Early diagnosis of nonviable pregnancy with endovaginal US

The mean diameter of the gestation sac and the presence or absence of a yolk sac or embryo and/or cardiac pulsations on endovaginal ultrasound (US) images were correlated with normal and abnormal outcomes of pregnancy. Sixty-two patients who were less than 10 weeks pregnant (menstrual age) underwent endovaginal US. In 59 patients with gestation sacs greater than or equal to 8 mm, the absence of a yolk sac predicted a nonviable pregnancy with a sensitivity of 67% and a specificity of 100%. In 35 patients with gestation sacs greater than or equal to 16 mm, the absence of an embryo predicted a nonviable pregnancy with a sensitivity of 50% and a specificity of 100%. When the absence of cardiac pulsations was added to the latter group of patients, the sensitivity was 100% and the specificity was 100%. The combination of these criteria (gestation sac size; demonstration of yolk sac, embryo and/or cardiac pulsations) enabled the early (less than 10 weeks menstrual age) diagnosis of a nonviable pregnancy with endovaginal US.     

Abnormal pregnancy: early diagnosis by US and serum chorionic gonadotropin levels

Simultaneous sonography and quantitative serum human chorionic gonadotropin (HCG) levels from 126 women with threatened abortion were compared. Of 56 women with normal outcome, 39 (70%) had a gestation sac greater than or equal to 5 mm in mean sac diameter, and in each case the HCG level was 1,800 milli-international units (mIU/ml) or greater. The serum HCG levels strongly correlated with the gestation sac sizes to a mean sac diameter of 25 mm. Of 70 abnormal pregnancies, 31 demonstrated a gestation sac. Of these, 20 women (65%) had disproportionately low HCG levels relative to sac size, including 12 in whom the HCG level was less than 1,800 mIU/ml. One woman with an early molar pregnancy had a disproportionately elevated HCG level. Correlation of sonograms with a simultaneous measurement of serum HCG level is a useful method for evaluating threatened spontaneous abortion. A disproportionately low HCG level relative to gestation sac size is evidence for an abnormal pregnancy.     

Ultrasound evaluation of ectopic pregnancy including correlation with human chorionic gonadotrophin levels

A total of 267 patients referred for ultrasound examination because of clinical suspicion of ectopic pregnancy were studied prospectively. The outcome was correlated with the ultrasound findings and human chorionic gonadotrophin levels using a quantitative serum assay. The value of the following in the diagnosis of ectopic pregnancy are assessed: ultrasound criteria for early diagnosis of intrauterine pregnancy before visualization of a viable fetus, the discriminatory zone of hCG and extrauterine abnormalities.     

血清HCG与β-HCG、游离β-HCG的相关性研究

目的:探讨血清中β-HCG、游离β-HCG与HCG含量的相关性,寻求它们之间的换算关系。方法:用磁分离酶联免疫技术测定不同组别血清标本中的HCG、β-HCG、游离β-HCG含量,计算β-HCG、游离β-HCG与HCG的相关系数,并作t检验。结果:正常妊娠孕妇血清中β-HCG、游离β-HCG与HCG含量间呈明显正相关,其中孕14-21周孕妇组P<0.05,其余孕妇组P<0.001,异位妊娠孕妇组P>0.05。结论:正常妊娠孕妇血清中β-HCG、游离β-HCG与HCG有明显的相关性;异位妊娠孕妇中没有明显相关性。     

Ectopic pregnancy: evaluation with endovaginal color flow imaging.

Endovaginal sonography and endovaginal color flow imaging were compared in 155 patients with clinical suspicion of ectopic pregnancy. Sixty-five patients (42%) had surgically confirmed ectopic pregnancies. Thirty-six of the pregnancies were diagnosed with endovaginal sonography alone, the criteria being an extrauterine sac or ectopic fetus (sensitivity, 54%). Sixty-two ectopic pregnancies were diagnosed with endovaginal color flow imaging (sensitivity, 95%) when an ectopic fetus or sac was seen or placental flow was identified in an adnexal mass separate from the ovary and uterus. The diagnosis of ectopic pregnancy was excluded with endovaginal sonography (specificity, 98%) and endovaginal color flow imaging (specificity, 98%) by finding an intrauterine gestation, nonvisualization of an adnexal mass, and absence of placental flow. Three false-positive and three false-negative diagnoses were made with endovaginal color flow imaging (positive predictive value, 97%). The addition of color Doppler flow imaging to endovaginal sonography allows increased sensitivity in the detection of ectopic pregnancy.     

Early rheumatoid arthritis: a review of MRI and sonographic findings

OBJECTIVE: The introduction of anti-tumor necrosis factor alpha agents has opened new prospects in therapeutic management of patients with early rheumatoid arthritis, thereby creating new demands on radiologists to identify patients with aggressive disease at an early stage. As a result, imaging techniques such as MRI and sonography have developed during the past few years. CONCLUSION: This article illustrates the imaging findings that may be encountered with these techniques in patients with early rheumatoid arthritis.     

