STUDY ABOUT CLINICAL APPLICATION OF BRAIN ATLAS IN PAEDIATRICS

Objectives To explore clinical application on brain atlas in paediatrics. Methode: Brainatlas was applied in diagnosis and treatment of paediatric diseases and its clinical value was discussed in 1990～2001. The manifestation of these diseases in brain atlas were analysed and the manifestation of CT of 67 cases andmanifestations of EEG of 37 cases with that of BA were compared. Results The changes of cerebral electrical ac-tivity of these diseases were reflected objectively and showed directly in BA. Conclusion Brain atlas not only canpoint out quality of disease but also define position of disease. Therefore, brain atlas has important clinical valuein paediatrics.     

CONTRAST STUDY ON CT AND BA IN ACUTE CEREBROVASCULAR DISEASES

Objective: To explore contrast application on CT and BA in acute cerebrovascular diseases.Method: CT and BA were examined in 718 patients with acute cerebrovascular disease. Results: The different changes of CT and BA were showed in 718 patients with acute cerebrovascular disease.Conclusion: There were separately different advantage and shortcoming in CT and BA in diagnosis of acute cerebrovascular diseases. The value of clinical application of BA was important in acute cerebrovascular diseases.     

CONTRAST STUDY ON CT AND BA IN 3000 PATIENTS

Brain atlas(BA)is an important diagnostictechnique after CT and MRI·By clinical experi-ence,there were some advantages in BA·BA cansupplement shortage of CT·But there was also someshortages in BA·The contrast study between CTandBA in3000patients was reported as follows now:Data and MethodGeneral data:In3000patients,male was1490cases(49·7%),female was1510cases(50·3%)·Largest age was82years old·Smallest age was3days·Clinical disease examined:Acute cerebrovascu-lar diseases we…     

CONTRAST STUDY ON BA AND CT IN INTRACRANIAL TUMOUR

Objectives: To make contrast study on Brain Atlas (BA) and CT in intracranial tumour. Method: BA and CT were examined in 30 patients with intracranial tumour. Result: 30 patients have different manifestation in BA and CT. Conclusion: The applied value of BA was higher in diagnosis and treatment of intracranial tumour.     

定制旋转铰链式膝关节假体置换治疗膝关节周围侵袭性骨肿瘤的临床观察

Objective To evaluate the clinical efficacy of knee joint replacement with patienttailored rotating hinge prosthesis in patients with invasive perigenual bone tumor.Methods Between January 2000 and January 2005, clinical data of 27 patients with invasive perigenual bone tumor were retrospectively analyzed, including 13 cases of distal femoral tumor and 14 of proximal tibial tumor,comprising 16 cases of giant cell tumors, 9 of osteosarcomas, 1 of synovial sarcomas and 1 of malignant fibrous histiocytomas.All the patients received resection of the tumor, knee-joint replacement with patienttailored rotating hinge prosthesis and postoperative rehabilitation.Patients with malignant tumor also underwent routine chemotherapy after surgery.MSTS scoring was used to evaluate the knee joint function in patients during the postoperative follow-up.Results All the patients were followed up for 11 to 122 months, with median time of 64.5 months.All the patients survived 6 months of follow-up, with a mean MSTS score of 22.2±3.5 and the rate of good knee joint function being 81.5% (22/27).In a recent follow-up, 23 patients were alive and 4 patients dead.Prosthesis-related complications developed in 4 patients.The mean MSTS score was 21.0 ±2.3, and the rate of good knee joint function was 72.7% (16/22) in 22 surviving patients.The overall rate of survival in all the patients was 85.2% (23/27) at five years after treatment.Conclusion The knee-joint replacement with patient-tailored rotating hinge knee prosthesis is associated with a good efficacy in treatment of invasive perigenual bone tumor.     

THE APPLIED STUDY ON BRAIN ATLAS AND BRAIN ULTRASONIC EXAMINATION IN DIAGNOSIS OF NEWBORN HYPOXIC ISCHEMIC ENCEPHALOPATHY

35 patients with HIE(hypoxic ischemic encephalopathy)were reported in this paper.In these patients,mild was 12 cases,middle was 16 cases,serious was 7 cases.The relation of HIE and perinatal factor was explored.The velocity of blood flow of anterior cerebral artery,middle cerebral artery,posterior cerebral artery and basilar artery were examined by brain ultrasonograph B.     

