恶性胶质瘤与单发脑转移瘤的扩散加权成像鉴别诊断研究

目的:探讨扩散加权成像对恶性胶质瘤与单发脑转移瘤的鉴别作用。方法:回顾自2006年6月份以来,入我院治疗的确诊为恶性胶质瘤与单发脑转移瘤的患者,在不同的b值下应用扩散加权成像进行扫描,获取瘤体及瘤周和正常侧组织的信号值及ADC值,评价不同b值下,扩散加权成像对恶性胶质瘤与单发脑转移瘤的鉴别作用。结果:共纳入患者40例,其中恶性胶质瘤患者25例,单发脑转移瘤患者15例。通过对照发现,两组患者的瘤体区域信号值及瘤周ADC值差异有统计学意义（P＜0.05）。信号值差异最佳b值、截点分别为5 000s/mm2、226.4×10-3mm2/s,敏感性为86.7%,特异性为56%,阳性预测值为54.2%,阴性预测值为87.5%;ADC值差异最佳b值、截点分别为1 000s/mm2、1.40×10-3mm2/s,敏感性为100%,特异性为88%,阳性预测值为79%,阴性预测值为100%。结论:随着b值的改变,扩散加权成像对恶性胶质瘤与单发脑转移瘤的鉴别作用有所改变,以ADC最佳b值和截点为1 000s/mm2、1.40×10-3mm2/s时鉴别作用最佳,敏感性为100%,特异性为88%,阳性预测值为79%,阴性预测值为100%。     

DTI在高级别胶质瘤及转移瘤鉴别诊断中价值初探

 目的　初步研究DTI在高级别胶质瘤和转移瘤鉴别诊断中的作用。方法　对 8例高级别胶质瘤、6例转移瘤患者进行常规MRI及DTI检查 ,测量患侧感兴趣区ADC、FA值 ,部分求出与对侧相应部位兴趣区比值 ,行组间统计学分析。结果　两组间肿瘤实性部分、肿瘤囊性部分ADC值及瘤周水肿ADC比值、FA比值差异无显著性 ,水肿周围正常白质ADC及FA比值两组间差异有显著性。结论　水肿周围正常白质ADC、FA比值的测定有利于高级别胶质瘤与转移瘤的鉴别诊断 ,DTI较常规MRI可更好地观察肿瘤与脑白质的关系。     

磁共振扩散加权成像及ADC值测量对非小细胞肺癌肺门纵隔淋巴结的鉴别诊断价值

  目的  探讨磁共振扩散加权成像(DWI)以及表观扩散系数(ADC)值对非小细胞肺癌肺门纵隔淋巴结转移的鉴别诊断价值。  方法  收集45例南昌大学第二附属医院肿瘤科收治的经皮穿刺活检或纤维支气管镜检查病理确诊为非小细胞肺癌(NSCLC)的初治患者, 对其行术前常规胸部SE序列MRI平扫和纵隔DWI扫描(b值分别为600、800和1 000 s/mm2), 测量并记录不同b值时肺门纵隔淋巴结的ADC值, 以术后病理结果作为诊断的金标准, 分析非小细胞肺癌肺门纵隔淋巴结的DWI与ADC值特点。  结果  45例患者共送检淋巴结791枚, 其中在DWI上测得ADC值的淋巴结共计68枚, 包括32枚转移性淋巴结和36枚反应增生性淋巴结。最合适的b值为600 s/mm2, 在此条件下, 转移性淋巴结的平均ADC值为(1.73±0.24)×10-3mm2/s, 反应性增生淋巴结的平均ADC值为(2.67±0.16)×10-3mm2/s, 转移性淋巴结组平均ADC值明显小于反应性增生淋巴结组(P < 0.001)。转移性淋巴结不同病理类型间的平均ADC值差异无统计学意义(P > 0.05)。当以平均ADC值< 2.32×10-3mm2/s为阈值诊断非小细胞性肺癌肺门纵隔淋巴结有无转移时, 其准确度、敏感度、特异度、假阳性率、假阴性率、阳性预测值和阴性预测值分别为82%、71%、92%、31%、8%、76%和90%。  结论  DWI对NSCLC患者肺门纵隔淋巴结良恶性的鉴别具有较高的诊断价值, 是一种快速可行的影像学技术。      

