扶正降黏胶囊对冠心病患者血小板活化、血液流变学及血脂的影响

目的 :观察扶正降黏胶囊对冠心病患者血小板活化、血液流变学及血脂的影响。方法 :将 6 9例冠心病患者随机分为中药组 39例和常规组 30例 ,中药组在西药常规治疗的基础上服用扶正降黏胶囊 ,常规组采用西药常规治疗。两组病例治疗前后均做α 颗粒膜蛋白 (CD6 2P)、溶酶体完整膜蛋白 (CD6 3)、凝血酶敏感蛋白 (TSP)、血液流变学指标 (全血比黏度高切、全血比黏度低切、血浆比黏度、血细胞比容、红细胞聚集指数、凝血因子Ⅰ )及总胆固醇 (TC)、三酰甘油 (TG)、高密度脂蛋白 (HDL CH)检测 ,并与正常组作对照。结果 :中药组CD6 2P、CD6 3、TSP、全血比黏度高切、全血比黏度低切、血浆比黏度、血细胞比容、红细胞聚集指数、凝血因子Ⅰ、TC等项指标降低 (P<0 .0 5 ,P <0 .0 1)、HDL CH升高 (P <0 .0 5 ) ;与常规组治疗后相比 ,CD6 2P、全血比黏度低切、血浆比黏度、血细胞比容、红细胞聚集有显著性差异 (P <0 .0 5 )。结论 :扶正降黏胶囊可较好地改善冠心病患者的血小板活化率、多项血液流变学指标及血脂水平 ,临床疗效确切 ,与西药配合应用明显优于单纯西药治疗     

更年期综合征血脂与血液流变学改变及其临床意义

目的　探讨更年期综合征女性血脂与血液流变学改变及其机制。方法　测定 110例更年期综合征妇女 (观察组) 和 100例健康妇女 (对照组) 的血脂、血液流变学共 15项指标。实验数据采用SPSS软件进行统计、t检验和相关性分析。结果　对照组与观察组的血清总胆固醇, 甘油三酯, 载脂蛋白A, 载脂蛋白B, 低、中、高剪切率全血粘度, 血浆粘度, 血沉, 血细胞比容, 血沉方程K值, 全血还原粘度, 红细胞聚集指数和红细胞刚性指数差异均存在显著性意义 (P<0 .05)。甘油三酯与高密度脂蛋白、高密度脂蛋白与载脂蛋白A呈显著相关(P<0 .05)。结论　更年期综合征患者具有明显血脂和血流改变, 治疗应着重降脂、稀释血液、改善微循环, 以减少动脉粥样硬化、血栓等疾病发生的危险。     

突发性耳聋患者血液流变学及血脂的变化

目的 探讨突发性耳聋患者血液流变学及血脂的改变.方法 选取我院2010年1月-2010年12月间收治的突发性耳聋患者46例作为观察组,选取同期在本院进行体检的正常者30例作为对照组,检测全血高切粘度、全血中切粘度、全血低切粘度、血浆粘度血脂变化.结果 观察组男女患者全血高切、中切、低切粘度及血浆粘度均显著高于对照组（P＜0.05）;观察组男女患者胆固醇、甘油三酯、高密度脂蛋白胆固醇水平均显著高于对照组（P＜0.05）.结论 突发性耳聋患者存在有血液流变学及血脂测定变化.     

胆固醇与动脉粥样硬化性血管病变的研究

目的观察血脂对血液流变学的影响,探讨胆固醇与动脉粥样硬化性血管病变之间的关系.方法选择年龄40～60岁者200人,进行血脂和血液流变学检测,按血脂异常判断标准分为正常血脂、高胆固醇血症、高三酰甘油血症和混合型高脂血症四组,对四组的血液流变学指标进行组间比较.结果高胆固醇血症组和高三酰甘油血症组的全血粘度比正常血脂组增高(P＜0.001);高三酰甘油血症组和混合型高脂血症组比高胆固醇血症组的血细胞压积和血浆粘度增高(P＜0.05).结论血脂水平与全血粘度成正比,总胆固醇水平与动脉粥样硬化程度呈正相关,胆固醇致动脉粥样硬化作用是缺血性心脑血管疾病的主要危险因素.     

次声对大鼠血液流变特性的影响

目的：研究次声对大鼠血液流变特性的影响。使用频率8Hz,强度为90dB与120dB的次声每日对大鼠作用2h,观察血液流变特性的变.结果,120dB作用7d与90dB作用14d后导致了血细胞比容、全血高切粘度、全血低切粘度等血液流变指标改变,而120dB作用14d,90dB作用28d后这些变化的指标又都恢复。结论一定范围内的次声作用可引起强度相关的血液变变学改变,而且这些改变是可恢复的。     