CEREBROCARDIAC SYNDROME ON PATIENTS OF OVER SEVENTY AGE AND EEG STUDY

Objectives: To observe cerebrocardiac syndrome on patients of the over seventy age and it's change of EEG. Methods: Brain CT and ECG were examined in 50 patients of the over seventy age with cerebrocardiac syndrome. Results: There were obvious changes in the brain CT and ECG. Conclusion: There were obvious changes of brain CT and ECG in cerebrocardiac syndrome of over seventy age patients.     

EFFECT OF ACUPUNCTURE ON BRAIN ACTIVATION: A fMRI STUDY

<正> Functional brain mapping in motor task and somatosensory stimulation using echo planar MRI Functional brain mapping was performed with a 1.5T clinical MRI apparatus. Single shot gradient echo echo-planar imaging (EPI) sequence was employed. Normal volunteers were studied with the task of grasping hand or opposition of fingers at the frequency of 3 Hz, median nerve electro-stimulation, pure somatosensory     

Atomization inhalation of terbutaline and budesonide efficiently improved immunity and lung function of AECOPD patients

Chronic obstructive pulmonary disease （COPD） is a syndrome of chronic progressive airflow limitation as a result of chronic inflammation of the airways and lung parenchyma. COPD patients always have airway hyperreactivity （AHR）, so how to reduce AHR becomes the key purpose of clinical treatment. It is hypothesized that combined inhalation of corticosteroids and β2-agonists can reduce the AHR in COPD. In this study, atomization inhalation of budesonide and terbutaline plus conventional therapies was applied to treat AECOPD （acute exacerbation of chronic obstructive pulmonary disease） patients for two weeks. The results showed that additional inhalation of budesonide and terbutaline could upregulate serum IL-2 levels, the percentages of CD3^＋ T and CD4^＋ T cells, and CD4/CD8 ratio, and decrease eosinophils and serum CRP level more efficiently than conventional treatment in patients with AECOPD. And the lung function of the atomization inhalation group was improved more obviously after the treatment compared with the conventional treatment group. Thus, atomization inhalation of terbutaline and budesonide can control AECOPD effectively, and has wide clinical perspective in controlling and preventing the exacerbation of COPD. Cellular ＆ Molecular Immunology. 2008;5（4）：287-291.     

Sequential transcatheter arterial chemoembolization,three-dimensional conformal radiotherapy,and high-intensity focused ultrasound treatment for unresectable hepatocellular carcinoma patients

The purpose of this study was to evaluate the outcome of patients with unresectable hepatocellular carcinoma(HCC) treated by sequential therapy of transcatheter arterial chemoembolization(TACE),three-dimensional conformal radiotherapy(3-DCRT) and high-intensity focused ultrasound(HIFU).From October,2005 to September,2010,120 patients with unresectable HCC received the sequential treatments of several courses of TACE followed in 2-4 weeks by 3-DCRT and then a single session of HIFU with a curative intent.The median tumor irradiation dose was 40 Gy.Tumor response,toxicity and overall survival rate were analyzed.Clinicopathologic factors affecting the primary technique effectiveness and overall survival rates were investigated by univariate analysis or multivariate analysis.All 120 HCC patients were followed up by the last follow-up time.Among these patients,hepatic toxicities due to treatment were notable in 9 cases.Gastrointestinal bleeding after the overall treatment occurred in 2 cases,leukopenia of grade III was detected in 1 case,radiation-induced liver disease(RILD) was observed in 2 patients,and first-and second-degree skin burn around the HIFU treatment zone were observed in 2 patients and 1 patient,respectively.Among 120 patients,23,83 and 14 cases achieved partial response,stable disease and progressive disease,respectively.The overall survival rates at 1 year,3 years and 5 years were 70%,35% and 15%,respectively,with a median survival time of 26 months.Both Child-Pugh liver function grading and radiation dose were determined to be independent predictors for overall survival revealed by the multivariate analysis.It is concluded that the sequential therapy of TACE,3-DCRT and HIFU is a promising therapeutic regimen for unresectable HCC.     

偏瘫宁的研制及其临床应用和脑电地形图研究

目的观察中西药配伍合剂"偏瘫宁"治疗缺血性脑血管病的临床疗效及脑电地形图改变.方法对6660例缺血性脑血管病患者进行了"偏瘫宁"疗效及脑电地形图观察,并与采用脉通治疗的30例结果对比.结果临床症状和肌力恢复程度及脑电地形图治疗后有明显改善,总有效率为96.7%,而对照组脉通治疗的有效率为80.0%,两组对比,有显著性差异(P＜0.05).结论"偏瘫宁"对缺血性脑血管病有较好的临床疗效,无毒副作用,可推广应用.脑电地形图有很好应用价值.     