MRI瘤周影像组学鉴别高级别胶质瘤与脑内单发转移瘤的应用价值

目的:探讨MRI瘤周影像组学鉴别高级别胶质瘤与脑内单发转移瘤的应用价值。方法:回顾性分析2015年1月至2020年6月经手术病理证实的39例高级别胶质瘤及28例脑内单发转移瘤的术前磁共振T2WI序列影像资料。使用3D-slicer软件手动分割获得瘤体的体积感兴趣区,并分别提取瘤周5 mm及10 mm的影像组学特征。使用最小值最大值归一化及最优特征筛选对影像组学特征进行降维,最后采用R语言软件建立Logistic回归模型,并使用K折交叉验证模型的稳定性。绘制受试者工作特征曲线(ROC)评估组学模型的诊断效能。结果:基于术前MRI瘤周5 mm的影像组学模型在鉴别高级别胶质瘤及脑内单发转移瘤中的敏感性、特异性及曲线下面积(AUC)分别是0.692、0.946和0.91;基于术前MRI瘤周10 mm影像组学模型在鉴别高级别胶质瘤及脑内单发转移瘤中的敏感性、特异性及AUC分别是0.872、0.893和0.93。采用K折交叉验证对模型的稳定性进行验证,瘤周5 mm及10 mm影像组学模型的平均AUC分别是0.80、0.75,提示模型具有较高的诊断效能。结论:MRI瘤周影像组学有助于术前鉴别高级别胶...     

常规MRI与1H-MRS结合鉴别高级别脑胶质瘤与单发性脑转移瘤

目的 探讨常规磁共振成像（MRI）与氢质子磁共振波谱（1H-MRS）相结合在高级别脑胶质瘤与单发性脑转移瘤中诊断及鉴别诊断的价值。方法 选取我院收治经手术病理组织学证实的高级别脑胶质瘤患者27例与单发性脑转移瘤患者21例,进行常规MRI及1H-MRS检查。分析比较常规MRI的影像表现特征及1H-MRS代谢产物［N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）］变化情况。结果 常规MRI显示仅病变部位和水肿程度在两者间存在差异（P＜0.05）。1H-MRS高级别脑胶质瘤与单发性脑转移瘤瘤体区Cho／NAA值比较差异有统计学意义（P＜0.05）,而NAA／Cr、Cho／Cr值比较差异无统计学意义（P＞0.05）;两者瘤周区Cho／Cr、Cho／NAA值比较差异均有统计学意义（P＜0.05）,而NAA／Cr值比较差异无统计学意义（P＞0.05）。结论 常规MRI与1H-MRS相结合使高级别脑胶质瘤与单发性脑转移瘤诊断及鉴别诊断的准确性得到进一步提高,具有较高的临床应用价值。     

3.0T MR扩散加权成像对肺实性良恶性病变的鉴别诊断效能及b值优化探讨

背景与目的磁共振扩散加权成像(diusion-weighted imaging,DWI)是唯一能在活体检测组织内水分子扩散运动的无创影像检查技术,能在宏观成像中反映活体组织中水分子的微观扩散运动。本研究旨在探讨3.0T磁共振成像(magnetic resonance imaging,MRI)DWI联合相控阵线圈和并行阵列采集空间敏感度编码技术(arrayspatial sensitivity encoding technique,ASSET)对肺实性良恶性病变的鉴别诊断效能,并优化最佳b值。方法经病理或临床随访证实的20例肺良性病变和96例肺恶性肿瘤(共120个病灶)在3.0TMR扫描仪上行T2加权像(T2 weighted imaging,T2WI)、T1加权像(T1 weighted imaging,T1WI)、脂肪抑制T2WI以及不同b值DWI(200s/mm2、500s/mm2、800s/mm2、1,000s/mm2)扫描,得到各b值的DWI图和表观扩散系数(apparent diusion coecient,ADC)图,分别测量各b值下病变的DWI信号强度、ADC值,比较各b值组的信噪比(signal-to-noise ratio,SNR)、对比噪声比(contrast-to-noise ratio,CNR)、ADC值,并绘制各b值的受试者操作特征曲线(receiver operating characteristic curve,ROC),得出ADC值对肺实性良恶性病变的鉴别诊断效能,优化DWI诊断肺部实性良恶性病变的最佳b值。结果不同b值组间SNR、CNR差异均有统计学意义(P<0.001,P=0.002)。肺良性和恶性病变组ADC值均随b值增加而逐渐变小,差异有统计学意义(P<0.001,P<0.001)。4组不同b值的ROC曲线下面积(areaundercurve,AUC)分别为0.831、0.876、0.813、0.785,均有诊断意义(AUC>0.5);b=500s/mm2时获得的ADC值的诊断效能最大,鉴别良恶性病变的最佳阈值为1.473×10-3mm2/s,敏感度和特异度分别为80%和84%。结论 3.0TMRDWI联合相控阵线圈和ASSET技术对肺实性良恶性病变的鉴别诊断有较高价值,b=500s/mm2时获得的ADC值诊断效能较高。     

