Evaluation of Combinations of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine with Clinically Used Antiretroviral Drugs

Drug combination studies of 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) with FDA-approved drugs were evaluated by two different methods, MacSynergy II and CalcuSyn. Most of the combinations, including the combination of the two adenosine analogs EFdA and tenofovir, were essentially additive, without substantial antagonism or synergism. The combination of EFdA and rilpivirine showed apparent synergism. These studies provide information that may be useful for the design of EFdA combination regimens for initial and salvage therapy assessment.     

Effect evaluation of health education in 80 cases of type 2 diabetes

Background:Carefullyplanned,organizedandsystematice-ducationcanhelppeoplevoluntarilyadopthealthybehaviorandlifestyle,removeorreduceharmfulfactorstohealth.Diabetesisametabolicendocrinedisease,andhealtheducationdoesasupple-mentaryeffecttoit'streatment.Objective:Toinvestigatetheeffectofhealtheducationontype2diabetestreatment.Unit:RongjunGeneralHospitalofShandongProvince.Subjects:80in-patientswithtype2diabeteswereinvestigat-ed,including30malesand50females,aged40-50yearsoldwiththecoursesofdiseas…     

Effect evaluation of health education in 80 cases of type 2 diabetes

To investigate the effect of health education on type 2 diabetes treatment.Main Prognosis indes:Self-made questinnaire,consisted of name,sex,age,education degree,course of disease,mental state,common problems and need of diabetes knowledge.Result:Before education,88.9% of diabetes patients didn‘t know the common problems,85% could‘t control diet,81% couldn‘t obey medical order,8 cases needing insulin injection get no suitable instruction,3 cases couldn‘t reach expected blood glucose level.All patients expect corresponding educatio.Trough 1 year of follow-up survey after education,95% of the patients got diabetes-related knowledge,100% could control diet,but 30% couldn‘t keep for long time,90% could stick to taking drugs on time and insulin user could grasp right dosage and method.Conclusion:health education to patients with type 2 diabetes can improve their self-protection.help them establish healthy life style,cooperate with doctors and improve their living quality.     

Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma

Asthma is a chronic inflammatory lung disease with considerable unmet medical needs for new and effective therapies. Cytosolic phospholipase A(2)α (cPLA(2)α) is the rate-limiting enzyme that is ultimately responsible for the production of eicosanoids implicated in the pathogenesis of asthma. We investigated a novel cPLA(2)α inhibitor, PF-5212372, to establish the potential of this drug as a treatment for asthma. PF-5212372 was a potent inhibitor of cPLA(2)α (7 nM) and was able to inhibit prostaglandin (PG)D(2) and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells (0.29 and 0.45 nM, respectively). In a mixed human lung cell population, PF-5212372 was able to inhibit ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (2.6, 2.6, and 4.0 nM, respectively) but was significantly less effective against PGE(2) release (>301 nM; p < 0.05). In an in vitro cell retention assay, PF-5212372 retained its potency up to 24 h after being washed off. In a sheep model of allergic inflammation, inhalation of PF-5212372 significantly inhibited late-phase bronchoconstriction (78% inhibition; p < 0.001) and airway hyper-responsiveness (94% inhibition; p < 0.001), and isolated sheep lung mast cell assays confirmed species translation via effective inhibition of PGD(2) release (0.78 nM). Finally, PF-5212372 was assessed for its ability to inhibit the contraction of human bronchi induced by AMP. PF5212372 significantly inhibited AMP-induced contraction of human bronchi (81% inhibition; p < 0.001); this finding, together with the ability of this drug to be effective in a wide range of preclinical asthma models, suggests that inhibition of cPLA(2)α with PF-5212372 may represent a new therapeutic option for the treatment of asthma.     

