Effects of Alcoholism and Instructional Conditions on Speed/Accuracy Tradeoffs

The speed and accuracy of neuropsychological performance in alcoholics and nonalcoholics were assessed for each item within a four-test computerized battery. Subjects were randomly assigned to one of three instructional conditions: Speed-emphasis instructions, Accuracy-emphasis instructions, or Typical instructions emphasizing speed and accuracy equally. Across conditions, alcoholics were less accurate and took longer to perform than controls. Examining speed and accuracy components separately within each condition, as predicted, the greatest differences in accuracy scores between alcoholics and controls appeared in the Speed-emphasis condition, while the greatest group differences in speed scores appeared in the Accuracy-emphasis condition. The results indicate that the relationships between speed and accuracy are dissimilar between alcoholics and controls; alcoholics exhibit speed/accuracy tradeoffs in that they are unable to adjust performance to meet speed or accuracy demand without suffering substantial compromise in the other aspect of performance. These results have implications for future studies concerning methodological approaches to speed and accuracy assessment and provide support for an information-processing deficit associated with chronic alcohol abuse.     

Overt Behavior Problems and Serotonergic Function in Middle Childhood Among Male and Female Offspring of Alcoholic Fathers

A large body of literature indicates that the serotonergic system is involved in behavioral regulation, as evidenced by the inverse relationship between impulsive aggression and serotonergic function found in adult alcoholics and nonalcoholics. However, studies of this relationship among child and adolescent offspring of alcoholics (COAs) have not previously been done. This study examines the potentially parallel relationship between behavioral dysregulation and low serotonergic function in young COAs. The relationship is of potential interest as a phenotypic marker of biological vulnerability to aggressiveness, which itself has been hypothesized to be a risk factor for later antisocial alcoholism. The present work is part of an ongoing prospective study of the development of risk for alcohol abuse/dependence and other problematic outcomes in a sample of families subtyped by the fathers' alcoholism classification. We examined the relationship between overt behavior problems in middle childhood (mean age = 10.5 ± 1.7 years) and whole blood serotonin (5-HT) in a subsample of the offspring ( N = 32 boys and 12 girls). Using a Child Behavior Checklist (CBCL) index of behavioral under-control, we obtained results indicating that high total behavior problem (TBP) children had lower levels of whole blood 5-HT than did low-TBP children ( p < 0.01). These results support the hypothesis that there is an inverse relationship between whole blood serotonin levels and behavior problems in young male and female COAs. A father's alcoholism status was not significantly related to his child's 5-HT level, i.e., the child's phenotypic expression of behavioral dysregulation was more reliably connected to serotonergic function than was paternal alcoholism.     

The Role of Relationship Intimacy in Consistent Condom Use Among Female Sex Workers and Their Regular Paying Partners in the Dominican Republic

Prior research has demonstrated an important link between relationship intimacy and condom use. Limited research has been conducted on this connection within the realm of female sex work. We examined the association between perceived relationship intimacy and consistent condom use among 258 female sex workers and 278 male regular paying partners who participated in a cross-sectional survey in the Dominican Republic. In multivariate analysis, higher intimacy among sex workers and regular paying partners was negatively associated with consistent condom use. Among those reporting higher perceived intimacy, male participants were more than twice as likely to report consistent condom use as female participants. Female sex workers in relationships of higher perceived intimacy are at greater risk of HIV/AIDS than their male regular paying partners. Gender-sensitive HIV prevention programs are needed to address the differential influence of relationship intimacy on condom use in the context of sex work.     

The Significance of Family History Status in Relation to Neuropsychological Test Performance and Cerebral Glucose Metabolism Studied with Positron Emission Tomography in Older Alcoholic Patients

Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [¹⁸F]fluorodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients were divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.     

Characteristics of Individuals and Couples Seeking HIV-1 Prevention Services in Dar Es Salaam, Tanzania: The Voluntary HIV-1 Counseling and Testing Efficacy Study

The objective of this paper is to describe the baseline characteristics, risk behavior, and HIV prevalence of individuals and couples who enrolled in the Voluntary HIV Counseling and Testing Efficacy Study at the study site in Dar es Salaam, Tanzania. Participants were recruited through flyers, radio, and outreach to schools and workplaces to participate in a randomized clinical trial testing the effectiveness of HIV voluntary counseling and testing (HIV VCT) for prevention of new HIV and STD infections. Recruitment was stratified to include men and women enrolling alone and as couples. Baseline data were collected in face-to-face interviews, then participants were randomized to receive HIV VCT or health information. A total of 1,427 participants were recruited, 708 women and 719 men; 444 participants enrolled as part of a couple. HIV seroprevalence for those who received VCT at baseline was 21% overall (12% men, 30% women). Those enrolled as couples reported less sexual risk behavior than those enrolled as individuals. Both couples and individuals reported high rates of unprotected sexual intercourse with commercial partners. Overall 45% of participants self-reported an STD symptom (54% of women and 36% of men), and men were more likely to have received treatment for their symptoms. A large number of individuals and couples responded to advertisements for VCT in Dar es Salaam, Tanzania. High rates of HIV seroprevalence and couple serodiscordance, self-reported STD symptoms, and sexual risk behavior indicate that at-risk participants were recruited. Implications for delivery of HIV VCT and related services are discussed.