髂内动脉球囊阻断术在凶险性前置胎盘伴胎盘植入患者剖宫产术中运用效果及安全性

目的分析髂内动脉球囊阻断术在凶险性前置胎盘伴胎盘植入患者剖宫产术中运用效果及安全性。方法选择2015年6月‐2017年6月收治的凶险性前置胎盘伴胎盘植入患者共62例,依据患者意愿将患者分为对照组30例和观察组32例。对照组为剖宫产手术,观察组在剖宫产术中采用双侧髂内动脉球囊阻断术,其中子宫全切术患者共26例,依据是否进行髂内动脉球囊阻断术分为全切对照组12例及球囊组14例。观察两组术中出血量、输入红细胞(RBC)量、手术及住院时间、子宫切除率及新生儿窒息率,对比两个亚组术中出血量、输入RBC量、手术及住院时间。结果观察组术中出血量、输入RBC量及子宫切除率较对照组明显减少(P 0.05),两组患者手术时间、住院时间及新生儿窒息率对比差异无统计学意义(P0.05)。两亚组术中出血量、输入RBC量、手术时间及住院时间对比差异无统计学意义(P0.05)。结论凶险性前置胎盘伴胎盘植入患者剖宫产术中进行髂内动脉球囊阻断术可有效减低术中出血量和子宫切除率。     

不同设备引导下动脉临时球囊阻断技术在凶险性前置胎盘剖宫产术中的临床应用

目的 探讨不同设备引导下动脉临时球囊阻断技术在前置胎盘剖宫产术中疗效评定及特点。方法收集昆钢医院放射科自2016年7月至2018年8月配合产科、超声科开展不同设备引导下临时球囊阻断患者共26例。26例患者均经超声和 (或) MRI诊断凶险性前置胎盘, 在不同的引导设备下行双侧髂内或髂总动脉预埋临时球囊, 待胎儿取出时立即充盈球囊阻断髂动脉血流, 根据产科手术进度及出血情况适时撤出球囊。结果 本组26例患者动脉临时球囊预埋阻断均获得成功, 其中1例患者因发现右侧子宫动脉假性动脉瘤形成, 行栓塞治疗。26例患者阻断时间3～15 min, 术中出血量400～1 000 m L。病例无子宫切除及术后输血, 所有新生儿均存活。结论针对凶险性前置胎盘患者在剖宫产术中行动脉临时球囊阻断, 能够减少剖宫产术中出血量及相关并发症的发生率。该技术具有创伤小、安全性高、疗效确切等特点, 近年来已在临床推广应用。     

髂内动脉球囊阻断术在伴有胎盘植入的凶险性前置胎盘患者剖宫产手术中的应用效果

目的观察髂内动脉球囊阻断术在伴有胎盘植入的凶险性前置胎盘患者剖宫产手术中的应用效果。方法选取2012年2月至2016年9月郑州圣玛妇产医院妇产科收治的62例患者,按照随机数表法分为对照组和观察组,各31例。对照组接受常规剖宫产手术,观察组在对照组基础上接受髂内动脉球囊阻断术。比较两组患者术中出血量、红细胞输入量、手术时间、住院时间、子宫切除率及新生儿窒息发生率。结果观察组患者术中出血量、红细胞输入量少于对照组,手术时间和住院时间短于对照组,差异有统计学意义(P<0.05)。两组患者子宫切除率、新生儿窒息发生率比较,差异无统计学意义(P>0.05)。结论对伴有胎盘植入的凶险性前置胎盘患者剖宫产手术中实施髂内动脉球囊阻断术,能够减少出血量和红细胞输入量,缩短手术时间和住院时间,加快产后康复。     

双侧髂内动脉球囊封堵术控制凶险性前置胎盘剖宫产术中出血的临床分析

目的:对凶险性前置胎盘剖宫产手术出血患者的双侧髂内动脉球囊封堵术治疗效果进行研究分析。方法:选取我院自2014年1月至2016年12月收治的64例凶险性前置胎盘剖宫产术中出血患者,将患者随机分为观察组和对照组两个组别,其中,观察组采用双侧髂内动脉球囊封堵术进行止血处理,对照组患者采用常规止血措施,观察对比两组患者的止血效果。结果:两组患者均成功止血,其中,观察组3例患者进行子宫切除,子宫切除率为9.4%,对照组12例患者子宫切除,约占比率为37.5%,并且观察组患者术后并发症发生情况以及手术时间、术后恢复时间等指标效果均比对照组好,P0.05,差异具有统计学意义。结论:双侧髂内动脉球囊封堵术进行凶险性前置胎盘剖宫产术中出血治疗,具有较好的作用效果,值得临床推广应用。     

双侧髂内动脉球囊预置术在凶险性前置胎盘合并胎盘植入治疗中的应用

目的探讨双侧髂内动脉球囊预置术在凶险性前置胎盘合并胎盘植入治疗中的应用价值。方法对2例术前均经彩色超声检查或MRI检查明确诊断为凶险性前置胎盘合并胎盘植入的患者,在剖宫产术前行双侧髂内动脉球囊预置术,术中在进入子宫、娩出胎儿的同时,临时阻断双侧髂内动脉血流,观察出血及新生儿情况,术后4h拔除双侧髂内静脉球囊导管,术后24h拔除动脉鞘管,关注术后并发症情况。结果2例双侧髂内动脉阻断时间分别为15、22min,术中出血量分别为600、1000ml。术后恢复均良好,均未发生并发症。结论双侧髂内动脉球囊预置术治疗凶险性前置胎盘合并胎盘植入,对挽救产妇生命、保留子宫、减少产后出血有着重要意义,值得在临床推广应用。     