磁共振弥散加权成像在脊柱转移瘤和脊柱感染性病变鉴别诊断中的应用

目的比较脊柱转移瘤和感染性病变的磁共振弥散加权成像(DWI)与表观扩散系数(ADC)值的不同特点,为二者鉴别诊断提供参考。方法选取30例脊柱转移瘤患者和24例脊柱感染患者为观察对象,分别为脊柱转移瘤组和脊柱感染组,2组患者均进行磁共振弥散加权成像检查。比较脊柱转移瘤病变和感染病变的磁共振弥散加权成像(DWI)、表观扩散系数(ADC)值以及对比噪声比(CNR)。结果 30例脊柱转移瘤组患者的弥散加权图像中,全部为高信号。24例脊柱感染疾病组患者的弥散加权图像中,18例患者为低信号,4例为等信号,2例患者为高信号。以DWI高信号作为脊柱转移瘤的诊断指标,诊断的敏感性为100.0%(30/30),特异性为91.67%(22/24),准确性为96.30%(52/54)。以DWI低信号作为脊柱感染病变的诊断指标,诊断的敏感性为75.05%(18/24),特异性为0.0%(0/30),准确性为33.33%(18/54)。脊柱转移瘤组患者病灶平均ADC值为(0.72±0.12)×10^-3mm^2/s,明显低于脊柱感染组患者的(1.43±0.14)×10^-3mm^2/s,比较差异有统计学意义(t=20.06,P<0.05)。脊柱转移瘤组患者病灶平均CNR值为(27.46±4.35),明显高于脊柱感染组患者的(13.58±3.14),差异有统计学意义(t=13.12,P<0.05)。结论脊柱转移瘤患者磁共振弥散加权成像以高信号为主,而感染性疾病以低信号为主,而且脊柱感染性疾病的ADC值明显高于脊柱转移瘤病变。磁共振弥散加权成像检查对于脊柱转移瘤和感染性疾病的鉴别诊断具有重要意义。     

影响初发幕上恶性脑胶质瘤瘤周水肿的相关因素分析

背景与目的：既往研究表明脑胶质瘤瘤周水肿的程度可作为脑胶质瘤的预后判断指标之一。因此研究PTBE的影响因素将有助于临床上制订更有针对性的防治PTBE的措施,以提高疗效．改善预后。但目前对PTBE的影响因素的相关研究不多,且结论存在诸多争议。本研究旨在从临床特点、MRI影像学和组织病理学角度研究幕上初发恶性胶质瘤伴发瘤周水肿（peritumoral brain edema, PTBE）的因素。方法：回顾性总结104例经手术病理证实的WHOⅡ-Ⅳ级幕上初发恶性脑胶质瘤患者的各种临床资料（包括年龄、性别、MRI影像学特征、病理学以及肿瘤相关标记物Ki-67、P53、MGMT的表达）,用统计学方法分析上述各因素与PTBE程度之间的相关性。FFBE量化评分标准：从MRI影像上测量水肿的最大直径分为3级：0级：无水肿;1级：水肿最大直径≤1cm;2级：水肿最大直径〉1cm。结果：104例巾共75例（72．1％）伴发PTBE,29例（27．9％）无水肿。单因素分析结果显示阳BE与年龄、病理级别、肿瘤增强程度、坏死程度以及Ki-67LI的表达相关（P〈0．05）,而与肿瘤直径、性别及P53、MGMT的表达无关（P〉0．05）：多因素分析结果显示FFBE与增强和坏死有关（P〈0．05）,两种独立凶素同时存在时,出现PTBE的累积概率达97％以上。结论：患者年龄、病理级别、MRI影像显示的肿瘤强化程度及坏死程度、肿瘤标记物KI-67LI的表达是影响幕上初发恶性胶质瘤PTBE的相关因素,其中MRI影像显示的肿瘤强化及坏死程度是独立影响因素．两者同时存在时伴发PTBE的累积概率达97％以上。     

