不同设计人工晶状体植入术后3年后囊膜混浊的研究

目的研究不同材料和不同设计的人工晶状体植入术后3年的后囊膜混浊(posterior capsular opacification,PCO)发生率及PCO形态。方法回顾性研究132眼老年性白内障患者,由同一医生进行超声乳化联合人工晶状体(in-traocular lens,IOL)植入术,根据IOL的不同分为4组:Storz Hydroview H60M组(33眼),Silicone折叠式硅胶IOL组(29眼),AcrySof三片式IOL组(36眼)和聚甲基丙稀酸甲酯(poly-methyl methacrylate,PMMA)组(34眼)。术后3年随访患眼的最佳矫正视力(best corrected visual acuity,BCVA),扩瞳后采集PCO数码图像,分析不同IOL组PCO的形态及PCO发生率。结果各种IOL的PCO形态各异,H60M组和AcrySof组分别有10眼和15眼后囊形成皱折,而Silicone和PMMA组为片状混浊。虽然各组BCVA和BCVA下降率差异没有显著性(P>0.05),但PCO发生率差异有非常显著性,分别是AcySof组5.6%,Silicone组30.3%,H60M组31%和PMMA组55.9%。结论AcrySof疏水丙烯酸酯三片式折叠IOL,有直角边缘设计,术后3年能明显降低PCO的发生。     

两种不同材料折叠人工晶状体植入术后后发障的临床观察

为探讨人工晶状体(IOL)材料与后囊膜混浊(PCO)发生的关系,我们随访了门诊施行超声乳化白内障摘除术(PHACO)联合疏水性丙烯酸IOL(AcrySof)或疏水性硅凝胶IOL(CeeOn911A)植入的患者术后一年PCO的发生情况。一、材料和方法选择2002～2004年在北京协和医院和澳门仁伯爵医院老年性白内障患者中行PHACO术联合疏水性AcrySofIOL或疏水性硅凝胶CeeOn911AIOL两种不同材料折叠IOL植入的病例;除外合并糖尿病、高度近视、青光眼、葡萄膜炎等患者。随访资料完整、手术中顺利将IOL植入囊袋内且随访时间达一年的患者119例(137眼)。其中植…     

不同边缘形状的人工晶状体与后发性白内障的临床研究

目的　观察直角边缘和弧形边缘折叠式人工晶状体植入术的临床效果 ,探讨手术因素 ,以及人工晶状体材料和边缘形状等因素对后发性白内障发生的影响。方法　观察 14 0例 (14 0只眼 )白内障患者超声乳化白内障吸除囊袋内折叠式人工晶状体植入术后的视力、晶状体囊袋和人工晶状体情况。直角边缘组 90只眼 ,术中植入疏水性丙烯酸酯直角边缘人工晶状体 ,随访时间 (14± 8)个月 ;弧形边缘组 5 0只眼 ,术中植入非疏水性丙烯酸酯弧形边缘人工晶状体 ,随访时间 (18± 8)个月。结果　晶状体后囊膜混浊直角边缘组 8只眼 (8 9% ) ,弧形边缘组 19只眼 (38 0 % ) ,两组比较差异有非常显著意义 (P <0 0 1)。环形撕囊口大小适中直角边缘组 76只眼 ,无晶状体后囊膜混浊发生 ;弧形边缘组 4 1只眼 ,其中 10只眼 (2 4 4 % )出现晶状体后囊膜混浊 ,两组比较差异有非常显著意义 (P<0 0 1)。环形撕囊口过大或偏位直角边缘组 14只眼 ,其中晶状体后囊膜混浊 8只眼 (5 7 1% ) ;弧形边缘组 9只眼 ,全部发生晶状体后囊膜混浊 (10 0 0 % ) ,两组比较差异有显著意义 (P <0 0 5 )。行激光晶状体后囊膜切开术直角边缘组 1只眼 (1 1% ) ,弧形边缘组 5只眼 (10 0 % ) ,两组比较差异有显著意义(P <0 0 5 )。结论　手术操作、人工晶状     

