妇炎消泡腾栓的制备及应用

目的:制定妇炎消泡腾栓的制备工艺及质量标准,并观察其临床疗效。方法:用薄层色谱法对妇炎消泡腾栓的主药进行鉴别;对150例各类阴道炎患者进行疗效观察,并与复方甲硝唑栓治疗的150例患者进行比较。结果:质控方法可靠;妇炎消泡腾栓临床疗效好,总有效率达96.7%,与复方甲硝唑栓治疗组比较,差异有统计学意义。结论:该制剂制备工艺可行,质量可控,疗效显著,应用前景良好。     

复方莪术油治疗宫颈人乳头状瘤病毒感染102例疗效观察

目的:观察复方莪术油栓治疗宫颈人乳头状瘤病毒感染的疗效。方法:选取宫颈人乳头状瘤病毒感染患者102例,依据治疗方法不同分为治疗组和对照组各51例,对照组甲硝唑泡腾片进行治疗,观察组复方莪术油栓进行治疗,比较两组临床疗效。结果:治疗后观察组总有效率98.04%高于对照组78.43%,差异有统计学意义(P<0.05)。结论:复方莪术油栓治疗宫颈人乳头状瘤病毒感染的效果优于甲硝唑泡腾片治疗效果。     

复方甲硝唑阴道栓应用于阴道炎治疗的效果研究

目的：分析复方甲硝唑阴道栓应用于阴道炎治疗的临床效果。方法：选取该院2014年1月至2015年1月期间收治的100例阴道炎患者的临床资料,将其随机分为对照组和观察组,每组50例。对照组采用常规消炎药物进行治疗,观察组应用复方甲硝唑阴道栓进行治疗。比较两组患者的治疗效果。结果：观察组治疗总有效率为98.00％,对照组治疗总有效率为84.00％,差异具有统计学意义（P＜0.05）。结论：复方甲硝唑阴道栓治疗阴道炎的效果显著,且用药安全,值得临床推广与应用。     

复方甲硝唑阴道栓治疗阴道炎的疗效分析

目的:剖析阴道炎用复方甲硝唑阴道栓的疗效.方法:回顾性剖析2016年1月至12月间该科接收的104例阴道炎患者的临床病历资料,并按治疗方式将所选病例分成实验与对照两组(n=52).实验组子以复方甲硝唑阴道栓治疗,对照组予以甲硝唑治疗.观察两组用药期间不良反应的发生情况,比较临床疗效.结果:实验组不良反应发生率为3.85％,对照组为13.46％.实验组明显低于对照组(P＜0.05).实验组疗效总有:对阴道炎病患采取复方甲硝唑阴道栓疗法,用药安全可靠,临床疗效显著,值得借鉴.     

复方芙蓉泡腾栓并碳酸氢钠片治疗外阴阴道假丝酵母菌病临床观察

目的 探讨治疗外阴阴道假丝酵母菌病并减少其复发的有效途径.方法 外阴阴道假丝酵母菌病人140例,随机分为观察组80例,对照组60例,观察组采用2-4%碳酸氢钠液坐浴后配合复方芙蓉泡腾栓及碳酸氢钠片阴道放置治疗,对照组采用单纯复方芙蓉泡腾栓阴道放置治疗,两组连续用药6天为一疗程.结果 观察组疗效及远期随访的复发率与对照组比效差异有显著性.结论 复方芙蓉泡腾栓并碳酸氢钠片阴道放置治疗外阴阴道假丝酵母菌病疗效好,值得临床上推广应用.     

中西药物结合妇炎贴治疗慢性盆腔炎疗效观察

[目的]观察应用抗生素、康妇消炎栓和妇炎贴综合治疗慢性盆腔炎的临床疗效。[方法]将150例慢性盆腔炎患者随机分为三组：A组50例应用抗生素联合康妇消炎栓直肠给药；B组50例应用抗生素联合妇炎贴外贴下腹部；C组50例应用抗生素联合康妇消炎栓、妇炎贴综合治疗。治疗均以7d为1个疗程，休息10d后再进行下一个疗程，观察2个疗程后判定疗效。[结果]A组总显效率78％，B组总显效率86％，C组总显效率98％，C组疗效明显优于其他两组（P〈0．01）。[结论]抗生素联合康妇消炎栓和妇炎贴综合治疗慢性盆腔炎疗效显著。     

甲硝唑泡腾颗粒剂的制备与临床观察

甲硝唑泡腾颗粒剂的制备与临床观察丁召兴，吕瑞琴，姜秀清，杨淑莲（附属医院药剂科妇产科２５６６０３）甲硝唑是治疗阴道滴虫引起妇科病的有效药物。作者采用泡腾成份将其制成泡腾颗粒剂用于患者，临床观察１０８例，总有效率１００％。１药物组成及制备方法１．１药物...     

复方甲硝唑阴道栓治疗阴道炎65例临床观察

目的：观察复方甲硝唑阴道栓治疗阴道炎的临床疗效。方法选取我科收治的阴道炎患者120例,随机分为观察组65例和对照组55例。观察组使用复方甲硝唑阴道栓治疗,对照组选用达克宁栓联合制霉菌素治疗,治疗过程中观察2组不良反应和症状体征变化。7 d为1个疗程,2个疗程后观察2组临床疗效,并观察2组治疗第4周和第6周的复发情况。结果观察组治疗总有效率95.4%,对照组治疗总有效率78.2%,观察组总有效率明显高于对照组,差异具有统计学意义（P〈0.05）;治疗后第4周和第6周观察组的复发率明显低于对照组,差异具有统计学意义（P〈0.05）。结论复方甲硝唑阴道栓治疗阴道炎的临床疗效明显,值得推广使用。     

复方甲硝唑阴道栓治疗阴道炎疾病的临床观察

目的 观察和分析复方甲硝唑阴道栓治疗阴道炎疾病的临床效果.方法 选取阴道炎的患者108例,将其随机分为对照组和观察组,各54例.对照组予以制霉素口服治疗;观察组予以复方甲硝唑栓阴道给药治疗,比较两组用药效果.结果 观察组治愈36例、好转15例、无效3例,总有效率为94.5%,疗效明显优于对照组74.1%;随访3个月,观察组复发3例(复发率5.6%),明显少于对照组11例(复发率20.3%).两组总有效率和复发率比较,差异均具有统计学意义(P<0.05).结论 复方甲硝唑阴道栓治疗阴道炎疾病的临床效果较佳,应当在临床实践中进行进一步加大应用与推广.     

复方甲硝唑阴道栓治疗阴道炎患者的效果体会

目的研究阴道炎应用复方甲硝唑阴道栓的临床疗效。方法 2016年4月至2018年5月本科接诊的阴道炎患者92例,采用随机数表法进行分组:研究组和对照组各有46例。研究组实行复方甲硝唑阴道栓治疗,对照组实行常规药物治疗。分析两组的疗效,并作比较。结果研究组的临床总有效率为100.0%,比对照组的86.96%高,组间差异显著(P0.05)。结论通过对阴道炎患者施以复方甲硝唑阴道栓治疗,可显著提升其病情控制的效果,改善预后,建议采纳。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.