磁共振扩散加权成像在肾细胞癌脑转移诊断中的应用

目的:探讨磁共振扩散加权成像（MRI DWI）在肾细胞癌（RCC）脑转移诊断中的应用价值。方法:采用回顾性研究方法分析2014年2月至2016年5月在我院诊治的140例RCC患者,所有患者都给予常规MRI T1WI与T2WI序列诊断,同时给予DWI序列的ADC值测定与诊断价值判定。结果:所有患者的MRI图像均显示清晰,病理确诊为RCC脑转移40例,RCC 100例。39例RCC脑转移患者的T2WI序列表现为高信号,36例T1WI序列表现为高信号;78例RCC患者的T2WI序列表现为高信号,72例T1WI序列表现为高信号,对比差异都有统计学意义（P＜0.05）。140例患者肾实质ADC值是（2.21±0.32）×10-3 mm2/s,同时,患者肾脏实性肿瘤ADC值是（1.54±0.37）×10-3 mm2/s,对比差异有统计学意义（t=4.298,P＜0.05）;RCC患者的ADC 值为（1.26±0.21）×10-3 mm2/s,RCC脑转移患者的ADC 值为（1.59±0.30）×10-3mm2/s,RCC脑转移的ADC 值明显高于RCC患者（P＜0.05）。将阈值设定为1.355×10-3 mm2/s,通过DWI对RCC患者的脑转移进行诊断,得出其特异性为92.1%,敏感性为85.0%。结论:在诊断RCC患者的脑转移时,ADC值和DWI可以提供重要依据,两者有很好的应用价值。     

脑转移瘤瘤周水肿相关分子生物学因素研究进展

脑转移瘤瘤周水肿指脑转移肿瘤周围脑实质内水分的异常增多,是影响患者生活质量和治疗疗效的关键因素之一,其发生机制复杂,影响因素众多。可能与血管内皮生长因子及其受体、水通道蛋白-4、金属基质蛋白酶-9、白细胞介素-6、乏氧诱导因子及其他分子生物学因素有关,上述分子生物学因素的深入研究可以为瘤周水肿的防治、监测、治疗及预后提供依据。瘤周水肿的治疗除传统的脱水治疗外,相关分子生物学因素的运用可以为其提供新的途径和方向,其中水通道蛋白-4激动剂或拮抗剂,血管内皮生长因子受体拮抗剂已逐步在临床中得到初步应用。本文就脑转移瘤瘤周水肿相关分子生物学因素进行综述。      

Relationships Between Choline Magnetic Resonance Spectroscopy,Apparent Diffusion Coefficient and Quantitative Histopathology in Human Glioma

This study sought to correlate quantitative presurgical proton magnetic resonance spectroscopic imaging (¹H- MRSI) and diffusion imaging (DI) results with quantitative histopathological features of resected glioma tissue. The primary hypotheses were (1) glioma choline signal correlates with cell density, (2) glioma apparent diffusion coefficient (ADC) correlates inversely with cell density, (3) glioma choline signal correlates with cell proliferative index. Eighteen adult glioma patients were preoperatively imaged with ¹H-MRSI and DI as part of clinically-indicated MRI evaluations. Cell density and proliferative index readings were made on surgical specimens obtained at surgery performed within 12 days of the radiologic scans. The resected tissue location was identified by comparing preoperative and postoperative MRI. The tumor to contralateral normalized choline signal ratio (nCho) and the ADC from resected tumor regions were measured from the preoperative imaging data. Counts of nuclei per high power field in 5–10 fields provided a quantitative measure of cell density. MIB-1 immunohistochemistry provided an index of the proportion of proliferating cells. There was a statistically significant inverse linear correlation between glioma ADC and cell density. There was also a statistically significant linear correlation between the glioma nCho and the cell density. The nCho measure did not significantly correlate with proliferative index. The results indicate that both ADC and spectroscopic choline measures are related to glioma cell density. Therefore they may prove useful for differentiating dense cellular neoplastic lesions from those that contain large proportions of acellular necrotic space.     