两种AcrySof折叠式人工晶体植入后囊膜混浊的临床研究

目的：观察两种设计不同的AcrySof丙烯酸酯折叠式人工晶体(intraocular lens,IOL)对晶状体后囊膜混浊(posterior capsule opacification,PCO)的影响。方法：114例(114只眼)随机分为两组(1)试验组：59例(59眼)，植入一体式AcrySof折叠式IOL。(2)对照组：55例(55眼)，植入三体式AcrySof折叠式IOL。术后半年散大瞳孔观察Soemmering环和PCD情况。结果：瞳孔区PCD，试验组4只眼(6．8％)，混浊多为轻微皱褶。对照组11只限(20％)，试验组PCD明显少于对照组，差异有显著意义(P＜0．05)。两组术后Soemmering环边界均清晰而试验组更加明显，且撵周也形成明显的细胞增殖区。结论：一体式AcrySof折叠IOL具有独特设计的襻使晶状体后囊膜皱褶大为减少，远期PCO明显下降。     

3种不同型号AcrySof Toric人工晶状体在囊袋内稳定性的比较

目的 评价AcrySof Toric人工晶状体(intraocular lens,IOL)在囊袋内的稳定性,并比较3种不同型号AcrySof Toric IOL(T3、T4、T5)在囊袋内的稳定性是否有差异.方法 对33例(33眼)伴有角膜规则散光的白内障患者,采用颞侧透明角膜切口超声乳化术植入AcrySof Toric折叠式散光型IOL.其中9眼术前角膜散光≤1.50 D,植入T3型AcrySof Toric IOL(T3组);12眼术前角膜散光1.50～2.25 D,植入T4型AcrySof Toric IOL(T4组);12眼术前角膜散光>2.25 D,植入T5型AcrySof Toric IOL(T5组);观察术前、术后3个月、术后6个月裸眼视力及最佳矫正视力、角膜散光情况;术后6个月测量所有IOL在囊袋的旋转度,并进行统计分析.结果 术后裸眼视力及最佳矫正视力均较术前(0.1～0.2)明显提高;各组患者角膜散光手术前后差异均无统计学意义;术后3个月、6个月所有IOL在囊袋的旋转度均在11°以内,术后3个月T3、T4、T4分别为(1.5±1.0)°、(1.7 ±1.3)°、(1.8±1.2)°,术后6个月分别为(1.5±1.1)°、(1.7±1.2)°、(1.9±1.1)°,且3组间两两比较差异均无统计学意义.结论 3种不同型号AcrySof Toric IOL在囊袋内均有良好的稳定性.     

不同表面处理及设计人工晶状体对后囊膜混浊影响的量化分析

目的：使用EPCO2000定量比较不同表面处理及设计人工晶状体(IOL)对后囊膜混浊(PCO)发生的影响。

方法：回顾性研究,随访观察2016-03/11在我院行白内障超声乳化吸除联合人工晶状体植入术后1a的年龄相关性白内障患者600例971眼。按IOL类型分为4组：ZCB00组43眼,ZA9003组365眼; HQ-201HEP组340眼,Human Optics组223眼。充分扩瞳后获取后照法图片,使用EPCO2000进行PCO程度评分并将各组进行比较分析。

结果：PCO累及瞳孔中央3mm的有167眼(17.2%),发生显著性PCO或已行Nd：YAG激光后囊膜切开术的有78眼(8.0%); 按IOL光学面材料疏水性分组,疏水组总分0.000(0.000,0.012)显著低于亲水组0.127(0.056,0.242)(P<0.05); 按IOL光学面肝素修饰与否分组,无肝素修饰组总分0.127(0.056,0.242)低于肝素修饰组0.175(0.067,0.371)(P<0.05); 按IOL一片式及三片式设计分组,一片式组总分0.000(0.000,0.012)显著低于三片式组0.120(0.041,0.247)(P<0.05); 按襻成角分组,襻成角0°组总分0.107(0.000,0.212)低于襻成角5°组0.142(0.051,0.298)(P<0.05)。

