pDC的表型及数量.结果:活动性RA患者外周血中CD123+ CD11c-pDC(1.69％±0.97％)与OA组(5.38％±2.31％)相比含量减少,差异具有统计学意义(P＜0.05),与健康对照组(5.63％±2.33％)相比含量减少,差异具有统计学意义(P＜0.05),后两者相比差异无统计学意义(P＞0.05).关节液中两组CD123+ CD1 1c-pDC含量差异无统计学意义(P＞0.05),pDC与DAS28评分及疾病的活动度指标RF、ESR、CRP无相关性.结论:初发RA患者体内外周血中CD123+ CD1 1c pDC含量减少与机体免疫功能紊乱有关,这对进一步阐明RA的发病机制及探索新的靶向治疗起到一定的积极作用.     

Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients

It has been known that the occurrence of rheumatoid arthritis (RA) was closely correlated with DNA hypomethylation in CD4+ T cells, in which DNA methyltransferase plays a certain role. This study therefore investigated the effect of miR-126 on CD4+ T cell subgroup in RA patients and the alternation of DNA hypomethylation, in an attempt to provide new sights into the pathogenesis and treatment of RA. CD4+ T cells separated from RA patients were transfected with miRNA (miR)-126 expression vector or miR-126 inhibitor expression vector. The expression levels of CD11a, CD70 and DNMT1 mRNA were examined by real-time PCR. Protein levels of CD11a and CD70 were tested by flow cytometry while DNMT1 protein level was quantified by Western blotting. DNA was modified by sodium bisulfite and was sequenced for the methylation status of promoters of CD11a and CD70 genes. Both mRNA and protein expressions of CD11a and CD70 genes in CD4+ T cells were elevated by miR-126 transfection, along with decreased DNMT1 protein level but not mRNA level. The methylation degree of promoters of both CD11a and CD70 genes were significantly depressed after miR-126 transfection. The transfection by miR-126 inhibitor effectively reversed such effects. In RA patients, elevated miR-126 may promote the expression of CD11a and CD70 via the induction of hypomethylation of gene promoters by depressing DNMTI1 protein levels.     

Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells

The carbohydrate chains represented by mucins (MUCs) are expressed by a variety of normal and malignant secretory epithelial cells and induce a variety of immunoreactions. To find new mucins related to the pathogenesis of rheumatoid arthritis (RA), we examined high-molecular-weight molecules inducing cytokines on human peripheral blood mononuclear cells (PBMCs) in synovial fluid from affected joints. We found a high-molecular-weight substance that induces interleukin 6 production on PBMCs in RA synovial fluid on gel filtration. MUC-1 was present in the resulting fractions, although they had been purified by CsCl density gradient centrifugation. We also found that MUC-1 was expressed on synovial cells and infiltrating inflammatory mononuclear cells on the sublining layer and lymphoid follicles in RA synovial tissues. CD68-positive superficial synovial cells colocalized with MUC-1 and CD68-positive macrophages were in contact with MUC-1-positive mononuclear cells. These findings imply that mucins, including MUC-1, may be related to immunoinflammatory reactions in the pathogenesis of RA.     

类风湿性关节炎患者外周血芳香烃受体表达与Th17细胞相关性研究

目的 检测类风湿性关节炎患者(RA)外周血单个核细胞芳香烃受体(AhR)的表达情况,分析其表达与Th17细胞相关性并初步探讨AhR在RA发病中的作用机制.方法 Ficoll密度梯度法分离75例RA患者(其中活动期RA患者40例,缓解期RA患者35例)及70例健康对照者外周血单个核细胞(PBMC),酶联免疫吸附实验(EUSA)检测细胞裂解上清中AhR蛋白表达.流式细胞术检测75例RA患者Th17细胞表达比例.分析RA患者AhR蛋白表达与Th17细胞比例及其他临床指标的相关性.结果 RA患者PBMC内AhR表达[(91.25±15.27) ng/L]高于健康对照组[(41.81 ±9.72) ng/L],差异有统计学意义(t=3.191,P＜0.01).活动期RA患者AhR表达与缓解期RA患者表达差异无统计学意义(P＞0.05).RA患者PBMC中AhR水平与Th17细胞表达呈正相关(r=0.361,P=0.0015).RA患者PBMC中AhR表达与血清IL-17水平呈正相关,与其他临床指标无相关性(r=0.324,P=0.006).结论 RA患者PBMC中AhR表达升高,且与Th17细胞和血清中IL-17水平呈正相关,推测RA中AhR可能正向调控Th17细胞分化,促进IL-17表达.     

Leflunomide,a novel immunomodulating drug,inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis

Objective and Design: A novel immunomodulating drug, leflunomide has been shown recently to be effective and well tolerated in patients suffering from rheumatoid arthritis (RA). The present study evaluated the effect of the drug on cell adhesion in RA. Material and Treatment: Peripheral blood and synovial fluid mononuclear cells were obtained from a clinical trial, undertaken primarily to evaluate the efficacy and pharmacokinetic profile of multiple-dose pulsing leflunomide therapy in RA patients. PB MNC and corresponding synovial fluid (SF) MNC for in vitro homotypic aggregation (HA) assay were obtained from healthy volunteers and RA patients with active disease not treated with leflunomide in vivo. Methods: Expression of activation antigens (CD25, CD54, CD69, CD71, HLA-DR) on peripheral blood mononuclear cells (PB MNC), as well as ex vivo ability of cells to aggregate spontaneously were determined in patients before entering into the clinical trial and at the end of 6 months treatment. HA was measured by aggregation in vitro. Data were compared by Student's t-test. Results: There was a decreased expression of activation antigens and decreased spontaneous MNC clustering after leflunomide therapy. We found in the in vitro study that HA of PB and SF MNC was mainly mediated through β2-integrin molecules. The active metabolite of leflunomide, A77 1726, effectively suppressed both spontaneous and phorbol-ester (PMA)-induced HA. Disruption of cell aggregates by A77 1726 was dose-dependent and, most likely, unrelated to the quantitative modulation of integrin receptors. Conclusions: Results from this study support the idea that leflunomide elicits its immunomodulatory action, at least partially, by modulating the adhesion process. accepted by M. J. Parnham     