Two Different Methods of Region-of-Interest Placement for Differentiation of Benign and Malignant Breast Lesions by Apparent Diffusion Coefficient Value

Purpose: We aimed to investigate the influence of different methods of region-of-interest (ROI) placement onapparent diffusion coefficient (ADC) values in breast tumours and their accuracy in differentiating benign versusmalignant tumors in mass and nonmass lesions. Methods and Materials: In this prospective study, 79 patients with98 breast lesions, from 2015 until 2017, were investigated by 1.5-T breast MRI. Histopathology evaluation were donefor all malignant lesions and most of the benign ones. ADC values were measured in normal breast tissue and by twoways of ROI placement in the breast lesions (mass and non-mass): 1- ROI covering the whole lesion, 2- ROI in thehighest part (most restricted area) of the lesion in DWI images. The accuracy of these two approaches were compared.Results: The age range was 17-68 years with mean age 43.3 ± 9.9 years. 49% of the lesions were benign and 51% oftumors were malignant. Our results revealed that the measured ADC values in normal breast tissue were higher thanbreast lesions (P≤0.01). Appropriate cut off determination in non-mass was not valid by both methods, but in mass inthe first way was 1.45×10 -³mm²/s and in the most restricted part was 1.16×10-³ mm²/s. ADC values differed significantlybetween the two ways of ROI placement in mass lesions (P<.001). Most restricted part ADC showed the best diagnosticperformance in mass lesions with area under curve 0.88 versus 0.82. Conclusion: ROI placement has significant impacton the meseaured ADC values of breast lesions and ROIs in most restricted parts were more accurate than whole-lesionROIs. Cut-off values differed significantly based on the methods of measurement.     

ADC值测量在颅脑DWI高信号肿瘤诊断中的价值

目的:探讨ADC值测量对颅脑DWI高信号肿瘤的诊断价值.方法:对46例DWI高信号肿瘤分类,并测量其ADC值.结果:胶质瘤、转移瘤、脑膜瘤、淋巴瘤ADC值分别为(0.90±0.16)×10-3mm2/s、(0.75±0.21)×10-3mm2/s、(0.86±0.11)×10-3mm2/s、(0.91±0.16)×10-3mm2/s,各肿瘤之间的ADC值无显著性差异(P＞0.05),低级别胶质瘤与高级别胶质瘤之间ADC值有统计学差异(P＜0.05).结论:对DWI高信号肿瘤ADC值测量可以提供脑肿瘤的组织成分信息,ADC值可预测胶质瘤级别.     

AKT1 and AKT2 Promote Malignant Transformation in Human Brain Glioma LN229 Cells

OBJECTIVE To confirm the role played by AKT1 and AKT2 in the β-catenin/Tcf-4 signaling pathway in promoting malignant transformation of glioma cells. METHODS LN229 cells were divided into five groups:a control group, acetone(ACE)group, acetylsalicylic acid(ASA; aspirin)group,ASA+AKT1 plasmid group and ASA+AKT2 plasmid group. Western blot and PCR were used to detect the expression of AKT1 and AKT2 after dealing with ASA and transferring AKT1/2 genes into LN229 cells. Cell proliferation was determined by flow cytometry, cell invasion was evaluated by transwell assay and cell apoptosis was detected with annexin V staining. The molecules regulating proliferation and invasion were examined by western blot analysis.RESULTS Aspirin down-regulates AKT1 and AKT2 expression by modulating R-catenin/Tcf-4 activity.AKT1 and AKT2 can enhance cell proliferation and invasion by up-regulating the expression of cyclin-D and matrix metal loprotein-9(MMP-9)in LN229 glioma cells. CONCLUSION AKT1 and AKT2 play an important role in the β-catenin/Tcf-4 signaling pathway promoting malignant transformation; AKT1 is more effective than AKT2.AKT1 and AKT2 may be potential targets for brain glioma therapy and an effective way to prevent metastasis of gliomas.     

Diagnostic Significance of Apparent Diffusion Coefficient Values with Diffusion Weighted MRI in Breast Cancer: a Meta-Analysis

