Association of β-adrenergic receptor genes polymorphisms with incidence of subsequent cardiovascular events in Han Chinese patients with coronary artery disease

Background Sequence variants in the 13-adrenergic receptor （ADRB） genes have a close relationship with the development of coronary artery disease （CAD） and the patient＇s prognosis. However, there is a lack of data on the role of the variants in ADRBs genes in Han Chinese patients with CAD. We aimed to investigate the association of genetic variants in the ADRB1 and ADRB2 genes with the incidence of major adverse cardiac event （MACE） in Han Chinese patients with CAD. Methods A total of 545 Han Chinese patients with CAD undergoing percutaneous coronary intervention （PCI） were recruited to the study and followed for one year. Three variant sites in ADRB1 （rs1801253） and ADRB2 （rs1042713 and rs1042714） were genotyped. The effect of the ADRB1 and ADRB2 genotypes on MACE within one year was assessed. Results There were 47 cases of MACE during follow-up. There was no significant difference in the incidence of MACE among patients carrying different genotypes of the three variants in ADRB1 and ADRB2 （Log-rank, all P 〉0.05）. Cox regression analysis showed no association between three variants in ADRB1 and ADRB2 genes and the incidence of MACE during one-year follow-up, the adjusted hazard ratios （95% confidence interval） for rs1801253, rs1042713 and rs1042714 were 1.05 （0.54-2.02）, 1.24 （0.58-2.64）and 1.66 （0.81-3.42）, respectively. Conclusion Our data did not support a relationship between the three polymorphisms of ADRB1 （rs1801253） and ADRB2 （rs1042713 and rs1042714） genes and risk of subsequent cardiovascular events after PCI in Han Chinese patients with CAD.     

Cerebral microbleeds — prevalence, distribution and risk factors in northeast population without preceding large-area stroke

Background  Cerebral microbleeds (CMBs) occur frequently in patients suspected of cerebrovascular disease and they are the principle radiographic findings in patients with sub-clinical neurological impairment. The objective of this study was to assess the prevalence, distribution, severity and associated clinical features of CMBs in a prospective hospital patient based cohort undergoing brain MRI for suspected cerebrovascular disease, excluding cases with known intracranial hemorrhage or prior large-area stroke.
Methods  The study population consisted of 447 patients who were evaluated with T2*-gradient echo sequences to detect the CMBs lesion number, location, and their association with white matter hyperintensities and clinical parameters, including blood pressure.
Results  CMB lesions were presented in 95 of the 447 patients (21.3%). The distribution of CMBs was 43.95% cortical, 19.77% thalamic, 14.41% in the brainstem, 11.58% cerebellar, 6.21% periventricular white matter, 5.64% involving the basal ganglia regions, and 0.28% involving the hippocampus. There was a statistically significant association between the presence of CMBs and advancing age (adjusted OR 2.082, P <0.01), the severity of hypertension (adjusted OR 2.208, P <0.01). Also there was a statistically significant (P <0.01) correlation between the presence of CMBs and the severity of hypertension and white matter lesions.
Conclusions  CMBs occur frequently in patients with no prior large-area stroke who were referred for brain MRI for suspected cerebrovascular disease. The severity of CMBs correlates with the severity of hypertension and the presence of cerebral white matter changes detected by MRI.

     

Original article ：Cerebral microbleeds prevalence,distribution and risk factors in northeast population without preceding large-area stroke

Background Cerebral microbleeds （CMBs） occur frequently in patients suspected of cerebrovascular disease and they are the principle radiographic findings in patients with sub-clinical neurological impairment. The objective of this study was to assess the prevalence, distribution, severity and associated clinical features of CMBs in a prospective hospital patient based cohort undergoing brain MRI for suspected cerebrovascular disease, excluding cases with known intracranial hemorrhage or prior large-area stroke. Methods The study population consisted of 447 patients who were evaluated with T2＊-gradient echo sequences to detect the CMBs lesion number, location, and their association with white matter hyperintensities and clinical parameters, including blood pressure. Results CMB lesions were presented in 95 of the 447 patients （21.3%）. The distribution of CMBs was 43.95% cortical, 19.77% thalamic, 14.41% in the brainstem, 11.58% cerebellar, 6.21% periventricular white matter, 5.64% involving the basal ganglia regions, and 0.28% involving the hippocampus. There was a statistically significant association between the presence of CMBs and advancing age （adjusted OR 2.082, P 〈0.01）, the severity of hypertension （adjusted OR 2.208 P 〈0.01）. Also there was a statistically significant （P 〈0.01） correlation between the presence of CMBs and the severity of hypertension and white matter lesions. Conclusions CMBs occur frequently in patients with no prior large-area stroke who were referred for brain MRI for suspected cerebrovascular disease. The severity of CMBs correlates with the severity of hypertension and the presence of cerebral white matter changes detected by MRI.     