Early gestation: correlation of HCG levels and sonographic identification

Previous reports have indicated that an intrauterine gestational sac is not usually detected when the maternal serum human chorionic gonadotropin (HCG) is less than 6000 mIU/ml. In order to evaluate this observation, maternal serum HCG concentrations were correlated with sonographic uterine findings in 49 patients with normal early intrauterine pregnancies. Of 37 patients in whom a gestational sac was seen, simultaneous HCG levels were 1800 mIU/ml or more in 36 cases and 357 mlU/ml in one case. In 12 cases in which a gestational sac was not detected, the serum HCG levels were 1400 mIU/ml or less. Thirteen patients had HCG levels of less than 6000 mlU/ml. A linear relation was found between gestational sac size and the exponential rise of HCG levels in early pregnancy (p less than 0.001). Of the 13 patients in whom HCG levels were less than 6000 mIU/ml, the gestational sac measured 10 mm or less in each case. Currently, a gestational sac is always seen when the HCG level is greater than 1800 mIU/ml. Comparison of serum HCG levels with sonographic detection of the gestational sac seems to be a useful method of evaluating early pregnancy.     

Suspected ectopic pregnancy: endovaginal and transvesical US

Until the advent of endovaginal ultrasonography (US), transvesical US was the only US technique availab le for evaluation of patients with suspected ectopic gestation. A study was undertaken to assess the predictive ability of transvesical and endovaginal US and determine whether endovaginal US could be used alone. Fifty-three patients who had a positive pregnancy test finding and who were at risk for ectopic pregnancy were examined with both endovaginal and transvesical US. Twenty-nine were examined retrospectively and 24 were examined prospectively. Standard sonographic criteria were used to differentiate between intrauterine pregnancy and ectopic gestation. The clinical or pathologic diagnosis was ectopic pregnancy in 18 patients (34%), normal intrauterine pregnancy in 19 (36%), and abnormal intrauterine pregnancy in 16 (30%). Endovaginal US increased the sensitivity of detecting a live ectopic pregnancy (from 6% to 17%). Endovaginal US, by allowing early diagnosis of intrauterine pregnancy, significantly increased the diagnostic accuracy for ectopic pregnancy (from 60% to 83%). Endovaginal US provided significant additional information in women referred for sonography with a suspected ectopic gestation. On the basis of these findings it is concluded that endovaginal US can be used alone in the majority of women with suspected ectopic gestation.     

Renal dysplasia: sonographic findings

In 38 pediatric patients (predominantly neonates) with a proved pathologic diagnosis of renal dysplasia, a variety of sonographic appearances were seen. When the obstruction was at the level of the ureteropelvic junction (12 patients, 12 kidneys), the typical appearance was of a large kidney containing multiple large or moderate-sized cysts. When the obstruction was at the level of the distal ureter (14 patients, 14 kidneys), a smaller kidney containing a few cysts of variable sizes was usually seen. When the obstruction was at the level of the urethra (eight patients, 13 kidneys), the kidney was typically small with few or no cysts. In four patients (seven kidneys) in whom no cause of the obstruction was evident, the kidneys were small and echogenic. There was one case of segmental dysplasia.     

Gastric trichobezoar: sonographic findings

Ultrasonographic diagnosis of trichobezoar may be relatively specific. A broad band of high-amplitude echoes can be seen superficially, with complete sonic shadowing behind. The authors describe a patient in whom the diagnosis was made prior to conventional barium studies and in whom the question of trichobezoar had not been raised clinically.     

Diagnosis of ectopic pregnancy: endovaginal vs transabdominal sonography

During a 25-month period, 193 women with the clinical diagnosis of suspected ectopic pregnancy had transabdominal and endovaginal sonograms. Most had quantitative determinations of serum human chorionic gonadotropin (HCG). Endovaginal sonography was diagnostic of ectopic pregnancy in 23 (38%) of the 60 patients with surgically proved ectopic pregnancies: transabdominal sonography was diagnostic in 13 patients (22%). All 83 intrauterine pregnancies were identified with endovaginal sonography, compared with 34 identified with transabdominal sonography. Endovaginal sonography was somewhat more helpful in the diagnosis of missed abortion and blighted ovum. Eighty endovaginal sonograms were classified as indeterminate as compared with 141 transabdominal studies. This indeterminate group included patients with complete abortions, ectopic pregnancies without sonographic evidence of an extrauterine gestation, incomplete abortions, and patients with subsequent negative serum levels. As in prior reports, endovaginal sonography was superior to transabdominal sonography in the evaluation of suspected ectopic pregnancies. Overall, endovaginal sonography was diagnostic in 113 patients, whereas transabdominal sonography was diagnostic in 52 patients. The finding of an extrauterine fetal pole or embryo was diagnostic for an ectopic pregnancy. Pelvic fluid, the appearance of the endometrium, and a single positive serum HCG determination were not helpful in making the diagnosis of ectopic pregnancy.     