结论：一片式疏水性直角边缘设计的丙烯酸酯IOL可以更有效地减少PCO形成。     

两种Nd:YAG激光后囊切开方式对不同材料人工晶状体损伤的观察

目的观察Nd:YAG激光后囊膜切开方式对不同材料的人工晶体(IOL)损伤的情况。方法对86例(124只眼)IOL眼晶状体后囊膜混浊(posterior capsule opacity,PCO)患者随机分为两组行Nd:YAG激光后囊膜切开术。A组64眼采用环行切开后推膜瓣法,人工晶体包括:PMMA23眼、疏水性丙烯酸26眼、硅凝胶15眼。B组60眼行十字形切开法,人工晶体包括:PMMA21眼、疏水性丙烯酸25眼、硅凝胶14眼。术前术后常规眼前段检查、测视力、眼压。结果截囊成功率100%。发生IOL损伤16眼,其中A组6眼(9.38%),B组10眼(16.67%),两种方式对相同材料的人工晶体损伤的机率相似(均p>0.05),不同材料的耐受强弱依次为PMMA、疏水性丙烯酸、硅凝胶,均为轻度损伤。结论两种方式对不同材料损伤的机率依次为硅凝胶、疏水性丙烯酸、PMMA,但环行切开后推膜瓣法可以减少Nd:YAG激光后囊膜切开术IOL损伤机率。     

不同丙烯酸材料的人工晶状体对后发性白内障的影响

目的 探讨三种不同的丙烯酸材料的人工晶状体应用于白内障超声乳化吸除联合人工晶状体植入术后对后发性白内障的影响作用.方法 超声乳化白内障吸除联合人工晶状体植入术的960例白内障患者(964只眼),Sensar组310只眼,Acrysof三片组332只眼,Acrysof一片组322只眼,术后定期随访18～28个月,观察视力、后发性白障的发生情况.结果 术后随访24月时,发生1级以上后囊膜混浊SensarIOL组的发生率(13.5%),明显高于Acrysof一片式IOL组及Acrysof三片式IOL组的发生率(7.5%,3.7%).经卡方检验,P值均<0.05,有显著性差异,而Acrysof三片式IOL组后囊膜混浊的发生率较Aerysof 一片式IOL组高,P<0.05.结论 AcrySof丙烯酸式一片式人工晶状体植入后出现后发性白内障的发生率在三组中最低.可以减少后发性白内障的发生降低Nd:YAG激光的使用率,提高手术效果,是现代白内障手术可选择的理想的人工晶状体.     

不同丙烯酸材料的人工晶状体对后发性白内障的影响

目的 探讨三种不同的丙烯酸材料的人工晶状体应用于白内障超声乳化吸除联合人工晶状体植入术后对后发性白内障的影响作用.方法 超声乳化白内障吸除联合人工晶状体植入术的960例白内障患者(964只眼),Sensar组310只眼,Acrysof三片组332只眼,Acrysof一片组322只眼,术后定期随访18～28个月,观察视力、后发性白障的发生情况.结果 术后随访24月时,发生1级以上后囊膜混浊SensarIOL组的发生率(13.5%),明显高于Acrysof一片式IOL组及Acrysof三片式IOL组的发生率(7.5%,3.7%).经卡方检验,P值均<0.05,有显著性差异,而Acrysof三片式IOL组后囊膜混浊的发生率较Aerysof 一片式IOL组高,P<0.05.结论 AcrySof丙烯酸式一片式人工晶状体植入后出现后发性白内障的发生率在三组中最低.可以减少后发性白内障的发生降低Nd:YAG激光的使用率,提高手术效果,是现代白内障手术可选择的理想的人工晶状体.     

不同丙烯酸材料的人工晶状体对后发性白内障的影响

目的 探讨三种不同的丙烯酸材料的人工晶状体应用于白内障超声乳化吸除联合人工晶状体植入术后对后发性白内障的影响作用.方法 超声乳化白内障吸除联合人工晶状体植入术的960例白内障患者(964只眼),Sensar组310只眼,Acrysof三片组332只眼,Acrysof一片组322只眼,术后定期随访18～28个月,观察视力、后发性白障的发生情况.结果 术后随访24月时,发生1级以上后囊膜混浊SensarIOL组的发生率(13.5%),明显高于Acrysof一片式IOL组及Acrysof三片式IOL组的发生率(7.5%,3.7%).经卡方检验,P值均<0.05,有显著性差异,而Acrysof三片式IOL组后囊膜混浊的发生率较Aerysof 一片式IOL组高,P<0.05.结论 AcrySof丙烯酸式一片式人工晶状体植入后出现后发性白内障的发生率在三组中最低.可以减少后发性白内障的发生降低Nd:YAG激光的使用率,提高手术效果,是现代白内障手术可选择的理想的人工晶状体.     

