Differential diagnosis of two disorders that produce common orofacial pain symptoms

Severe orofacial pain often is diagnosed as trigeminal neuralgia, with little distinction made as to which type--typical or atypical. In addition, osteonecrosis of the jaws quite often produces symptoms which mimic trigeminal neuralgia. Unless diagnosed correctly, a patient suffering from a condition of "dead bone" may be referred for unnecessary neurosurgery. The general dentist often is the one doctor who can make the proper diagnosis and guide the patient toward the proper treatment.     

Diagnosis and management of non-dental orofacial pain

Careful history-taking improves diagnosis of non-dental orofacial pain, a not uncommon group of conditions. Accurate diagnosis of conditions such as chronic idiopathic facial pain, temporomandibular disorders, burning mouth syndrome and trigeminal neuralgia is essential if inappropriate dental treatment is to be avoided. There are few investigations to help in the diagnostic process and many of these patients have other forms of chronic pain. All the conditions are best treated using a holistic approach. Drugs, such as tricyclic antidepressants and anticonvulsants, are often effective and surgery can be highly successfully in trigeminal neuralgia. Patient education is paramount. CLINICAL RELEVANCE: Although the majority of pain seen in general dental practice is dental in origin, chronic non-dental orofacial pain must be recognized as its management is entirely different.     

Dental perspectives on neuropathic origin

The most common cause of intraoral pain is odontogenic and rarely presents a diagnostic challenge. Pain in a tooth site area that is not dental or periodontal in origin may be difficult to diagnose and treat. Successful management of non-odontogenic pain complaints is inherently dependent on taking a detailed 'pain history'. Treatments that are irreversible and potentially harmful to the underlying dentoalveolar structures must be avoided when the diagnosis is uncertain. Information gleaned from the pain history usually provides a provisional or working diagnosis, and this diagnosis must later be confirmed by specific testing (based on response to medication trials, imaging, laboratory tests, etc.). Patients who suffer from chronic pain conditions are likely to show comorbidity with other pain problems (e.g., neuropathic pain with background muscle discomfort or temporomandibular disorders and headache problems). Thus, in more complex patients, the various elements that comprise the chronic pain condition must be identified and managed, for adequate resolution of the symptoms.     

Spontaneous pain attacks: neuralgic pain

Paroxysmal orofacial pains can cause diagnostic problems, especially when different clinical pictures occur simultaneously. Pain due to pulpitis, for example, may show the same characteristics as pain due to trigeminal neuralgia would. Moreover, the trigger point of trigeminal neuralgia can either be located in a healthy tooth or in the temporomandibular joint. Neuralgic pain is distinguished into trigeminal neuralgia, glossopharyngeal neuralgia, Horton's neuralgia, cluster headache and paroxysmal hemicrania. In 2 cases trigeminal neuralgia is successfully managed with a neurosurgical microvascular decompression procedure according to Jannetta. Characteristic pain attacks resembling neuralgic pain result from well understood pathophysiological mechanisms. Consequently, adequate therapy, such as a Janetta procedure and specific pharmacological therapy, is available.     

Computer-aided diagnoses of chronic head pain: explanation, study data, implications, and challenges

The differential diagnosis of diseases and disorders having head pain as a symptom is often a difficult challenge for health care professionals. The complexity of this problem, the need for computer aided diagnosis, and the assumptions upon which one diagnostic software program was developed are discussed. A database driven user-oriented Internet website was offered at no charge to headache sufferers, and this vehicle provided the data source for research. The software program compares consistent user surveys to 253 expert profiles compiled from searches of the best available material in the medical/dental literature. A database of 1288 consistent user surveys was studied and analyzed for this paper. Findings discussed are: 1. the large amount of users (63%) who do not match any expert profile to a reasonable degree of medical certainty; 2. the significance of the relatively large amount of headache sufferers (17%) whose diagnosis or diagnoses are solely within the realm of dentistry; and 3. the importance of differentiating between discriminating and substantiating diagnostic criteria. Many users do not fit existing algorithms for chronic head pain. Data generated by this computer-aided diagnostic software program challenge some current paradigms and concepts of diagnosis. The data generated question "correct to a reasonable degree of medical certainty," challenge "a preponderance of the evidence" as scientific diagnostic standards, and also question whether rendering a working diagnosis is possible on each and every patient.     

