单侧线状型汗孔角化症1例

单侧线状型汗孔角化症１例范志，钱兴财（南京医学院附一院皮肤科，２１００２９）１９９８年Ｍｉｋｈａｉｌ等｀［１］将汗孔角化症分为六型：经典斑块型；浅表播散型，单侧线状型，播散性浅表性光线性汗孔角化症；显著角化过度型，增生性炎症型。另有经典斑块型和浅表播...     

汗孔角化症的研究新进展

汗孔角化症是一种少见的慢性皮肤病，以中央轻度萎缩边缘堤状角质嵴围绕的皮损为特征，最近我们首次定位了弥漫性浅表性光化性汗孔角化症基因。本文就汗孔角化症的分型、临床表现、组织病理学、病因和治疗等作简要综述。     

增生性炎症型汗孔角化症1例

增生性炎症型汗孔角化症１例李铁男，刘岩沈阳市第七人民医院皮肤科（邮政编码１１０００３）增生性炎症型汗孔角化症是汗孔角化症中的一种少见类型，现将作者所见１例报告如下。患者男，５８岁。１０年前于臀部起数个绿豆大小淡褐色丘疹，不痒。以后皮疹渐大、增多，躯干...     

汗孔角化症的分子遗传学研究进展

汗孔角化症是一组少见的角化异常性单基因遗传性皮肤病。近年来国内外的研究较多，并取得了不少进展。现就近几年来关于汗孔角化症的遗传学研究进展作一综述。     

偏侧性汗孔角化症1例

报告1例偏侧性汗孔角化症。患者男，49岁，自出生后于左膝关节伸侧出现多个环状褐色斑，逐渐扩大，渐波及左侧躯体，部分皮损为线条状角化性斑块，伴瘙痒。无家族史。皮肤组织病理检查结果符合汗孔角化症。     

溃疡性全身性汗孔角化症

汗孔角化症(Mibelli氏病)是一种罕见的常染色体显性遗传性角化性皮肤病,发生于初生儿、儿童或少年。男性发病是女性的2倍。另有一型为播散性浅在光化性汗孔角化症,好发于年龄较大的人及暴露部位,为Chernosky等所报告。此病尚有如下异型如角化过度疣状型、增殖型、Freund氏播散性掌蹠小点状、Mibelli氏带状和Mibelli氏线状等型汗孔角化症。本文报告一例以前未见报告过的溃疡性全身性汗孔角化症患者。     

播散性浅表光线性汗孔角化症一例及其家系报告

汗孔角化症（PK）属常染色体显性遗传，是一组少见的慢性进行性角化性皮肤病，病理上以表皮角化不全柱为特征；临床上以边缘堤状疣状隆起、中央轻度萎缩为特征。现报告1例播散性浅表光线型汗孔角化症患者及其家系调查。     

汗孔角化症1例

汗孔角化疵是一种少见的遗传角化性皮肤病，临床上以边缘环堤状隆起、中央凹陷性皮损为特征，组织病理表现打特征性的角化不全柱。本文报道1例可能是线型和斑块型共存的汗孔角化症患者.     

汗孔角化症的研究新进展

汗孔角化症是一种少见的慢性皮肤病 ,以中央轻度萎缩边缘堤状角质嵴围绕的皮损为特征 ,最近我们首次定位了弥漫性浅表性光化性汗孔角化症基因。本文就汗孔角化症的分型、临床表现、组织病理学、病因和治疗等作简要综述     

浅表性播散性汗孔角化症一家系4代11例

浅表性播散性汗孔角化症是一种光见的遗传性角化性皮肤病。近期我们遇到一家系4代11例本症患者，现报道如下。     

前列腺癌组织中血管生成拟态形成的分子通路研究进展

血管生成拟态(vasculogenic mimicry,VM)是近年来发现的一种肿瘤血液供应的新方式,随着研究的深入,正受到越来越多的关注。前列腺癌组织中亦发现有VM的存在,其形成可能与通路HIF-1α→VEGFα→Eph A2→MMPs→Laminin5γ2→VM有关。本文综述了近几年国内外对该通路中相关因子的研究进展,为下一步前列腺癌VM的基础研究提供思路。     

Decrease in eosinophils infiltrating into the skin of patients with dipeptidyl peptidase‐4 inhibitor‐related bullous pemphigoid

Bullous pemphigoid (BP) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as BP180 or BP230 are produced. Dipeptidyl peptidase (DPP)‐4 inhibitors have become commonly used to treat diabetes. As DPP‐4 inhibitors are more commonly prescribed for diabetes, BP related to DPP‐4 inhibitors has been reported and has attracted attention. Therefore, we retrospectively investigated patients who were diagnosed with BP in order to examine characteristics of DPP‐4 inhibitor‐related BP (nine patients; median age, 85 years) in comparison with non‐DPP‐4 inhibitor‐related BP (21; median age, 85 years). There was no significant difference in Bullous Pemphigoid Disease Area Index between DPP‐4 inhibitor‐related BP patients and non‐DPP‐4 inhibitor‐related BP patients, except for erosions/blisters score in mucosa. Laboratory tests revealed no significant differences between DPP‐4 inhibitor‐related BP patients and non‐DPP‐4 inhibitor‐related BP patients in total white blood cell count, eosinophil count, neutrophil count and the titer of anti‐BP180 antibody. The number of eosinophils infiltrating into the skin was significantly lower in patients with DPP4 inhibitor‐related BP than in patients with non‐DPP4 inhibitor‐related BP. Our results showed that DPP‐4 inhibitor‐related BP has some distinct pathological characteristics from BP not associated with DPP‐4 inhibitor.     