Aims: Apparent diffusion coefficient (ADC) values of nodes in diffusion-weighted imaging (DWI) are widelyused in differentiating metastatic from non-metastatic lymph nodes. The purpose of this meta-analysis was todemonstrate whether DWI could contribute to the precise diagnosis of breast cancer (BC) with and withoutlymph node metastasis (LNM). Materials and Methods: English and Chinese electronic databases were searchedfor relevant studies followed by a comprehensive literature search. Two reviewers independently assessed themethodological quality of the included trials based on the quality assessment of diagnostic accuracy studies(QUADAS). Summary odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated.Results: Final analysis of 624 BC subjects (patients with LNM = 254, patients without LNM = 370) wereincorporated into the current meta-analysis from 9 eligible cohort studies. Combined ORs of ADCs suggested thatADC values in BC patients without LNM were higher than in patients with LNM (OR=0.56, 95%CI: 0.11-1.01,p=0.015). Subgroup analysis stratified by country indicated a low ADC value in BC patients with LNM ratherthan those without LNM among Chinese (OR=1.27, 95%CI: 0.89-1.66, p<0.001), Italians (OR=0.75, 95%CI:0.13-1.38, p=0.018), and Egyptians (OR=1.27, 95%CI: 0.71-1.84, p<0.001). The findings of subgroup analysisby MRI machine type revealed that ADC values from diffusion MRI may be potential diagnostic indicatorsfor BC using Non-Philips 1.5T (OR=1.10, 95%CI: 0.84-1.36, p<0.001). Conclusions: The main findings of ourmeta-analysis demonstrated that increased signal intensity on DWI and decreased signals on ADC are helpfulin diagnosis of BC patients with or without LNM. DWI could therefore be an important imaging investigationin patients suspected of BC.     

磁共振弥散加权成像对脊柱转移瘤放疗疗效的评估

[目的]探讨磁共振弥散加权成像（DWI）对脊柱转移瘤放疗疗效的评估价值。[方法]收集30例脊柱转移瘤患者放疗前、后2个月的磁共振图像,所有患者均进行常规MRI及DWI序列。比较常规MRI序列与DWI序列对病灶的检出率。同时对照分析30例患者放疗前、后的DWI信号、ADC值。[结果]放疗前常规MRI扫描共发现病灶48个,累及42个椎体。DWI序列发现病灶56个,累及48个椎体。放疗结束后2个月复查MRI,SET1WI上脊柱转移瘤信号不变或略有下降。FSET2WI上20例信号轻度下降,10例不变。而在临床症状有改善的26例病例中,相对于放疗前,转移瘤DWI信号明显降低。在b=650s／mm2的DWI中,脊柱转移瘤放疗前表观扩散系数（ADC）值为（0．72±0．21）×10-3mm2／s,放疗后ADC值升高到（1．32±0．22）×10-3mm2／s;相邻正常椎体骨髓的ADC值较转移瘤低,且放疗前后没有变化。f结论]DWI序列既可以提高MRI对脊柱转移瘤的检出率,也可以用于监测和评估脊柱转移瘤的放疗疗效。     

全身扩散加权成像在恶性淋巴瘤诊断与疗效评估中的价值

Objective  

The aim was to evaluate the role of whole body diffusion weighted imaging (WB-DWI) of magnetic resonance in the diagnosis and efficacy evaluation of malignant lymphoma.     

Diffusion weighted MR imaging in the differential diagnosis of haemangiomas and metastases of the liver

Background

The purpose of the study was to evaluate the value of diffusion-weighted imaging in the differential diagnosis of haemangiomas from metastases of the liver.

Patients and methods.

We analyzed 69 lesions in 38 patients (33 haemangiomas; 36 metastases) in the retrospective study. Diffusion-weighted imaging was performed using a breath-hold single-shot echo-planar spin echo sequence with three b factors (0, 500 and 1000 sec/mm²), and apparent diffusion coefficients (ADCs) were calculated. For the quantitative evaluation, signal intensity of the lesions, lesion-to-liver signal intensity ratios, ADC of the lesions, and lesion-to-liver ADC ratios were compared between the groups. The statistical significance was determined by student’s-t test.

Results

With the b factor 500 sec/mm², no statistical significance was achieved (p>0.05). With the b factor of 1000 sec/mm², both the signal intensity and lesion-to-liver signal intensity ratio of the metastases were significantly higher than those for haemangiomas (p<0.001). The cut-off value at 2.6 yielded a sensitivity of 86% and a specificity of 82% for the lesion-to-liver signal intensity ratio. The ADC, and lesion-to-liver ADC ratio of the metastases were significantly lower than those of haemangiomas (p<0.001). With cut-off value of 1.7, ADC ratio had a sensitivity of 88% and a specificity of 72% for ADC lesion/liver.

Conclusions

Diffusion-weighted imaging with high b value may help in the differential diagnosis of metastases from haemangiomas of the liver.