Manual treating of 2cases with cer-vicogenous arrhythmia

MATERIALSANDMETHODSMaterials２caseswerediagnosedasarrhythmiawithoutclearreasonsbyECGandwereconfirmedthattheydidn＇tsufferedorganicdiseases．Allthecasesreceivedanti－arrhythmiaandheartmusclenutritiondrugsanddidn＇tgaingoodeffects．Methodspatientwasinsittingposition．Doctorstoodback，relaxcervical，shoulderandbackmusclesinorderwithpinch，grasp，massageandrollingmaneuver．Plug，extension，rotationshakingheadmethod．Doctorstoodonlateralposteriorside，onehandsupportedupperpartofhead，theo…     

Report of 2 cases with brachium potine syndrome

INTRODUCTIONBrachiumpotinesyndromeisalsocalledpotinecerebellumlesionsyndrome,islocalizedatfacial,acoustic,trigeminalandvestibulenerveroots.Inclinic,lesioninthiszoneisrare.Wemettwocasesrecently.Bothofcaseswereacuteonset,withhypertensionhistory.Firstsymptomsweredizziness,unstabilityofgait,facialhemianes-thesia,cornealreflexdullness,poorhearinganddystaxia.CerebralMRIshowedbrachiumpotinewithlongT1andT2,signaloffocuswithclearmargin,enhancescanshowedslightorapparentreinforce-ment.Todetermine…     

World Journal of Emergency Medicine成功进入Web of Science Q2区

2020年6月29日,科睿唯安公司正式公布2019年度SCI收录期刊引证报告(Journal Citation Reports,JCR):World Jounal of Emergency Medicine(WJEM)喜获影响因子1.743,进入Web of Science Q2区。WJEM是由浙江大学和浙江大学医学院附属第二医院主办并向国内外公开发行的国际性英文学术期刊。     

Do measures of body fat distribution provide information on the risk of type 2 diabetes in addition to measures of general obesity? Comparison of anthropometric predictors of type 2 diabetes in Pima Indians

OBJECTIVE: To investigate which anthropometric measurements of obesity best predict type 2 diabetes in a population of Pima Indians and whether additional information on diabetes risk could be obtained by combining measures of general obesity with measures of body fat distribution. RESEARCH DESIGN AND METHODS: We conducted a prospective study of 624 men and 990 nonpregnant women >18 years of age without diabetes. Subjects were followed a mean of 5.25 years for the development of type 2 diabetes (using 1997 American Diabetes Association criteria). RESULTS: A total of 322 new cases of type 2 diabetes (107 men and 215 women) were diagnosed during follow-up. Baseline obesity measurements were highly correlated and predicted diabetes in proportional hazards models adjusted for age. BMI had the highest hazard ratio in men and women, with age-adjusted hazard ratios per SD of 1.73 (95% CI 1.44-2.07) and 1.67 (1.45-1.91), respectively. According to receiver-operating characteristic analysis, BMI and waist-to-height ratio were the best predictors of diabetes in men, while in women BMI, waist-to-height ratio, waist circumference, and waist-to-thigh ratio were the best predictors. The predictive abilities of models containing BMI were not significantly improved by including other measures of general obesity or measures of the body fat distribution. CONCLUSIONS: Throughout its range, BMI was an excellent predictor of type 2 diabetes risk in Pima Indians and was not significantly improved by combining it with other measures of general adiposity or body fat distribution.     

Habituation of single CO2 laser–evoked responses during interictal phase of migraine

A reduced habituation of averaged laser–evoked potential (LEP) amplitudes was previously found in migraine patients. The aim of the present study was to assess the habituation of single LEP responses and pain sensation during the interictal phase in migraine patients. Fourteen migraine patients were compared with ten control subjects. The pain stimulus was laser pulses, generated by CO₂ laser, delivered to right supraorbital zone. Patients were evaluated during attack–free conditions. The LEP habituation was studied by measuring the changes of LEP amplitudes across and within three consecutive repetitions of 21 non–averaged trials. In migraine patients the N2–P2 wave amplitudes did not show a tendency toward habituation across and, above all, within the three repetitions. Anomalous behaviour of nociceptive cortex during the interictal phase of migraine may predispose patients to headache occurrence and persistence.