Reactive perforating collagenosis

This uncommon condition was first described by Mehregan, Scwartz and Livingood (1967). It is one of the true perforating disorders where collagen is extruded through the epidermis and it is believed that superficial trauma, in genetically predisposed individuals, leads to this skin response.
Four cases have been studied, three of whom are siblings and the fouth an isolated case.
Routine histopathology, electronmicroscopy and monoclonal antibody studies are described. These techniques are directed to explain the mechanism of this disease which has previously been suggested as due to a primary disorder of dermal collagen. Dermal damage does not induce lesions and a more superficial trauma seems to be the initiating event. Epidermal and dermal factors and inter-relationships are discussed.     

Reactive perforating collagenosis and phototraumatism

Two pairs of siblings are reported suffering from reactive perforating collagenosis. The clinical features were recurrent crusted papules with a central keratinaceous plug. The plug was sometimes encircled by a narrow yellowish ring and a wider red ring, giving the appearance of a cockade. Lesions recurred spontaneously or were provoked by superficial injury to sun-exposed skin (phototraumatism). There were no other changes in the general health of these patients.     

Reactive perforating collagenosis and Down''s syndrome

A new association is described between reacting perforating collagenosis and Down's syndrome in a child with lupoid hepatitis.     

Reactive perforating collagenosis in Hodgkin's disease

Two patients with Hodgkin's disease developed a condition that has been termed "reactive perforating collagenosis." In both cases, pruritus was severe and seemed to be responsible for the vigorous rubbing and scratching that caused the skin lesions. In one patient, the lesions disappeared upon remission of Hodgkin's disease. Perforating collagenosis has been described in children as a hereditary disease, and has also been described in adults with diabetes and on hemodialysis. On the basis of the changes seen in our two patients with Hodgkin's disease, we suggest that perforating collagenosis is simply a consequence of intense scratching.     

反应性穿通性胶原病

报告1例反应性穿通性胶原病.患者女,37岁.面部、四肢出现多发性红色丘疹8个月,无系统疾病病史.皮损组织病理柃查示表皮内有杯状角栓,角栓下方为变性的胶原,并与真皮相通,弹性纤维染色阴性.诊断:反应性穿通性胶原病.