稳定性二氧化氯含漱液治疗牙龈炎的临床研究

目的　验证稳定性二氧化氯含漱液 (口腔爽含漱液 )治疗牙龈炎的临床效果。方法　采用双盲临床对照试验方法 ,选择 10 0名患有牙龈炎的 17～ 2 0岁的男女学生作为研究对象 ,随机分成两组 ,每组 5 0人 ,男女均等。试验组给以口腔爽含漱液 ,对照组给以口泰含漱液 ,观察两组受试者使用含漱液 7d前后的牙龈指数和菌斑指数的变化 ,依此来评价口腔爽含漱液的临床效果。结果　使用口腔爽含漱液受试者的平均牙龈指数和菌斑指数分别减少0 .6 6和 0 .91,均有统计学显著性意义 (P <0 .0 0 1) ;与对照组分别为 0 .6 4、1.0 6比较 ,差异无显著性意义 (P >0 .5 0 )。结论　口腔爽含漱液对治疗牙龈炎、控制牙菌斑有明显效果 ,与口泰无显著差别 ,且口感好 ,未发现任何副作用 ,是一种新型的口腔含漱液 ,值得在临床上推广应用。     

强氧化水溶液治疗牙龈炎的临床试验

目的:研究强氧化水溶液治疗牙龈炎的临床效果。方法:采用临床对照试验方法选择2008年12月至2009年1月在我院口腔科门诊就诊的50名牙龈炎患者,作为研究对象随机分成两组每组25人,试验组给予强氧化水溶液含漱,对照组给以生理盐水含漱,观察两组受试者使用含漱液5d前后的牙龈指数和菌斑指数的变化。评价两种含漱液的临床效果。结果:两组的牙龈指数和菌斑指数的基线无差异。两组应用不同的含漱液漱口5d后,牙龈指数均有降低,但无明显差异(P>0.05);而菌斑指数在强氧化水组有明显降低(P<0.05),对照组则变化不明显。结论:强氧化水溶液对治疗牙龈炎、控制牙菌斑有明显效果且无毒无味无刺激,可以用于临床治疗牙龈炎和控制牙菌斑。     

不同含漱液控制菌斑和消除牙龈炎症效果的比较

目的：研究护齿含漱剂、口泰含漱液、万宝林牙齿、口腔清洁液在控制菌斑和牙龈炎的作用．方法：选择２０３例牙龈炎患者，随机分为护齿含漱剂组、口泰含漱液组、万宝林牙齿、口腔清洁液组、多贝尔氏液组和蒸馏水组，用药前后检查牙龈指数（ＧＩ）、牙龈出血指数（ＳＢＩ）、菌斑指数（ＰＬＩ）．结果：用药后护齿含漱剂、口泰含漱液、万宝林牙齿、口腔清洁液组的ＧＩ、ＳＢＩ、ＰＬＥ均比用药前有明显降低（ｐ＜０．０１），且优于多贝尔氏液和蒸馏水组．结论：护齿含漱剂、口泰含漱液、万宝林牙齿、口腔清洁液能有效控制菌斑及牙龈炎     

NovaMin生物活性玻璃离子牙膏抗牙菌斑和牙龈炎的临床研究

目的：评价NovaMin生物活性玻璃离子牙膏抗牙菌斑和牙龈炎的临床功效。方法：遵照随机、双盲、对照的试验原则,按纳入和排除标准将100名年龄在20～48岁的受试者随机分成试验组（使用NovaMin生物活性玻璃离子牙膏）和空白对照组（使用同一公司生产的普通牙膏）,采用菌斑指数和牙龈出血指数评价受试者的牙龈健康状况。结果：试验组菌斑指数和牙龈出血指数与试验前相比在统计学上有显著性差异,试验6周后牙龈出血指数和菌斑指数分别降低了58．8％和16．4％;而对照组菌斑指数和牙龈出血指数在统计学上无显著性差异（P〉0．05）。结论：本研究提示NovaMin生物活性玻璃离子牙膏能通过减少龈上菌斑和减轻牙龈出血而显著改善牙龈健康状况。     

西帕依固龈含漱液治疗慢性牙龈炎的临床效果观察

目的：观察西帕依固龈含漱液治疗慢性牙龈炎的临床疗效.方法：选取慢性牙龈炎患者150例作为研究对象,随机分研究组和对照组.研究组使用西帕依固龈含漱液,对照组使用朵贝氏液含漱.对比两组病例牙龈充血水肿改善情况,龈沟出血指数以及菌斑指数的变化情况.结果：研究组治疗后牙龈指数临床总有效率92％,龈沟出血有效率88％,菌斑指数有效率80％,均优于对照组的80％、72％和64％,两组比较差异具有统计学意义（P＜0.05）.结论：西帕依固龈含漱液治疗牙龈炎疗效较好、较安全,有较好的临床应用前景.     

