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Mosca F Stracqualursi A Persi A Portale TR Zappalà O Latteri S 《Il Giornale di chirurgia》2005,26(8-9):302-306
The Authors report on a patient admitted several times for the occurrence of five multiple metachronous primary malignancies (laryngeal carcinoma, endometrial adenocarcinoma, rectal cancerous polyp, Vaterpapilla carcinoma and transverse colon cancer). All five carcinomas were independent primary cancers and the lenghty time intervals between the onsets of each individual tumours confirm their independent non-metastatic origin. Classification, pathogenesis, genetic and environmental interactions of these tumours are discussed; in the case reported a family history of colon cancer was present, while no genetic markers abnormalities or chronic exposure to carcinogens were found. The case report suggests that an aggressive, appropriate surgical approach together with a through follow-up monitoring offers a chance of long-term survival for patients with metachronous malignant primary tumours. 相似文献
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IntroductionThe occurrence of multiple primary synchronous or metachronous malignancies is a described phenomenon. Such cases may have genetic predisposition or could be related to environmental risk factors but may also be sporadic. We are reporting a unique combination of triple primary synchronous malignancies in the same patient.Case presentationA 71 year old man presented with constipation and per rectal bleeding with a palpable mass 5–6 cm from the anal verge on physical examination. Colonoscopy with biopsy confirmed adenocarcinoma of rectal origin. After multi-disciplinary tumor board meeting, the patient received neoadjuvant chemoradiation therapy followed by single-stage surgery. Re-staging work up showed the presence of pancreatic lesion. Incidental finding of a gastric nodule upon surgical exploration which was confirmed to be a gastrointestinal stromal tumor. The patient had an uneventful postoperative course.DiscussionMultiple primary malignancies of the gastrointestinal system has previously been reported in the literature; whether in the form of double, triple, quadruple or even quintuple primaries. Furthermore, gastrointestinal malignancies have been reported to be combined with extra-intestinal malignancies. However, this unique combination of pancreatic adenocarcinoma, rectal adenocarcinoma and gastric gastrointestinal stromal tumor has not been previously reported in the literature. Single-stage multiple resections was successful.ConclusionWe are reporting a unique case of three primary malignancies involving the rectum, pancreas and stomach. For such patients, there is no clear guidelines regarding management or surveillance, but rather should be individualized. 相似文献
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Multiple intracerebral microhemorrhages associated with primary aldosteronism: a case report 总被引:1,自引:0,他引:1
Miyata K Imaizumi T Horita Y Hashimoto Y Tanno K Koide A Niwa J 《No shinkei geka. Neurological surgery》2003,31(11):1223-1227
We have observed dot-like low intensity spots (a dot-like hemosiderin spot: dotHS) on T2*-weighted (T2*-w) MRI, subsequently diagnosed histologically as previous microbleeds associated with lipohyalinosis, amyloid angiopathy and cerebral small vessel disease (SVD) including an intracerebral hematoma (ICH) and a lacunar infarction. According to the literature, primary aldosteronism (PA), characterized by hypertension, is related to SVD. A 49-year-old female with a long history of untreated hypertension secondary to PA was admitted to our hospital for medical examinations on July 18th, 2000. She had the stepwise development of dementia, dysarthria and gait disturbance (right hemiparesis). CT and MRI demonstrated multiple lacunar infarctions. She was readmitted to our hospital on Jan 23rd, 2002. A neurological examination revealed right hemiparesis, dysarthria and consciousness disturbance. CT on admission demonstrated ICH in the left midbrain. Six days after the hemorrhage, T2*-w MRI showed thirty-two dotHSs in the basal ganglias and the cortical-subcortical regions. The incidence of ICH in patients with hypertension secondary to PA is reported to be higher than in patients with essential hypertension. Multiple dotHS may be associated with ICH, lacunar infarction, and severe microangiopathy related to hypertension secondary to PA. 相似文献
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Naganuma H Mashiko K Hanai M Abe T 《Kyobu geka. The Japanese journal of thoracic surgery》2006,59(3):241-243
A 60-year-old woman has been followed under the diagnosis of De Bakey type Illb acute aortic dissection. She developed sudden backache, and the diagnosis based on the emergent computed tomography (CT) was De Bakey type I dissection. At the operation, previous De Bakey type Illb dissection was far from the new dissection observed in the ascending aorta and arch aorta. We replaced the ascending aorta and aortic arch with woven Dacron graft (arch first technique) under retrograde cerebral perfusion. Since the residual dissection (De Bakey type III) in the multiple aortic dissection has tendency to dilate fast, intensive follow-up of the patient would be necessary. 相似文献
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Niimi S Hayashi S Hayakawa Y Tsunoo H Koshikawa T 《Kyobu geka. The Japanese journal of thoracic surgery》2002,55(13):1167-1169
A case of multiple lung cancer with cavity was reported. Chest X-ray and chest computed tomography (CT) showed two abnormal shadows with consolidation in the right S1 and S2b. The shadow in S2b had a cavity. Right upper lobectomy and right middle lobe partial resection was performed and the histopathological examination revealed adenocarcinoma. This case deserves attention of difficulty in differentially diagnosis on the chest X-ray and chest CT from pulmonary tuberculosis. 相似文献
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Mohamad Bydon Dimitrios Mathios Javier J. Aguayo-Alvarez Cherry Ho Ziya L. Gokaslan Ali Bydon 《The spine journal》2013,13(10):1379-1386
Background context
Intramedullary ependymomas constitute the most frequent type of intramedullary tumor. In patients with neurofibromatosis type 2 (NF2), multiple intramedullary ependymomas are known to occur. In the non-NF2 population, however, the presence of multiple synchronous intramedullary ependymomas is exceedingly rare.Purpose
In this article, the authors report the second case in the literature of multiple primary synchronous intramedullary ependymomas. To the best of the authors knowledge, this report represents the first to provide a detailed pathology of all lesions, thereby giving an added level of confidence on the primary synchronous nature of the lesions. The authors have also performed a review of the literature regarding multifocal intramedullary ependymomas.Study design
A review article and case report.Conclusions
The concomitant localization of two primary intramedullary spinal cord ependymomas in the setting of nongenetic predisposition is an uncommon phenomenon. In this article, the authors present the second report of multiple, synchronous intramedullary ependymomas. A detailed review of the literature reveals that the presence of multiple intramedullary lesions in non-NF2 patients is both rare and deserving of further study. 相似文献11.