Results of hydrophilic acrylic,hydrophobic acrylic,and silicone intraocular lenses in uveitic eyes with cataract: comparison to a control group

PURPOSE: To evaluate the uveal and capsular biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses (IOLs) in eyes with uveitis. SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: This prospective study comprised 72 eyes with uveitis and 68 control eyes having phacoemulsification and IOL implantation by 1 surgeon. Patients received 1 of the following IOLs: foldable hydrophilic acrylic (Hydroview, Bausch & Lomb), hydrophobic acrylic (AcrySof, Alcon), or silicone (CeeOn 911, Pharmacia). Postoperative evaluations were at 1, 3, and 7 days and 1, 3, and 6 months. Cell reaction was evaluated by specular microscopy of the anterior IOL surface and the anterior and posterior capsule reaction, by biomicroscopy. RESULTS: Small round cell deposition was observed on all IOLs in the immediate postoperative period, especially in eyes with uveitis. This reaction decreased 3 to 6 months after surgery. Although the CeeOn 911 had a higher mean grade of small cells, there was no statistical difference between the 3 IOL types after 6 months in the uveitis and control groups. Foreign-body giant cells (FBGCs) increased after 1 week to 1 month. The AcrySof IOLs had the highest number of FBGCs; after 6 months, there was a statistically significant difference between the AcrySof and Hydroview uveitis groups (P =.036) and the AcrySof and CeeOn 911 uveitis groups (P =.003) but there was no difference among the 3 IOL types in the control group. Lens epithelial cell outgrowth persisted on the Hydroview IOLs in control eyes and regressed on all 3 IOL types in uveitic eyes and on the AcrySof and CeeOn 911 IOLs in control eyes (P =.0001). Anterior capsule opacification (ACO) was more severe on all IOL types in uveitic eyes and on the CeeOn 911 IOL in control eyes. Posterior capsule opacification (PCO) was more severe in uveitic eyes. The Hydroview group had more severe PCO than the AcrySof and the CeeOn 911 groups in uveitis and control eyes. Six months postoperatively, the difference was significant (P =.0001). There was no significant difference between the AcrySof and CeeOn 911 IOLs. CONCLUSIONS: Intraocular lens biocompatibility is inversely related to inflammation. Hydrophilic acrylic material had good uveal but worse capsular biocompatibility. Hydrophobic acrylic material had lower uveal but better capsular biocompatibility. Silicone showed a higher small cell count (mild) and more severe ACO but achieved PCO results comparable to FBGC results and better than those with the AcrySof lens 6 months after surgery. Despite the differences in IOL biocompatibility, all patients benefited from the surgery.     

Uveal and capsular biocompatibility of 2 foldable acrylic intraocular lenses in patients with uveitis or pseudoexfoliation syndrome: comparison to a control group

PURPOSE: To evaluate the uveal and capsular biocompatibility of hydrophilic acrylic (Hydroview) and hydrophobic acrylic (AcrySof) intraocular lenses (IOLs) after phacoemulsification in eyes with pseudoexfoliation syndrome (PEX) or uveitis and compare the results with those in a control group. SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria.METHODS: This prospective nonrandomized comparative trial comprised 143 eyes recruited consecutively. Of these, 49 eyes had PEX, 43 had uveitis, and 51 served as controls. A standardized surgical protocol was used. Cell reaction, anterior (ACO) and posterior (PCO) capsule opacification, and flare were evaluated 1 year after cataract surgery. RESULTS: Regarding uveal biocompatibility, the number of foreign-body giant cells (FBGCs) increased in proportion to associated ocular pathologies in both IOL groups. The difference between the Hydroview control and Hydroview uveitis groups was statistically significant. The number of FBGCs was greater on AcrySof IOLs than on Hydroview IOLs in all 3 groups. The difference in FBGCs between the 2 IOL types was statistically significant in the control and PEX groups. Regarding capsular biocompatibility, lens epithelial cell (LEC) outgrowth was inversely correlated with intraocular inflammation. Outgrowth was statistically significantly higher with Hydroview IOLs, occurring in 85% in the control group, 45% in the PEX group, and 28% in the uveitis group (P <.0001). With AcrySof lenses, the percentages were 0%, 8%, and 4%, respectively. The PEX and uveitis groups were more likely to develop ACO than the control group (P <.012). There was no statistically significant difference in ACO between the 2 IOL types in the 3 patient groups. The PCO was statistically significantly greater in the uveitis group than in the control group (P <.026) and statistically significantly more dense on Hydroview than on AcrySof IOLs in all 3 patient groups (P <.002). Flare was statistically significantly higher in the uveitis group than in the PEX and control groups with both IOL types (P <.012). There was no statistically significant difference in flare between the 2 IOL types. CONCLUSIONS: Uveal and capsular biocompatibility depends on the intensity of ocular inflammation. The greater the inflammation, the less the biocompatibility of hydrophilic and hydrophobic acrylic materials. AcrySof stimulated more FBGCs. The Hydroview material had better uveal but poorer capsular biocompatibility than AcrySof. The sharp optic edge effect of the AcrySof IOL and the advantages of the Hydroview lens in normal eyes are less apparent in compromised eyes.     