两种球囊预置术在凶险性前置胎盘合并胎盘植入患者剖宫产术中的应用价值比较

目的比较双侧髂内动脉球囊预置术和腹主动脉球囊预置术在凶险性前置胎盘合并胎盘植入患者剖宫产术中的应用价值。方法选取2015年3月至2019年3月嘉兴市妇幼保健院收治的凶险性前置胎盘合并胎盘植入的单胎妊娠患者131例,其中2015年3月至2017年10月在剖宫产术前行双侧髂内动脉球囊预置术的63例患者作为对照组,2017年11月至2019年3月在剖宫产术前行腹主动脉球囊预置术的68例患者作为研究组。比较两组患者胎儿接受的辐射剂量、胎儿介入透视时间、术中子宫切除率、球囊首次充盈阻断血流后子宫创面渗血开始增多所需时间等。结果研究组患者在行球囊预置术过程中,胎儿接受的辐射剂量及胎儿介入透视时间均少于对照组,术中子宫切除率低于对照组,球囊首次充盈阻断血流后子宫创面渗血开始增多所需时间多于对照组,差异均有统计学意义（均P＜0.05）。结论两种球囊预置术在凶险性前置胎盘合并胎盘植入的术中具有一定的有效性及安全性。相较于双侧髂内动脉球囊预置术,腹主动脉球囊预置术在介入透视时间及胎儿接受的辐射剂量方面更具有优势。     

髂内动脉球囊阻断术在植入型凶险性前置胎盘剖宫产术中的应用疗效分析

目的探讨髂内动脉球囊阻断术在植入型凶险性前置胎盘剖宫产术中的应用价值。方法选择凶险性前置胎盘伴胎盘植入产妇86例临床资料,其中50例选择髂内动脉球囊阻断术（球囊组）,36例仅行剖宫产术（对照组）。比较2组术中出血量、术中输血量、手术时间、术后住院时间、子宫切除率及相关并发症。结果球囊组术中出血量（1 585.3±769.9）mL及术中输红细胞量（4.5±3.8）U,均小于对照组术中出血量（2 044.1±1 362.9）mL及术中输红细胞量（6.8±4.9）U（P < 0.05）;球囊组子宫切除率40.00%,膀胱损伤率12.00%,与对照组子宫切除率44.44%、膀胱损伤率11.11%,差异均无统计学意义（P>0.05）;球囊组有1例发生术后右下肢动脉血栓,对照组未发生。结论植入型凶险性前置胎盘剖宫产术中采用髂内动脉球囊阻断术,可减少出血量及输血量,并不能有效降低子宫切除率,且有血栓形成风险。     

术前预防性应用双侧髂内动脉球囊封堵术对凶险性前置胎盘孕妇剖宫产术中出血的影响

目的 研究术前预防性应用双侧髂内动脉球囊封堵术对凶险性前置胎盘孕妇剖宫产术中出血的影响.方法 回顾性分析宝鸡市妇幼保健院2000年4月至2015年4月86例凶险性前置胎盘孕妇的临床资料,其中46例患者术前应用了双侧髂内动脉球囊封堵术设为介入组,另外40例患者在术前未应用双侧髂内动脉球囊封堵术设为对照组,比较两组患者术中的出血量,子宫切除率以及术后的并发症等.结果 两组术中使用球囊填塞,胎盘植入率,子宫切除率和产后出血率的差异无统计学意义(P均>0.05),对照组患者术中平均出血率显著高于介入组(t=-26.534,P<0.01).两组患者的新生儿体质量和发生窒息的例数比较,差异均无统计学意义(P>0.05).结论 凶险性前置胎盘孕妇剖宫产术前预防性应用双侧髂内动脉球囊封堵术,可以降低孕妇在手术中的出血量,降低子宫切除率,减少术后并发症.     

凶险性前置胎盘伴胎盘植入剖宫产术中 应用髂内动脉球囊阻断术效果分析

目的探讨髂内动脉球囊阻断术在凶险性前置胎盘伴胎盘植入病人行剖宫产中应用的意义。方法随机选取行剖宫产的凶险性前置胎盘伴胎盘植入病人82例,根据其时在术中是否应用髂内动脉球囊阻断术,将其分为观察组（52例）和对照组（30例）,对比2组产妇分娩过程中出血量、输注红细胞量、手术时长、新生儿窒息率以及子宫切除率和住院时长等指标水平。结果与对照组比较,观察组病人失血量和输注红细胞量少（P < 0.01）,术后住院时间和手术时间短（P < 0.01和P < 0.05）,剖宫产子宫切除率低（P < 0.05）,而凝血障碍率和电解质紊乱率高（P < 0.05）;但2组病人低血压、感染、新生儿窒息等情况发生率差异均无统计学意义（P>0.05）。结论在凶险性前置胎盘伴胎盘植入行剖宫产分娩手术时,应用髂内球囊阻断术能够有效降低子宫切除率,减少术中出血量,有利于术后产妇的康复。     

双侧髂内动脉临时球囊阻断在凶险性前置胎盘剖宫产术中的应用

<正>凶险性前置胎盘(pernicious placenta previa,PPP)的定义1993年由Chattopadhyax等~([1])提出,是指前置胎盘而且胎盘附着在子宫疤痕处,常常伴有胎盘植入,需要以剖宫产术结束妊娠。伴有胎盘植入者术中常并发术中大出血,有时甚至需要切除子宫以挽救生命,严重危害产妇的健康及预后。凶险性前置胎盘治疗往往需要多学科合作,近年来,杭州市第一人民医院血管外科与产科协作,剖宫产术前双侧髂内动脉植入阻断球囊,术中临时阻断双侧髂内动脉治疗凶险性前置胎盘,取得较好的疗效,现报道如下。1资料与方法     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.