偏瘫宁治疗缺血性脑血管病前后脑电地形图研究

目的:探讨脑电地形图在缺血性脑血管病疗效判断上的应用价值。方法:通过对300例缺血性脑血管病治疗前后脑电地形图改变的对比评价。结果:脑电地形图在治疗前后有明显改变。结论:脑电地形图可以做为缺血性脑血管病疗效观察的一个有效指标。     

APPLIED STUDY ON BRAIN ATLAS AFTER AND BEFORE TREATMENT BY SIBELIUM IN ISCHEMIC VASCULAR DIZZINESS

目的:探讨西比灵的临床疗效和脑电地形图的应用价值。方法:应用西比灵治疗300例缺血性血管性头晕患者,通过临床症征和脑电地形图观察其疗效。结果:西比灵治疗缺血性血管性头晕有效率为100％,脑电地形图在治疗前后有明显改变。结论:西比灵是治疗缺血性血管性头晕的较理想药物。脑电地形图是观察西比灵疗效和作用机理的有效指标。     

脑电地形图在西比灵治疗血管性头晕前后的应用研究

目的：探讨西比灵的临床疗效和脑电地形图的应用价值。方法：应用西比灵治疗３００例缺血性血管性头晕患,通过临床症征和脑电地形图观察其疗效。结果：西比灵治疗缺血性血客性头晕有效率为１００．０％,脑电地形图在治疗前后有明显改变。结论：西比灵是治疗缺血必血管性头晕的理想药物,脑电地形图是观察西比灵疗效和作用机理的有效指标。     

抗脑瘤口服液治疗脑瘤前后脑电地形图研究

目的：探讨脑电地形图在脑瘤疗效判断上的应用价值。方法：通过对30例脑瘤治疗前后脑电地形图改变进行对比评价。结果：脑电地形图在治疗前后有明显改变。结论：脑电地形图可以作为脑瘤疗效观察的一个有效指标。     

急性缺血性脑血管病治疗前后彩色脑电地形图对比研究

本文报告了50例急性缺血性脑血管病给予脑活素和脉络宁治疗前后的彩色脑电地形图改变。结果显示:50例患者治疗后彩色脑电地形图δ频带较治疗前δ频带功率明显降低,α频带功率明显升高,本文提示脑电地形图是观察急性缺血性脑血管病疗效的一个敏感指标。     

脑电地形图在儿科临床的应用研究

我们于1990～1992年将脑电地形图应用于儿科临床,并对其实用价值进行了研究探讨。本组102例,其年龄为新生儿期～14岁。疾病包括:癫痫27例,血管性头痛15例,病毒性脑炎14例,新生儿缺氧缺血性脑病14例,精神发育迟缓9例,脑外伤后遗症4例,脑发育不全6例,其他13例。对上述疾病的脑电地形图表现作了分析,并对其中67例同时作脑CT,37例同时作脑电图者的结果进行了对比。从而提出脑电地形图可客观地反映,直观地显示患者各种病变脑电活动变化,其不仅可提示病变的性质而且可确定病变的部位。因此在儿科有重要应用价值。     

丁基苯酞软胶囊治疗缺血性脑血管疾病的疗效分析

目的 对我院缺血性脑血管疾病患者应用丁基苯酞软胶囊进行治疗,了解该药应用过程中的具体疗效。方法 2016年2月~2017年2月我院共收治缺血性脑血管疾病患者60例,随机将患者分为观察组与对照组,每组30例。对照组按照常规的治疗方式应用长春西汀注射液治疗,观察组患者在对照组患者治疗的基础上增加应用丁基苯酞软胶囊治疗,比较两组患者临床疗效。结果 治疗一个疗程结束后,观察组有效率76.67%高于对照组50.00%,差异有统计学意义（P＜0.05）;治疗结束后,观察组平均NIHSS评分（6.52±1.03）分,对照组平均NIHSS评分（7.97±1.43）分,观察组患者NIHSS评分较低,两组患者结果存在差异,有统计学意义（P＜0.05）。结论 在临床治疗缺血性脑血管疾病时,与传统的治疗药物相比较,应用丁基苯酞软胶囊具有显著的疗效且具有一定的安全性,能够保护脑神经,减轻因血小板集中而造成的缺血性脑血管疾病症状。另外,该药物应用后用药患者均未发生不良反应,值得在临床治疗中推广应用。