High intensity running results in an impaired neuromuscular response in ACL reconstructed individuals

Anterior cruciate ligament (ACL) reconstruction reestablishes electromyographic activity during moderate activities such as walking but is unclear if this is also the case in sports activities such as high intensity running that results in accumulation of metabolic fatigue. Nine bone-patella tendon-bone ACL reconstructed athletes were evaluated 19.2 (5.7) months post-operatively using a telemetric electromyographic system. The neuromuscular response of vastus lateralis and biceps femoris muscles was tested bilaterally on separate occasions during 10 min running at moderate intensity (20% below the lactate threshold) and 10 min running at high intensity (40% above the lactate threshold). During moderate intensity running, electromyographic activity did not change for either leg. During high intensity running, electromyographic activity did not change for the vastus lateralis of the ACL reconstructed leg [267.8 (142.8)–263.8 (128.9) μV, P > 0.05] while it increased significantly [294.2 (120.6)–317.1 (140.5) μV, P = 0.03] for the vastus lateralis of the intact leg. High intensity exercise that is associated with accumulation of metabolic fatigue, results in an impaired neuromuscular response for the vastus lateralis muscle of the ACL reconstructed leg.     

Knee laxity after ACL reconstruction with a BPTB graft

The objective of the study was to compare prospectively short-term and mid-term results after ACL reconstruction with special focus on changes in instrumented knee laxity. METHODS: The original study group included prospectively 58 patients who underwent arthroscopically assisted ACL reconstruction with BPTB graft in a two-tunnel technique between 1991 and 1993. Seven patients were lost to follow-up, leaving 51 patients for a first follow-up at 6 months and a second follow-up at 3-6 years (mean 4.3 years). Clinical results were evaluated by means of the Lysholm score and the IKDC score. Laxity was assessed using a KT-1000 arthrometer applying an 89 N anterior load in 20 degrees of flexion. Increased laxity was defined as a 3 mm increase in AP translation between the first and the second follow-up. RESULTS: At mid-term follow-up pivot shift was negative in 86% of cases. IKDC score: normal = 28%, nearly normal = 44%, abnormal = 24%, severely abnormal = 4%. KT-1000: < 3 mm = 68%, 3-5 mm = 24%, > 5 mm = 8%. The mean KT-1000 side-to-side difference was 1.08 (0.17) mm at 6 months and 2.01 (0.29) mm at 3-6 years. The difference was statistically significant (P < 0.005). According to the defined criteria, seven patients had increased laxity at the second follow-up, suggesting a malfunction of the graft due to stretch-out or injury. In this subgroup the mean KT-1000 measurements were 0.86 (0.26) mm at the first follow-up and 5.93 (0.54) mm at the second follow-up. In five of these patients, a malposition of the tunnels was identified as a possible cause. In the remaining group, KT-1000 measurements did not differ significantly between the first and the second follow-up [1.12 (0.20) mm versus 1.37 (0.21) mm]. CONCLUSIONS: Increase in AP laxity occurred in 14% of our cases between the first and the second follow-up. In most of these cases increased laxity was due to inadequate surgical technique, especially malposition of bony tunnels. If tunnel position was correct, there was no evidence for elongation of grafts over time as a general principle.     

VO2 slow component correlates with vastus lateralis de-oxygenation and blood lactate accumulation during running.

BACKGROUND: In the present study, vastus lateralis de-oxygenation was monitored contemporarily with VO2 changes along a severe constant intensity running exercise, after the 3rd min up to volitional exhaustion. Blood lactate accumulation was also measured before, during and after running. METHODS: Eleven male amateur soccer players volunteered for the study. Subjects mean age, height, and body weight were 22.9+/-2 yrs, 177.5+/-6.2 cm, 71.7+/-4 kg, respectively. Measurements were carried out during running on a treadmill. Ventilatory and gas exchange parameters were measured at the mouth on a breath-by-breath basis. For blood lactate concentration accumulation measurement, capillary blood samples were taken from the fingertip. The oxygenation of the vastus lateralis muscle were measured by a continuous wave NIRS portable instrument. By means of two pretests the onset of [La]b accumulation and its associated velocity (vOBLA), and the peak of oxygen uptake and its associated velocity (vVO2,peak) were assessed. The test consisted of running on the treadmill up to volitional exhaustion at a constant velocity corresponding to vOBLA plus 50% of the difference between vVO2,peak and vOBLA (v50%Delta). RESULTS: The principal finding of this study was that vastus lateralis de-oxygenation changes measured during running correlate with a) oxygen uptake changes between the 3rd min of exercise and the time corresponding to the subject's volitional exhaustion; b) blood lactate concentration increments measured at the 3rd and the 6th min of exercise and at the time corresponding to the subject's volitional exhaustion. CONCLUSIONS: In conclusion, the results of the present study support our hypothesis that the vastus lateralis de-oxygenation contributes consistently to the VO2 slow component development in running.     