Changes in Plasma Angiotensin Ⅱ and Circadian Rhythm of Blood Pressure in Hypertensive Patients with Sleep Apnea Syndrome Before and After Treatment

Objective To explore the changes in plasma angiotensin II (Ang II) and circadian rhythm of blood pressure among hypertensive patients with sleep apnea syndrome (SAS) before and after continuous positive airway pressure (CPAP) or surgical treatment.Methods A total of 180 essential hypertension patients were enrolled in our study.The determination of plasma Ang II concentration,ambulatory blood pressure (ABP),and polysomnography (PSG) monitoring were performed before and 3 months after CPAP or surgical treatment.Results Patients were classified into three groups by their apnea-hypopnea index (AHI):essential hypertension group (EH group,n=72;AHI<5),essential hypertension with mild SAS group (EH+mild SAS group,n=60,5≤AHI<20),and essential hypertension with moderate and severe SAS group (EH+moderate-severe SAS group,n=48,AHI≥20).The concentrations of plasma AngⅡ in the above three groups were 13.42±3.27,16.17±3.82,and 18.73±4.05 ng/mL respectively before treatment,and AngⅡ concentration in EH patients combined with SAS was significantly higher than that in EH group (all P<0.05).After treatment the values in the latter two groups significantly decreased to 14.67±2.56 and 15.03±3.41 ng/mL respectively (P<0.05).The incidence of non-dipper blood pressure curve in EH patients was 31.9%,and those in hypertensive patients with mild SAS and moderate-severe SAS were 51.7% and 58.3%,respectively before treatment.The incidence of non-dipper blood pressure curve in the EH patients with mild SAS was significantly higher than that of patients with EH alone (P<0.05).After CPAP treatment or surgery,the incidence of non-dipper blood pressure curve in the two SAS groups was significantly decreased to 38.3% and 39.6%,respectively (P<0.05).Conclusions Ang II might play a role in blood pressure variability in patients with obstructive SAS.CPAP or surgical treatment can improve blood pressure disorder and decrease plasma Ang II level in patients with obstructive SAS.     

Di-（n-butyl）-phthalate-induced Oxidative Stress and Depression-like Behavior in Mice with or without Ovalbumin Immunization

Objective To investigate the relationship between atopic allergy and depression and the role of DBP in the development of depression. Methods BALB/c mice were randomly divided into eight groups: saline; ovalbumin(OVA)-immunized; saline+DBP(0.45 mg/kg·d); saline+DBP(45 mg/kg·d); DBP(0.45 mg/kg·d) OVA-immunized; DBP(45 mg/kg·d) OVA-immunized; saline+hydrocortisone(30 mg/kg·d); and hydrocortisone(30 mg/kg·d)-exposed OVA-immunized. Behavior(e.g. open-field, tail suspension, and forced swimming tests), viscera coefficients(brain and spleen), oxidative damage [e.g. reactive oxygen species(ROS), malondialdehyde(MDA), and glutathione(GSH)], as well as levels of IgE and IL-4, were then analyzed. Results In the saline and OVA groups, the degree of depression symptoms in mice increased with increasing DBP concentration. Additionally, the OVA-immunity groups were associated with more serious depressive behavior compared with the same exposure concentration in the saline group. Oxidative damage was associated with a dose-dependent increase in DBP in the different groups. IL-4 and IgE levels were associated with low-dose DBP stimulation, which changed to high-dose inhibition with increasing DBP exposure, possibly due to spleen injury seen at high DBP concentrations. Conclusion Development of an atopic allergy has the potential to increase the risk of depression in mice, and it seems that DBP helps OVA to exert its effect in our present model. Moreover, the results of our study implicate a certain connection between brain oxidative stress and depression, which deserves a further exploration.     

Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes

Background Type 2 diabetes is a chronic disease characterized by a progressive loss of beta cell functions. However, the evaluation of beta cell functions is either expensive or inconvenient for clinical practice. We aimed to elucidate the association between the changes of insulin responsiveness and the fasting plasma glucose （FPG） during the development of diabetes.
Methods A total of 1192 Chinese individuals with normal blood glucose or hyperglycemia were enrolled for the analysis. The early insulinogenic index （△I30/△G30）, the area under the curve of insulin （AUC-Ⅰ）, and homeostasis model assessment were applied to evaluate the early phase secretion, total insulin secretion, and insulin resistance respectively. Polynomial regression analysis was performed to estimate the fluctuation of beta cell functions. Results The △I30/△G30 decreased much more rapidly than the AUC-Ⅰ accompanying with the elevation of FPG. At the FPG of 110 mg/dl （a pre-diabetic stage）, the AI30/AG30 lost 50% of its maximum while the AUC-Ⅰ was still at a compensated normal level. The AUC-Ⅰ exhibited abnormal and decreased gradually at the FPG of from 130 mg/dl to higher （overt diabetes）, while the △I30/△G30 almost remained at 25% of its maximum value. When hyperglycemia continuously existed at 〉 180 mg/dl, both the AI30/AG30 and AUC-Ⅰ were totally lost.
Conclusion The increased fasting plasma glucose reflects progressive decompensation of beta cell functions, and could be used to guide the strategy of clinical treatments.     

A comparison of elderly （20-65 yrs） life style with body mass index （BMI）〈and〉25

Objective：compare the habits and features of obese （BMI〉25） and normal （BMI〈25） individuals and express a method to ameliorate the life styles using a cross-sectional experiment. Methods：A total of 220 randomly selected cases were divided into case group （n= 110） and control group （n= 100） according to the calculated BMI level. Samples with BMI〉25 kg/m^2 were assigned to the case （obsess） group and those with BMI ranging from 20 to 25 were assigned to control （normal） group. The Miller-Smith life style questionnaires consisting 20 questions each with 5 different answers were given to both groups. Data of the questionnaires were collected and analyzed using t-test and Chi-square with SPSS. Results：No significant differences were found among the two groups in terms of the mean age, gender, level of education, marital status, insurance, breakfast, lunch or dinner, fried meat, legumes, eaffeinated beverages, the length of sleep during 24 h, cigarette smoking and losing job or spouse. However, in regards to use of vegetables, sausage, fried potatoes, enriched breads, low fat milk, low salt, candies and chocolates significant relations were found （P〈0.05）. Conclusion： The present study suggests one way to control obesity and prevent diseases is to ameliorate the life styles. There is a relation between health and stress and irregularity of meals, such as breakfast skipping, is associated with overweight and obesity in adolescence.     

Direct infarct artery stenting without predilation and no—reflow in patient with acute myocardial infarction（摘要）

Direct infarct artery stenting without predilation and no-reflow in patient with acute myocardial infarction(摘要 )@李新明$Department of cardiology, Hainan Provincial Hospital!HaiKou 570311, China. @李斌$Department of cardiology, Hainan Provincial Hospital!HaiKou 570311, China. @陈关良$Department of cardiology, Hainan Provincial Hospital!HaiKou 570311, China.…     

Study on the Serum Levels of Placenta Growth Factor During Normal Pregnancy and in Patients with Pregnancy Induced Hypertension

目的 :检测正常妊娠及妊娠高血压综合征 (妊高征 )患者血清胎盘生长因子 ( Pl GF)的水平 ,探讨 Pl GF与妊高征发病的关系。方法 :采用酶联免疫吸附法 ( ELISA)检测 5 1例不同孕期健康孕妇 (正常妊娠组 )及 33例妊高征患者 (妊高征组 )血清 Pl GF水平。结果 :1正常妊娠过程中 ,Pl GF在早孕期最低为 ( 1 72 .89± 82 .76) ng.L-1,中孕期开始大幅度升高至 ( 62 3.0 5± 1 66.2 2 ) ng.L-1,晚孕期达高峰 ( 833.84± 35 8.2 4 ) ng;2妊高征组 Pl GF平均水平为 ( 32 5 .70± 1 62 .2 1 ) ng.L-1,显著低于正常妊娠晚孕期水平 ( P<0 .0 0 1 ) ,并随妊高征病情加重 ,Pl GF水平呈逐渐下降趋势 ( P<0 .0 0 1 )。结论 :妊娠过程中 ,Pl GF对胎盘血管的形成有重要调节作用 ,Pl GF的下降与妊高征发病有关。     

Serum metrix metalloproteinase-9 combined with homocysteine, IL-6, TNF-α, CRP, HbAlc and lipid profile in the incipient diabetic nephropathy with or without macrovascular diseases

