Mixed tumour of submandibular salivary gland. Case report

The authors present the case of 14 years male child with tumour located on submandibular salivary glands. It was proceeded the biopsy and tumour excision, the tissue fragments being further processed at paraffin, sectioned and than stained HE, PAS, Alcian-Blue, Van Gieson and Gordon-Sweet. The first biopsy performed from the latero-cervical ganglion revealed the presence of an benign tumour of salivary gland. Totally excision of the tumour emphasized the presence of a salivary gland encapsulated tumour, sized 2.5/2.5/2 cm, nodule shaped, white colored, hard consistency. Histopathologic examination revealed the existence of a proliferating encapsulated tumor, well separated from the normal adjacent tissue. The small sized tumour cells with moderate cytoplasm induce formation of glandular lumens, some of them with cystic dilatation, with mucous content. Other tumour cells form small cords or nests. The tumour stroma forms mucoid areas, some with osteoid appearance. We have presented a case of a 14 years aged child with pleomorphic adenoma with rare location within the submandibular salivary gland. The post biopsy rapid increase of the tumour imposed the totally surgical gland excision.     

Renal carcinoma metastatic to the peritoneum. Case report

OBJECTIVE: We describe the case of a young male presenting with non-specific abdominal symptoms on follow-up after radical nephrectomy for renal carcinoma leading to the finding of local recurrence and peritoneal metastases. A second exploratory laparotomy was carried out for tumor reduction, but it was followed by fast peritoneal recurrence. Despite the treatment with alpha interferon, three months later he developed multiple hepatic metastases. CONCLUSIONS: Peritoneal involvement by renal cell carcinoma is rare and implies a bad prognosis.     

Chiasmal compression from metastatic cancer to the pituitary gland.

A case of chiasmal compression and panhypopituitarism from carcinoma of the breast metastatic to the pituitary gland is presented. A review of the subject of metastatic disease of the pituitary emphasizes the paucity of clinical involvement in most cases. Posterior pituitary insufficiency is the most common manifestation, with anterior pituitary involvement being much rarer, and chiasmal compression the least common.     

Carcinoid tumour metastasis to the submandibular gland: a case report

Carcinoid tumours are slow growing tumours of neuroendocrine origin that primarily affect the gastrointestinal tract and pulmonary system. They can behave aggressively, with regional and distant metastases, although metastases to the head and neck region are uncommon. We present a rare case of carcinoid metastasis to the submandibular gland, which to the best of our knowledge has not been previously reported in the literature.     

Endolymphatic sac tumor metastatic to the spine. Case report

Endolymphatic sac tumors (ELSTs) are aggressive papillary lesions of the temporal bone. Although histologically benign, they may exhibit invasive growth and destruction of the skull base. Patients generally present with symptoms referable to the lesion's location within the middle or posterior cranial fossa. Although well characterized as a distinct entity, ELSTs involved in metastatic dissemination have never been reported. In the present report the authors describe a case of ELST metastatic to the spine treated with resection.     

Adenocarcinoma of the salivary gland metastatic to the pituitary gland: case report

OBJECTIVE AND IMPORTANCE: A case of metastasis to the pituitary gland from a ductal adenocarcinoma of the salivary gland is presented. Metastasis to this site is rare, and a salivary gland source has never previously been described. CLINICAL PRESENTATION: This patient presented with hypopituitarism, including diabetes insipidus. INTERVENTION: A craniotomy was performed to alleviate visual loss. The histological features of the sellar tumor were identical to those of a tumor removed from the parotid gland 18 months earlier. CONCLUSION: Although intrasellar tumors originating from embryonic rests of salivary gland tissue have been reported, metastasis from a malignant neoplasm arising within a true salivary gland is also possible and should not be excluded from consideration for patients in whom a salivary gland-like tumor is discovered in the sella turcica.     

Myelolipoma of the adrenal gland. Case report

Myelolipoma is a rare, benign, endocrinologically nonfunctioning adrenal tumor composed of fatty tissue with foci of hematopoietic cells. Clinical diagnosis and surgical removal are extremely rare. We report a case of large myelolipoma (10 x 6 x 6 cm) that was removed surgically in a 54-year-old man in whom the mass was studied preoperatively by sonogram, CT and angiography.     

Response to paclitaxel and carboplatin in metastatic salivary gland cancer: a case report

BACKGROUND: Malignant tumors of the salivary gland are rare entities that are treated primarily by surgical resection. For patients with recurrent or unresectable disease, options include radiation therapy or chemotherapy; however, responses are few and of short duration. Patients with metastatic disease have been treated with chemotherapy, but, again, response rates have been low and of short duration. METHODS: A 52-year-old man was seen with a mass on his tongue. A biopsy revealed adenocarcinoma of a minor salivary gland. Ten months after surgical resection, neck dissection, and radiation therapy, the patient was found to have metastatic disease to the lung. Chemotherapy was initiated with carboplatin and paclitaxel. RESULTS: The patient obtained a complete response after six cycles of carboplatin and paclitaxel. CONCLUSIONS: The use of carboplatin and paclitaxel in the setting of metastatic salivary gland cancer is a viable option.     

Spinal intramedullary metastatic medulloblastoma. Case report

Metastatic spread of medulloblastoma along the neuraxis by leptomeningeal seeding through the cerebrospinal fluid pathways is well known. The occurrence of extracranial metastases outside the neuraxis has been well established, but the occurrence of intramedullary spinal cord metastases not related to surface seeding is rare. A histologically documented case of the latter type is described.     

Colon cancer metastatic to the lung and the thyroid gland

The clinical diagnosis of primary thyroid cancer is uncommon, constituting 1.5% of all cancers in the United States. Clinically diagnosed metastatic cancer to the thyroid gland is rare. Colon cancer is one of the most common cancers in the United States, with a high propensity to metastasize; 30% to 40% of patients have metastatic disease at the initial diagnosis. The most common sites of metastasis from colon cancer are the regional lymph nodes, the liver, the lung, and the peritoneum. Colon cancer metastasis to the thyroid gland is rare, with only a few reported cases, mainly in the pathology literature. These cases describe metastasis from colon cancer to the thyroid gland that became apparent years after the initial diagnosis of colon cancer and were usually associated with dissemination to the liver, the lung, or both. We report a case of colonic adenocarcinoma metastatic to the thyroid gland and lung without involvement of the liver. A review of the literature is also included.     

Metastatic melanoma of the pituitary gland. Case report

The authors report on the clinical features and imaging studies in a case of metastatic melanoma of the pituitary gland. Cerebral metastatic melanoma and pituitary metastasis from any source are commonly associated with systemic metastasis, whereas pituitary metastatic melanoma without widespread disease dissemination is distinctly rare. This 46-year-old man presented with diabetes insipidus and anterior pituitary dysfunction 5 years after he underwent resection of a cutaneous malignant melanoma of the neck. Magnetic resonance imaging demonstrated the presence of melanin within a sellar tumor mass. Transsphenoidal resection was performed and histopathological examination of tumor material confirmed metastatic melanoma. Postoperative [18F]fluorodeoxyglucose-positron emission tomography revealed no other focus of hypermetabolism in the patient's body.