共查询到20条相似文献,搜索用时 78 毫秒
1.
目的 观察慢性心力衰竭患者心脏再同步治疗(CRT)后有反应和无反应者之间左心室瘢痕负荷的差异性,评价左心室瘢痕负荷对CRT疗效的影响.方法 对30例2006年至2010年因慢性心力衰竭在南京医科大学第一附属医院接受CRT的患者进行静息核素心肌显像检查,应用相位分析技术检测左心室瘢痕负荷、收缩期相位时间标准差( phase S D)和带宽(BW)并用来评价心脏同步性.以术后6个月超声心动图的检测结果及随访6个月内是否因心力衰竭住院作为分组标准,左心室射血分数(LVEF)提高≥0.05且无因心力衰竭住院的患者入选反应组,LVEF提高<0.05或者入院1次以上的患者入选无反应组,观察两组之间左心室瘢痕负荷和同步性指标之间的差异.结果 30例患者中反应组19例(男8例),无反应组11例(男8例).两组之间术前临床资料相似,年龄、性别均差异无统计学意义;有反应组术前QRS时限显著大于无反应组[(163.0±7.7)ms对(134.6±11.8) ms,P<0.05];两组术前LVEF差异无统计学意义,但术后有反应组显著高于无反应组(0.49±0.02对0.33±0.15,P<0.01).两组患者左心室瘢痕负荷和CRT术后左心室同步性差异具有统计学意义,有反应组患者的左心室瘢痕负荷明显低于无反应组(24.6%±3.6%对36.5%±3.9%,P=0.022);有反应组左心室同步性较好,收缩期相位时间标准差明显小于无反应组(28.1°±4.4°对56.1°±6.9°,P<0.01),收缩期带宽明显小于无反应组(88.0°±13.9°对170.1°±24.4°,P<0.01).左心室瘢痕负荷和心脏同步性对CRT疗效具有明显的影响.结论 接受CRT的慢性心力衰竭患者,左心室瘢痕负荷和CRT术后心脏同步性与CRT疗效密切相关. 相似文献
2.
目的 应用组织多普勒研究心脏再同步化治疗(CRT)术后A-V、V-V间期优化对心脏同步性能及心功能的影响,探索A-V、V-V间期优化在增强CRT临床疗效中的作用.方法 32例慢性心力衰竭患者接受CRT治疗,于术后7天、3个月、6个月进行A-V、V-V间期优化,观察心脏同步性和心功能变化.采用彩色超声诊断仪进行图像采集及下线分析.结果 经观察,术后7天、3个月、6个月的A-V间期需行优化的例数分别为28例、10例、6例,V-V间期需行优化的例数分别为29例、6例、5例.与CRT术前相比:CRT治疗术后未优化时的左室12节段组织速度达峰时间标准差明显改善[(68.8±26.4)ms与(41.6±23.1)ms,P<0.01],左室射血分数增加[(28±4)%与(31±3)%,P<0.05],主动脉瓣前向血流速度时间积分增加[(13.6±3.1)cm与(15.5±4.3)cm,P<0.05],舒张早期跨二尖瓣血流峰速和舒张早期心肌组织运动峰速的比值下降(13.1±5.3与9.3±4.3,P<0.05),左室舒张充盈时间延长[(313.2±93.6)ms与(368.6±97.1)ms,P<0.05].与术后未优化时相比:术后7天优化心脏同步性指标进一步改善(P<0.05),心功能指标无明显改变;术后3个月、6个月优化与术后7天优化相比,心脏同步性指标无明显改变,P>0.05;术后6个月优化的左室射血分数增加,左室舒张充盈时间延长,P<0.01.结论 CRT术后7天,A-V、V-V间期优化治疗改善心脏同步指标;术后6个月优化进一步改善心功能. 相似文献
3.