Objective ： To evaluate the changes of serum matrix metalloproteinase-9 （romp-9） in patients of incipient diabetic nephropathy with or without macrovascular disease and to analyze the factors associated with homocysteine（hcy）, interleukin-6（IL-6）, tumor necrosis factor-alpha （TNF-α）, highly sensitive C-reactive protein （hsCRP）, HbAlc and lipid profile in those patients in order to know whether this marker or other factors are more important to induce diabetic macrovascular disease. Methods： Type 2 diabetes mellitus（T2DM） subjects with incipient diabetic nephropathy with or without macrovascular disease were selected for participation and divided into 2 groups. The patients in group 1 （n= 38） used insulin, and patients in group 2 （n=34） were treated with an oral antidiabetic drug. Then serum mmp-9, hey, IL-6 and TNF-α in these patients were measured, and compared to the healthy subjects as control （n= 16）. The results were analyzed by SPSS13. Results： Serum romp-9 and hcy of the patients having incipient diabetic nephropathy with macrovascular disease were higher than that of patients without macrovascular disease （P〈0.01）. For insulin-injected patients, whether they accompanied with macrovascular diseases or not, the serum levels of romp-9, hcy, IL-6 and TNF-α were all lower, but no significant statistics compared with non-insulin used patients or the healthy subjects. The serum level of romp-9 was more correlated with the serum hcy in antidiabetic drug used patients. （P〈0. 000） Conclusion： The serum level of romp-9 plays an important role of pathogenesis in the macrovascular disease in the incipient diabetic patients, and the serum level of hcy also can reflect the severely degree of macrovascular disease in these patients, insulin can reduce these markers.     

血浆同型半胱氨酸水平与急性脑梗死的关系

目的:探讨血浆同型半胱氨酸(Hcy)与急性脑梗死的关系以及叶酸、VitB12干预的作用。方法:149例急性脑梗死患者(脑梗死组)和同期40例健康体检者(对照组)采用酶联免疫法测定血浆Hcy;其中脑梗死组筛选出高Hcy血症患者85例,再随机分为叶酸、VitB12治疗组43例及常规治疗组42例作对照研究,观察其干预效果。结果:脑梗死组血浆Hcy水平明显高于对照组,高Hcy在脑梗死患者所占比率显著高于对照组,差异有统计学意义(P<0.01);叶酸、VitB12干预后治疗组血浆Hcy水平较治疗前明显下降(P<0.01),干预组治疗效果优于常规治疗组(P<0.01)。结论:血浆Hcy升高是急性脑梗死患者的重要危险因素,叶酸、VitB12治疗可降低血浆Hcy水平,对预防和治疗脑梗死具有重要意义。     

慢性肾衰竭患者血浆同型半胱氨酸检测及相关因素分析

目的研究慢性肾衰竭（chronic renal failure,CRF）患者血浆总同型半胱氨酸（total homocysteine,tHcy）浓度的变化,并对其相关因素进行分析。方法采用荧光偏振免疫分析法检测122例CRF患者和130例正常对照组血浆tHcy浓度,同时检测其血清叶酸、VitB12浓度,并对它们之间的关系进行分析。结果血浆tHcy浓度CRF患者显著高于正常对照组（P〈0.01）,且慢性肾病（chronic kidney disease,CKD）Ⅴ期患者显著高于Ⅳ期患者（P〈0.01）,Ⅳ期患者显著高于Ⅲ期患者（P〈0.01）;正常对照组中血浆tHcy浓度男性显著高于女性（P〈0.05）,而CRF患者组血浆tHcy浓度男性略高于女性,但无显著性差异（P〉0.05）;血清叶酸浓度、VitB12浓度CRF患者均显著低于正常对照组（P〈0.01）。相关分析显示,两组血浆tHcy浓度与血清叶酸、VitB12浓度均呈负相关性。结论CRF患者血浆tHcy浓度明显升高,且随着病情的加重,血浆tHcy浓度呈逐渐上升趋势,检测血浆tHcy浓度对了解CRF患者病情具有重要意义。叶酸、VitB12缺乏可能是诱发CRF患者血浆tHcy浓度升高的重要因素之一。     

冠心病及高血压患者血浆同型半胱氨酸和一氧化氮水平的变化

目的探讨冠心病及高血压患者血浆同型半胱胺酸、一氧化氮水平的变化。方法选取本院2018年7月至2019年7月收治的65例冠心病合并高血压患者为冠心病组,并选取同期收治的55例单纯高血压患者为高血压组。比较两组血浆同型半胱氨酸,一氧化氮水平。结果冠心病组血浆同型半胱氨酸浓度明显高于高血压组(P<0.05),冠心病组一氧化氮浓度明显低于高血压组(P<0.05)。结论血浆同型半胱氨酸的增高与冠心病的发生密切相关,血浆同型半胱氨酸浓度与一氧化氮水平呈负相关,且血浆同型半胱氨酸水平与血管受损程度有一定的相关性。     

