共查询到20条相似文献,搜索用时 15 毫秒
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M. A. Quinn M. Jalland R. Wein M. Kloss 《The Australian & New Zealand journal of obstetrics & gynaecology》1981,21(2):93-95
Summary: Tylose gel containing either 10 mg prostaglandin F2α or sterile water was inserted into the posterior vaginal fornix of 130 patients either 12 hours or 4 hours before suction curettage. No benefit in terms of cervical softening or blood loss was noted in patients who received the prostaglandin gel. 相似文献
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Andrew Korda Rodney P. Shearman Ian D. Smith 《The Australian & New Zealand journal of obstetrics & gynaecology》1972,12(3):166-169
Summary: Fourteen pregnancies between the 12th and 19th weeks of gestation were terminated by intra-uterine administration of prostaglandin F2α . In 7 patients the method of administration was transcervically into the extra-ovular space; in the other 7, administration was directly into the amniotic sac. The methods of administration, the doses used, the side effects and results are discussed. The findings indicate that intra-amniotic administration is the procedure of choice: firstly, because of the incidence of genital tract infection after transcervical administration; secondly, because 3 patients in the transcervical group had incomplete abortions and required anaesthesia for curettage; and finally, the induction-abortion interval was significantly less when the drug was administered into the uterine cavity. 相似文献
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Arnold Gillespie C. D. Matthews O. Petrucco 《The Australian & New Zealand journal of obstetrics & gynaecology》1974,14(2):95-98
Summary: Ninety-eight patients were given prostaglandin F2α for the induction of mid-trimester abortion. In 42 the PGF2α was administered by the extra-amniotic route and 37 aborted. A further 56 received the PGF2α intra-amniotically and 55 aborted. Dose regimens are compared. 相似文献
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Alastair H. MacLennan Roslyn C. Green 《The Australian & New Zealand journal of obstetrics & gynaecology》1980,20(2):87-90
Summary: The effect on labour of 50 mg intravaginal PG F2α or a standard intravenous oxytocin regimen was compared in 2 randomised trials involving a total of 83 patients, 23 of whom had experienced spontaneous rupture of the membranes (S.R.O.M.) and 60 of whom had artificial rupture of the membranes (A.R.M.) to induce labour. In each trial, labour had not been initiated by membrane rupture alone. In both trials only 20% of the patients receiving PG F2α required further augmentation of labour with intravenous oxytocin. The mean length of labour in patients receiving PG F2α was 2.5 hours shorter in the A.R.M. trial and 3.0 hours shorter in the S.R.O.M. trial than the mean length of labour in patients receiving intravenous oxytocin (P < 0.01). In the A.R.M. trial, the PG F2α -treated group had significantly less analgesic requirements (P < 0.001). Although more normal deliveries occurred in the patients treated with PG F2α than oxytocin in both trials, die numbers did not reach statistical significance.
No side effects occurred in the PG F2α -treated patients or their babies and this method was much preferred by patients and nursing staff alike. 相似文献
No side effects occurred in the PG F
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Alastair H. MaeLennan Roslyn C. Green 《The Australian & New Zealand journal of obstetrics & gynaecology》1980,20(2):80-83
Summary: A randomised double-blind trial involving 90 patients was set up to compare the efficacy of 25 mg PG F2α , 50 mg PG F2α and a placebo on cervical ripening when given in a vaginal tylose gel on the evening before surgical induction of labour. Preliminary stretching of the cervix and sweeping of the fetal membranes was not undertaken. In the 30 control patients, labour was not initiated and the mean improvement in the cervical score before surgical induction the next morning was 0.86. In the group of 30 patients receiving 25 mg PG F2α , labour commenced during the night in 9 patients and the mean improvement in the cervical score was 3.76 (P < 0.0005); the corresponding figures for the 30 patients receiving 50 mg of PG F2α were 10 patients coming into labour and cervical score improvement of 4.63 (P < 0.0005). he difference in the mean improvement of the cervical score between the 2 prostaglandin groups was not significant. Significantly fewer prostaglandin-treated patients needed augmentation during labour with intravenous oxytocin (P < 0.025) and there was a significant increase in the spontaneous delivery rate in the combined prostaglandin-treated group (P < 0.025). There was no statistical difference in the outcome of labour between the 2 prostaglandin groups. It was not possible to predict the patients whose cervices would not respond to PG F2α pretreatment (15%) or those in whom labour would be initiated (30%). No side effects were experienced. 相似文献
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O. YLIKORKALA Associate Professor H. PAATERO Registrar L. SUHONEN Senior Resident L. VIINIKKA Senior Lecturer 《BJOG : an international journal of obstetrics and gynaecology》1986,93(9):950-954
Summary. To study the role of the antiaggregatory and vasodilatory prostacyclin (PGI2 ) during human delivery, serial urine samples collected from 13 women delivered vaginally and from eight delivered abdominally were assayed for 6-keto-prostaglandin F1α (6-keto-PGF1α a breakdown product of PGI2 ) by high-performance-liquid-chromatography and radioimmunoassay. In women delivered vaginally the mean urinary 6-keto-PGF1α concentration was 41.9 (SE 8.3) ng/mmol creatinine, before the onset of labour and increased progressively to a maximum of 186.5 (SE 47.6) ng/mmol creatinine 2 h after delivery irrespective of the use of oxytocin and epidural analgesia. In women delivered by caesarean section under epidural anaesthesia, the urinary 6-keto-PGF1α rose from 33.4 (SE 4.2) ng/mmol creatinine to 2153 (SE 314) ng/mmol creatinine 2 h after section. In both groups the increased levels had fallen by 24 h postpartum to levels below those found before delivery. In neonatal urine 6-keto-PGF1α concentrations were some 12–30 times higher than those in postpartum urine. Thus, vaginal and abdominal delivery is accompanied by significant increases in maternal PGI2 release, perhaps in the myometrium and/or intrauterine tissues. This may be of significance in the regulation of fetoplacental blood flow and in the prevention of intra- and postpartum thrombosis. 相似文献