心脏再同步治疗后心室电重构和室性心律失常与左心室逆重构关系探讨 总被引:1,自引:1,他引:0
目的 探讨慢性心力衰竭患者心脏再同步治疗(CRT)后心室电重构和室性心律失常与左心室逆重构的关系.方法 入选因心力衰竭于我院行CRT的患者,随访术后即刻与术后6个月体表心电图与超声心动图,记录术后6个月期间窒性心律失常发作次数.根据术后6个月左心室收缩末容积缩小比例( ΔLVESV)≥15%与否分为有效组与无效组,对比组间QRS时限变化(ΔQRSd)和室性心律失常事件,对左心室逆重构程度与ΔQRSd和室性心律失常事件进行相关性分析,寻找CRT治疗后室性心律失常的预测因素.结果 共入选43例患者,有效组29例,无效组14例,组间基线资料与术后应用药物等差异无统计学意义.全部患者CRT后6个月QRSd无变化(P=0.50),有效组QRSd明显缩短(P<0.01),无效组无变化(P=0.08).组间ΔQRSd差异有统计学意义(P=0.02).全部患者CRT后ΔLVESV与△QRSd呈正相关(r=0.523,P<0.01).CRT 6个月内室性早搏(PVCs)与室性早搏连发(PVCruns)次数分析显示,log(PVCs)与log(PVC runs)在组间差异有统计学意义(P<0.01),log (PVCs)和log.(PVC runs)均与ΔLVESV呈正相关(P<0.01).多元回归分析显示,ΔLVESV是log (PVCs)的独立预测因素(β=2.36,P<0.01),ΔLVESV和男性是log( PVC runs)的独立预测因素(β=2.88,P<0.01;β=-0.74,P=0.03).结论 CRT后左心室逆重构与电重构及室性心律失常发生减少相关.左心室逆重构程度及性别对CRT患者术后室性心律失常事件有预测意义. 相似文献
4.
目的观察心脏再同步化治疗(CRT)的疗效和红细胞分布宽度(RDW)与CRT反应性的关系。方法回顾性分析2007年10月至2016年3月在兰州大学第一医院心脏中心住院的患者45例,依据CRT术后是否有反应分为两组:有反应组(n=27)和无反应组(n=18)。对比分析患者术前及术后6个月随访时的临床资料,采用多因素logistic回归分析CRT反应性的相关因素。结果 CRT治疗后有反应者27例,有反应率为60%。CRT术后两组患者心功能分级间差异具有统计学意义(P0.05)。与治疗前相比,有反应组患者CRT术后的心功能分级、左室射血分数(LVEF)、左室舒张末期内径(LNEDD)、左室舒张末容积(LVEDV)、QRS波群时限(QRSd)、6 min步行距离(6MWD)和明尼苏达生活质量问卷(MLHFQ)均得到显著改善,而无反应组患者CRT术后只有LVEF、LVEDV和QRSd得到显著改善,差异均具有统计学意义(P0.05);组间比较结果显示,CRT术后有反应组患者的心功能分级和LVEF与无反应组差异具有统计学意义(P0.05)。术前心功能分级、QRS≥150 ms、△QRSd、RDW水平和植入心脏再同步化治疗除颤器是CRT后反应性的独立相关因素(P0.05)。结论评估心功能分级、QRS波群和RDW水平是CRT前的重要内容,这对CRT术后的反应性有重要意义。 相似文献
5.
目的 心脏再同步治疗(CRT)能明显改善患者临床症状,逆转心肌重构,称之为CRT超反应.本文主要分析CRT术后,患者超反应的预测因子.方法 采用回顾性研究,2005年1月至2010年6月共有124例随访资料完整的CRT或心脏再同步治疗除颤器(CRT-D)纳入分析,分为超反应组及其他反应组.并在CRT术后第6个月随访时,进行临床评估及超声心动图评价.心功能(NYHA分级)提高≥1级,左心室射血分数(LVEF) ≥0.45或增加2倍以上称为超反应.结果 两组患者在基线状态除QRS时限[(160.2±36.1)ms对(139.6±32.5)ms,P=0.01],完全左束支阻滞比例(95%对82%,P=0.02)、心力衰竭症状出现时间[(21.0±14.6)个月对(36.0±25.3)个月,P=0.02]差异有统计学意义外,其余参数在基线状态差异无统计学意义;有17%的患者出现超反应.6个月随访时超反应组与其他反应组在心功能分级、脑钠肽(BNP)、QRS时限、LVEF及因心力衰竭住院率方面有明显改善.结论 完全左柬支阻滞及心力衰竭症状出现较短的患者CRT反应较好. 相似文献
6.
