2639例眼睑肿物临床病理分析

目的探讨眼睑肿物的疾病谱系及病理特征。方法为存档资料分析。收集1997年1月至2006年12月10年间存档的2639例眼睑肿物临床组织病理学资料进行分析。结果位于良性病变前5位的分别是炎性病变、色素痣、乳头状瘤、皮样囊肿及表皮样囊肿、上皮囊肿;位于恶性肿瘤前5位的分别是基底细胞癌、皮脂腺腺癌、淋巴瘤、鳞状细胞癌、黑色素瘤。此5种恶性肿瘤患者的平均年龄分别为61、61、48、57及52岁。基底细胞癌和皮脂腺腺癌患者性别倾向不明显,黑色素瘤和淋巴瘤女性患者较多,鳞状细胞癌男性患者较多。结论基底细胞癌和皮脂腺腺癌仍是最常见的眼睑恶性肿瘤,淋巴瘤位于第三位且有增加的趋势。眼睑恶性肿瘤主要发生于60岁以上的老年人。（中华眼科杂志．2008．44：3841）     

212例眼睑肿物临床病理分析

目的探讨眼睑肿物的组织病理类型及手术方法。方法回顾性研究。收集南京中医药大学附属八一医院眼科2006年1月至2016年5月收治的212例眼睑肿物患者临床病理资料进行分析。结果眼睑肿物病理类型中,良性病变前5位分别是皮样囊肿及表皮样囊肿、色素痣、疣样改变、皮脂腺囊肿、乳头状瘤。恶性肿瘤前3位分别是基底细胞癌、鳞状细胞癌、睑板腺癌。平均发病年龄分别为66.70、75.71岁及74.50岁。研究中所有患者均经手术切除,病理诊断明确,其中良性肿瘤采用单纯肿物切除,恶性者采用控制性病变切除,二者均采用滑行、旋转皮瓣修复创面,对缺损大者行眼睑再造术。结论对眼睑肿物的病理分类和分型,有助于眼睑肿物的诊断,为疾病诊治提供了参考依据。     

2734例眼睑肿物的临床病理分析

目的 探讨眼睑肿物的组织病理类型及其变化.方法 为回顾性系列病例研究.收集复旦大学附属眼耳鼻喉科医院眼科病理室从1993年1月至2005年12月间存档的眼睑肿物临床组织病理学资料进行分析.结果 眼睑病变的临床表现多样,病理类型繁多.在2734例眼睑肿物中,炎性病变1462例,占53.47%;肿瘤性病变1248例,占45.65%.眼睑肿瘤中,良性肿瘤875例,占71.11%;恶性肿瘤373例,占29.89%.恶性肿瘤前3位分别是基底细胞癌、皮脂腺癌(包括睑板腺癌和蔡氏腺癌)、鳞状细胞癌.平均发病年龄分别为64.16、63.30、60.38岁.基底细胞癌以60～70 岁年龄组为多.睑板腺癌在40岁以上各年龄组发病率均较高.结论 对眼睑肿物的病理分类和分型,有助于眼睑肿物的病理诊断,为疾病诊治提供了参考依据.     

眼睑肿物105例临床分析

目的：探讨眼睑肿物的临床、病理学分类,为眼睑肿物的诊断和治疗提供依据。 方法：回顾性分析本院眼科近2a来收治的105例105眼眼睑肿物患者的病理学资料,对眼睑肿物的病理分类进行回顾性分析。 结果：眼睑肿物105例105眼中良性肿瘤共101例101眼,恶性肿瘤4例 4眼。良性肿瘤中占前5位的是炎性肉芽组织22例 22 眼,脂溢性角化病16例16眼,鳞状细胞乳头状瘤13例13眼,皮内痣12例12眼,表皮样囊肿12例 12 眼。恶性肿瘤中基底细胞癌2例 2眼,睑板腺癌和恶性黑色素瘤各1例1眼。 结论：明确的临床病理分型诊断有助于眼睑肿物的手术治疗及预后。     

