HIV/AIDS患者抗病毒治疗效果评估及基因型耐药分析

目的 对人类免疫缺陷病毒(HIV)携带者和艾滋病(AIDS)患者(简称HIV/AIDS患者)抗病毒治疗效果进行评估并分析其基因型耐药情况.方法 选取2018年6月至2020年6月无锡市第二人民医院收治的81例HIV/AIDS患者作为研究对象.对所有患者进行抗病毒治疗,测定CD4+T淋巴细胞计数与病毒载量,分析抗病毒失败...     

杭州市萧山区HIV/AIDS患者抗病毒治疗情况及影响因素

目的 探讨现阶段萧山区HIV/AIDS患者抗病毒治疗情况及影响因素.方法 采用回顾性研究的方法,将2004年1月-2017年12月在杭州市萧山区疾病预防控制中心登记的所有HIV/AIDS患者的报告卡和随访记录表资料进行筛选,对符合入选标准的数据采用x2检验分析人口学特征、艾滋病相关特征、高危行为、社会支持差异,并对患者...     

255例HIV/AIDS抗病毒治疗临床分析

目的了解本地抗病毒治疗的艾滋病病毒感染者或病人(HIV/AIDS)的临床特征及治疗效果。方法观察2008年1月至2018年12月底初次接受HAART随访观察的HIV/AIDS患者临床资料,回顾性分析抗病毒治疗及时性、可及性及治疗效果。结果共255名患者纳入研究,平均(40.63±12.71)岁,以(31~40)年龄组最多,占27.45%,已婚或同居的167例(65.49%),农村患者226例(88.63%),225例(88.24%)为异性性传播,220例患者基线CD4水平为(297.54±181.41)个/mm3,治疗6个月后上升至(418.42±203.54)个/mm3。从确诊到开始HAART的平均时间由22.05个月缩短到4.32个月;确诊1个月内即获得HAART的患者比例由14.29%上升至81.08%。结论抗病毒治疗后HIV/AIDS免疫重建效果明显。HAART的治疗时机不断提前,可及性不断提高,从确诊到获得治疗的时间逐渐缩短。     

心理干预在提高HIV感染者/AIDS患者中医药抗病毒治疗静脉采血依从性的应用体会

<正>艾滋病(AIDS)主要是通过性接触、血液和母婴传播。在我国艾滋病的发病存在地域性的特点,云南文山主要是静脉吸毒传播,由于吸毒人群同时伴有性乱行为,通过性传播感染者越来越多。艾滋病的致死性后果及患者在病程中所经受的各种压力,给艾滋病病毒感染者和艾滋病患者造成严重的心理负担,这对他们的生存质量及治疗效果造成了极大的影响。因此,对HIV感染者/AIDS患者的心理状况的研究就显得尤为重要。云南省文山州中医医院     

AIDS抗病毒治疗效果分析

菏泽市于2004年1月开始对符合治疗条件的艾滋病(AIDS)病人进行免费抗病毒治疗,截止2007年12月底共治疗88例.目前病人治疗情况平稳,疗效稳定.现将4年来抗病毒治疗效果总结如下.     

中医药对HIV/AIDS抗病毒治疗患者CD4+T淋巴细胞长期变化的影响

目的 探讨中医药治疗对HIV/AIDS患者接受抗病毒治疗后CD4⁺T淋巴细胞计数长期变化趋势的影响。方法 以“艾滋病综合防治数据信息系统”和“中医药治疗艾滋病数据库”为数据来源,回顾性收集2004年参与河南中医项目地区的HIV/AIDS患者的基线信息及随访年的CD4⁺T淋巴细胞计数。按是否参与中医项目分为中医治疗组和非中医治疗组,利用倾向性评分匹配法来控制组间差异,并观察两组患者CD4⁺T淋巴细胞计数的变化趋势。结果 本研究共纳入2 046例HIV/AIDS患者,其中中医治疗组973例,非中医治疗组1 073例,匹配后共得到723对病例,组间差异无统计学意义(P>0.05)。两组CD4⁺T淋巴细胞计数年变化趋势图显示,CD4⁺T淋巴细胞计数<200个/μL和200～350个/μL的HIV/AIDS患者在治疗初期CD4⁺T淋巴细胞计数显著升高,中医治疗组升高得更快。当CD4⁺T淋巴细胞计数达到350个/μL左右时,组间差异消...     

Meta分析结合病例报道进行艾滋病合并生殖器疱疹的耐药研究

生殖器疱疹(GH)已经跃升为全球第三大性传播疾病,艾滋病患者(本文为HIV-1阳性患者)合并GH感染率高达50%~90%。常规的阿昔洛韦类治疗GH在普通人群中的耐药率低于1%,在HIV-1(+)患者中明显升高达4.2%~7.1%。通过分析两个HIV患者中耐药GH的临床病例,给HIV合并耐药GH的诊疗提供参考,揭示HIV患者中发生耐药GH面临的挑战。     

492例艾滋病抗病毒治疗病人停药原因及影响因素分析

目的:探索艾滋病抗病毒治疗病人停药原因及影响因素,减少停药情况发生.方法:采用回顾性整群抽样研究方法,选取南阳市2002—2019年间接受艾滋病抗病毒治疗出现过停药情况的艾滋病病毒感染者作为研究对象,分析停药发生时间、原因、影响复治因素等.结果:共纳入492例病例,266例(54.07％)在开始治疗一年内停药,不同治疗...     