目的 评价心脏再同步化治疗(CRT)对慢性心力衰竭患者的临床和超声心动图疗效,总结CRT无效的原因.方法 研究施行CRT的患者53例,男37例,女16例,年龄41~82岁.患者术前均采用血流多普勒和组织多普勒的方法进行收缩不同步的评价,术前和术后6个月进行美国纽约心脏病学会(NYHA)心功能分级评价、心电图和超声心动图检查.临床有效者定义为术后6个月NYHA心功能分级改善1级以上的患者.超声心动图有效者定义为术后6个月左室收缩末容积缩小>15%或左室射血分数绝对值增加>5%的患者.结果 CRT术后6个月时,7例患者死亡,46例患者存活.其中NYHA心功能分级至少改善1级者40例,临床有效率为75.5%;超声心动图有效者37例(69.8%).术后6个月:左心室缩小;左室射血分数由(27.4±6.7)%增加到(40.4±10.0)%,P<0.01;左心房内径缩小;二尖瓣反流减少;肺动脉收缩压由(49.6±13.6)mm Hg(1 mm Hg=0.133 kPa)降低为(38.7±14.5)mm Hg.窦性心律组(42例)的超声有效率显著高于心房颤动组(11例).在窦性心律患者中,与CRT无效组(10例)相比,有效组(32例)起搏前的QRS较宽(P<0.05),肺动脉收缩压较低(P<0.05),左室射血前时间较长(P<0.05);起搏前两组间腔室大小、LVEF、二尖瓣反流面积和组织多普勒的各个收缩不同步参数的差异无统计学意义.结论 CRT能改善心力衰竭患者的左室收缩功能和左室重构,减少二尖瓣反流,降低肺动脉收缩压.窦性心律组的CRT疗效优于心房颤动组.在非缺血性心肌病和左束支传导阻滞患者占多数的研究中,QRS宽度、左室射血前时间和肺动脉收缩压可能预测CRT的疗效. 相似文献
7.
《临床心血管病杂志》2017,(1)
目的:分析我院行心脏再同步化治疗(CRT)前后心力衰竭(心衰)患者血清半乳糖凝集素3(Gal-3)、脑钠肽(BNP)水平变化及其对近期预后的影响。方法:对本院50例心衰患者的随访资料进行分析,随访时间12个月,根据患者是否接受CRT治疗分为CRT组及对照组,采用酶联免疫法(ELISA)检测治疗前及治疗后1、3、6、12个月血清Gal-3和BNP水平,并行超声心动图检查,评估心脏功能。结果:随访至12个月,CRT组和对照组Gal-3水平无明显变化,两组BNP水平均显著下降,且CRT组显著低于对照组(P0.05);CRT组左室舒张末容积(LVEDV)、左室收缩末容积(LVESV)均减小(P0.05),左室射血分数(LVEF)明显升高(P0.05);CRT组患者心衰再入院率显著低于对照组(分别为20%、52%,P=0.019),发生心脏不良事件再入院者基础Gal-3和BNP水平更高。结论:血清Gal-3在心衰患者治疗前后无明显变化,基础Gal-3和BNP水平高者近期预后较差。 相似文献
8.