眼睑肿物临床病理分析及眼睑缺损修复探讨

目的分析眼睑肿物的临床及病理学分类,探讨手术方法及肿物切除术后跟睑及其周围组织缺损的修复。方法回顾性分析我院73例眼睑肿物基本资料、病理分类、治疗方式、治疗结果,探讨肿物切除术后眼睑缺损个体化修复方式。结果73例（73眼）眼睑肿物中,良性病变62例（84．9％）,恶性肿瘤11例（15．1％）。良性病变类型中,以皮样、表皮样囊肿25例,基底细胞乳头状瘤12例,炎性肉芽肿6例,皮脂腺囊肿6例,皮内痣、混合痣5例等为多见。恶性病变中基底细胞癌9例,鳞状细胞癌2例。73例眼睑肿物均行手术切除,切除后眼睑缺损修复方法有：44例直接缝合切缘皮肤,15例游离松解切缘皮肤后对位缝合,5例取左上臂内侧皮肤植皮修复,7例行颧颞部皮瓣移植修复,1例行鼻唇沟皮瓣移植修复,1例行滑行睑板结膜瓣修复,植皮及皮瓣移植均成功存活,疗效良好。恶性肿瘤随访期间尚未见转移。结论眼睑肿物中良性病变多于恶性病变,恶性病变中以基底细胞癌最为常见,手术切除是治疗的有效方式,术后眼睑缺损的个体化修复重建在维持眼睑形态、防止眼睑畸形、保护眼表功能方面具有重要意义。     

眼睑肿物44例临床分析

目的　探讨眼睑肿物的临床、病理学分类及手术方法。方法　回顾性分析 1996年～ 2 0 0 1年收治 4 4例眼睑肿物患者年龄分布及病理分类 ;结合病例讨论肿物切除及整形术应注意的问题。结果　恶性肿瘤中居前 2位者为基底细胞癌、睑板腺癌 ,良性肿瘤中居前 2位者为色素痣 ,血管瘤和多发性神经纤维瘤。 39例手术切除 ,2例睑板腺癌术后复发再手术 ,后愈合好 ,2例死亡 ,余患者疗效好。结论　对眼睑肿物进行分析有利于临床诊断以及指导治疗方案     

眼睑基底细胞癌复发病例的临床病理分析

目的：研究眼睑基底细胞癌复发病例的组织病理学特征,为临床诊断、治疗及预后的综合判断提供依据。方法：对２８例复发的眼睑ＢＣＣ标本进行常规石切片、ＨＥ染色及光镜观察,结果：多数ＢＣＣ（１９例占６４．３％）复发癌细胞的形态及组织结构发生了不同改变;随着复发次数的增多,癌细胞更易向邻近组织蔓延,预后不良。结论：复发ＢＣＣ更具有破坏性,手术切除应当广泛、彻底、避免复发     

Pathology of eyelid tumors

The eyelids are composed of four layers: skin and subcutaneous tissue including its adnexa, striated muscle, tarsus with the meibomian glands, and the palpebral conjunctiva. Benign and malignant tumors can arise from each of the eyelid layers. Most eyelid tumors are of cutaneous origin, mostly epidermal, which can be divided into epithelial and melanocytic tumors. Benign epithelial lesions, cystic lesions, and benign melanocytic lesions are very common. The most common malignant eyelid tumors are basal cell carcinoma in Caucasians and sebaceous gland carcinoma in Asians. Adnexal and stromal tumors are less frequent. The present review describes the more important eyelid tumors according to the following groups: Benign and malignant epithelial tumors, benign and malignant melanocytic tumors, benign and malignant adnexal tumors, stromal eyelid tumors, lymphoproliferative and metastatic tumors, other rare eyelid tumors, and inflammatory and infections lesions that simulate neoplasms.     

Clinicopathologic study of malignant eyelid tumours

Background: Early diagnosis of malignancy of eyelids can save the visual system from metastasis. The study was carried out to determine its pattern of prevalence, which will be a milestone for the ophthalmologists to design a clinical strategy for early intervention. Methods: Retrospectively, we studied 155 eyelid cases from 2000 to June 2009 carried out through histopathologic confirmation. The cases other than malignancy were excluded. Results: A total of 37 malignant eyelid tumours were seen. There were 40.6 per cent male cases. Sebaceous gland carcinoma was the commonest (40.5 per cent) finding, followed by squamous cell carcinoma (27 per cent), basal cell carcinoma (24.3 per cent), basosquamous carcinoma (5.4 per cent) and malignant melanoma (2.7 per cent). Conclusions: As the most common tumour in the region, sebaceous gland carcinoma might be due to geographical and environmental variations and requires immediate consultation and histopathologic diagnosis of lid lesions above 40 years of age for treatment strategies.     