Hamstring and calf muscle activation as a function of bodyweight support during treadmill running in ACL reconstructed athletes

Rehabilitation after injury and reconstruction to the anterior cruciate ligament is thought to require a gradual reintroduction of loading, particularly during resumption of running. One strategy to achieve this is via the use of a reduced-gravity treadmill but it is unknown, if and how muscle activity varies in the reduced gravity conditions compared to regular treadmill running. Nineteen healthy participants and 18 male patients at the end of their rehabilitation (8 with a bone-patellar-bone graft, 10 with a hamstring graft) participated in this multi-muscle surface electromyography (sEMG) running study. The hamstrings and triceps surae were evaluated during a 16 km/h running while at 6 different relative bodyweight conditions from 50% (half weight-bearing) to 100% (full weight-bearing). Muscle activation was examined individually as well as normalized to a composite “entire” activation and considered across the entire gait cycle using Statistical Parametric Mapping. The healthy participants showed differences between the 50–100% BW and 60–100% conditions and in the hamstring graft group for 60–100% and 80–100% conditions. No differences were seen comparing all loading conditions in the bone-patellar-bone graft group. For the hamstrings, from 70% BW and above, there appear to be no difference in activation patterns for any of the groups.The activation patterns of the hamstrings was essentially the same from 70% indicated bodyweight through to full weight bearing when running at 16 km/h. Accordingly, when running at this relatively high speed, we do not expect any adverse effects in terms of altered motor patterns during rehabilitation of these muscles.     

Muscle activation of vastus medialis obliquus and vastus lateralis during a dynamic leg press exercise with and without isometric hip adduction

ObjectivesTo investigate the effects of submaximal and vigorous isometric hip adduction on the vastus medialis obliquus (VMO) and vastus lateralis (VL) activity during the leg press exercise from 90° of knee flexion until full extension.DesignExperimental.SettingUniversity biomechanics laboratory.ParticipantsTen healthy male college students.Main outcome measuresElectromyographic (EMG) activation of VMO, VL and hip adductor longus (HAL) of the dominant leg were recorded during double leg press (LP), leg press with submaximal isometric hip adduction force (LP+), and leg press with vigorous isometric hip adduction force (LP++). The VMO, VL muscle activation, as well as the VMO/VL ratio between different leg press exercises were analyzed by MANOVA over concentric and eccentric phases, and in 15° increments of knee flexion motion. The effect size was calculated.ResultsNeither LP+ nor LP++ changed the overall VMO-VL activation patterns. Specific to knee angle, however, small to medium effect size was shown with incorporation of isometric hip adduction to the leg press exercise for VMO/VL ratio.ConclusionTargeted training using the leg press exercise to the last 45° of knee extension/flexion with vigorous hip adduction may be useful in promoting a greater VMO/VL ratio.     

Athletes with an ACL reconstruction show a different neuromuscular response to environmental challenges compared to uninjured athletes

BackgroundEvidence suggests that neuromuscular alterations in patients with an anterior cruciate ligament reconstruction (ACLR) are rooted in neurocognitive and proprioceptive deficits. The aim of this study was to assess neuromuscular control of athletes with ACLR under increased cognitive and environmental challenges.Research questionDo athletes with ACLR show a different neuromuscular response to cognitive and environmental challenges relative to controls?MethodsCross-sectional study. Twenty athletes who had an ACLR (age: 23.7 ± 4.3 years, 14 males, time post-surgery: 258.6 ± 54 days) and twenty uninjured controls (age: 21.4 ± 1.5 years, 14 males) performed a stepping down-task in four environmental conditions: no additional challenges, while performing a cognitive dual-task, while undergoing an unpredictable support surface perturbation, and with the cognitive dual-task and unpredictable perturbation combined. Muscle activations of the vastus medialis (VM), vastus lateralis, hamstrings medialis (HM), hamstrings lateralis (HL), gastrocnemius medialis, gastrocnemius lateralis (GL) and gluteus medius were recorded with surface EMG. A three-way ANOVA with main effects for group, dual-task and perturbation was used to compare muscle activations.ResultsAthletes with ACLR show larger HM (ES = 0.45) and HL activation (ES = 1.32) and lower VM activation (ES = 0.72), compared to controls.Athletes with ACLR show a significantly smaller increase in VM (ES = 0.69), VL (ES = 0.53) and GL activation (ES = 0.52) between perturbed and unperturbed tasks compared to controls. Furthermore, under cognitive loading a significantly larger decrease in HM activation (ES = 0.40) and (medial) co-contraction (ES = 0.75) was found in athletes with ACLR compared to controls.SignificanceAthletes with ACLR show an altered neuromuscular response which might represent an arthrogenic muscle response. They show less additional adaptation to perturbed tasks compared to controls, potentially as result of altered proprioceptive input. Furthermore a larger influence of increased cognitive loading on the neuromuscular control was found in athletes with ACLR, indicating that also neurocognitive limitations may contribute to altered neuromuscular control.     