Superficial esophageal cancer: esophagographic findings correlated with histopathologic findings

PURPOSE: To retrospectively determine and evaluate the findings of superficial esophageal cancer at esophagography and to correlate the esophagographic findings with the depth of tumor invasion. MATERIALS AND METHODS: The institutional review boards required neither their approval nor informed patient consent for this retrospective study. One hundred thirteen patients with superficial esophageal cancer who underwent esophagectomy at three institutions were included in this study. Double-contrast esophagograms were reviewed independently by two reviewers. For assessment of histopathologic findings, pathology reports were reviewed. Findings at esophagography, including morphologic type of the lesion, lesion extent, presence or absence of elevated or depressed component, margin and extent of elevated or depressed component, presence or absence of nodularity, extent of nodularity, esophageal luminal narrowing, and esophageal wall rigidity, were compared between mucosal and submucosal cancers by using chi2, Fisher exact, and independent-sample t tests. RESULTS: Of 122 histopathologically proved superficial esophageal cancers in 113 patients, 100 (82%) were detected at esophagography. The most common morphologic type was the plaquelike form; 50 (50%) such lesions were depicted at esophagography. Morphologic types were significantly different between the mucosal and submucosal cancers (P < .001). Protruded and plaquelike lesions were more frequent among submucosal cancers, whereas most flat lesions were mucosal cancers. An elevated component (P < .001), a rigid esophageal wall (P < .001), and a lobulated or irregular margin of the elevated component (P = .023) were significantly more frequent among submucosal cancers. Also, total extent of the lesion (P < .001), size of the largest nodule (P < .001), and extent of nodularity (P = .036) were significantly larger in the submucosal cancers. CONCLUSION: In the evaluation of patients with superficial esophageal cancer, esophagography appears to be helpful for diagnosing the tumor and differentiating mucosal from submucosal cancers.     

Estimating splenic volume: sonographic measurements correlated with helical CT determination

OBJECTIVE: The purpose of this study was to determine which sonographic measurements of the spleen most closely correlate with splenic volume as determined on helical CT. MATERIALS AND METHODS: From October 17, 2000, to April 27, 2001, 142 consecutive patients prospectively underwent abdominal helical CT and sonography as part of an evaluation for liver disease. Calculations of splenic volumes were based on 10-mm unenhanced images. Maximum length (ML) and width (W), thickness (T), and craniocaudal length (CCL) were measured sonographically. Standard ellipsoid volume formulas (with the addition of new ellipsoid coefficients) and linear regression formulas were calculated for 117 patients whose examinations were performed within 30 days of each other. Mean percent differences, standard deviations, and 95% confidence intervals (CI) were calculated. RESULTS: We calculated the average difference between sonography- and CT-measured volume and the 95% CI for each of the four initial sonographic volume estimates with the ellipsoid method using two lengths and linear regression using two lengths and compared them to CT-determined volume. The ellipsoid formulas were then adjusted for bias. Linear regression formulas were derived in which splenic volumes were separately calculated on the basis of each of the two lengths. Mean percent differences and standard deviations for ellipsoid formulas with varying coefficients using the three length measurements were also calculated. CONCLUSION: Sonographic measurements allow accurate determination of splenic volume. Estimating splenic volume with the formula 0.524 x W x T x (ML + CCL) / 2 provides the greatest overall accuracy.     

Extraarticular snapping hip: sonographic findings

OBJECTIVE. The aim of the study was to determine the sonographic findings of snapping hip and to correlate the findings with the presence or absence of pain. MATERIALS AND METHODS. Twenty patients with snapping hip were examined with sonography. Conventional and dynamic sonographic examinations of both hips were performed using a 5.0- or 7.0-MHz transducer. RESULTS. Conventional sonographic studies allowed identification of various structural abnormalities (tendinitis, bursitis, synovitis) and helped to document tenderness along the course of specific tendons. Dynamic sonographic studies revealed 26 cases of snapping hip. In 24 of these 26 cases, the underlying cause was clearly identified. Twenty-two snapping hips were caused by an abnormal movement of the iliopsoas tendon, and two were caused by iliotibial band friction over the greater trochanter. One patient reported a bilateral snapping sensation that could not be documented on sonography. Snapping hip was elicited by a wide variety of hip movements. Sonography established an immediate temporal correlation between the jerky tendon motion and the painful snap reported by the patient. Only 14 cases of snapping hip were painful. CONCLUSION. Conventional sonographic studies can identify signs of tendinitis, bursitis, or synovitis. Dynamic sonographic studies revealed the cause of snapping hip in most patients. Snapping hip is characterized on sonography by a sudden abnormal displacement of the snapping structure. In our study, a significant proportion of the cases of snapping hip were not painful.