Renin-angiotensin system in atherosclerosis

The renin-angiotensin system(RAS) has been demonstrated to play a critical role in initiation and progression of atherosclerosis, thereby contributing to development cardiovascular diseases. Angiotensin II(Ang II), major substrate in RAS, stimulates atherosclerosis through various processes such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic effects of Ang II are mediated by reactive oxygen species(ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.