《中西医结合心脑血管病杂志》2019,(16)
目的探讨不同病因慢性心力衰竭病人实施心脏再同步化治疗(CRT)的临床疗效。方法根据心力衰竭病因,将76例实施CRT手术的慢性心力衰竭病人分为缺血性心肌病组(36例)和非缺血性心肌病组(40例),所有病人实施CRT手术后均进行3个月随访,比较两组临床疗效、心功能指标、心脏彩超指标和死亡率。结果 CRT术后3个月,非缺血性心肌病组临床总有效率高于缺血性心肌病组,差异有统计学意义(77.50%与66.67%,P0.05)。CRT术后3个月,两组B型利钠肽(BNP)水平均较手术前降低(P0.05),6 min步行距离均较手术前增加(P0.05),且术后3个月,非缺血性心肌病组BNP水平和6 min步行距离优于缺血性心肌病组(P0.05)。CRT术后3个月,两组左心室射血分数(LVEF)均较手术前增高(P0.05),左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心房容积(LAV)均较手术前降低(P0.05);且非缺血性心肌病组LVEF高于缺血性心肌病组(P0.05),LVEDD、LVESD和LAV均低于缺血性心肌病组(P0.05)。结论对不同病因慢性心力衰竭病人实施CRT均可取得一定的临床疗效,改善心功能,且非缺血性心肌病病人疗效及心功能改善更明显。 相似文献
9.
目的:以心室收缩不同步作为心脏再同步化治疗的筛选标准,观察心脏再同步化(cardiac resynchronization therapy,CRT)治疗慢性心力衰竭(CHF)的临床疗效。方法:26例CHF患者经过严格的超声筛选后行CRT,全部患者均经冠状静脉窦植入左心室电极,电极位置尽量与超声提示的左心室收缩最延迟部位一致,术后随访(13.8±10.4)个月。结果:2例患者随访中死亡,其余24例患者治疗后心功能、患者活动度、心率变异性均明显改善(P0.05),左心室舒张末内径从(77.0±9.4)mm缩小至(68.7±10.2)mm(P0.05),左心室内各室壁收缩期达峰时间标准差从(48.4±17.9)ms减少至(30.2±18.6)ms(P0.05)。术后1个月左心室16,12及6节段达最小容积点时间的标准差和最大时间差均有明显减低(P0.05)。结论:CRT是CHF治疗的有效方法,术前应用常规超声心动图及组织多普勒成像技术(TDI)等多项技术来评价患者心室运动的失同步是CRT的有效筛选手段。 相似文献
10.
目的探讨心脏再同步化治疗(CRT)在扩张型心肌病(DCM)与缺血性心肌病(ICM患者治疗中的作用,评价CRT治疗后DCM与ICM患者心电图及心功能变化。方法选取鹤壁市人民医院心血管内科于2013年9月至2016年9月符合心脏再同步化治疗标准并成功植入CRT的慢性心衰患者80例,包括43例DCM患者和37例ICM患者,分别在术前3 d、术后12个月行NYHA心功能分级评价,并在治疗前后评价患者6 min步行距离、QRS宽度、左室射血分数(LVEF)、左心室舒张末期容积(LVEDV),同时运用酶联免疫法(ELISA)检测患者的BNP,比较两组患者治疗前后心功能相关指标的变化。结果 DCM组患者CRT应答率高于ICM组患者(81.40%vs. 49.70%,P=0.003),CRT应答者术后12个月的NYHA心功能分级、6 min步行距离、BNP、QRS宽度、LVEF、LVEDV及较术前有明显改善(P0.05),与ICM组相比,DCM组CRT应答者LVEF增高较为显著[9.2(0.8,17.6) vs. 5.2(2.5,12.7),P=0.023],DCM组LVEDV减少更为显著[30.4(20.8,81.6)vs. 17.2(31.4,65.8),P=0.014],差异有统计学意义(P0.05)。结论 CRT是心力衰竭治疗的有效方法,并且对扩张型心肌病治疗效果更佳。 相似文献
11.