Atypical pain in the mandible caused by trigeminal neuralgia

A 58-year-old woman came to her dentist with atypical pain on the right side of the mandible. The pain diminished with the use of carbamazepine, paracetamol and diclofenac, and eventually disappeared completely. Magnetic resonance imaging, undertaken at the advice of a neurologist, showed no structural lesions and confirmed the diagnosis of idiopathic trigeminal neuralgia. Trigeminal neuralgia is a condition which often can be diagnosed on the basis of the clinical history and the specific symptoms. The condition can be divided into idiopathic and symptomatic trigeminal neuralgia. It is important to consider a possible trigeminal neuralgia in case of atypical pain in the oral region in order to prevent unnecessary dental procedures.     

Standards for the History,Examination, Diagnosis,and Treatment of Temporomandibular Disorders (TMD): A Position Paper

Abstract

The differential diagnosis of diseases and disorders having head pain as a symptom is often a difficult challenge for health care professionals. The complexity of this problem, the need for computer aided diagnosis, and the assumptions upon which one diagnostic software program was developed are discussed. A database driven user-oriented Internet website was offered at no charge to headache sufferers, and this vehicle provided the data source for research. The software program compares consistent user surveys to 253 expert profiles compiled from searches of the best available material in the medical/dental literature. A database of 1288 consistent user surveys was studied and analyzed for this paper. Findings discussed are: 1. the large amount of users (63%) who do not match any expert profile to a reasonable degree of medical certainty; 2. the significance of the relatively large amount of headache sufferers (17%) whose diagnosis or diagnoses are solely within the realm of dentistry; and 3. the importance of differentiating between discriminating and substantiating diagnostic criteria. Many users do not fit existing algorithms for chronic head pain. Data generated by this computer-aided diagnostic software program challenge some current paradigms and concepts of diagnosis. The data generated question “correct to a reasonable degree of medical certainty,” challenge “a preponderance of the evidence” as scientific diagnostic standards, and also question whether rendering a working diagnosis is possible on each and every patient.     

Trigeminal autonomic cephalalgias

The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders characterised by lateralized symptoms: prominent headache and ipsilateral cranial autonomic features, such as conjunctival injection, lacrimation and rhinorrhea. The TACs are: cluster headache (CH), paroxysmal hemicrania (PH), short‐lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short‐lasting neuralgiform headache attacks with cranial autonomic features (SUNA) and hemicrania continua (HC). Their diagnostic criteria are outlined in the International Classification of Headache Disorders, third edition‐beta (ICHD‐IIIb). These conditions are distinguished by their attack duration and frequency, as well as response to treatment. HC is continuous and by definition responsive to indomethacin. The main differential when considering this headache is chronic migraine. Other TACs are remarkable for their short duration and must be distinguished from other short‐lasting painful conditions, such as trigeminal neuralgia and primary stabbing headache. Cluster headache is characterised by exquisitely painful attacks that occur in discrete episodes lasting 15–180 min a few times a day. In comparison, PH occurs more frequently and is of shorter duration, and like HC is responsive to indomethacin. SUNCT/SUNA is the shortest duration and highest frequency TAC; attacks can occur over a hundred times every day.     

Temporomandibular disorders in headache patients

Objective: To identify the frequency of signs and symptoms of temporomandibular disorder (TMD) and its seve-rity in individuals with headache. Study Design: 60 adults divided into three groups of 20 individuals: chronic daily headache (CDH), episodic headache (EH) and a control group without headache (WH). Headache diagnosis was performed according to the criteria of International Headache Society and the signs and symptoms of TMD were achieved by using a clinical exam and an anamnestic questionnaire. The severity of TMD was defined by the temporomandibular index (TMI). Results: The TMD signs and symptoms were always more frequent in individuals with headache, especially report of pain in TMJ area (CDH, n=16; EH, n=12; WH, n=6), pain to palpation on masseter (CDH, n=19; EH, n=16; WH, n=11) which are significantly more frequent in episodic and chronic daily headache. The mean values of temporomandibular and articular index (CDH patients) and muscular index (CDH and EH patients) were statistically higher than in patients of the control group, notably the articular (CDH=0.38; EH=0.25;WH=0.19) and muscular (CDH=0.46; EH=0.51; WH=0.26) indices. Conclusions: These findings allow us to speculate that masticatory and TMJ pain are more common in headache subjects. Besides, it seems that the TMD is more severe in headache patients. Key words:Temporomandibular dysfunction, headache disorders.     

Differential Diagnosis of Headaches

The clinical practitioner is faced daily with myriad pain complaints. Headache is a most common complaint, with pain arising from odontogenic, neurologic, and myogenic sources. The practitioner needs to be familiar with various headache symptoms in order to make an accurate diagnosis of each patient's problems.