A retrospective study of 2228 cases with eyelid tumors

AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS: Most eyelid tumors were epidermal in origin (1080, 48.5%), followed by miscellaneous (885, 39.7%) and adnexal tumors (263, 11.8%). Among all the tumors, 292 (13.1%) were malignant lesions, 1910 (85.7%) benign and 26 (1.1%) premalignant lesions. Most malignant tumors originated from epidermal cells (60.0%), followed by adnexal cells (34.6%). The most common malignant tumors were basal cell carcinomas (56.5%) followed by sebaceous carcinoma (34.6%), squamous cell carcinomas (3.8%) and lymphoma/plasmocytoma (1.7%). The benign and premalignant eyelid lesions mostly originated from epidermal cells (46.4%) followed by miscellaneous cell sources (45.2%), including melanocytic nevus (33.8%), seborrheic keratosis (13.7%), squamous cell papilloma (13.0%) and epidermal cysts (11.5%). CONCLUSION: Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.     

354例眼睑皮脂腺癌预后因素分析

目的 分析眼睑皮脂腺癌患者的预后相关因素。设计 回顾性病例系列。研究对象 2006-2020年北京同仁医院手术治疗的354例眼睑皮脂腺癌患者。方法 回顾患者的临床诊疗信息及随访资料,根据第八版美国抗癌联合会(AJCC)分期标准对肿瘤进行分期。用Logistic回归分析复发相关因素,用Kaplan-Meier法绘制生存曲线并用log-rank法进行检验。主要指标 患者性别、年龄、居住地区、发病部位、肿瘤大小及分期、病程、是否复发或转移。结果 354例患者入组时平均年龄(61.68±11.55)岁,女性212例(59.89%)。214例(60.45%)上睑发病。病程中位时长为6.00(3.00,17.00)个月。T1、T2、T3、T4期肿瘤分别为166例(46.89%)、129例(36.44%)、36例(10.17%)、23例(6.50%)。68例(19.21%)术后复发。22例肿瘤转移,其中3例因转移离世。5年、10年转移率分别为4.69%(n=10)、7.98%(n=17),总转移率为10.33%。年龄较大(P=0.035)及AJCC分期较重(P=0.012)是术后复发的危险因素。结论...     

眼睑皮脂腺癌治疗的研究进展

眼睑皮脂腺癌是最常起源于睑板腺和睫毛皮脂腺的恶性肿瘤,居眼睑恶性肿瘤的第2位。由于其高复发率和高转移率,已经受到人们的重视。最新研究和临床经验表明,早期发现,早期诊断,以手术为主,化疗、放疗、冷冻为辅的综合性治疗是提高眼睑皮脂腺癌存活率的关键。但是,随着现代治疗手段的应用,逐渐倾向于避免眼眶内容摘除的保守性治疗方法,这些方法有望减少复发和转移的发生率。本文就眼睑皮脂腺癌的治疗新进展作一综述。     

眼睑肿块病理学分析477例

目的分析眼睑肿块临床和病理学特点。方法回顾性分析我院自1996年至2005年收检的477例眼睑肿块标本,所有标本均经HE染色及部分进行免疫组织化学检查。所有标本都经过病理科医师明确诊断。结果良性病变307例,包括：痣69例,乳头状瘤64例,各种囊肿57例,血管瘤23例,脂性肉芽肿23例,钙化上皮瘤19例,脂溢性角化15例,其他37例;恶性肿瘤170例,包括：基底细胞癌75例,皮脂腺癌56例,鳞状细胞癌20例,恶性淋巴瘤12例,恶性黑色素瘤5例,其他2例。较罕见病变有：囊样腺性癌、乳头状瘤恶变、汗腺腺瘤、汗腺纤维瘤及神经痣各1例,眼睑结核及神经纤维瘤各2例,畸胎瘤3例。结论眼睑肿块以良性病变多见,占64.36%;眼睑恶性肿瘤占35.64%,以基底细胞癌、皮脂腺癌和鳞状细胞癌多见。