吲哒帕胺与苯那普利联用治疗高血压心功能不全

目的：观察吲哒帕胺与苯那普利治疗原发性高血压合并心功能不全疗效。方法：对原发性高血压合并心功能不全患者21例进行治疗，4周后观察血压、心功能、心率、血脂、血糖、血电解质、肝肾功能变化。结果：治疗4周后观察到血压稳定下降，有效率90．5％（P＜0．01）；心功能改善，有效率85．7％（P＜0．01）；心电图缺血性改变有恢复，副作用轻微。结论：苯那普利和利尿剂吲哒帕胺     

苯那普利治疗高血压伴心功能不全疗效观察

目的：观察苯那普利治疗高血压伴心功能不全的疗效和血流动力学变化。方法：高血压病伴心功能不全２６例患者，在常规强心利尿治疗的基础上给予苯那普利治疗，观察血压、血流动力学和心功能改变。结果：口服苯那普利４周降压有效率９２．３％，治疗心功能不全有效率８８．５％，血流动力学指标ＳＶ、ＣＯ、ＣＩ、ＥＦ明显改善。结论：苯那普利是治疗高血压病伴心功能不全安全、有效的ＡＣＥＩ抑制剂。     

特拉唑嗪与苯那普利治疗轻中度高血压病的效果比较

为观察特拉唑嗪与苯那普利的降压疗效，将高血压患者４８例随机分成２组，２４例给予特拉唑嗪，另２４例给予苯那普利，疗程为８周，结果：两组血压均较治疗前明显下降，特拉唑秦降压总有效率达９１．７％，与苯那普利相似，组间无显著异。     

苯那普利与卡托普利治疗肾性高血压的疗效对比

目的：比较苯那普利与卡托普利治疗肾性高血压的降压效应与安全性。方法：８４例肾性高血压患者随机接受苯那普利（１０～２０ｍｇ／ｄ）与卡托普利（３７．５～７５．０ｍｇ／ｄ）治疗４周。结果：苯那普利与卡托普利的降压总有效率在偶测血压监测时分别为９２．５％和９０．５％，两组降压疗效比较无显著性差异（Ｐ〉０．０５），两组治疗前后血压比较均有显著性差异（Ｐ〈０．００１），但两组之间降压幅度比较无显著性差异（Ｐ〉     

非洛地平和苯那普利对原发性高血压作用比较

目的 比较非少地平与苯那普利对原发性高血压患的降压作用,并评价其对肾功能的影响。方法 ８０例轻、中度发性高血压患,随机单盲自身前后对照,苯那普利５￣１０ｍｇ／ｄ,或非洛地平５￣１０ｍｇ／ｄ,４周后测定诊室血压（ＣＢＰ）,血ＢＵＮ、Ｃｒ,尿β２－ＭＧ的变化。结果 两组治疗后血压均明显下降（Ｐ〈０．０１）,非洛地平降压作用略优于苯那普利,但苯那普利治疗后尿β２－ＭＧ减少。结论 非洛地平降压作用优于     

缬沙坦、苯那普利及卡托普利对老年高血压效果的观察及护理

目的：观察缬沙坦、苯那普利及卡托普利对老年高血压的作用。方法：选择120例2～3级老年原发性高血压患者,分为三组,缬沙坦组（n=40）、苯那普利组（n=40）、卡托普利组（n：40）,分别进行治疗前、后三组之间降压幅度比较。结果：缬沙坦治疗老年原发性高血压与苯那普利、卡托普利一样有效;但缬沙坦组未见干咳现象,而苯那普利组、卡托普利组干咳发生率分别为2．7％、13．7％。结论：高血压虽然是一种慢性病,但并不可怕,如果能在医生指导下进行治疗和休养,仍能够长寿。     

苯那普利治疗原发性高血压的临床效果

目的 评价苯那普利的降压作用及其对高血压伴心功能不全的疗效。方法 选取89例应用其它抗高血压药物疗效不佳的原发性高血压患者，其中31例合并心功能不全。给予苯那普利，剂量10－20mg/d，治疗4周，治疗前后监测血压、心率、心电图。结果 苯那普利降压总有效率为94％；对高血压伴心功能不全者，其心功能不全改善的有效率为87％。结论 苯那普利降压疗效可靠、安全、并能改善心功能不全。     

苯那普利治疗原发性高血压的临床效果

目的评价苯那普利的降压作用及其对高血压伴心功能不全的疗效。方法选取89例应用其它抗高血压药物疗效不佳的原发性高血压患者,其中31例合并心功能不全。给予苯那普利,剂量10-20mg／d,治疗4蒯,治疗前后监测血压．心率、心电图。结果苯那普利降压总有效率为94％;对高血压伴心功能不全者,其心功能不全改善的有效率为87％。结论苯那普利降压疗效可靠、安全,并能改善心功能不全。     

苯那普利治疗高血压病25例疗效观察

苯那普利治疗高血压病２５例疗效观察尹晓隽杨立新河南省电力医院内科郑州４５００５２关键词盐酸苯那普利；原发性高血压；左心室舒张功能苯那普利是一种新型的血管紧张素转换酶抑制剂。作者应用苯那普利治疗高血压病２５例，观察其对高血压病患者降压效果、左室舒张功能...     

帕罗西汀对原发性高血压伴心理障碍患者降压疗效的影响

目的 通过观察应用或不用我西汀后降压药物对原发性高血压伴心理障碍的患者疗效的不同变化,了解帕罗西汀对这类高血压患者者的辅助治疗作用。方法 原发性高血压患者７６例,抑郁症、焦虑症、颖病症量表测定后分组。无心理障碍者作为Ａ组２６例,单纯口服苯那普利１０ｍｇ,每天１次,共１４天,伴心理障碍者随机分成两组,一组单纯应用苯那普利治疗为Ｂ组２６例,药物剂量、用法同Ａ组;另一组应用苯那普利加帕罗西汀治疗为Ｃ组２     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.