肉芽肿性口周皮炎一例

患者,男,49岁。10年前无明显诱因下颌出现红斑、丘疹,逐渐增多。皮肤科检查：下颌片状红斑,其上可见红色粟粒大丘疹,少许鳞屑,密集分布。组织病理检查：可见上皮样细胞肉芽肿及淋巴细胞浸润。 诊断：肉芽肿性口周皮炎。给予多西环素0.1 g,每日2次口服,0.1%他克莫司局部外用,治疗40天后皮疹完全消退。     

肉芽肿性口周皮炎二例

报告2例肉芽肿性口周皮炎。例1男,6岁。面部红斑、丘疹5个月就诊。曾外用糖皮质激素软膏后皮疹渐增多。例2女,28岁。口周、鼻周红斑、小丘疹2个月余就诊。2例均表现为面部腔口周围直径1—3mm大小的淡红色坚实小丘疹,皮损组织病理检查：真皮毛囊周围上皮样细胞肉芽肿改变。结合临床表现及组织病理学检查,2例均确诊为肉芽肿性口周皮炎。例1口服琥乙红霉素颗粒200mg/次,每日4次、1％克林霉素凝胶和0．03％他克莫司软膏外用,治疗2个月后皮疹完全消退,1个月后口周皮疹又复发。例2在行组织病理活检后皮疹自行消退,提示本病具有临床自愈倾向。     

肉芽肿性口周皮炎二例

报告2例肉芽肿性口周皮炎.例1男,6岁.面部红斑、丘疹5个月就诊.曾外用糖皮质激素软膏后皮疹渐增多.例2女,28岁.口周、鼻周红斑、小丘疹2个月余就诊.2例均表现为面部腔口周围直径1 ～3mm大小的淡红色坚实小丘疹,皮损组织病理检查:真皮毛囊周围上皮样细胞肉芽肿改变.结合临床表现及组织病理学检查,2例均确诊为肉芽肿性口周皮炎.例1口服琥乙红霉素颗粒200 mg/次,每日4次、1％克林霉素凝胶和0.03％他克莫司软膏外用,治疗2个月后皮疹完全消退,1个月后口周皮疹又复发.例2在行组织病理活检后皮疹自行消退,提示本病具有临床自愈倾向.     

口周皮炎

口周皮炎是易被忽略的临床常见疾病,具有独特的临床表现,其病因尚不完全明了。该文对其病因及发病机制、临床表现、诊断及预后作一综述。     

口周皮炎致病因素的相关性分析

目的探讨影响口周皮炎发病的危险因素,为制定治疗和预防方案提供依据。方法对入选的120例口周皮炎患者及同期110例非口周皮炎患者进行问卷调查及实验室检查,并对相关因素进行单因素分析及多因素Logistic回归分析。结果单因素分析显示,年龄、咽拭子真菌涂片、系统性疾病、发病前用药史、女性口服避孕药及妊娠在两组间差异无统计学意义(P>0.05),将筛选出的有统计学意义的变量进行多因素Logistic回归分析,结果显示女性、幽门螺杆菌感染、鼻炎或鼻窦炎、进食过热食物和辛辣刺激食物的饮食习惯、日晒、精神因素、劳累和过敏性疾病史为口周皮炎发病的致病危险因素(P<0.05)。结论积极治疗幽门螺杆菌感染、鼻炎、鼻窦炎,减少日晒,形成良好的饮食习惯、放松心情、避免过度劳累对于口周皮炎的治疗和预防具有一定作用。     

牛奶对儿童口周湿疹样皮炎致病原因分析

牛奶对儿童口周湿疹样皮炎致病原因分析王晓（青海红十字医院皮肤科，西宁市８１００００）儿童口周湿疹样皮炎在临床较常见，病因不十分清楚。我科对此做了观察，结果如下。一般资料：于门诊获本症患者７４例，男５１例，女２３例。年龄３月～１２岁。１岁以下１９例，１...     

口周皮炎患者唾液中幽门螺杆菌检测

口周皮炎病因不明。有人认为与胃黏膜幽门螺杆菌(Helicobacter pylori,Hp)感染有关。笔者应用PCR技术检测唾液中Hp,以此探讨口周皮炎发病与唾液中Hp感染之间的关系。     

幽门螺杆菌感染与口周皮炎之间关系的探讨

口周皮炎患者大多伴有不同程度的消化道不适感,对７３例口周皮炎患者用酶联免疫吸附法检测幽门螺杆菌抗体,结果显示６１例患者阳性。给予口周皮炎患者进行抗幽门螺杆的三联治疗,疗效显著。     

