小细胞肺癌胰腺转移病例2例

目的：探讨小细胞肺癌胰腺转移的诊治。方法：对2例临床诊断的小细胞肺癌胰腺转移的患者回顾性分析。结果：2例患者分别经过＂EP＂方案全身化疗,淀粉酶值下降至正常,胰腺转移灶吸收。结论：通过针对小细胞肺癌的全身化疗,胰腺转移癌合并胰腺炎能得到缓解,提高了患者生活质量,并延长其生存时间。     

Huge splenic metastasis from hepatocellular carcinoma; a case report

A 62-year-old man was admitted to the hospital because of a left upper quadrant mass. He had undergone treatment for hepatocellular carcinoma for 1 year and 7 months. Dynamic CT and angiography revealed a huge hypovascular mass in the spleen. An autopsy confirmed a splenic metastasis of hepatocellular carcinoma with a massive hemorrhage.     

Basal cell carcinoma arising in a seborrheic keratosis: a case report

Seborrheic keratosis are one of the most common benign epidermic tumors in clinical practice. Malignant transformation is exceptional and occurs by the involvement of human papilloma virus. We report a case of seborrheic keratosis of the armpit in a 55 year-old woman whose biopsy revealed the presence of a basal cell carcinoma.     

Squamous cell carcinoma arising in a papillary carcinoma of the thyroid: a case report

BACKGROUND: primary squamous cell carcinoma (scc) of the thyroid is a rare malignant tumor that needs to be distinguished from other neoplasms. Cases of papillary carcinoma merging in association with squamous cell carcinoma are extremely rare. AIM: the characteristics of such association will be studied herein through a review of literature. CASE REPORT: we report a case of an 87-year-old patient presented with an enlarged right lobe of the thyroid. Thyroid scintigraphy revealed a cold nodule. Clinically, malignancy was suspected. Histopathologic diagnosis was a well-differentiated scc associated with areas of papillary carcinoma. Exhaustive clinical, endoscopic and radiological examinations did not reveal any primary site of scc or any contiguous spread from neighboring structures. Surgery was followed by radiotherapy, but the patient died 6 months later. CONCLUSION: the coexistence of epidermoide and papillary carcinomas in the thyroid gland must be known because of its prognostic impact.     

Brachytherapy reirradiation with hyaluronate gel injection of paraaortic lymphnode metastasis of pancreatic cancer: paravertebral approach--a technical report with a case

Paraaortic lymph nodal (PALN) recurrence is not a rare scenario of abdominal malignancies including pancreas cancer, even after radiotherapy. The role and indication of reirradiation is limited because it is often associated with significant late toxicity in the surrounding normal organs. We developed a new approach and technique of brachytherapy to overcome this difficult situation, with a paravertebral approach and hyaluronate gel injection (HGI). We encountered a patient with pancreatic cancer who developed PALN metastasis as in-field recurrence, 6 months after resection of pancreatic cancer with 50 Gy of preoperative radiotherapy. The applicator brachytherapy needles and gel injection needles were advanced by percutaneous paravertebral approach under local anesthesia, and by injection of a hyaluronate gel to separate the surrounding small intestines and the target. A single fraction of 18 Gy was delivered to the tumor (75.6 Gy equivalent in conventional schedule calculated with LQ model at α/β = 3) and total estimated D2cc (the minimum dose to the most irradiated volume of 2 cc, calculated at α/β = 2) in the small intestines was 61.6 GyE with HGI and 80.6 GyE without. No complications have been observed for six months. Three months later, FDG accumulation had disappeared, the tumor size was reduced, and serum CA-19-9 value decreased from 5150 U/mL to 36.6 U/mL (normal range < 37.5). Conclusively, the brachytherapy with the HGI procedure by paravertebral approach was thought safe and effective in reirradiation of PALN recurrence.     

Cellular and cordless telephones and basal cell carcinoma: a case report

During a 1-yr period, a 50-yr-old man had developed 6 basal cell skin cancer lesions on his scalp and face, 5 of which were localized on the right side of his head. The man had used an analog cellular telephone during 1987-1992; after 1992, he used a digital cellular telephone. In addition, he had used a cordless telephone since 1997. He always placed a phone on his right ear during phone calls. The right side of this individual's head contained 5 of the 6 tumors that eventually developed.     

LYVE-1在子宫颈鳞状细胞癌中的表达与癌组织淋巴管生成及淋巴道转移关系研究

目的:观察子宫颈鳞状细胞癌中淋巴管的分布特点及增殖状态,研究肿瘤淋巴管生成与淋巴道转移的关系。方法:收集80例子宫颈鳞状细胞癌及其相应的正常宫颈组织标本,采用免疫组化双标记技术,运用淋巴管特异标记物LYVE-1检测微淋巴管密度(MLD),LYVE-1与Ki-67进行双标免疫组化染色检测淋巴管增殖活性。结果:宫颈鳞状细胞癌肿瘤边缘区淋巴管多呈管样扩张状,而肿瘤其他区域多呈闭索状。宫颈鳞状细胞癌组织中MLD较正常宫颈组织显著性增高(P0.05),MLD在肿瘤边缘区、低分化宫颈鳞状细胞癌组、伴淋巴结转移组中显著增高,在临床分组间差异无统计学意义。宫颈鳞状细胞癌中淋巴管内皮细胞Ki-67指数较正常宫颈组织增高(P0.05),肿瘤边缘区Ki-67阳性表达的微淋巴管比肿瘤其他区域、有淋巴结转移组比无淋巴结转移组有显著性增高(P0.05)。结论:宫颈鳞状细胞癌组织中存在淋巴管生成,淋巴管主要分布在肿瘤边缘区且淋巴管内皮细胞增殖活性增高。淋巴管密度与宫颈鳞状细胞癌分化程度、淋巴道转移有关,与临床分期无明显关系。检测淋巴管密度和增殖状态对预测淋巴道转移可提供一定的理论依据。     