Behcet's disease with HIV infection: response to antiretroviral therapy

The differential diagnosis of oral ulcerations in a patient with AIDS/HIV infection is often challenging to the clinician. While old diseases have appeared in a new garb, many new ones are also being recognized. The association of Behetaet's disease and AIDS/HIV infection has been recently recognized. We present an HIV-positive patient having oro-genital aphthosis conforming to the diagnostic criteria for Behetaet's disease. Erythema nodosum, periphlebitis, erythematous papulopustular lesions, half and half nails, ocular congestion, raised ESR and dimorphic anemia were some other features present. He had low CD4+/CD8+ counts. He had no other HIV-related disease. He responded well to triple anti-retroviral treatment alone. The possible pathomechanism of the occurrence of both diseases is also discussed.     

Incidence of sexually transmitted diseases and HIV infection related to perceived HIV/AIDS threat since highly active antiretroviral therapy availability in men who have sex with men

OBJECTIVE: Concerns have been expressed regarding increase in risky sex because of the availability of antiretroviral treatments in Western countries. GOAL: The goal of this longitudinal study was to investigate the association between highly active antiretroviral therapy (HAART)- and postexposure prophylaxis-related beliefs and the incidence of sexually transmitted diseases (STDs) and new HIV infections in men who have sex with men (MSM). STUDY: Data on the incidence of STDs and new HIV infection, and the level of agreement with different HAART- and PEP-related beliefs from 151 HIV-negative MSM were compiled. RESULTS: Of all MSM, 65.6% tested negative for any STDs and 7 men HIV seroconverted. Perceiving less HIV/AIDS threat since HAART availability and younger age were significantly associated with a higher incidence of STDs. Perceiving less need for safe sex since HAART availability was significantly associated with an increased likelihood of HIV seroconversion. CONCLUSIONS: The results support the assumption that there is an association between the incidence of STDs and a decreased perception of HIV/AIDS threat resulting from HAART availability. Less perceived need for safe sex since HAART availability was associated with HIV seroconversion.     

Prophylactic antiretroviral therapy after sexual exposure to HIV: 93 cases

PATIENTS AND METHODS: We studied prospectively the feasibility of post exposure prophylaxis against HIV in 93 subjects consulting after sexual exposure at STD Center of Hopital Saint-Louis. Among the 93 subjects, 76 were men (45 homosexual) and 17 women. RESULTS: Delay to consultation was 38 h. Among sexual exposure 90 p. 100 were anal or vaginal intercourse and 10 p. 100 oral intercourse. Fifty percent were unprotected. Seventy-five percent of source subject HIV status was unknown, but controlled negative in 14 p. 100 of cases. Three subjects were infected initially. Seventy-two subjects were treated, with triple regimen, for 30 days without severe adverse event. Twenty-five percent were lost to follow up before the end of treatment, only 54 controlled their serology after the end of treatment (after 1 month: 70 p. 100, after 2 months: 51 p. 100 and after 4-6 months: 13 p. 100). DISCUSSION: This study underlines the difficulty in obtaining clinical and serological control after post exposure prophylaxis, even in a STD Department involved in prevention and counseling.     

高效抗反转录病毒治疗对艾滋病体液免疫及预后的影响

目的探讨高效抗反转录病毒治疗对艾滋病体液免疫及预后的影响。方法选择2015年1月至2016年9月长沙市第一医院诊治的100例艾滋病患者为研究对象,按照是否接受规律高效抗反转录病毒治疗将其分为观察组与对照组,每组50例患者。观察组患者接受规律高效抗反转录病毒治疗,使用药物为拉米夫定+齐多夫定+奈韦拉平,连续治疗12个月为1个疗程;对照组患者为依从性差,未规律服药者。结果干预后,观察组患者体液免疫相关指标中,IgG、IgA、sIgA和IgM水平均显著高于对照组患者(均P0.05);观察组患者出现的皮肤结核感染、念珠菌感染、间质性肺炎、隐孢子虫腹泻等比例均显著低于对照组患者(均P0.05)。结论针对艾滋病患者行高效抗反转录病毒治疗,可以显著提高机体体液免疫能力,减少机会感染发生率。     

高效抗逆转录病毒治疗艾滋病的毒副作用研究

目的:探讨高效抗逆转录病毒治疗艾滋病毒副作用,以期更好治疗该疾病。方法:选取2009年5月至2012年5月117例艾滋病患者为研究对象,对其不同的高效抗逆转录病毒治疗进行毒副作用比较。结果:共出现毒副作用患者43例,其中胃肠道反应21例,比率为48.84%,皮疹、骨髓抑制、脂肪重分布均为5例,比率均为11.63%,乳酸酸中毒2例,比率为4.65%,肝肾功能损害、神经系统损害、末梢神经炎均3例,比率为6.98%,胃肠道反应和其他毒副作用比较差异显著(P0.05)。结论:高效抗逆转录病毒治疗艾滋病早期有较多毒副作用,在临床上要加以监测。