The immunoneuroendocrine role of melatonin 总被引:19,自引:0,他引:19
Georges J. M. Maestroni 《Journal of pineal research》1993,14(1):1-10
Abstract: A tight, physiological link between the pineal gland and the immune system is emerging from a series of experimental studies. This link might reflect the evolutionary connection between self-recognition and reproduction. Pinealectomy or other experimental methods which inhibit melatonin synthesis and secretion induce a state of immunodepression which is counteracted by melatonin. In general, melatonin seems to have an immunoenhancing effect that is particularly apparent in immunodepressive states. The negative effect of acute stress or immunosuppressive pharmacological treatments on various immune parameters are counteracted by melatonin. It seems important to note that one of the main targets of melatonin is the thymus, i.e., the central organ of the immune system. The clinical use of melatonin as an immunotherapeutic agent seems promising in primary and secondary immunodeficiencies as well as in cancer immunotherapy. The immunoenhancing action of melatonin seems to be mediated by T-helper cell-derived opioid peptides as well as by lymphokines and, perhaps, by pituitary hormones. Melatonin-induced-immuno-opioids (MHO) and lymphokines imply the presence of specific binding sites or melatonin receptors on cells of the immune system. On the other hand, lymphokines such as -γ-interferon and interleukin-2 as well as thymic hormones can modulate the synthesis of melatonin in the pineal gland. The pineal gland might thus be viewed as the crux of a sophisticated immunoneuroendocrine network which functions as an unconscious, diffuse sensory organ. 相似文献
12.
13.
Changes in connexin43, the gap junction protein of astrocytes, during development of the rat pineal gland 总被引:2,自引:0,他引:2
Abstract: The abundance of gap junctions between rat pineal astrocytes formed by connexin43 (Cx43) was studied during development. Levels and distribution of Cx43 were measured by immunoblotting and indirect immunofluorescence, respectively. The amount of Cx43 in cells located within the gland was low until about the 7th postnatal day and increased to adult values between the 14th and 21st days postpartum. Although astrocytes, recognized by their vimentin immunoreactivity, were scarce before birth, they were abundant by the 7th postnatal day suggesting that the low levels of Cx43 found at this age corresponded to a low expression of this protein. Localization of the immunoreactivity to Cx43 and vimentin showed a close correlation, indicating that mature or immature pineal astrocytes form gap junctions made of Cx43. Since Cx43 levels attained their adult values at about the time the innervation and the functional state of the gland reached maturity (2–3 weeks after birth), it is proposed that astrocyte gap junctions are involved in the function of the adult rat pineal gland. 相似文献
14.
Martinez-Cecilia D Arjona-Sanchez A Gomez-Alvarez M Torres-Tordera E Luque-Molina A Valenti-Azcarate V Briceno-Delgado J Padillo FJ Lopez-Cillero P Rufian-Pena S 《World journal of gastroenterology : WJG》2008,14(12):1949-1951
Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. 相似文献
15.
Abstract: Herein we documented the response of pineal melatonin production to electrolytes known to be effective on pineal function in view of a possible circadian stage dependence. We studied the release of melatonin by perifused rat pineal glands at 2 different circadian stages corresponding to the middle of the light and dark periods, i.e., respectively, 7 and 19 HALO (Hours After Light Onset, L:D = 12:12). The initial efflux rates were, as expected, much higher in the perifusates of glands removed from rats sacrificed during the dark phase than of those removed during the light phase. After 3 hr of perifusion, melatonin release reached similar levels which were found constant up to the 8th hr of perifusion, whatever the circadian stage. Perifusion of the glands with physiological concentrations for the rat of calcium (5.2 mmol/1) and magnesium (1.34 mmol/1) resulted in a stimulatory effect on the pineal glands removed from rats sacrificed in the middle of the dark period (19 HALO), whereas no effects were observed on the pineal glands removed from rats sacrificed during the light (7 HALO). Lithium (0.28 and 0.55 mmol/1) was ineffective on melatonin release in pineal glands removed 7 and 19 HALO. Our results show differences in the initial efflux rates of melatonin and in the response of perifused pineal glands to calcium and magnesium according to the circadian stage. 相似文献
16.
17.