冠状动脉粥样硬化性心脏病患者同型半胱氨酸与血脂指标的相关性分析*

目的?探讨冠状动脉粥样硬化性心脏病（以下简称冠心病）患者同型半胱氨酸水平（Hcy）与甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、脂蛋白a水平的相关性,进一步阐明Hcy与冠心病病理生理过程中的重要作用。方法?选取2016年1月1日—2018年12月31日于新疆医科大学第一附属医院住院确诊为冠心病的患者400例作为研究组。另取同期该院健康体检者390例作为对照组。分别对两组Hcy与各项血脂指标间进行Kendall''stau-b相关性检验;比较Hcy<15μmmol/L及≥15μmmol/L时的血脂水平,并对结果进行分析。结果?研究组Hcy水平较对照组高（P?<0.05）,TG、TC、LDL-C、ApoA1、ApoB较对照组低（P?<0.05）。研究组Hcy与TG、TC、LDL-C、ApoA1及ApoB呈正相关（r?=0.231、0.184、0.137、0.117和0.162,P?<0.05）。Hcy≥15μmmol/L组TG、TC、LDL-C、脂蛋白a、ApoA1及ApoB较Hcy<15μmmol/L组高。结论?Hcy为冠心病的独立危险因素。Hcy与血脂水平有相关性。建议降脂治疗的同时降低血浆Hcy水平可能有助于预防冠心病的发生和发展。     

广东珠海地区健康体检者血浆总同型半胱氨酸水平的分布特点

目的 观察广东珠海地区体检人群血浆总同型半胱氨酸(tHcy)水平及其分布特点,分析与血浆tHcy相关的因素.方法 选取2013年1～12月在广东省珠海市中山大学附属第五医院检测血浆tHcy及相关生化指标的健康体检者1 136例,对血浆tHcy水平分布特点及与血浆tHcy相关的因素进行统计学分析.结果 广东珠海地区人群中血浆tHcy几何均数男性(16.11 μmol/L)高于女性(12.92 μmol/L,P＜0.01);如以血浆tHcy＞10.00 μmol/L则诊断为高同型半胱氨酸血症(HHcy),则男性的检出率为97.81％,高于女性的86.67％.血浆tHcy水平随年龄的增长有升高趋势.多重线性回归分析显示性别、年龄和血浆肌酐影响血浆Hcy的水平.结论 广东珠海地区体检人群血浆tHcy水平及HHcy的捡出率较高,且随年龄的增长有升高的趋势.性别、年龄和血浆肌酐可以影响血浆tHcy水平.     

青中年人群微量白蛋白尿患病率与心血管疾病危险因素的关系

目的　探讨微量白蛋白尿患病率与心血管疾病危险因素的关系。方法　选择 775例 (男 32 6例 ,女 4 4 9例 )年龄 2 0～ 5 0岁的社区人群 ,测定其体重指数 (BMI)、血压、空腹血糖、血脂谱 ;收集晨尿检测尿白蛋白、尿肌酐浓度 ,并计算尿白蛋白 /尿肌酐的比率。根据有无高血糖、高血压或高三酰甘油 /低高密度脂蛋白胆固醇 (高TG/低HDL C)血症分为 4组 ,即正常组 (A组 )、1种代谢紊乱组 (B组 )、2种代谢紊乱组 (C组 )及代谢综合征组 (D组 ) ,评价微量白蛋白尿与代谢紊乱的关系。结果　①糖尿病患者微量白蛋白尿的患病率为 2 2 .2 % ,显著高于正常血糖者 (5 .2 % ,P =0 .0 0 2 ) ;高TG/低HDL C血症者微量白蛋白尿的患病率为 8.3% ,显著高于正常血脂者 (4.0 % ,P =0 .0 12 ) ;高血压患者与正常血压者的差异无显著性。②随代谢紊乱加重 ,尿白蛋白浓度显著升高 (协方差分析 ,P <0 .0 1) ,微量白蛋白尿患病率升高 (趋势分析 ,P =0 .0 0 3)。③ 4组间尿肌酐浓度、尿白蛋白 /尿肌酐的差异无显著性。结论　①糖尿病、高TG/低HDL血症人群的微量白蛋白尿的发病率显著升高。②随代谢紊乱加重 ,微量白蛋白尿患病率亦升高     