Influence of three-piece and single-piece designs of two sharp-edge optic hydrophobic acrylic intraocular lenses on the prevention of posterior capsule opacification: a prospective, randomised, long-term clinical trial

BACKGROUND: Posterior capsule opacification (PCO) is still a major long-term complication of modern cataract surgery. We evaluated the impact of sharp-edged intraocular lenses (IOLs) with different haptic designs made from the same hydrophobic acrylic material on posterior and anterior lens capsule opacification. SETTING: Eye clinic of Kaunas University of Medicine, Lithuania. Prospective randomised clinical study. METHODS: Seventy-four eyes of 74 patients scheduled for cataract surgery were included in a prospective randomised clinical study. Thirty-seven eyes of 37 patients received a three-piece acrylic hydrophobic (AcrySof, MA3OBA, Alcon) IOL; and thirty-seven eyes of 37 patients received a one-piece acrylic hydrophobic (AcrySof, SA3OAL, Alcon) IOL. Visual acuity, anterior capsule opacification (ACO), capsular folds, capsulorrhexis/optic overlapping and posterior capsule opacification (PCO) were evaluated. ACO was assessed subjectively. PCO values in the entire IOL optic area and in the central 3 mm optic zone were assessed using a photographic image-analysis system (EPCO2000). Follow-ups were performed postoperatively at 1 day, 6 months, 1 year and 2 years. RESULTS: There were no significant differences in best corrected visual acuity, grade of ACO and capsulorrhexis/optic overlapping between IOL types during the follow-up period. Patients in the one-piece acrylic hydrophobic IOL group more frequently presented with capsular folds behind the IOL optic area than those in the three-piece IOL group. In the three-piece acrylic hydrophobic IOL group, PCO values (mean (SD)) of the entire IOL optic area were significantly lower six months postoperative (three-piece: 0.002 (0.009); one-piece: 0.007 (0.017); p=0.04), one year postoperative (three-piece: 0.004 (0.016); one-piece: 0.026 (0.041); p=0.001) as well as one year postoperative in the central 3 mm optic zone (three-piece: 0.000 (0.0002); one-piece: 0.019 (0.049); p=0.001). However, two years postoperative, the PCO values of the groups did not show significant differences (entire IOL optic area: three-piece, 0.136 (0.223); one-piece, 0.154 (0.190); p=0.18; central zone: three-piece, 0.023 (0.065); one-piece: 0.020 (0.039); p=0.44). CONCLUSION: The 2 year follow-up after cataract surgery showed no significant difference in ACO and PCO development between three-piece and one-piece acrylic hydrophobic intraocular lenses.     

Uveal and capsular biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses.