低强度脉冲电磁场对兔心血管系统的影响

目的: 探讨低强度脉冲电磁场(pulsed electromagnetic fields,PEMFs)对心血管系统的影响,为心血管疾病的预防和治疗提供新的思路和理论依据.方法: 30只雌性5 mo龄新西兰大耳白兔随机等分为3组: ①对照组用常规饲料喂养.②高脂组用高脂、高胆固醇饲料饲养.③磁场组用高脂、高胆固醇饲料饲养,并暴露于强度为8×10-4 T的脉冲磁场环境中(f=15 Hz).饲养8 wk后,分别检测血液流变学、血脂以及心功能等指标,并对主动脉进行解剖学观察,对心肌与肝脏进行组织病理学检查.结果: ①磁场组的血液流变学指标与高脂组比较,差异有显著性意义(P<0.01);与对照组比较,磁场组只有全血高切黏度(ηb1)、低切还原黏度(ηb2′)和红细胞聚集指数(AI)等3项指标的差异具有显著性意义(P<0.01).②与高脂组比较,磁场组的血清总胆固醇和三酰甘油降低明显(P<0.01),高密度脂蛋白反而有明显升高(P<0.01);与对照组比较,磁场组三酰甘油和高密度脂蛋白的差异没有显著性意义(P>0.05);③与高脂组比较,磁场组各项心功能指标的差异均具有显著性意义(P<0.01);与对照组比较,磁场组LVET,PEP,ICT以及ICT/LVET均没有显著性差异(P>0.05).④对主动脉内壁大体观察,肉眼清晰可见高脂组弥漫有大量条纹状白色斑块,致使管壁增厚、变硬、管腔狭窄;磁场组内膜表面仅见少量针头大小斑点,血管弹性正常;对照组内膜光滑,未见任何病变.⑤肝脏HE染色后,镜下观察高脂组可见大量脂肪空泡,而磁场组与对照组肝组织无明显病变.⑥心肌HE染色后,镜下可见高脂组细胞质中出现大小不等的脂肪空泡,散在于肌原纤维间,而磁场组与对照组镜下观察无明显病变.结论: 低强度PEMFs对心血管疾病有明显的预防和治疗作用.     

胆固醇与动脉粥样硬化性血管病变的研究

目的：观察血脂对血液流变学的影响，探讨胆固醇与动脉粥样硬化性血管病变之间的关系。方法：选择年龄40～60岁者200人，进行血脂和血液流变学检测，按血脂异常判断标准分为正常血脂、高胆固醇血症、高三酰甘油血症和混合型高脂血症四组，对四组的血液流变学指标进行组间比较。结果：高胆固醇血症组和高三酰甘油血症组的全血粘度比正常血脂组增高（P〈0．001）；高三酰甘油血症组和混合型高脂血症组比高胆固醇血症组的血细胞压积和血浆粘度增高（P〈0．05）。结论：血脂水平与全血粘度成正比，总胆固醇水平与动脉粥样硬化程度呈正相关，胆固醇致动脉粥样硬化作用是缺血性心脑血管疾病的主要危险因素。     

急性脑梗死患者血液流变学及血细胞参数的变化

目的　探讨急性脑梗死患者血液流变学及全血细胞 2 5项参数的变化。方法　对12 7例脑梗死患者和 5 3例建康人的血液流变学及全血细胞参数进行比较。结果　 (1)除红细胞分布宽度和平均红细胞血红蛋白含量外 ,观察组急性期其它指标与对照组比较均有显著差异 (P <0 .0 5～ 0 .0 1) ;(2 )观察组恢复期全血低切粘度、全血低切还原粘度、全血高切相对指数、全血低切相对指数、血浆粘度、红细胞压积、红细胞聚集指数、白细胞计数、平均红细胞血红蛋白含量恢复到对照组水平 (P >0 .0 5 ) ;(3)观察组治疗前后红细胞计数和平均血小板体积有显著差异 (P <0 .0 5 )。结论　血液流变学及血细胞参数异常可能与脑梗死的发生有关     

孕期血脂水平、血液流变学与孕妇妊娠结局的关系

目的探究孕期妇女血脂、血液流变学水平的表达及其与妊娠结局的关系。方法选取2016年1月至2018年8月在本院行产前检查并分娩的孕产妇240例为研究对象。根据是否存在妊娠期合并症将患者分为合并症组(97例)、正常组(143例)。比较两组血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血液流变学[血沉(ESR)、全血低切粘度(LWBV)、全血高切粘度(HWBV)、红细胞压积(HCT)、血浆黏度(PV)]水平差异及妊娠结局(胎儿窘迫、早产儿、低出生体质量、新生儿窒息、巨大儿等);分析血脂水平异常与正常者、血液流变学水平异常与正常者的妊娠结局差异。结果合并症组血脂TC、TG、LDL-C水平均高于正常组,HDL-C水平低于正常组; ESR、LWBV、HWBV、HCT、PV水平高于正常组;早产儿、低出生质量、新生儿窒息、巨大儿发生率亦高于正常组,差异均有统计学意义(P<0. 05)。血脂异常者早产儿、低出生体质量、新生儿窒息、巨大儿发生率高于血脂正常者,血液流变学异常者胎儿窘迫、早产儿、低出生体质量、新生儿窒息、巨大儿发生率高于血液流变学正常者,差异均有统计学意义(P<0. 05)。结论妊娠期合并症造成不良妊娠结局的机制与血脂水平、血液流变学水平异常有关。     

Svate,ILIB对心脑血管病患者血液流变学影响的比较

通过蝮蛇抗栓酶 ( Svate)、He- Ne激光血管内照射疗法 ( IL IB)治疗心脑血管病患者各 30例 ,比较治疗前后血液流变学的变化 ,结果表明 ,用药组、IL IB组诸多血液流变指标均显著改善 ( P<0 .0 5) ;全血粘度 (高切、低切 )、血浆粘度、红细胞压积等指标的改善 ,用药组优于 ILIB组 ( P<0 .0 5) ,血沉、血胆固醇、血甘油三酯等指标的改善 ,IL IB组非常显著的优于用药组 ( P<0 .0 1)。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.