Effect of suturing the femoral portion of a four-strand graft during an ACL reconstruction

Purpose

A suture passed along the part of the graft that will be inserted into the femoral tunnel is widely used by surgeons, because it could prevent the graft sliding on the femoral fixation device during pulling from the tibial side. The aim of this study was to evaluate the biomechanical effects of suturing the intratunnel femoral part of the graft during an anterior cruciate ligament (ACL) reconstruction.

Methods

Bovine digital extensor tendons and tibias were harvested from 20 fresh-frozen mature bovine knees ranging in age from 18 to 24 months. Quadruple-strand bovine tendons were passed through the tibial tunnel and secured distally with a bioabsorbable interference screw. In one half of all grafts (N = 10), the looped-over part of the graft was sutured in a whipstitch technique over a distance of 30 mm (Group 1). In one half of all grafts (N = 10), the looped-over part was left free from any suture (Group 2). The grafts were preconditioned at 50 N for 10 min, followed by cyclic loading at 1 Hz between 50 N and 250 N for 1,000 cycles. Load-to-failure test was then carried out at a rate of 1 mm/s.

Results

There was no statistically significant difference between mean stiffness at pullout and yield load between the two groups. In all specimens on Group 1, failure occurred following to partial breaking and then slipping of the tendons between the screw and the tunnel. Concerning Group 2, in six cases failure occurred as described for Group 1 specimens. In the remaining four cases, failure occurred entirely through the ligament mid-substance.

Conclusions

Suturing in a whipstitch fashion the femoral portion of the graft doesn’t affect the mechanical proprieties of the ACL graft. When suspension fixation device is used, suturing the looped-over part of the graft could be helpful in order to provide equal tension in all of the strands of the graft at time of tibial fixation.     

Effect of a carbohydrate-electrolyte drink on endurance capacity during prolonged intermittent high intensity running

OBJECTIVE: To examine the effect of a carbohydrate-electrolyte solution on endurance capacity during prolonged intermittent running. METHODS: Nine subjects (eight men and one woman) ran to exhaustion on a motorised treadmill on two occasions separated by at least 10 days. After an overnight fast, they performed repeated 15 second bouts of fast running (at 80% Vo2MAX for the first 60 minutes, at 85% Vo2MAX from 60 to 100 minutes of exercise, and finally at 90% Vo2MAX from 100 minutes of exercise until exhaustion), separated by 10 seconds of slow running (at 45% Vo2MAX). On each occasion they drank either a water placebo (P) or a 6.9% carbohydrate-electrolyte (CHO) solution immediately before the run (3 ml/kg body mass) and every 20 minutes thereafter (2 ml/kg body mass). RESULTS: Performance times were not different between the two trials (112.5 (23.3) and 110.2 (21.4) min for the P and CHO trials respectively; mean (SD)). Blood glucose concentration was higher in the CHO trial only at 40 minutes of exercise (4.5 (0.6) v 3.9 (0.3) mmol/1 for the CHO and P trials respectively; p < 0.05), but there was no difference in the total carbohydrate oxidation rates between trials. CONCLUSION: These results suggest that drinking a 6.9% carbohydrate-electrolyte solution during repeated bouts of submaximal intermittent high intensity running does not delay the onset of fatigue.




     

The combination of tibial anterior translation and axial rotation into a single biomechanical factor improves the prediction of patient satisfaction over each factor alone in patients with ACL reconstructed knees

Purpose

The purpose of this study was to identify biomechanical factors, in both reconstructed and healthy knees, that correlate with patient satisfaction after ACL reconstruction.