PURPOSE: To evaluate the long-term response of 6 types of 3-piece intraocular lenses (IOLs) by assessing the cellular reaction on the anterior IOL surface, the behavior of posterior and anterior capsule fibrosis, and flare. SETTING: Department of Ophthalmology, Medical School, University of Vienna, Vienna, Austria. METHODS: One hundred eighty eyes were prospectively randomized to receive 1 of 6 IOLs: hydrophilic acrylic Hydroview (Bausch & Lomb) or MemoryLens (ORC); hydrophobic acrylic AcrySof MA60BM (Alcon) or AMO Sensar AR40 (Allergan); hydrophobic silicone CeeOn 920 or CeeOn 911A (Pharmacia). The patients had standardized cataract surgery, postoperative medication, and follow-up. One year after surgery, 155 eyes were assessed. The cellular reaction was evaluated by specular microscopy of the anterior IOL surface. Anterior and posterior capsule opacification (PCO) was assessed semiquantitatively by biomicroscopy. Flare was measured with a Kowa FC-1000 laser flare-cell meter. RESULTS: Regarding uveal biocompatibility, the hydrophobic acrylic IOLs showed the highest incidence of late foreign-body cell reaction (AcrySof, 30%; AR40, 17%) followed by the hydrophilic acrylic (MemoryLens, 8%; Hydroview, 4%) and silicone (CeeOn 920, 4%; CeeOn 911A, 0%) (P =.0044). In all cases, the cellular reaction was low grade and clinically insignificant. Regarding capsular biocompatibility, some eyes developed lens epithelial cell (LEC) outgrowth on the anterior IOL surface. The highest incidence was in the hydrophilic acrylic group (Hydroview, 85%; MemoryLens, 27%) followed by the hydrophobic acrylic (AcrySof, 4%; AR40, 3%). No silicone IOL had LECs on the anterior surface. The difference among IOL groups was significant (P =.0001). Anterior capsule opacification was more predominant in the hydrophobic IOL groups. Posterior capsule opacification of the central 3.0 mm area was lowest in the groups with a sharp-edged optic (CeeOn 911A, AcrySof) followed by the round-edged silicone (CeeOn 920), hydrophobic acrylic (AR40), and hydrophilic acrylic IOLs (P =.0001). There was a significant difference in flare between the AR40 lens and the Hydroview, MemoryLens, CeeOn 911A, and CeeOn 920 (P <.004). There was no statistically significant difference in the postoperative cell count at 1 year. The power calculation showed that the sample size was sufficient. CONCLUSIONS: The differences in cellular reaction, although clinically mild in normal eyes, indicate that there were more giant cells with hydrophobic acrylic IOLs and an increased tendency toward LEC outgrowth with hydrophilic lenses. The incidence of PCO was lowest in the hydrophobic IOL groups, especially in groups with a sharp-edged optic. Second-generation silicone IOLs with a sharp edge had good uveal and capsular biocompatibility 1 year after surgery.     

Effect of intraocular lens optic edge design and material on fibrotic capsule opacification and capsulorhexis contraction

PURPOSE: To examine the influence of intraocular lens (IOL) optic edge design and optic material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex OptiEdge silicone IOL with a sharp posterior optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm(2)) was determined objectively. RESULTS: One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P<.05). In the silicone group, the mean was 31% and 26%, respectively (P<.05). The mean fibrotic PCO score was lower in eyes with a sharp-edged acrylic IOL than in eyes with a round-edged acrylic IOL (0.26 and 0.93, respectively; P<.05) and in eyes with a sharp-edged silicone IOL than in eyes with a round-edged silicone IOL (0.24 and 0.82, respectively; P<.001). At 1 year, the mean capsulorhexis area was statistically significantly smaller in eyes with a sharp-edged silicone IOL than in eyes with a round-edged silicone IOL (P<.05). CONCLUSIONS: Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.     

Posterior capsule opacification and Nd:YAG capsulotomy rates after implantation of silicone,hydrogel and soft acrylic intraocular lenses: a two-year follow-up study

PURPOSE: To compare the posterior capsule opacification (PCO) and neodymium:YAG (Nd:YAG) laser posterior capsulotomy rates associated with three different posterior chamber foldable intraocular lenses (IOL). METHODS: We retrospectively evaluated the rates of PCO and Nd:YAG laser capsulotomy in 1150 eyes two years after standard phacoemulsification with a no-stitch 3.5mm clear corneal incision (CCI) and in-the-bag implantation of one of three types of IOL: 190 eyes received a one-piece round-edged hydrogel IOL (Hydroview H60M, Bausch & Lomb); 475 eyes a three-piece round-edged silicone IOL (AMO PhacoFlex SI-40NB, Allergan); 485 eyes a three-piece square-edged soft acrylic lens (AcrySof MA60MA, Alcon). RESULTS: The PCO and Nd:YAG laser capsulotomy rates were respectively 43.15% and 20.5% in the Hydroview H60M group, 27.57% and 9.68% in the AMO PhacoFlex SI-40NB group, 10.5% and 2.47% in the AcrySof MA60MA group. CONCLUSIONS: PCO and Nd:YAG laser capsulotomy rates were significantly higher in the Hydroview H60M group and significantly lower with the AcrySof MA60MA lenses, which combine a bioactive constitutive material with the square-edged optic design.     

