球帽附着体种植覆盖义齿修复牙槽嵴重度萎缩无牙下颌

目的：总结分析BEGO种植体系统球帽附着体固位覆盖义齿，修复重度牙槽骨萎缩无牙下颌的临床应用与效果。方法：对重度牙槽骨萎缩、普通义齿固位极度不良的7例下颌无牙颌患者，在下颌骨前牙区植入2-3枚BEG0柱形螺旋种植体，共植入种植体17枚，后期采用球基台作球帽附着体固位覆盖义齿修复，定期复诊观察评价种植和覆盖义齿修复效果。结果：全部17枚种植体均顺利一期愈合，愈合周期平均3个月，球帽附着体覆盖义齿修复后经6-12个月观察，义齿稳定、咀嚼功能恢复理想，容貌改善明显，患者满意。结论：种植体支持球帽附着体固位覆盖义齿修复牙槽骨重度萎缩无牙下颌，可有效恢复咀嚼功能，改善患者容貌，提高患者生活质量，同时球帽附着体修复，简单经济，易于保持口腔清洁，可以推广。     

球帽附着体种植覆盖全口义齿在下颌无牙领的应用

目的:了解球帽附着体种植覆盖义齿及脱钙人牙基质材料(DDM)在牙槽骨萎缩的下颌无牙颌的临床应用效果.方法:采用Frialit-2及Xive种植系统及骨又生-脱钙人牙基质材料(DDM)同期对17例牙槽骨萎缩的下颌无牙颌进行2枚种植体支持固位式球帽覆盖全口义齿修复.结果:经过1～2年的临床观察,种植体稳固,义齿功能优良,明显提高了患者的生活质量.结论:对严重萎缩牙槽嵴的下颌无牙颌患者,采用脱钙人牙基质材料(DDM)及种植覆盖总义齿进行修复,能有效地恢复功能,临床效果满意.     

种植磁附着体在全口义齿修复中的临床应用

目的　探讨种植磁附着体全口义齿对下颌牙槽嵴重度吸收的无牙颌患者的修复效果。方法　采用CDIC 牙种植体及配套磁性附着体,为8例下颌牙槽嵴重度吸收的无牙颌患者在下颌两侧第一前磨牙区各植入1枚种植 体,5个月后制作下颌全口义齿并在组织面粘固磁体。对粘固磁体前、后及粘固磁体后6个月的义齿固位力、咀嚼 效率和最大咬合力进行测试。结果　种植磁附着体全口义齿在粘固磁体后及粘固后6个月的固位力、咀嚼效率、 最大咬合力均较放置磁体前明显提高,其差异具有统计学意义(P<0·01)。结论　对牙槽嵴重度吸收的无牙颌患 者,采用种植磁附着体全口义齿修复能显著提高义齿的固位力、咀嚼效率及最大咬合力。     

种植体支持球帽附着体固位下颌覆盖全口义齿的临床应用

目的评价种植体支持球帽附着体固位下颌覆盖全口义齿的临床应用效果。方法 2006年6月至2010年5月完成种植体支持球帽附着体固位下颌覆盖全口义齿修复15例,每位患者植入2枚种植体,共植入30枚,随访时间1～4年。结果 15例种植体支持球帽附着体固位下颌覆盖全口义齿患者的义齿稳固,咀嚼功能良好。X线片显示随访期间种植体周围未见明显的骨吸收。结论种植体支持球帽附着体固位覆盖义齿临床效果可靠,可作为下颌无牙颌患者首选修复方式。     

磁性附着体种植覆盖义齿修复下颌牙槽骨重度吸收无牙颌患者的临床观察

目的：探讨磁性附着体种植覆盖义齿修复下颌牙槽骨重度吸收无牙颌患者的临床效果。方法：对下颌牙槽骨重度吸收、牙槽嵴低平的患者,在下颌尖牙位置植入2枚种植体,3—6个月后完成磁性附着体覆盖义齿修复。每隔6个月复诊一次,观察覆盖义齿使用情况,并结合口内检查和X线检查评价使用效果。结果：修复完成后2—3年,种植体骨结合良好,未见明显骨吸收;义齿固位良好,患者对美观及功能效果满意。结论：磁性附着体种植覆盖义齿修复下颌牙槽骨重度吸收无牙颌患者,能明显示改善义齿固位和咀嚼效果。     

种植磁性覆盖义齿的临床效果观察

目的探讨种植磁附着体全口义齿对下颌牙槽嵴重度吸收的无牙颌患者的修复效果。方法采用C D I C牙种植体及配套磁性附着体,为15例下颌牙槽嵴重度吸收的无牙颌患者在下颌两侧第一前磨牙区各植入1枚种植体,4～6个月后制作下颌全口义齿并在组织面粘固磁体。进行咀嚼效率和患者满意度测定。结果种植磁附着体全口义齿在粘固磁体后及粘固后2周的固位力和咀嚼效率均较放置磁体前明显提高,且患者满意度提高。结论磁性固位种植体覆盖义齿用于牙槽骨严重吸收的无牙颌患者修复治疗的临床效果好。     