Methods

Seventeen patients who had undergone unilateral ACL reconstruction were reviewed 9 years post-op. Patients completed subjective questionnaires and underwent manual knee laxity testing (Lachman-Trillat, KT-1000, and pivot shift) and automated laxity testing. During automated testing, both legs were rotated into external rotation and then internal rotation until peak rotational torque reached 5.65 Nm. Load-deformation curves were generated from torque and rotation data. Features of the curves were extracted for analysis. Total leg rotation and anterior laxity during KT-1000 testing were combined into a single factor (Joint Play Envelope or JPE). Patients were divided into groups based on patient satisfaction scores (Group 1: Higher Satisfaction, Group 2: Lower Satisfaction, Group 3: Unsatisfied). Load-deformation curve features and manual laxity testing results were compared between groups 1 and 2 to determine which biomechanical factors could distinguish between the groups. Diagnostic screening values were calculated for KT-1000 testing, the pivot shift test, total leg rotation and JPE.

Results

During manual testing, no significant differences in biomechanical factors were found when comparing reconstructed knees in group 1 and group 2. When comparing the reconstructed and healthy knees within group 2, the reconstructed knees had a significantly higher displacement during the KT-1000 manual maximum test (p?<?0.002). When considering the reconstructed knees alone, neither the result of the pivot shift test nor KT-1000 testing could distinguish between group 1 and group 2. During automated testing, there were no significant differences between the groups when comparing the reconstructed lower limbs. The healthy lower limbs in group 2 had more maximum external rotation (p?<?0.02) and decreased stiffness at maximum external rotation (p?<?0.02) when compared to the healthy lower limbs in group 1. Total leg rotation was unable to distinguish between group 1 and group 2. JPE could distinguish between group 1 and group 2 when considering the reconstructed limb alone (p?<?0.02). All four diagnostic screening values for JPE were equal or higher than in the other criteria. JPE also showed the most significant correlation with patient satisfaction.

Conclusions

Joint Play Envelope is an objective measure that demonstrated improved predictive value as compared to other tests when used as a measure of satisfaction in patients with ACL reconstructed knees.

     

Sensitivity to changes over time for the IKDC form, the Lysholm score, and the Cincinnati knee score A prospective study of 120 ACL reconstructed patients with a 2-year follow-up

The purpose of this study was to determine: (1) the sensitivity to changes over time for the IKDC form, the Lysholm score, and the Cincinnati knee score, (2) the relationship between the IKDC form, the Lysholm score and the Cincinnati knee score, (3) the criterion validity of each graded variable included in the IKDC form, and (4) if a functional knee test should be included as a graded variable and part of the final result of the IKDC form. We included in this prospective study 120 subjects who underwent ACL reconstruction with follow-up times of 3 and 6 months, and 1 and 2 years after surgery. Outcome measurements were the graded variables of the IKDC form (IKDC1–4 and IKDC-final), the Lysholm score, the Cincinnati knee score, a visual analogue scale for patient’s satisfaction, knee joint laxity measurement (KT-1000 knee arthrometer), and two functional knee tests (the triple jump and stairs hopple tests). The IKDC1, IKDC2, IKDC-final, and the Lysholm score were not sensitive to changes over time. The Cincinnati knee score was highly sensitive to changes over time and showed significantly improved outcome between each follow-up. IKDC1–4 showed high criterion validity, indicating that the IKDC1–4 is a good means of documenting clinical examination at one follow-up, but not of detecting changes over time. The functional knee tests were significant outcome measurements after ACL reconstruction, and should be reported separately. Received: 20 December 1997 Accepted: 5 November 1998     

Cardiac response during various activities in patients with ischemic heart disease evaluated by an ambulatory ventricular monitor (VEST)