Contact dermatitis

In recent years, there has been a dramatic rise in our understanding of contact dermatitis. This paper is a review of our knowledge of the mechanisms involved in contact dermatitis and related phenomena, the investigation of these events and the emergence of significant new allergens during the last 5 years.     

糖尿病相关皮肤病易感基因的研究进展

皮肤病变是糖尿病常见的并发症,其病因机制尚不清楚,近期研究发现部分与糖尿病相关的皮肤病变（如：银屑病、白癜风、黑棘皮病等）与糖尿病具有相同的易感基因,本文总结了最近5年此类皮肤病与糖尿病相关易感基因的研究进展。     

Dermatophyte Infection of the Penis

ABSTRACT: Penile involvement was seen in 19.5% of 261 patients, aged 11 to 30 years, with tinea cruris. It was more common in patients under the age of (20 years (p < 0.05). The increased incidence is probably related to the use of langota. a semiocclusive undergarment that may favor the growth of dermatophytes.     

中国大陆免疫抑制剂相关型Kaposi肉瘤(1995—2020年)回顾性分析

 目的:了解中国大陆地区近25年免疫抑制剂相关型Kaposi肉瘤的临床特征和诊治现状。方法:通过中国知网、万方、维普和Pubmed检索1995—2020年中国大陆地区免疫抑制剂相关型Kaposi肉瘤相关文献,进行数据分析和总结。结果:共纳入文献40篇,共计42例患者。患者平均年龄47.4岁;男女患病比例3.67 ∶1;多发生在肾移植术后使用一种或多种免疫抑制剂/糖皮质激素;于用药后2～3个月或1～2年发病。较多累及全身皮肤,其中下肢多见,也可累及内脏器官或淋巴结。治疗以减少或停用或更换免疫抑制剂/糖皮质激素为主,必要时可联合其他治疗方案。结论:在临床上长期使用免疫抑制剂或激素后应警惕Kaposi肉瘤的发生,减少或停用或更换免疫抑制剂/糖皮质激素后多预后良好。     

调Q激光祛纹身的回顾性研究

目的 对我院近十年激光祛纹身治疗的疗效进行回顾性研究.方法将这些病例根据纹刺时间长短分类,分为≥10年的纹身和＜10年的纹身,并比较了纹身的特点,激光祛除纹身的疗效.结果激光祛纹身的疗效与纹身的颜色、染料成分、纹刺的深浅等因素有关,≥10年1次激光祛纹身术后有效率与＜10年有效率两者比较,差异均有统计学意义(P＜0.05);≥10年和＜10年激光治疗4次后有效率比较,差异也均有统计学意义(P＜0.05);≥10年和＜10年激光治疗色素沉着副反应发生率比较,差异也均有统计学意义(P＜0.05).结论现在的纹身虽然越来越美观,但激光祛除的难度增大,治疗次数增多.     

Cutaneous amyloidosis: a concept review

Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.     

AGE AND GENDER DIFFERENCES IN THE IMPACT OF PSORIASIS ON QUALITY OF LIFE

Background. The impact of psoriasis upon the quality of life contributes significantly to the overall morbidity associated with the disease. An older age at onset of psoriasis and being a man have been associated previously with lower psychosocial morbidity. In order to further evaluate these potentially important mitigating factors, we examined the relation of age and gender on some aspects of psoriasis-related psychosocial morbidity. Methods. Two hundred and fifteen consenting psoriasis patients, representing a wide range of disease severity, were studied. They included 110 men and 105 women, age range 19–87 years (age: mean ± SD: 48·0 ± 15·9 years); all endorsed a list of 30 items (by checking a “Yes” or “No”) pertaining to life events related to psoriasis that they had experienced in the previous one month. The patients self-rated the severity of their psoriasis. The patients were categorized into four age groups of 18–29 years (N = 28), 30–45 years (N = 77), 46–65 years (N = 76), and > 65 years (N = 34), respectively, for the statistical analyses. Results. No age or gender differences in the severity of psoriasis were observed. Patients of both sexes in the 18 to 29 and 30 to 45 year age groups reported more frequent (P 0·05) problems related to both appearance/socialization and occupation/finances, in contrast to patients in the 46–65 and over-65-year age groups. No gender differences (P 0·05) were observed in the frequency of items related to appearance and socialization; however, men reported greater work-related stresses. Conclusion. Psoriasis has a greater impact upon the quality of life of patients in the 18 to 45 year age range and affects the socialization of both sexes equally. Men face greater work-related stresses as a result of their psoriasis.     

进入性(性交)疼痛控制研究

目的:探讨女性学相关体系的形成,促进其为临床实践服务。方法:利用近20年来的临床经验以及相关的药学、药理学、药效学研究,借鉴世界上有关性与神经与大脑机制的最新研究成果,引入医学伦理学、循证医学、流行病学的理念、方法,进行梳理、综合、调适。结果:传统医学(疾病医学)与性医学在"病"的判定上存在差异,两者分别以"生存"与"生存质量"为标准;进入性疼痛不能愉悦并不影响生存,因而不为传统医学正视,这是大量患者无处求医的根源;按传统医学模式对进入性疼痛治疗,难以进行实验室检验,并少有阳性发现,因而治疗也难有针对性。利用循证医学理念、方法,容易达到预期目的。进入性疼痛的病理确实存在生理因素,如由较强的痛感可引起神经超敏反应;由神经递质产生负情绪可导致内分泌系统抑制;阴道黏膜的高拉伸性需要在高敏感的状态下修复等;因此,要加强相应的临床治疗学研究。结论:对进入性疼痛控制的系统研究,将有利于丰富女性学内容,促进其在临床上的应用与发展。