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C J Kim Y Okada A Ishida Y Arai T Tomoyoshi T Shiraishi 《Hinyokika kiyo. Acta urologica Japonica》1991,37(2):151-155
We report a case of adrenal myelolipoma with multiple calcification and hypertension. A 69-year-old woman visited our hospital with a complaint of right flank pain. Computed tomography demonstrated a right adrenal tumor which was a spherical mass with fat density and multiple calcification. Adrenal scintigraphy of I-131 adosterol demonstrated predominant accumulation of the right adrenal gland. Selective venous sampling disclosed a high aldosterone level (303.7 ng/dl) from the affected side. Right adrenalectomy was performed. Pathological diagnosis revealed adrenal myelolipoma with calcification. After the operation the patient became normotensive. The characteristics of the 12 cases of myelolipoma with calcification we found in the Japanese literature are also briefly reviewed. 相似文献
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SOSHU SATO NOBUO SHINOHARA SHIN SUZUKI TORU HARABAYASHI TOMOHIKO KOYANAGI 《International journal of urology》2004,11(5):269-275
AIM: To evaluate the incidence, nature and prognosis of multiple primary malignancies involving renal cell carcinoma (RCC) in Japan. METHODS: Between 1975 and 1998, 319 patients underwent an operation for RCC at Hokkaido University, Sapporo, Japan. The incidence of other primary malignancies was determined and classified as antecedent, synchronous or subsequent. Follow-up was obtained by thorough chart review or telephone interview, and ranged from 0 to 276 months (median 49.0 months). To analyze the influence of other primary malignancies on prognosis, overall and cause-specific survival rates of the patients with an antecedent or synchronous malignancy were compared to the remaining patients. RESULTS: Of the 319 patients there was at least one other malignancy in 38 patients (12%). Four patients had two other malignancies. The other malignancies were antecedent in 13, synchronous in 19 and subsequent in 10 patients. Twenty-two patients had gastrointestinal cancer. In cases of antecedent or synchronous diagnosis of other primary malignancies, RCC was commonly incidental, small or low-stage. Multivariate analysis using Cox's proportional hazards model showed that, for overall survival, the presence of other antecedent or synchronous malignancies was the second most significant prognostic factor, following the pathological stage of RCC. CONCLUSIONS: In Japanese patients with RCC, the incidence of other primary malignancies was not uncommon and these malignancies contributed to the prognosis of these patients. Therefore, the malignant potential of individual tumors should be paid careful attention in the management of these patients. 相似文献
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Kaneko M Matsumoto I Oda M Watanabe G 《Kyobu geka. The Japanese journal of thoracic surgery》2008,61(9):820-823
A 67-year-old male referred to our hospital for the close examination of abnormal chest X-ray findings. Chest X-ray films showed abnormal shadows in the right lung field. Chest computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed the 3 tumors which located in superior, middle and posterior mediastinum. The operation underwent under the diagnosis of neurogenic tumors originating from the right intrathoracic vagal nerve. At the operation, the tumors existed the vagal nerve distal to the recurrent laryngeal nerve and they were resected with the transection of vagal nerve. The masses were histologically diagnosed as schwannoma. We reported a rare case of multiple schwannoma arising from the intrathoracic vagal nerve. He had no postoperative complications, and he has been free from recurrence for 4 years postoperatively. 相似文献
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A 73-year-old male was admitted to our hospital with the complaint of difficulty and frequency of urination. Needle biopsy of the prostate was done and microscopic examination revealed adenocarcinoma. Bone scintigram showed multiple bone metastasis and he was diagnosed as having prostatic carcinoma stage D2. Intravenous pyelography revealed multiple out-pouching lesion of mid left ureter and left mild hydronephrosis. Fosfestrol was given for prostatic carcinoma and no treatment was given for multiple ureteral diverticula. Sixteen cases of multiple ureteral diverticula from Japan were collected and discussed. 相似文献