To assess the cardiac response to various exercise in ischemic heart disease (IHD), left ventricular function was continuously measured with an ambulatory ventricular monitor (VEST) in 3 normal subjects and 15 IHD patients. Treadmill exercise (early stage (E1), end stage (E2) and recovery standing state (RE], walking (WK) and climbing stairs (CS), was used for exercise. 15 IHD patients were divided into 4 groups by the LVEF response to treadmill exercise. In group 1 (G1), LVEF increased gradually at stage 1 and became plateau from stage 2 to end stage like normal group. In group 2 (G2), LVEF increased at stage 1 and became plateau from stage 2 but decreased from maximal EF more than 5% at end stage. In group 3 (G3), LVEF increased only at stage 1 and decreased immediately after stage 1 to end stage. The decrease of LVEF at end stage from standing was more than 5%. In group 4 (G4), LVEF decreased at stage 1 and became minimum at end stage. This grouping was well related to thallium redistribution (Tl RD) score and coronary arteriography (CAG) score. We could predict the severity of coronary artery disease from this grouping because all group 3 or 4 patients had severe coronary artery disease. VEST was useful for the evaluation for the tolerance to daily activities. Group 1, 2 and 3 tolerated daily activities while group 4 could not always. The degree of the increase in cardiac output during ischemia evaluated by VEST may be one of the useful index of the tolerance to exercise. In conclusion VEST was very useful for evaluating cardiac capacity of ischemic heart disease patients during various exercise.     

Relationship between electromyographic activity of knee joint muscles with vertical and posterior ground reaction forces in anterior cruciate ligament reconstructed patients during a single leg vertical drop landing task

ABSTRACT

The objective of the present study is to examine the relation between activity patterns of knee joint muscles with vertical and posterior ground reaction forces (VGRF and PGRF, respectively) in patients after anterior cruciate ligament reconstruction (ACLR). Twenty males post-ACLR participated in this cross-sectional study. The association between muscle activity with VGRF and PGRF was assessed during a single leg vertical drop-landing task. There were strong negative associations between preparatory VL, VM and MG activity and PGRF (P< 0.05). Strong positive associations were found between reactive VM and LH activity with PGRF (P< 0.05). Preparatory co-activation of VM: MH had significant negative associations with VGRF (P< 0.05) and reactive co-activation of VL:LH had a significant positive relation with PGRF(P< 0.05). Greater preparatory activity and co-activation of knee muscles were associated with lower peak PGRF and VGRF, whereas greater reactive activity and co-activation of knee muscles was associated with greater peak PGRF and VGRF. According to our findings, both activity and co-activation of knee muscles during the preparatory phase were associated with reduced PGRF and VGRF, respectively in ACLR patients; thus, incorporating exercises in order to increase preparatory activity and co-activation of knee joint muscles into rehabilitation programs in ACLR patients seems necessary.     

Non-contrast-enhanced CT findings of high attenuation within metastatic cervical lymph nodes in patients with stage I or II tongue carcinoma during a follow-up period

We present the non-contrast-enhanced CT finding of high attenuation within metastatic regional lymph nodes in two patients with stage I or II tongue carcinoma during a follow-up period. The attenuation values of these lesions were approximately 70 HU or more. One patient had a level I node, and the other had a level II node. Contrast-enhanced CT failed to reveal these hyperattenuated areas within the nodes. Histopathologic examination revealed that these hyperattenuated areas were strongly correlated with the area of marked keratinization of metastatic foci. If contrast-enhanced CT had been the only imaging technique used, these lesions might have been overlooked. The clinician should be aware of the characteristic findings of non-contrast-enhanced, as well as contrast-enhanced, CT when investigating lymph node metastases at an early stage in patients with stage I or II tongue carcinoma during the follow-up period.     

Role of the peripheral nervous system for an appropriate postural preparation during gait initiation in patients with a chronic inflammatory demyelinating polyneuropathy: A pilot study

BackgroundGait initiation is an automatized motor program that is preceded by anticipatory postural adjustments (APAs). During attentional tasks, these APAs can be modulated, producing multiple APAs. However, the role of the peripheral nervous system in the regulation of these APAs is unknown.Research questionThe objective of our study was to investigate whether APAs are also regulated by peripheral nervous afferents.MethodsWe assessed 21 patients suffering from chronic inflammatory demyelinating neuropathy and 20 healthy controls. Participants initiated gait with the right or left leg either freely (in the standard condition) or according to a visual trigger (i.e., the select condition). Kinetic and kinematic parameters of APAs and step initiation were recorded.ResultsThe select condition was related to a higher rate of multiple APAs compared to the standard condition, and was more attention-consuming in both groups. The group with a neuropathy showed longer APAs than the control group, associated with a longer time to recover from multiple APAs. Consequently, the step execution time was delayed in patients with a peripheral neuropathy.SignificanceThe impairment of the peripheral nervous system is therefore responsible for an alteration of the mechanisms underlying the recovery from multiple APAs during gait initiation. Our results are in favor of a role of proprioceptive afferents in the early peripheral regulation of motor errors. Further study on gait initiation in peripheral nervous disease could be helpful to better explore sensory-motor coupling in tasks requiring balance control.