��̩�͸������Ӻ���Һ�ڹ̶�����������Ԥ��������Ч�����о�

目的观察口泰和复方茶多酚含漱液在固定正畸治疗中对牙龈炎的防治效果。方法选取2005—2006年在遵义医学院附属口腔医院门诊进行固定正畸矫治的病例40例,随机分为两组(每组各20例),分别使用口泰和复方茶多酚含漱液,观察正畸治疗前及治疗后1,2,3个月时牙龈炎发生情况,对牙龈指数(GI)、菌斑指数(PLI)进行检测,并对两组情况进行比较。结果使用不同含漱液后两组之间的GI、PLI差异均有统计学意义(P<0.05或<0.01)。结论复方茶多酚含漱液对固定正畸患者牙龈炎症的预防效果优于口泰。     

几种含漱液的临床疗效观察

几种含漱液的临床疗效观察广东省口腔医院（５１０２６０）叶树芬本文收集了本院门诊中，将口炎含漱液、口泰含漱液、儿茶素含漱液分别应用于牙龈炎和复发性阿弗它口炎的疗效资料，报告如下：材料与方法牙龈炎患者２９５例，其中男性１５７例，女性１３８例，年龄１３一６...     

洗必泰漱口液对牙龈炎及牙菌斑作用的研究

目的:研究洗必泰对固定矫治患者牙龈炎及牙菌斑的临床作用.方法:①选择24例固定正畸伴有牙龈炎患者,年龄11～17岁,随机分成实验组和对照组.②洁治后8～10 d,记录指数牙的菌斑指数、牙龈指数作为基线值,对照组用安慰剂漱口,实验组以洗必泰漱口.③分别于4周、8周、12周后记录菌斑指数、牙龈指数.结果:8周、12周后,实验组各项指数明显低于对照组.结论:应用0.12%洗必泰漱口配合日常的口腔卫生措施,能有效减少固定正畸患者牙龈炎的发生.     

洁口净含漱液治疗牙龈炎口臭的临床疗效观察

目的：探讨洁口净含漱液对牙龈炎所致口臭的临床治疗效果。方法：受试者60名,随机分为两组,对照组30例采用龈上洁治术牙周基础治疗;实验组30例在对照组牙周基础治疗的同时,配合洁口净含漱液治疗。分别在基线、4周末进行检查,采用Halimeter口臭测试仪测量口臭值。结果：实验组与对照组比较,Halimeter口臭测试仪测量的口臭值出现显著性差异。结论：洁口净含漱液对牙龈炎所致口臭具有良好的治疗效果。     

口洁素防治正畸牙龈炎的临床效果评价

目的 观察口洁素含漱液治疗固定正畸牙龈炎的临床疗效.方法 选取18～ 33岁固定正畸成人牙龈炎患者30名,随机分成治疗组15例(使用口洁素含漱液和常规口腔卫生保健措施)和对照组15例(常规口腔卫生保健措施),持续用药2个月,治疗前后分别记录牙龈指数(GI)、菌斑指数(PLI)和龈沟出血指数(SBI),测定上颌A区第一前磨牙和第一磨牙,以及下颌2个中切牙的牙周情况,并进行统计学分析.结果 治疗后试验组患者GI、PLI和SBI值分别为0.66,2.92和3.70,对照组值分别为0.76,3.49和3.76,经统计学分析,试验组与对照组有显著性差异(P＜0.05).结论 口洁素含漱液能有效降低固定正畸治疗中牙龈炎症的发生率,值得临床推广.     

Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash

OBJECTIVE: To assess the antiplaque/antigingivitis efficacy of a hexetidine-containing mouthwash. METHODS: This examiner-blind, parallel group, controlled clinical study examined the effectiveness of a hexetidine (0.1%) mouthwash both in inhibiting the development of supragingival plaque and in reducing gingivitis. One hundred and thirty-four adult subjects completed the 2-week experimental gingivitis model study. Following baseline examinations, which included plaque index, modified gingival index and gingival bleeding index, subjects received a full dental prophylaxis. Subjects were randomly assigned to one of three mouthwashes (hexetidine 0.1%, chlorhexidine 0.12% (positive control) or a 5% hydroalcohol negative control) and commenced three times daily supervised rinsing as their sole method of oral hygiene. All indices were rescored after 2 weeks. RESULTS: Compared to the negative control group, the hexetidine group demonstrated a statistically significant inhibition and reduction of supragingival plaque and gingival inflammation with reductions of 6.3%, 33.5% and 56% for gingivitis, plaque and gingival bleeding, respectively. The results of the chlorhexidine group were used to validate the study. CONCLUSION: The study confirms the efficacy of a hexetidine rinse in reducing supragingival plaque and gingival inflammation.     