This article presents three categories that represent the most common types of headache pain. The most common symptoms for each type are discussed, and suggestions for treatment are offered.     

Orofacial neuralgia associated with a middle cerebral artery aneurysm

Chronic orofacial pain of neuropathic origin can present diagnostic and management dilemmas to dental practitioners and also affects the patient's quality of life. Intracranial aneurysms are a potential cause of stroke (e.g. sub‐arachnoid haemorrhage) that is usually associated with, high rates of mortality and morbidity. A patient who had been previously managed for symptoms of temporomandibular joint disorder (TMD) presented with sharp, shooting pain of moderate intensity. It was precipitated by swallowing, and radiated to the right throat, posterior border of the mandible, ear and temporomandibular joint. Clinical and radiological investigations ruled out odontogenic pain, TMD and other more common types of facial pain. Magnetic resonance imaging revealed a 7 × 6 mm aneurysm in the right middle cerebral artery (MCA) which was subsequently surgically clipped. Interestingly, the facial pain resolved after this procedure. Compression of the insular region of the brain innervated by the trigeminal, glossopharyngeal and vagus nerves provides a plausible explanation for the pain reported. To our knowledge, this is the first case of facial neuralgia associated with an aneurysm in the MCA which emphasizes the importance of a multidisciplinary approach in the diagnosis and management of unusual cases of chronic orofacial pain.     

非牙源性牙痛

急性牙痛是口腔急症的最常见主诉症状,除牙源性疼痛以外,很多非牙源性疾病也可引起牙痛,容易出现漏诊或误诊。文章对急性上颌窦炎、三叉神经痛、带状疱疹、颞下颌关节紊乱病、心源性牙痛和丛集性头痛等疾病引起的非牙源性牙痛进行阐述,为临床医生诊断牙痛疾病提供参考。     

The relationship between headache and symptoms of temporomandibular disorder in the general population

OBJECTIVES: To describe the relationship between headache and symptoms of temporomandibular disorder (TMD) in a general population, and to assess whether there are specific symptoms associated with headache. METHODS: A personal interview survey conducted in 1995 on 483 adult subjects from the metropolitan community of Segrate, northern Italy. RESULTS: The overall prevalence of headache in the past year was 21.2%. The prevalence of temporomandibular symptoms was 54.3%. Headache occurred significantly more in females than males (26.5 vs 15.4%), and in subjects with, rather than without, symptoms of TMD (27.4 vs 15.2%). Among symptoms, temporomandibular pain, temporomandibular joint sounds, and pain on movements of the jaw were associated with headache using a univariate analysis. After adjustment for confounding variables, a multiple logistic regression confirmed a significant relationship of headache with temporomandibular pain (OR 1.83, 95% CI, 1.07-3.15). CONCLUSIONS: In the general adult population there is an association between headache and symptoms of TMD. A functional evaluation of the stomatognathic system should be therefore considered in subjects with unexplained headache, even if chronic conditions and mechanical symptoms of temporomandibular disorder are absent.     

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??Acute toothache is the most common symptom of emergency cases in the dental department. There are many causes of nonodontagenic toothache besides for odontagenic pain??so misdiagnosis and missed diagnosis might occur. This review describes the nonodontagenic toothache caused by such diseases as acute maxillary sinusitis??trigeminal neuralgia??zoster herpes??temporomandibular disorders??cardiac pain??cluster headache??etc. and provides reference for clinical diagnosis of toothache disease.     

Paroxysmal hemicrania: Case studies and review of the literature

Paroxysmal hemicrania is a vascular-type headache that is characterized by short bouts of severe unilateral pain in the area of the orbit and temple. A chronic and episodic form that has been described is similar to cluster headache and reflects a distinctive temporal pattern. Signs associated with paroxysmal hemicrania include ipsilateral conjunctival injection and tearing with nasal congestion and rhinorrhea. The condition's absolute response to indomethacin pharmacotherapy differentiates paroxysmal hemicrania from cluster headache. Typical symptoms usually make for a relatively straightforward diagnosis of paroxysmal hemicrania, but it may masquerade as pulpitic or temporomandibular-joint-related pain and may even herald systemic disease or malignancy. Paroxysmal hemicrania is a rare syndrome; 111 cases have been reported in the literature thus far. All of these cases have been reported by “headache specialists”; no cases of paroxysmal hemicrania were found in the dental literature. In this review, a relatively large series of seven new cases is reported; all seven were seen in an orofacial pain clinic.     