Posterior capsule opacification and lens epithelial cell layer formation: Hydroview hydrogel versus AcrySof acrylic intraocular lenses

PURPOSE: To quantitatively compare the incidence of visually significant posterior capsule opacification (PCO) and lens epithelial cell (LEC) layer formation on the anterior surface of Hydroview hydrogel and AcrySof acrylic foldable intraocular lenses (IOLs) after implantation. SETTING: Single-surgeon ophthalmology practice, Orange Base Hospital, and Dudley Private Hospital, Orange, New South Wales, Australia. METHODS: This retrospective study comprised 166 eyes of 150 patients (after exclusions) who had cataract extraction and insertion of a foldable IOL in the capsular bag by a single surgeon using a standardized phacoemulsification technique from December 1997 to September 1998. The mean follow-up was 13.1 months (range 6.0 to 23.6 months). The eyes were divided into 2 groups based on the type of IOL implanted: Storz Hydroview H60M (81 eyes) or Alcon AcrySof MA30BA (85 eyes). A neodymium:YAG posterior capsule laser capsulotomy (PC YAG) was performed for an objective decrease in Snellen best corrected visual acuity (BCVA) of more than 1 line, significant visual symptoms, or both. This was used as a measure of visually significant PCO. An Nd:YAG anterior surface clearance (ASC YAG) was done for LEC layer formation anterior to the IOL to better visualize or facilitate treatment of PCO. The rates of PC YAG and ASC YAG after Hydroview and AcrySof IOL implantation were statistically compared. RESULTS: Forty-five eyes (55.6%) in the Hydroview IOL group and 3 eyes (3.5%) in the AcrySof IOL group required a PC YAG; the risk difference was 52.0% (P <.001). An ASC YAG was required in 27 eyes (33.3%) in the Hydroview group and 1 eye (1.2%) in the AcrySof group; the risk difference was 32.2% (P <.001). Survival analysis demonstrated that the only independent predictor of the incidence of PC YAG and ASC YAG over time was IOL type, with the Hydroview IOL group having a statistically significantly higher incidence of both procedures. CONCLUSION: There was a greater incidence of visually significant PCO and LEC layer formation on the anterior surface of Hydroview IOLs than of AcrySof IOLs.     

Preventive effect of a second-generation silicone intraocular lens on posterior capsule opacification

PURPOSE: To compare the preventive effect of a second-generation silicone intraocular lens (IOL) on posterior capsule opacification (PCO) with that of a soft acrylic IOL. SETTING: Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan. METHODS: After phacoemulsification, a silicone IOL (PhacoFlex II) was implanted in 1 eye and an acrylic IOL (AcrySof) in the contralateral eye of 5 rabbits. RESULTS: The posterior view 3 weeks after surgery showed slightly more PCO in 3 eyes with the PhacoFlex II lens than in eyes with the AcrySof IOL, with the PCO obscuring the iris structures. In 2 eyes with an AcrySof IOL, slightly more PCO was seen. Histopathological examination revealed that a bend and complex folds in the posterior capsule were formed with both the PhacoFlex II and AcrySof IOLs. However, the capsular bend formed by the PhacoFlex II lens, which was caused by its blunt edge, was not as sharp as that with the AcrySof IOL and more PCO was seen in all eyes with a PhacoFlex II lens. CONCLUSIONS: Capsular bend formation does not necessarily require a sharp optic edge. A truncated optic rim of a certain thickness appears to form a bend. The capsule-bending does not appear to be an all-or-nothing effect. There seems to be a transition. That a capsular bend forms despite a blunt rather than a sharp optic edge may explain why the second-generation PhacoFlex II IOL prevents PCO better than first-generation and PMMA IOLs.