血浆同型半胱氨酸水平与急性脑梗塞近期临床预后关系的研究

目的探讨血浆同型半胱氨酸水平与急性脑梗塞患者近期临床预后的关系。方法将151例初发急性脑梗塞患者根据其空腹高半胱氨酸(hcy)值分为非高同型半胱氨酸(NHhcy)组94例及高同型半胱氨酸(Hhcy)组57例,采用美国国立卫生研究院卒中量表(NIHSS)和BI指数评分,对两组患者神经功能缺损、日常生活能力进行追踪观察。结果 NHhcy组及Hhcy组在入院时、1个月、3个月NIHSS评分与日常生活能力评分无显著差异(P>0.05)。结论研究结果没有证据表明同型半胱氨酸水平对急性脑梗塞患者近期神经功能恢复有影响。     

35岁以上社区居民高血压患病率及总体心血管事件危险分析

目的:了解社区人群高血压患病情况,并进行总体心血管事件危险分析,为高血压分级管理提供依据。方法:按《国家基本公共卫生服务规范》(2009年版)居民健康档案健康体检项目要求进行社区检查,并以2009年基层版《中国高血压防治指南》为标准定义各种危险因素、亚临床靶器官损害和临床疾患及相关技术指标,对高血压患者依据血压水平和心血管危险因素进行总体心血管危险分层。结果:35岁以上居民体检1 143人,发现高血压420人,轻中度高血压占大多数(34.56%),重度高血压占2.19%,高血压前期比例较高(22.48%)。单纯收缩期高血压占体检人数的9.19%。高血压的知晓率46.67%,治疗率29.59%,控制率17.24%。高血压患者不同危险因素显示年龄、腹性肥胖、早发心血管病家族史的患病率高。根据420例高血压患者血压水平分层:低危285例(67.86%),中危110例(26.19%),高危25例(5.95%)。添加现存的危险因素或靶器官损害或临床疾患再进行危险分层:低危11例,2.62%;中危30例,7.14%;高危379例,90.24%,高血压高危患者比例明显增加(添加后90.24%与添加前5.95%比较,P<0.01)。结论:本组资料中35岁以上社区居民高血压患病率高,知晓率、治疗率、控制率低,高血压的社区管理仅仅根据患者血压水平进行分层,低估了高血压人群中的高危患者,添加现存的危险因素或靶器官损害或临床疾患再进行危险分层提高了高危患者检出率。心血管危险因素对高血压患者总心血管危险分层有着决定性的影响,治疗策略应根据初始危险分层进行。     

2型糖尿病视网膜病变患者血浆同型半胱氨酸变化及与胰岛素抵抗的关系

目的 探讨同型半胱氨酸(Hcy)对2型糖尿病视网膜病变(DR)发生、发展的影响,及其与胰岛素抵抗的关系.方法 检测144例2型糖尿病(T2DM)患者及50例同期健康体检者血浆总Hcy(tHcy)浓度及空腹血糖(FBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、血脂等,计算胰岛素抵抗指数(HOMA-IR).对上述临床资料进行回顾性研究.结果 视网膜病变组(DR组)血浆tHey水平高于非视网膜病变组(NDR)组及对照组(P<0.01);增殖型视网膜病变组(PDR组)tHey水平高于背景型视网膜病变组(BDR组)(P<0.05);多元线性逐步回归分析显示:FBG、HbA1C、HOMA-IR均为有显著意义的tHcy决定因素.结论 血浆tHcy水平升高是糖尿病视网膜病变发生、发展的一个重要的危险因子,与胰岛素抵抗相关.     

血清同型半胱氨酸及传统危险因素与冠心病相关性的临床研究

目的探讨血清同型半胱氨酸(HCY)及传统危险因素(胆固醇TC、甘油三酯TG)与冠心病间的关系。方法检测122例冠心病患者和100例健康人血清中HCY浓度及多项生化指标。结果冠心病组HCY和TG浓度明显高于对照组(P0.05),但彼此间并不存在相关性(P0.05);冠心病组高同型半胱氨酸血症(HHCY)的发病率明显高于对照组(P0.05);不论是冠心病患者还是健康人群,HCY浓度都与年龄存在明显的相关性(P0.05),与性别不相关。结论 HHCY可能是冠心病发生的一个独立危险因素;血清HCY的检测有助于冠心病的诊断;中老年人群应普查HCY浓度,以便更好的预防冠心病的发生。