LOCATOR附着体和改良式印模法在下颌全口覆盖义齿中的临床应用

目的 探讨LOCATOR附着体和改良式印模法的联合应用在下颌牙槽嵴低平患者全口义齿的临床应用。方法 选8例下颌牙槽嵴低平的无牙颌患者,于下颌尖牙区植入ITI种植体,种植体骨整合良好后用改良式印模法进行LOCATOR附着体全口义齿修复,于0,3,6,12月进行全口义齿满意度调查。结果 下颌全口覆盖义齿义齿稳定性较高,患者满意度提高。结论 改良印模法和LOCATOR附着体联合应用于下颌牙槽嵴低平无牙颌患者,可明显增加义齿固位力,患者满意度较高。     

下颌杆式种植覆盖义齿的临床应用体会

某些无牙牙合患者,牙槽骨严重吸收而牙槽嵴低平,肌附着位置高或牙槽嵴吸收后呈刀刃状,或舌体过大及动度过大者,传统全口义齿不能获得良好固定者,通常可采用种植覆盖义齿来改善义齿的支持和固位,从而提高咀嚼功能。笔者近两年来对５例下颌无牙牙合患者开展了某些式种...     

FRIALIT-2球帽固位种植覆盖义齿修复低平下颌牙槽嵴的疗效观察

目的：评价FRIALIT-2球帽固位的种植覆盖义齿修复下颌牙列缺失且牙槽嵴低平的临床效果。方法：将6例下颌牙列缺失且牙槽嵴低平的患者植入2颗FRIALIT-2种植法，利用FRIALIT-2球帽附着体固位制作覆盖义齿，进行12-24个月的临床追踪。结果：覆盖义齿的固位及使用效果均满意，种植体周围骨高度第一年平均降低0.8mm，有4颗种植体周围粘膜红肿，有3例患者需要重衬，有2例患者覆盖义齿折断，结论：球帽固位种植覆盖义齿是下颌牙列缺失且牙槽嵴低平者有效修复方式。     

种植体支持球帽附着体固位下颌覆盖总义齿的临床应用

目的：探讨球帽附着体固位的下颌种植覆盖总义齿的临床效果。方法：随机选择18例下颌牙列缺失的患者,植入2颗种植体,利用球帽附着体固位制作的覆盖义齿,随访6个月—4年,从患者主观感受和X射线检查两方面观察修复效果。结果：覆盖义齿的美观、舒适、固位稳定性好,咀嚼效率高。结论：种植体支持球帽附着体固位的下颌覆盖义齿修复下颌牙列缺失患者临床效果好。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。     

Ghlorhexidine as a root canal medicament for treating inflammatory lesions in the periodontal space

Abstract— The purpose of the present study was to investigate the therapeutic effect of intra-canal application of chlorhexidine on inflammatory root resorption. Dental pulps from monkey incisors were infected and resealed prior to extraction of the teeth. Root dentin was mechanically exposed and the teeth were replanted under aseptic conditions. After 4 weeks, the experimental teeth were dressed with chlorhexidine gel and resealed. Animals were sacrificed 4 weeks later, and their jaws prepared for histologic examination. Results showed that both marginal and apical periodontal inflammation and resorption were reduced in the chlorhexidine-treated teeth. It was concluded that the use of intra-canal chlorhexidine may be a useful adjunct in the treatment of inflammatory root resorption, but further human trials need to be undertaken before its clinical use can be recommended.     

小鼠牙髓干细胞同种异体移植后体内免疫反应初探

目的:初步探究小鼠牙髓干细胞同种异体移植后的全身免疫反应。方法:牙髓干细胞分离获得自C57BL/6 小鼠牙髓组织,培养至第3 代,与纳米羟基磷灰石(n-HA)复合培养形成复合物,扫描电镜观察其生长黏附情况。40只4周龄的C57BL/6 小鼠随机分成两组。实验组将复合物移植入上背部皮下,对照组将纳米羟基磷灰石植入上背部皮下,术后均使用外科方法严密缝合创口。两组动物术后均观察4周、6周处死,分离脾脏,制成脾淋巴细胞悬液,流式细胞仪测定CD4⁺、CD8⁺的值。结果:牙髓干细胞在体外与纳米羟基磷灰石结合良好;免疫组化染色实验组4周、6周均可见牙本质涎蛋白(dentin sialoprotein,DSP)阳性表达;实验组与对照组相比,术后4周、6周CD4⁺/CD8⁺值均无明显差异。结论:牙髓干细胞同种异体移植后,尚不能够引起机体的免疫排斥反应,其在体内仍具有低免疫原性,有望成为组织工程同种异体种子细胞来源。