Brainstem auditory evoked potentials in atypical facial neuralgia

Atypical facial neuralgia is an ill-defined syndrome of obscure etiology characterized by chronic facial pain. The diagnosis is one of exclusion, made only after carefully ruling out a variety of conditions that may cause orofacial pain. The present study detected brainstem abnormalities on the side of the facial pain through examination of brainstem auditory evoked potentials in two out of 12 patients who were clinically diagnosed as having atypical facial neuralgia. The recording of brainstem auditory evoked potentials provides a simple, well-standardized, noninvasive test that may be of value in the investigation of patients who have chronic facial pain.     

Masticatory problems after balloon compression for trigeminal neuralgia: a longitudinal study

Idiopathic trigeminal neuralgia (ITN) is a chronic neuropathic pain that affects the masticatory system. The objective of this study was to identify orofacial pain and temporomandibular characteristics, including temporomandibular disorder (TMD), in a sample of 105 ITN patients treated with compression of the trigeminal ganglion. The evaluations occurred before, 7, 30 (1 month), 120 (3 months) and 210 days (7 months) after surgery. The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), the Clinical Questionnaire (EDOF-HC) and Helkimo Indexes were used. Findings before neurosurgery were used as control for parameters. McNemar test and variance analysis for repetitive measurements were used for statistical analysis; 45.3% of the edentulous patients presented severe dental occlusion index; numbness was an important masticatory complaint in 42.6%; mastication became bilateral, but its discomfort continued during all period; headache and body pain reduced after surgery; TMD, present in 43.8% before surgery, increased but normalized after 7 months; jaw mobility compromise was still present, but daily activities improved after 7 months. We concluded that: (i) ITN relief reduced headache, body pain, depression and unspecific symptoms; and (ii) TMD before surgery and at 7 months suggests that this may be a contributory factor to patients' pain complaints.     

Headaches and myofascial temporomandibular disorders: overlapping entities,separate managements?

There are relevant clinical overlaps between some of the painful temporomandibular disorders (TMD) and headache conditions that may hamper the diagnostic process and treatment. A non‐systematic search for studies on the relationship between TMD and headaches was carried out in the following databases: PubMed, Cochrane Library and Embase. Important pain mechanisms contributing to the close association and complex relationship between TMD and headache disorders are as follows: processes of peripheral and central sensitisation which take place in similar anatomical areas, the possible impairment of the descending modulatory pain pathways and the processes of referred pain. In addition, the clinical examination does not always provide distinguishing information to differentiate between headaches and TMD. So, considering the pathophysiology and the clinical presentation of some types of headache and myofascial TMD, such overlap can be considered not only a matter of comorbid relationship, but rather a question of disorders where the distinction lines are sometimes hard to identify. These concerns are certainly reflected in the current classification systems of both TMD and headache where the clinical consequences of diagnosis such as headache attributed to or associated with TMD are uncertain. There are several similarities in terms of therapeutic strategies used to manage myofascial TMD and headaches. Considering all these possible levels of interaction, we reinforce the recommendation for multidisciplinary approaches, by a team of oro‐facial pain specialists and a neurologist (headache specialist), to attain the most precise differential diagnosis and initiate the best and most efficient treatment.     

颞下颌关节区疼痛患者全身伴随症状的初步研究

目的调查与颞下颌关节(TMJ)区疼痛伴随出现的全身症状的发生情况。方法选取TMJ区疼痛患者51例及TMJ区无疼痛的对照者31人,调查其TMJ症状及全身伴随症状。治疗半年后对TMJ区疼痛患者进行复查。应用一元线性回归和卡方检验对TMJ区疼痛与全身症状的相关性及伴随性进行统计学分析。结果与TMJ疼痛有相关性的症状包括头痛、背痛、手麻抖、肩颈痛、失眠、目眩、听力下降、眼痛和易疲劳(P<0.05)。患者组部分症状(头痛、肩颈痛、眼痛、耳鸣、目眩、眼下抽搐、易疲劳、手脚发凉、易烦躁、注意力不集中和消化不良)发生的比例显著高于对照组(P<0.01)。半年后与TMJ区疼痛伴随改善的症状有头痛、肩颈痛和易疲劳(P<0.05)。结论头部、肩颈等口腔颌面邻近器官的症状是TMJ区疼痛的主要伴随症状,与TMJ症状的改善有伴随关系。