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A. G. AHMED A. KLOPPER 《BJOG : an international journal of obstetrics and gynaecology》1983,90(4):312-316
Summary. The Schwangerschaftsprotein 1 (SP1 ,)α values in blood measured by rocket immunoelectrophoresis are affected by the addition of anticoagulants. When compared with values in serum, those in heparin plasma were much higher, while those in sequestrene ethylenediaminetetra acetic acid), sodium citrate and fluoride oxalate were lower. On the other hand, SP1 and SP1 β concentrations were not significantly affected in heparin or sequestrene and were only slightly depressed in sodium citrate and flouride oxalate. The effect of heparin on SP1 α in serum was dosedependent. We surmise that SP1 α forms a complex with heparin and that it may be involved in the coagulation system in pregnancy. 相似文献
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M. A. LUMSDEN Research Fellow R. W. KELLY Biochemist D. T. BAIRD Professor 《BJOG : an international journal of obstetrics and gynaecology》1983,90(12):1135-1140
Summary. Menstrual fluid was collected in a contraceptive diaphragm from 16 women with primary dysmenorrhoea and 12 matched control subjects without dysmenorrhoea. Prostaglandins F2α (PGF2α ), E2 (PGE2 ) and 6-oxo-prostaglandin F1α (6-oxo-PGFlα ) were extracted and measured using gas-chromatography: mass spectrometry (GC:MS). The concentrations of both PGF2α and PGE2 were higher on days 1 and 2 in the dysmenorrhoea group than in the control group and the concentration of PGF2α was higher on day 1 than on day 2 in the dysmenorrhoea group. The concentrations of 6-oxo-PGF1α (the stable metabolite of PGI2 ) were low in both groups. These results confirm suggestions that PGF2α is important in the aetiology of dysmenorrhoea and also indicate that PGE2 may be involved. 相似文献
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S. S. Ratnam K. S. Khew Christopher Chen T. C. Lim 《The Australian & New Zealand journal of obstetrics & gynaecology》1974,14(1):26-30
Summary: In a randomised study of 207 patients, labour was induced with oral prostaglandin E2 in 107 and intravenous oxytocin (Syntocinon) in the remainder, half in each group with medication alone, the other half with fore-water amniotomy as well. Prostaglandin and oxytocin were found to be more effective when preceded by amniotomy. Once labour was established, the time taken to achieve vaginal delivery was the same with either drug, as also the number of successful vaginal deliveries. There were 6 failed inductions, but no statistical significance in the percentage differences between PGE2 and oxytocin could be found. The two perinatal deaths which occurred could not be attributed to either drug. Oral PGE2 is therefore as effective as intravenous oxytocin with no observed hypertonus and little side-effects. 相似文献
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L. Lo MRCOG M.W. Ho MBBS P. Leung FRCOG 《The Australian & New Zealand journal of obstetrics & gynaecology》1994,34(2):149-153
Summary: Prostaglandins have been increasingly used in obstetrical practice for cervical ripening and induction of labour. We set out to investigate the effectiveness of prostaglandin E2 (PGE2 ) vaginal pessaries in inducing labour in the Chinese population in Hong Kong. In the period August, 1991 to August, 1992, we recruited 206 pregnant Chinese women who required induction of labour for various obstetrical indications into the trial. The study group had induction of labour by PGE2 vaginal pessaries and the control group underwent amniotomy plus oxytocin infusion. These patients were alternately assigned either method of induction. They were further divided into primiparous and multiparous (parity 1 and 2 only) groups.
Only 101 primiparas and 99 multiparas were available in the final analysis of the trial. Various aspects of labour, delivery, maternal and fetal outcome were compared. For primiparas, the traditional combined induction was the preferred method. For multiparas, both induction methods were quite satisfactory and there was a trend toward lesser blood loss and pethidine requirement in the PGE2 users. 相似文献
Only 101 primiparas and 99 multiparas were available in the final analysis of the trial. Various aspects of labour, delivery, maternal and fetal outcome were compared. For primiparas, the traditional combined induction was the preferred method. For multiparas, both induction methods were quite satisfactory and there was a trend toward lesser blood loss and pethidine requirement in the PGE
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K. K. Yeung J. C. K. Pang 《The Australian & New Zealand journal of obstetrics & gynaecology》1977,17(1):32-35
Summary: Oral prostaglandins E2 and F2a were used to augment amniotomy in the induction of labour in 173 patients. The success rate was significantly higher with prostaglandin E2 than with prostaglandin F2a (89% and 75%, respectively). This was achieved despite a significantly lower incidence of gastrointestinal side effects. No serious maternal or fetal complications occurred with either drug. It is concluded that oral prostaglandin E2 is more efficient than oral prostaglandin F2a in the induction of labour. 相似文献
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