The role of physical activity in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory auto-immune disease, causing progressive damage to the musculoskeletal system. Many patients with RA also suffer from accelerated muscle loss or cachexia, which contributes to the loss of physical function and quality of life. Physical activity plays a central role in the management of the disease as it is essential to maintain muscle strength and endurance, range of motion and the ability to perform activities of daily life. On the other hand, given the nature of the disease, there is always an increased risk for injury. There is a large amount of literature investigating the effect of exercise interventions on muscle function and disease activity. These studies show that exercise clearly improves muscle function without affecting disease activity. Studies including radiographic evaluation of joint damage as an endpoint also show that there is no evidence that exercise, even high-intensity exercise, increases inflammation or joint damage, although care should be taken with patients with severe baseline damage. Regarding daily physical activity (exercise is only one component of physical activity) there is hardly any research done showing either that physical activity is indeed decreased in patients or whether or not there is a relation between daily physical activity and disease activity. The results from studies looking at the effect of exercise on muscle mass or the ability to prevent or reverse cachexia are somewhat contradictory, but it seems that when the training dose is sufficiently large, gains in muscle mass can be achieved.     

Interleukin 4 inhibits polyclonal immunoglobulin secretion and cytokine production by peripheral blood mononuclear cells from rheumatoid arthritis patients

Rheumatoid arthritis (RA) is associated with T- and B-cell dysfunction. Immunoglobulin (Ig) production is under the control of T cells and their derived cytokines such as interleukin 2 (IL-2) and IL-4. Herein we studied the regulation of the production of immunoglobulins and cytokines by peripheral blood mononuclear cells from RA patients and controls. In the controls, IL-4 inhibited Ig production in response toStaphylococcus aureus and pokeweed mitogen stimulation. IL-2 induced maximal Ig production in association withStaphylococcus aureus, whereas it inhibited pokeweed mitogen-induced production. In patients, levels of Ig production in response to mitogens and cytokines were reduced, particularly for the response to IL 2. The inhibitory effect of IL-4 on mitogen-induced Ig production was observed in RA patients as in the controls. Spontaneous production of IL-6 was increased in RA patients. These levels were correlated with indicators of active disease such as sedimentation rate and Ritchie index. IL-4 inhibited the production of IL-6, IL-1, and tumor necrosis factor (TNF) by both controls and rheumatoid patients. Thus as first described for the T-cell response, mononuclear cells from RA patients display a reduced response to mitogens and cytokines which induce their B-cell differentiation into Ig-screening cells. However, IL-4 was able to inhibit Ig and cytokine production, properties suggesting a potential antiinflammatory role for this cytokine.     

A close association of body cell mass loss with disease activity and disability in Chinese patients with rheumatoid arthritis

OBJECTIVES:

To investigate the association of body cell mass loss with disease activity and disability in rheumatoid arthritis patients.

INTRODUCTION:

Rheumatoid cachexia, defined as the loss of body cell mass, is important but under-recognized and contributes to morbidity and mortality in patients with rheumatoid arthritis.

METHODS:

One hundred forty-nine rheumatoid arthritis patients and 53 healthy, non-rheumatoid arthritis control subjects underwent anthropometric measurements of body mass index and waist and hip circumferences. Bioelectrical impedance analysis was used to determine the subjects'' body compositions, including fat mass, skeletal lean mass, and body cell mass. The disease activity of rheumatoid arthritis was assessed using C-reactive protein serum, the erythrocyte sedimentation rate and the 28-joint disease activity score, while disability was evaluated using a health assessment questionnaire.

RESULTS:

Rheumatoid arthritis patients had lower waist-to-hip ratio (0.86±0.07 vs. 0.95±0.06; p<0.001) and lower skeletal lean mass indexes (14.44±1.52 vs. 15.18±1.35; p = 0.002) than those in the healthy control group. Compared with rheumatoid arthritis patients with higher body cell masses, those with body cell masses lower than median had higher erythrocyte sedimentation rates (40.10±27.33 vs. 25.09±14.85; p<0.001), higher disease activity scores (5.36±3.79 vs. 4.23±1.21; p = 0.022) and greater disability as measured by health assessment questionnaire scores (1.26±0.79 vs. 0.87±0.79; p = 0.004).

CONCLUSIONS:

The loss of body cell mass is associated with higher disease activity and greater disability in rheumatoid arthritis patients. Body composition determined by bioelectrical impedance analysis can provide valuable information for a rheumatologist to more rapidly recognize rheumatoid cachexia in rheumatoid arthritis patients.     

低氧微环境与类风湿性关节炎的发生与发展

氧是一种环境信号,参与调节细胞的生长分化及生物学表型调控.研究发现低氧影响免疫应答的性质与强度,参与急慢性炎症如类风湿性关节炎的发生及转归过程,其中低氧诱导因子(hypoxia inducible factor,HIF)的调控作用备受关注.类风湿性关节炎(rheumatoid arthritis,RA)是具有局部低氧特征的自身免疫性疾病,近年来的研究发现低氧微环境在其发展过程中起关键作用,拟就低氧及HIF在类风湿关节炎发病中作用的研究进展进行综述.