奥美拉唑联合克拉霉素、阿莫西林治疗口周皮炎疗效观察

目的探讨奥美拉唑联合克拉霉素,阿莫西林治疗口周皮炎的疗效。方法 90例口周皮炎患者随机分为两组,两组均外涂氯硫霜,3次/d。同时,治疗组口服奥美拉唑及克拉霉素,阿莫西林,两组疗程均为10天,疗程结束后随访6个月,判定疗效并观察复发率。结果治疗组有效率为89.13%,对照组为63.64%;治疗组复发率为11.11%,对照组为83.33%。两组有效率及复发率差异均有统计学意义(P均<0.005)。结论奥美拉唑联合克拉霉素、阿莫西林治疗口周皮炎疗疗效显著,复发率低。     

A Case of Herpes Zoster Granulomatous Dermatitis: Report of Wolf's Isotopic Response

Wolf''s isotopic response refers to the occurrence of a novel skin disease at the site of a preceding treated or untreated skin disease. Although the most common preceding skin disease was found to be herpes zoster (HZ), HZ-related dermatological phenomena are not well known in the literature. We report a case of HZ granulomatous dermatitis in a 77-year-old female with a previous history of hypertension, diabetes mellitus, chronic kidney disease, and HZ. She presented with a 3-month history of a pruritic skin lesion on her right thigh. The location of the lesion was consistent with a previous HZ site. Histopathological examination revealed lympho- histiocytic infiltration in the superficial dermis, forming a granulomatous structure. Based on clinical and histopathological findings, we made a diagnosis of granulomatous dermatitis at a previous HZ site. We assumed that the lesion arose from an isotopic response of Wolf. The patient was treated with topical steroids for 3 months and showed clearance of the lesion and symptom. We suggest that treatment should be based on the individual disease, which in our case was topical steroid.     

疱疹样皮炎误诊为药疹1例

患者女,22岁。全身泛发性红斑、水疱伴瘙痒12天。临床表现为全身对称性分布多数红斑,红斑基础上见绿豆至蚕豆大水疱,呈环状排列,尼氏征阴性。皮损组织病理示:表皮下水疱,疱底及周围真皮乳头内以中性粒细胞为主的炎性浸润。诊断:疱疹样皮炎。曾因发病前有明确服药史被误诊为药疹。     

Periokuläre Dermatitis

Background: Perioral dermatitis paradoxically sometimes spares the entire perioral region. There may be isolated periocular involvement (periocular dermatitis). Patients/methods: The records of 23 patients with only periocular dermatitis were reviewed with respect to the following parameters: clinical findings, history of atopy, topical facial treatment, prick and patch tests, CAP‐SX1, previous treatment, time to healing and relapses. 23 patients with no history of periocular dermatitis were matched for age and sex (case‐control study). Results: The predominant clinical finding in the affected group was micropapules primarily in the lateral corner of the eye and lower eyelid. The groups differed significantly (p < 0.05) with regard to the history of atopic diseases and reactive prick tests. 22 patients regularly used face‐care or eye‐care products. These patients did not differ significantly from the control group with regard to frequency and type of product used. 6 patients had been previously treated with topical corticosteroids. The time to healing was 2 – 8 weeks (median: 4 weeks). Conclusions: Periocular dermatitis is a variation on perioral dermatitis, whereby similar pathogenetic factors are observed. The elimination of topical corticosteroids and the gradual reduction of skin‐care products regularly lead to clearing of the condition.     

肉芽肿性松弛皮肤特殊类型的蕈样肉芽肿一例

目的 报告一例蕈样肉芽肿之极其罕见的肉芽肿性皮肤松弛.方法 对其临床、组织病理、免疫组化、超微结构和分子生物学进行研究.结果 在皮肤肿块内致密淋巴细胞、组织细胞和多核巨细胞浸润,少数淋巴细胞向表皮性.弹性纤维几乎完全消失.免疫组化示淋巴细胞表达CD3,CD45RO.分子生物学检查示T细胞受体β链基因重排.超微结构示巨噬细胞有许多绒毛样结构和溶酶体.结论 此例为一种罕见变异的蕈样肉芽肿.     

角质形成细胞在变应性接触性皮炎和特应性皮炎中的作用

角质形成细胞是表皮的主要组成细胞,既往认为是浸润的T淋巴细胞免疫攻击的被动靶细胞,但是许多研究已经证明,角质形成细胞参与皮肤的免疫反应。角质形成细胞在活化后表达一系列过量的细胞因子、趋化因子和黏附分子,积极地参与到一些慢性炎症性皮肤病如特应性皮炎和变应性接触性皮炎的发病机制中,参与、维持着炎症的发生发展全过程。