Atypical Fibroxanthoma in a 13‐Year‐Old Guatemalan Girl with Xeroderma Pigmentosum

Xeroderma pigmentosum (XP) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma (AFX) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFXs are rarely associated with children with XP. We report the case of a 13‐year‐old Guatemalan girl with the XP type C variant who developed one of the largest AFXs reported on a child's finger.     

Periungual Bowen's Disease in a 4‐Year‐Old Girl

Bowen's disease (BD), or cutaneous squamous cell carcinoma (SCC) in situ, is rare in children. BD usually occurs in Caucasian adults on sun‐exposed areas and may progress to invasive cutaneous SCC. Most cases of periungual BD have been linked to human papillomavirus infection. We report an immunocompetent child with periungual BD.     

A Gunpowder Tattoo in a 6‐Year‐Old Girl

Gunpowder tattoos result from explosion and subsequent traumatic implantation of pigmented granules into varying layers of the skin. This report details the case of a 6‐year‐old with a gunpowder tattoo on the face.     

Nonsyndromic Whorled Eyebrows in a Healthy 6‐Year‐Old Girl

Whorled eyebrows are an unusual and rarely described finding of unknown clinical significance. We present such a case in a 6‐year‐old healthy girl.     

Congenital Multiple Clustered Dermatofibroma in a 12‐Year‐Old Girl

Abstract: Congenital multiple clustered dermatofibroma (MCDF) is a rare, idiopathic, benign tumor presenting at birth as an asymptomatic hyperpigmented patch that is stable until puberty, at which time it enlarges and develops papules. Ultimately, MCDF appears to follow a stable, benign course. We present a case of a 12‐year‐old girl with congenital MCDF. To our knowledge, this is only the third reported case of congenital presentation of MCDF and the only case featuring atrophoderma‐like depression.     

Toxic Epidermal Necrolysis Triggered by Clobazam: A Case Report in a 13‐Year‐Old Girl

We present a case of toxic epidermal necrolysis (TEN) triggered by clobazam in a 13‐year‐old girl who was subsequently treated with intravenous immunoglobulin. In December 2013 the U.S. Food and Drug Administration released a warning that clobazam might cause “serious skin reactions” such as Stevens–Johnson syndrome or TEN and approved label changes.     

Angioedema After Squaric Acid Treatment in a 6‐Year‐Old Girl

Alopecia areata (AA) involves the immune‐related destruction of hair follicles, resulting in patches of complete hair loss, most often on the scalp. The topical sensitizer squaric acid dibutylester (SADBE) is a popular treatment option given its low side‐effect profile, hair regrowth potential, and lack of cross‐reactivity with other chemicals. We describe a unique case of a 6‐year‐old girl who developed angioedema after SADBE treatment for AA.     

Frey's Syndrome After Herpes Zoster Virus Infection in a 2‐Year‐Old Girl

Frey's syndrome is characterized by sweating and flushing in the temporal and preauricular areas after a salivary stimulus. It is caused by damage to the auriculotemporal nerve, hence the alternative name of auriculotemporal syndrome. We report the case of a 2‐year‐old girl presenting with postprandial unilateral flushing that developed after a herpes zoster infection.     

Bullous Allergic Contact Dermatitis to Pure Henna in a 3‐Year‐Old Girl

Abstract: Natural henna is known to have a very low allergic potential. We describe here an exceptional case of bullous contact dermatitis caused by pure henna.     

Post‐Chikungunya Rheumatic Disease in a 13‐Year‐Old Boy

Chikungunya is a mosquito‐borne viral infection that causes an acute febrile illness and can result in acute or chronic musculoskeletal disease. A 13‐year‐old boy presented with post‐Chikungunya rheumatic disease featuring connective tissue disease signs including digital ulcerations, cuticular dystrophy, dilated capillary loops, and digital tapering.     

A Rare Case of Atypical Myxoid Cellular Neurothekeoma in a 6‐Year‐Old Girl

Neurothekeoma (nerve sheath myxoma)is a benign tumor of probable nerve sheath origin. The atypical cellular variant of this tumor, showing a peculiar histologic pattern, has been very rarely reported in the literature. The atypical variant of cellular neurothekeoma is characterized by features such as large size, deep penetration extending into skeletal muscle and/or subcutaneous fat, diffuse infiltration borders, vascular invasion, high mitotic rate and marked cytologic pleomorphism. We describe a rare form of atypical myxoid cellular neurothekeoma in a 6‐year‐old girl.     

Linear Morhpea,Nevus Comedonicus,and Lichen Striatus in a 5‐Year‐Old Girl

Abstract: Linear morphea, lichen striatus, and nevus comedonicus are rare conditions. We describe a five‐year‐old girl in whom all three of these dermatoses are present.     

Scurvy in a 10‐Year‐Old Boy

Abstract: Scurvy, or hypovitaminosis C, is an uncommon condition that exists today primarily within certain unique populations—particularly the elderly subjects, patients with neurodevelopmental disabilities or psychiatric illnesses, or others with unusual dietary habits. Vitamin C is an essential nutrient in the human body, and is important in synthesizing collagen factor whose faulty production is responsible for most of the clinical manifestations of scurvy. These clinical manifestations can include dystrophic or corkscrew hairs, gingival hyperplasia, and weakened blood vessel walls, causing bleeding in the skin, joints, and other organs. Although rare in the Unites States, the presence of scurvy should not be forgotten because of its presence among susceptible populations. Moreover, with its diagnosis, treatment and cure is one of the simplest in modern medicine. We report a case of scurvy in a 10‐year‐old autistic child.     

Crusted Scabies Misdiagnosed as Erythrodermic Psoriasis in a 3‐Year‐Old Girl with Down Syndrome

Scabies is a highly contagious infestation with the Sarcoptes scabiei var hominis mite. The variety of clinical presentations make timely, accurate diagnosis problematic. We report the case of a 3‐year‐old girl with Down syndrome and crusted scabies initially misdiagnosed as erythrodermic psoriasis.     

Adalimumab‐Induced Cutaneous Lupus Erythematosus in a 16‐Year‐Old Girl with Juvenile Idiopathic Arthritis

Tumor necrosis factor α (TNF‐α) antagonists are used in the treatment of numerous autoimmune conditions. Adalimumab is the first monoclonal antibody to TNF‐α and is used to treat juvenile idiopathic arthritis. A growing body of literature associates anti‐TNF‐α therapies with several adverse dermatologic manifestations, including drug‐induced lupus erythematosus (LE). We describe a case of cutaneous LE in a 16‐year‐old girl treated with adalimumab for juvenile idiopathic arthritis. The temporal association between her presenting symptoms and adalimumab initiation and gradual improvement after stopping biologic therapy suggest adalimumab‐induced cutaneous LE. With increasing use of anti‐TNF therapies in children, the potential for drug‐induced LE should not be overlooked.