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2013年12月,美国预防、检测、评估和治疗高血压委员会(JNC)在《美国医学会杂志(JAMA)》发布了《2014美国成人高血压管理指南》第8版(以下简称JNC8),引起国际国内心血管领域不小的轰动,JNC8距JNC7的发布相距10年之久,这"十年磨一剑"的指南有哪些新意呢? 相似文献
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《临床合理用药杂志》2014,(11):99-99
2014年3月13日,在线发表于((JAMA Neurology))杂志(JAMA Neuro1 2014 Mar 13)上的一项由瑞典Sahlgrenska大学的PashtunShahim博士及其同事开展的研究表明,头部外伤后短时间内tau蛋白总水平不仅是临床确诊脑震荡的指标,还可预测症状的持续存在。其敏感性为85%,特异性80%。 相似文献
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2013年11月,美国心脏协会(American HeartAssociation,AHA),美国心脏病学会(AmericanColegeofCardiology,ACC)和美国疾病控制与预防中心(CentersforDisease Control and Prevention,CDC)共同制定并在线发表了《有效控制高血压的科学建议》(以下简称《建议》)。2013年12月17日,美国高血压学会(AmericanSocietyof Hypertension,ASH)联合国际高血压学会(InternationalSocietyofHypertension,ISH)抢先在JNC8前发布了《社区高血压管理临床实践指南》(以下简称《指南》)。经过艰难而漫长的孕育和等待,《2014年美国成人高血压管理指南(JNC8)》于12月18日在《美国医学会杂志》(JAMA)在线发布。多部指南的同时发布,令人眼花缭乱,反映了各国在有效控制血压方面所面临的挑战和做出的努力。 相似文献
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急性心肌梗死治疗策略 总被引:2,自引:2,他引:2
2005年3月6日美国Dartmouth医学院临床科学评估中心的Stukel等在美国医学会杂志(JAMA)发表题为“参加医疗保险的急性心肌梗死(AMI)患者介入治疗与药物治疗强度的区域性变化对长期预后的影响”(JAMA2005,293(11):1329)。这是对美国不同地区1994.1995年确诊的首次发生AMI的65~99岁老年患者158831例,接受经皮冠状动脉介入治疗(PCI)和药物治疗后,长期临床转归的研究结果。总体上各地区间患者基线AMI严重程度相近,且基线资料是与医疗保险合理资料相联系,根据患者所居住地区。 相似文献
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JAMA报道称,两个新的以青蒿素(artemisinin)为基础的复方(ACTs)可能是解决发展中国家疟疾问题的关键。 相似文献
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《Acta pharmacologica Sinica》2014,(3):I0003-I0003
The Editorial Board of the Acta Pharmacologica Sinica wishes to thank the following scientists for their unique contribution to this journal in reviewing the papers from November 1, 2013 to December 31, 2013 (including papers published and rejected). 相似文献
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刊登于JAMA Network美国的一项研究显示,规律的服用Omega-3脂肪酸可能有助于预防女性年龄相关黄斑变性(AMD). 相似文献
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据发表在美国医学会杂志(JAMA)上的哈佛医学院研究人员的报告,治疗心血管疾病的通用名药的疗效与品牌药的疗效一样好。 相似文献
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随着2005年8月份在一期新英格兰医学杂志(NEJM)和美国医学会志(JAMA)上发表的三项研究显示,J&J公司的药物洗脱性支架Cypher(Ⅰ)装置优于Boston Scientific公司的Taxus(Ⅱ)的研究结果,表明争夺药物洗脱性支架霸主地位的战争在升温。 相似文献
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阿司匹林治疗可以降低高危成人心血管疾病的风险,然而,女性是否和男性一样获益目前尚不清楚。美国Duke大学心血管科Berger等通过对随机对照试验进行性别特异的荟萃分析探讨阿司匹林心血管事件的一级预防作用是否因性别而异[JAMA,2006 Jan 18;295(3):306—13]。 相似文献
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Aim: The aim of the present study is to establish a population pharmacokinetic (PPK) model of valproate (VPA) in Chinese epileptic children to promote the reasonable use of anti-epileptic drugs. Methods: Sparse data of VPA serum concentrations from 417 epileptic children were collected. These patients were divided into 2 groups: the PPK model group (n=317) and the PPK valid group (n=100). The PPK parameter values of VPA were calculated by NONMEM software using the data of the PPK model group. A basic model and a final model were set up. To