Petrous metastasis of a lung small cell carcinoma

Malignant tumors of the temporal bone are rare. They include a wide histological variety. They are mostly primary tumors with an estimated incidence of 0.8-1.0 per 1,000,000 inhabitants per year 1. Metastases form an uncommon subgroup. The clinical features of these temporal bone metastases are nonspecific and predominantly consist of hearing loss, vertigo, facial palsy, tinnitus, headache, otalgia or otorrhoea 2. The aim of our publication is to report a rare case of metastasis in the temporal bone as initial manifestation of lung cancer.Our patient was a 44-year-old man who presented for a right mastoid swelling with a grade VI right facial nerve palsy. Imaging and biopsy confirmed the diagnosis of small cell lung carcinoma petrous metastasis. The treatment was palliative. An osteolytic lesion of the temporal bone in an elderly patient may fit with a primary tumor of the temporal bone. It must, also, suggest the diagnosis of metastasis. The malignant tumor most frequently responsible is breast cancer, but lung cancer must also be considered in smoking patients.     

High risk squamous cell carcinoma

Mrs MA, 70 years of age, has a history of scalp psoriasis dating over 10 years. She explained that the rash was slowly progressing and had failed to respond to an array of topical treatments offered. Within the right lateral aspect of the 12 x 14 cm lesion a thick nodule had recently developed. It looked like squamous cell carcinoma (SCC). Biopsy of the raised lesion confirmed SCC as did four other biopsies at the poles of the region of 'psoriasis'. Removing all surface debris confirmed this was one confluent scalp tumour. The large scalp SCC was excised with a 5 mm margin. During surgery there was an area of apparent involvement of galea. This layer was widely excised along with periosteum at that point. Histology confirmed complete excision. There was no other point at which deep levels were involved. Periosteum was not involved. The large defect was closed with a partial thickness skin graft harvested from the right anterior thigh.     

A case of squamous cell carcinoma that developed on chronic tar dermatosis

A 79-year-old Japanese man visited our clinic for evaluation of a large tumor on the left wrist and multiple keratotic tumors. He had handled creosote oil, which is a purified product of coal tar production, for 50 years. Physical examinations revealed poikiloderma with multiple hyperkeratotic tumors on the back of his hand and forearm bilaterally, and a cauliflower-like tumor, 80 x 60 x 15 mm in size, on the left wrist. Histopathologically, the large tumor showed a proliferation of atypical squamoid cells with many keratinization foci, indicating well-differentiated squamous cell carcinoma.     

Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study

BACKGROUND: The role of diet in the development of skin cancer is inconclusive, and the effect of the combined consumption of foods has never been reported. OBJECTIVE: We prospectively investigated the association between dietary patterns and cutaneous basal cell (BCC) and squamous cell (SCC) carcinoma. DESIGN: Principal components analysis of 38 food groups was used to identify dietary patterns in 1360 adults aged 25-75 y who participated in a community-based skin cancer study in Nambour, Australia, between 1992 and 2002. We obtained baseline information about diet, skin color, and sun exposure factors. Multivariate-adjusted relative risks (RRs) for BCC and SCC tumors were estimated by using negative binomial regression modeling. RESULTS: Two major dietary patterns were identified: a meat and fat pattern and a vegetable and fruit pattern. The meat and fat pattern was positively associated with development of SCC tumors (RR=1.83; 95% CI: 1.00, 3.37; P for trend=0.05) after adjustment for confounders and even more strongly associated in participants with a skin cancer history (RR=3.77; 95% CI: 1.65, 8.63; P for trend = 0.002) when the third and first tertiles were compared. A higher consumption of the vegetable and fruit dietary pattern appeared to decrease SCC tumor risk by 54% (P for trend = 0.02), but this protective effect was mostly explained by the association with green leafy vegetables. There was no association between the dietary patterns and BCC tumors. CONCLUSION: A dietary pattern characterized by high meat and fat intakes increases SCC tumor risk, particularly in persons with a skin cancer history.     

Metastatic carcinoma of the jaws: report of a case

Primary malignant tumors of the mouth and jaws usually do not present a diagnostic challenge to oral surgeons or otolaryngologists. However, recognition of metastatic tumors in the mouth and jaws is much more difficult. A case is presented of metastatic carcinoma from the lung to the soft tissue of the oral cavity. Histopathology of the lesions in the lung and oral cavity as well as the chest x-ray and the Panorex x-ray are presented. The patient refused palliative treatment, became malnourished, and died. A review of the pertinent literature is also presented.     

PTEN在早期宫颈鳞癌淋巴结转移中的作用及与Survivin的相关性

目的:探讨早期宫颈鳞癌组织中PTEN和survivin的表达与淋巴结转移的关系。方法:应用免疫组化S-P法检测45例宫颈上皮内瘤变、45例无腹膜后淋巴结转移宫颈鳞癌、35例有腹膜后淋巴结转移宫颈鳞癌3组组织中PTEN和Survivin的阳性表达水平。结果:PTEN在宫颈上皮内瘤变、无腹膜后淋巴结转移宫颈鳞癌、有腹膜后淋巴结转移宫颈鳞癌组织中表达的平均光密度值(A)分别为:0.346±0.038、0.226±0.029、0.159±0.041,PTEN的表达递减(P<0.05)。Survivin在三组组织中的平均光密度值(A)分别为:0.163±0.017、0.247±0.018、0.336±0.051,Survivin的表达递增(P<0.05)。结论:PTEN表达下调,Survivin表达上调,二者的表达呈负相关性,与宫颈鳞癌的淋巴结转移行为密切相关。