重度妊娠高血压疾病合并HELLP综合征的治疗和预后分析

目的:分析妊娠高血压疾病患者合并溶血、肝酶升高及血小板减少综合征(HELLP综合征)的临床表现、诊治及预后.方法:回顾14例HELLP综合征的诊治和预后情况,并对8例1型和6例2型HELLP综合征的生化及临床指标进行对比研究.结果:HELLP综合征在重度妊娠高血压患者中的发病率为5.1%,死亡1例(7.1%),围产儿死亡4例(26.7%).主要并发症为DIC、胎盘早剥、急性肾功能衰竭、肺水肿、肝被膜下出血及视网膜脱离.1型HELLP综合征患者的乳酸脱氢酶(LDH)值为(697±164)U/L,显著高于2型患者的(401±127)U/L(P＜0.05).1型HELLP综合征患者的并发症发生率,以及围产儿的并发症率均显著高于2型患者(P＜0.05).结论:HELLP综合征是重度妊娠高血压的严重并发症,且1型HELLP综合征的临床病情较2型HELLP更加严重,只有及时诊治,适时终止妊娠,才能降低母婴死亡率.     

重度妊娠高血压疾病合并HELLP综合征的治疗和预后分析

目的 探讨重度妊娠高血压疾病合并HELLP综合征的治疗和母婴预后情况.方法 42例重度妊娠高血压疾病合并HELLP综合征患者,其中I级HELLP综合征患者24例(Ⅰ级组),Ⅱ级HELLP综合征患者18例(Ⅱ级组),对比两组的生化指标及母婴结局.结果 Ⅰ级组、Ⅱ级组患者ALT、AST含量比较差异无统计学意义(P＞0.05),Ⅰ级组患者LDH含量显著高于Ⅱ级组(P＜0.05).Ⅰ级组患者产妇并发症发生率和胎儿并发症发生率均高于Ⅱ级组患者(P＜0.05).结论 HELLP综合征是重度妊娠高血压疾病的严重并发症,Ⅰ级HELLP综合征的临床病情比Ⅱ级更为严重.及时诊治,适时终止妊娠,才能降低母婴死亡率.     

妊娠高血压综合征并发溶血、肝酶升高及血小板减少综合征16例分析

目的分析妊娠高血压综合征（妊高征）并发溶血、肝酶升高及血小板减少（HELLP）综合征的发病率、诊断、治疗及预防。方法对我院10年妊高征并发HELLP综合征16例患者的临床资料进行回顾性分析。结果HELLP综合征在重度妊高症患者中发病率为8．9％。参考美国Tennessee大学制定的诊断标准，完全性HELLP综合征9例，部分性7例。治疗方法为严密监护母婴情况下积极治疗妊高征，早期适用糖皮质激素，适时终止妊娠。主要并发症为弥散性血管内凝血、肝被膜下血肿、胎盘早剥和急性肾功能衰竭等。16例中死亡1例，围产儿死亡5例，死亡率分别为6．3％及31．3％。结论HELLP综合征是重度妊高征的一种严重威胁母婴安全的并发症，及早发现并应用糖皮质激素治疗，可降低母婴死亡率。     

妊娠合并HELLP综合征35例临床分析

目的探讨妊娠合并HELLP综合征的病因及处理。方法回顾性分析35例妊娠合并HELLP综合征患者的诊断、治疗。结果HELLP综合征在妊娠高血压疾病患者中发病率为2.77%,重度子痫前期患者中的发病率为17%。治疗方法为严密监护母婴情况,积极治疗妊娠高血压疾病,早期使用糖皮质激素,适时终止妊娠。结论早期诊断、及时处理是改善母婴预后最有效的方法。     

重度妊娠高血压综合征并发HELLP综合征28例临床分析

目的探讨与分析重度妊娠高血压综合征并发HELLP综合征的发病率、诊断、治疗及预后。方法对我院5年来重度妊娠高血压综合征并发HELLP综合征28例患者的临床资料进行回顾性分析。结果HELLP综合征在重度妊高征患者中的发病率为21.05%,参考美国Tennessee大学制定的诊断标准,完全性HELLP综合征7例,部分性HELLP综合征21例。治疗方法为严密监护母儿情况下积极治疗妊高征,早期使用糖皮质激素,尽快终止妊娠。主要并发症为DIC、胎盘旱剥、肺水肿和急性肾功能衰竭等。28例患者中死亡5例,围产儿死亡11例,死亡率分别为17.86%及39.29%。结论HELLP综合征是重度妊高征的一种严重威胁母儿安全的并发症,及早发现并应用糖皮质激素治疗,可以降低母儿死亡率。     