validate the 2 models, the concentrations of PPK valid group were predicted by each model, respectively. The mean prediction error (MPE), mean squared prediction error (MSPE), root mean squared prediction error (RMSPE), weight residues (WRES), and the 95% confidence intervals (95% CI) were also calculated. Then, the values between the 2 models were compared. Results: The PPK of VPA was determined by a 1-compartment model with a first-order absorption process. The basic model was: Ka=3.09 (h^-1), V/F=20.4 (L), CL/F=0.296 (L/h). The final model was: Ka=0.251+2.24-(1-HS) (h^-l), V/F=2.8 8+0.157-WT (L), CL/F=0.106^0.98.CO+ 0.0157·AGE (L/h). For the basic model, the MPE, MSPE, RMSPE, WRES, and the 95% CI were -23.53 (-30.36,-16.70), 3728.96 (2872.72, 4585.20), 39.62 (34.34, 44.90), and-0.06 (-0.14, 0.02), respectively. For the final model, the MPE, MSPE, RMSPE, WRES, and the 95% CI were -1.16 (-4.85, 2.53), 1002.83 (1050.64,1143.61), 23.04 (21.12, 24.96), and 0.08 (-0.04, 0.20), respectively. The final model was more optimal than the basic model. Conclusion: The PPK model of VPA in Chinese epileptic children was successfully established. It will be valuable to facilitate individualized dosage regimens. 相似文献
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目的:通过文献分析,探讨利多卡因发生过敏性休克的特点和规律。方法:检索《中国生物医学文献数据库》(1978~2013年7月)、《中国知网》(1994~2013年7月)和《万方医学网》(1994~2013年7月)有关利多卡因引起过敏性休克的文献资料,针对患者年龄、性别、给药途径、原患疾病、ADR发生时间、临床表现、处理措施、愈后情况、是否有过敏史等进行统计分析。结果:在既往有药物过敏史者中发生率更高;77.38%的患者在用药后5 min内发生过敏性休克。结论:提示临床医生在用药前应仔细询问患者药物过敏史,用药过程应加强观察,全程监护。 相似文献
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Jia-an SUN De-zhi KONG Ya-qin ZHEN Qing LI Wei ZHANG Jiang-hua ZHANG Zhi-wei YIN Lei-ming REN 《中国药理学报》2013,(12):1568-1574
Aim: (+)Doxazosin is a long-lasting inhibitor of a1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the stereoselective binding of doxazosin enantiomers to the plasma proteins of rats, dogs and humans in vitro. Methods: Human, dog and rat plasma were prepared. Equilibrium dialysis was used to determine the plasma protein binding of each enantiomer in vitro. Chiral HPLC with fluorescence detection was used to measure the drug concentrations on each side of the dialysis membrane bag. Results: Both the enantiomers were highly bound to the plasma proteins of rats, dogs and humans [(-)doxazosin: 89.4%-94.3%; (+)doxazosin: 90.9%-95.4%]. (+)Doxazosin exhibited significantly higher protein binding capacities than (-)doxazosin in all the three species, and the difference in the bound concentration (Cb) between the two enantiomers was enhanced as their concentrations were increased. Although the percentage of the plasma protein binding in the dog plasma was significantly lower than that in the human plasma at 400 and 800 ng/mL, the corrected percentage of plasma protein binding was dog〉human〉rat. Conclusion: (-)Doxazosin and (+)doxazosin show stereoselective plasma protein binding with a significant species difference among rats, dogs and humans. 相似文献