H.P.J.M. Noteborn P.P. van Balen A.A. van der Gugten I.C. Hart I. Ebels C.A. Salemink 《Journal of pineal research》1993,14(1):11-22
Abstract: The use of antisera raised against bovine growth hormone (GH) and ovine prolactin (PRL) enabled the detection of related immunoreactive (ir) sequences of proteins in ovine pineal tissue. The isolation of PRL-like ir-material was accomplished using a 0.25 M ammonium sulphate (pH 5.5) extraction followed by ethanol precipitation, whereas the resulting 2.0 M ammonium sulphate (pH 7.0) precipitate contained a GH-like immunoreactivity. Gel chromatography of the GH-like immunoreactivity (Sephadex G-100) indicated the presence of several GH-like fragments ranging in the Mr range of 7,000 to 55,000. Analyses of the PRL-like ir-material found in pineal tissue on HPLC using a TSK 545-DEAE column led to the resolution into a single peak of immunoreactivity. A single peak of activity was also observed following chromatofocusing and hydrophobic interaction chromatography of the ir-peak from the TSK 545-DEAE column. The PRL-like ir-material inhibited the binding of [125I]ovine PRL-S14 to anti-ovine PRL antibodies without showing an affinity for binding to anti-rat PRL or anti-bovine GH antibodies. Scatchard analysis of the binding of pineal PRL-like ir-material and pituitary ovine PRL-S14 to liver membranes from day-20 pregnant rats revealed similar affinity constants (Ka of 4.7 ± 0.2 × 109 M-1). In addition, the replication of Nb 2 Node rat lymphoma cells was stimulated by pineal PRL-like ir-material, an effect known to be specific for lactogenic hormones. The pineal PRL-like immunoreactivity appeared on sodium dodecyl sulfate polyacrylamide gels as a single major band of Mr 24,000. The functional status of PRL-and GH-like ir-material in the ovine pineal remains to be determined, but evidence is presented that the overall protein synthesis rate of the rat pineal responded to circulating concentrations of PRL. 相似文献
18.
19.
20.
Gary S. Goldberg B.A. Bruce A. Orkin M.D. Lee E. Smith M.D. 《Diseases of the colon and rectum》1994,37(5):439-443
PURPOSE: Individuals who are seropositive for the human immunodeficiency virus are at high risk for opportunistic infection and anorectal disorders. Little prospective information is available regarding anorectal pathogens in these patients. METHODS: One hundred sixty-three HIV-seropositive patients presented to the colorectal clinic between 1989 and 1992. Forty-seven (29 percent) patients were thought to have an infectious process and were prospectively studied using a standardized multiculture protocol. RESULTS: Mean age was 33 (range, 19–59) years. All were male; high-risk behavior accounted for 87 percent of HIV transmissions. Presenting complaints included anorectal pain (79 percent), pus per anum (28 percent), and blood per anum (26 percent). Examination revealed perianal tenderness (60 percent), condyloma (38 percent), perianal ulcers (38 percent), and anal fissures (34 percent). Sixty-six sets of cultures were performed; 28 patients had one set, 15 had two sets, and 4 had three sets. Thirty-two of these 47 patients (68 percent) had positive cultures including herpes (50 percent), cytomegalovirus (25 percent),Neisseria gonorrhoeae
(16 percent), chlamydia (16 percent), acidfast bacilli (2 percent), and others (9 percent). Six of 32 patients with positive cultures had more than one organism cultured. Sixteen (50 percent) patients with positive cultures were treated medically, 8 (25 percent) were treated surgically and 8 (25 percent) were treated with both modalities. Sixty-one procedures were performed on 17 patients for condylomata. Eighteen patients had 20 procedures for abscesses, 50 percent of whom had positive cultures for other than common bowel flora; all improved. Fourteen patients underwent 33 procedures for perianal fistulas.Mycobacterium fortuitum
was cultured from one patient who required 13 procedures for abscesses and fistulas. Forty-five (96 percent) patients were followed for an average of 12.5 months ±2.9 SEM (range, 1–94 months). Symptoms were improved or resolved in 22 of 32 (69 percent) patients with positive cultures and in 11 of 13 (84 percent) with negative cultures. CONCLUSIONS: Specific pathogens may often be identified in human immunodeficiency virus-seropositive patients with anorectal disorders if aggressively sought. Although patients without specific pathogens identified may be expected to improve with planned empiric treatment, positive identification allows more directed therapy. 相似文献