口康宁漱口液治疗口腔粘膜炎的疗效研究

用随机法对１１８例口腔粘膜炎患者进行临床研究。试验组５９例，使用口康宁漱口液；对照１组２９例，使用多贝尔氏液；对照２组３０例，使用口泰漱口液。实验室研究显示，口康宁具有抗炎作用及良好的抗菌作用，是一种中，西医结合的新型漱口液。     

双黄连牙膏对牙菌斑、牙龈炎的控制效果

目的评价含有双黄连成分的牙膏在控制菌斑及牙龈炎症方面的效果。方法选取符合纳入标准的25名牙龈炎患者,随机分为2组。采用双盲法实验,一组使用含双黄连成分牙膏,另一组使用不含双黄连其它成分相同的牙膏。记录使用牙膏前及使用牙膏1、4、12周菌斑指数、牙龈指数、探诊出血情况,比较2组数据,评价含有双黄连成分的牙膏在控制菌斑及牙龈炎症方面的效果。结果双黄连组与对照组菌斑指数、牙龈指数、探诊出血均有改善,双黄连组疗效持续时间更长久。结论使用含双黄连成分牙膏可更好、更持久的消除菌斑,减少菌斑再附着,减轻牙龈炎症。     

The effect of locally released oxygen on the development of plaque and gingivitis in man

Abstract An experimental gingivitis study was designed to test the effect of a 5-min twice daily oxygen application on the development of plaque and onset of gingivitis A method for the local application of medical grade oxygen to the upper anterior teeth was developed, with the lower anterior teeth used as controls. Fourteen periodontally healthy dental students of average age 21.9 years participated in the study. There was no significant effect of oxygen on plaque formation, crevicular fluid flow, or the number of gingival bleeding sites. Experimental and control gingival segments exhibited bleeding on probing at an average of 6.6 days after cessation of mechanical plaque control, much earlier than reported in other experimental gingivitis studies.     

生物活性玻璃凝胶治疗菌斑性牙龈炎的4周临床研究

目的 评价生物活性玻璃凝胶治疗菌斑性牙龈炎4周后的临床有效性和不良事件的发生情况。方法 采用多中心、随机、双盲的临床研究方法,将124名受试者随机分成试验组(生物活性玻璃凝胶)和安慰剂组(同公司生产的不含主要有效成分的凝胶)。受试者早晚刷牙后分别用4g试验凝胶处理全口牙龈并保持3min。在受试者入组当天、第(14±2)天及第(28±2)天时进行随访检查,评价其龈沟出血指数(SBI)、菌斑指数(PLI)及随访期间不良事件的发生率。结果 在治疗第(28±2)天后,实验组SBI、PLI较基线值均出现明显降低(P<0.001);随访期间实验组不良事件的发生率为9.68%,安慰剂组1.61%,差异无统计学意义(P>0.05);且两组均无严重不良事件的报告。结论 生物活性玻璃凝胶可以缓解牙龈出血和抑制牙菌斑,可推荐用于治疗菌斑性牙龈炎症。     

A modification to the experimental gingivitis protocol to compare the antiplaque properties of two toothpastes

BACKGROUND AND AIMS: Randomised, blind, controlled experimental gingivitis and home-use study protocols are used to evaluate the efficacy of oral hygiene products. The present methodological study combined the two clinical trial designs to compare the preventive and therapeutic potentials of two toothpastes. MATERIAL AND METHODS: The study was a parallel group, randomised, double-blind design, initially involving 73 healthy dentate subjects. A 21-day experimental gingivitis protocol was combined with a 6-week (42 days) home-use protocol. At baseline, modified gingival index (MGI), gingival index (GI) and gingival bleeding (GB) were recorded. A dental prophylaxis was then performed. Subjects were allocated to either control fluoride or stannous fluoride toothpaste based on gender and GI. During the first 21-day period, subjects applied the allocated toothpaste, for 1 min twice a day, to a group of teeth in a plastic shield and brushed the remaining teeth with the same paste. From day 21 the shield was not placed, and subjects brushed all teeth with the toothpaste for 1 min twice per day up to day 42. MGI, GB and a plaque index (PI) were recorded on days 21 and 42. RESULTS: Sixty-nine and 67 subjects completed to days 21 and 42, respectively. For shielded teeth, PI, MGI and GB increased to day 21 and then after ceasing the use of the shield decreased to day 42. At day 21, PI favoured the stannous fluoride toothpaste, but differences did not achieve statistical significance for any parameter at days 21 or 42. For unshielded teeth, there were no significant differences between the toothpastes for any parameter at either time point. CONCLUSION: : The feasibility of combining two gingivitis clinical trial methodologies appears proven, and data on both the preventive and therapeutic chemical and mechanical efficacy of toothpastes can be obtained through such protocols. Specifically from the present study and consistent with some other reports, the plaque inhibitory properties of the stannous fluoride product are limited and do not always translate into an antiplaque/antigingivitis effect.