对50例重度妊娠高血压并发HELLP综合征患者进行治疗的方法及疗效分析

目的：探讨分析对重度妊娠高血压合并HELLP综合征患者进行治疗的方法,以及对母婴预后情况的影响。方法：选取2011年4月至2013年8月间我院收治的重度妊娠高血压合并HELLP综合征患者50例作为研究对象。其中,将患有I级HELLP综合征的患者分为I级组（30例）,将患有II级HELLP综合征的患者分为II级组（20例）,将两组患者的临床表现、生化指标及母婴预后情况进行分析和对比。结果：HELLP综合征是重度妊娠高血压患者最严重的并发症之一。本次研究结果显示,I级组患者的LDH含量、并发症的发生率、新生儿发生窒息和早产的几率均明显高于II级组患者（P<0.05）。由此可见,I级组患者的病情明显比II级组患者严重。结论：为重度妊娠高血压并发 HELLP 综合征患者,特别是患有I级 HELLP 综合征的患者及时进行诊断和治疗,并为其适时终止妊娠,可大大降低母婴的死亡率。     

5例重度妊高征并发HELLP综合征临床分析

目的:分析妊娠高血压综合征并发HELLP综合征的发病率、诊断治疗及预后。方法:回顾分析该院4年来妊高征并发HELLP综合征5例患者的资料。结果:5例患者中1例死亡,4例痊愈出院。新生儿存活4例,围产儿死亡1例。结论:HELLP综合征是重度妊高征的一种严重威胁母婴安全的并发症,对其及时诊断和处理、适时终止妊娠,可以改变妊娠结局,降低母儿死亡率。     

HELLP综合征24例临床分析

目的:探讨HELLP综合征的临床表现、诊断、治疗及预后。方法:对24例HELLP综合征患者的临床资料进行回顾性分析。结果:完全性HELLP综合征16例,部分性8例。治疗方法:严密监护母儿情况,积极治疗妊高征,选择性输注血制品,尽早使用糖皮质激素,适时终止妊娠。主要并发症为DIC、胎盘早剥、出血表现等。24例患者死亡1例,围产儿死亡2例,死亡率分别为4.17%及8%。结论:HELLP综合征是一种严重的产科并发症,应加强产前检查,早诊早治,适时终止妊娠,动态监测产后的临床表现和实验室指标,以期改善母儿预后。     

HELLP综合征31例临床分析

1982年,Weinstein[1]首先将妊娠高血压综合征(妊高征)患者伴有溶血、肝酶升高及血小板减少3大特征命名为HELLP综合征.HELLP综合征在重度妊高征患者中发病率较高,对母儿危害严重.国外资料表明,妊娠期高血压疾病中HELLP综合征发生率约占4%～16%[2].对HELLP综合征患者的及时诊断、正确处理,以及终止妊娠时机及方式的选择得当与否,均直接影响母婴预后.收集包头部分地区1996年至2006年收治的HELLP综合征患者31例,并将适时剖腹产作为其终止妊娠的主要手段,降低了围生期母儿死亡率,现将资料分析报道如下.     

妊娠期高血压疾病并发HELLP综合征17例临床分析

目的：探讨妊娠期高血压疾病并发溶血、肝酶升高及血小板减少综合征（HELLP综合征）诊断、治疗及预后。方法：对高血压并HELLP综合征17例患者临床资料进行回顾性分析。结果：HELLP综合征在妊娠期高血压疾病的发病率3.59%,17例中阴道分娩仅1例。剖宫产16例,剖宫产率94.11%,其中1例母体因肾功衰死亡,另1例母体术后并发多器官衰竭（MOST）死亡,余14例均存活,未发现明显后遗症。围产儿17例,胎死宫内2例,新生儿死亡2例。结论：早期诊断、综合性治疗、适时终止妊娠,可改善HELLP综合征患者的预后,降低母婴死亡率。终止妊娠方式首选剖宫产,终止妊娠时机为诊断后48小时,具体还应依病情的严重程度及孕周大小综合判断。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.