肺部少见原发性恶性肿瘤的诊断与治疗

目的 探讨肺部少见原发性恶性肿瘤的临床特点、诊断及治疗方法。方法 回顾性地总结了49例肺部少见原发性恶性肿瘤,对其病理、临床表现、X线表现、诊断及治疗情况结合文献进行分析。结果 49例肺部少见的原发性恶性肿瘤,约占同期手术切除的肺内肿瘤的0．70％（41／5872）。49例中1例行支气管镜活检,1例行颅骨转移活检,2例行淋巴结活检,4例行肺穿刺活检病理证实,其余41例进行了外科手术治疗,并经术后病理证实。结论 外科手术是肺部少见原发性恶性肿瘤主要的诊断和治疗手段。     

原发性十二指肠恶性肿瘤12例报告

原发性十二指肠恶性肿瘤发病率低，国内报道较少，预后差。为了提高对本病的认识，提高早期诊断率，从而达到早期手术、改善预后的目的，我们总结１２例进行临床分析，现报告如下。１临床资料１２例原发性十二指肠恶性肿瘤，均经手术后病理证实，其中男性５例，女性７例，...     

肺部少见的原发恶性肿瘤——附19例报告

目的：探讨肺部少见原发性恶性肿瘤的临床特点、诊断和治疗方法。方法：总结我院1987年-2006年的肺少见原发性恶性肿瘤共19例临床资料结合文献进行分析。结果：19例病人中肺平滑肌肉瘤3例,肺纤维肉瘤3例,肺软骨肉瘤1例,肺母细胞瘤2例,肺癌肉瘤1例,肺恶性淋巴瘤3例,支气管乳头状瘤恶变2例,肺恶性神经鞘瘤1例,肺恶性血管外皮瘤2例,肺恶性黑色素瘤1例。全组病人均经手术切除病变肺组织,其中肺叶切除17例,肺段切除1例,全肺切除1例。无手术及术后住院期死亡,无术后严重并发症。结论：手术是肺部少见原发性恶性肿瘤主要的诊断和治疗手段。     

肺部少见原发性恶性肿瘤(附14例报告)

目的　报道肺部少见的原发性恶性肿瘤。方法　收集吉林省肿瘤医院 1988～ 1999年经手术证实的 14例肺部少见原发性恶性肿瘤进行临床分析。结果　全组术前均未确诊 ,均误诊为原发性支气管癌。部分病例需借助特殊染色或免疫组化检查得以确诊。其中肺恶性淋巴瘤 5例 ,肺平滑肌肉瘤 4例 ,肺母细胞瘤 2例 ,血管内皮细胞瘤 2例 ,肺炎性假瘤癌变 1例。 3年生存率 41.7% ,5年生存率 33.3% ,2年死亡率 2 5 %。结论　对肺部少见的原发性恶性肿瘤术前诊断较困难 ,易误诊。外科手术为首选治疗方式。     

原发性输尿管恶性肿瘤15例报告

原发输尿管肿瘤在临床上较少见,在泌尿系肿瘤中亦不多见,我们自１９８５年１月—１９９８年３月共收治１５例,现报告如下。１临床资料本组共１５例,男１３例,女２例,年龄４７岁～６８岁,平均５６．２岁。左侧１１例,右侧４例。输尿管上段肿瘤３例,下段１２例。有...     

肺部少见的原发恶性肿瘤——附19例报告

目的:探讨肺部少见原发性恶性肿瘤的临床特点、诊断和治疗方法。方法:总结我院1987年~2006年的肺少见原发性恶性肿瘤共19例临床资料结合文献进行分析。结果:19例病人中肺平滑肌肉瘤3例,肺纤维肉瘤3例,肺软骨肉瘤1例,肺母细胞瘤2例,肺癌肉瘤1例,肺恶性淋巴瘤3例,支气管乳头状瘤恶变2例,肺恶性神经鞘瘤1例,肺恶性血管外皮瘤2例,肺恶性黑色素瘤1例。全组病人均经手术切除病变肺组织,其中肺叶切除17例,肺段切除1例,全肺切除1例。无手术及术后住院期死亡,无术后严重并发症。结论:手术是肺部少见原发性恶性肿瘤主要的诊断和治疗手段。     

食管贲门少见的原发性恶性肿瘤5例

近１０年来，我科共行食管、贲门恶性肿瘤切除手术５３７例。原发于食管、贲门部位的癌肉瘤、平滑肌肉瘤、恶性黑色素瘤、非何杰金氏恶性淋巴瘤少见，我科收住经病理证实者共５例，占同期该部位切除恶性肿瘤的０．９３％（５／５３７），现报告如下。临床资料本组病例均为...     

原发性输尿管恶性肿瘤25例诊治经验

原发性输尿管恶性肿瘤较为少见,我院１９６４～１９９８年共收治原发性输尿管恶性肿瘤２５例,报告如下。１　临床资料本组２５例,男性２０例,女性５例,年龄３８～６８岁,中位年龄４８．６岁。左侧１５例,右侧１０例;肿瘤位于输尿管下段１８例,中段４例,上段３例。病史最长１３年,最短２５天。全部病例均有血尿,其中全程无痛性肉眼血尿１０例,镜下血尿１５例。血尿伴尿路刺激症状８例,血尿伴腰部不适及叩击痛１７例。尿液癌细胞检查８例,４例阳性。同位素肾图检查,患侧肾功能严重受损８例,无功能肾６例,轻度肾功能受损８例…     

妇科恶性肿瘤合并多原发性恶性肿瘤10例

 目的　探讨多原发性恶性肿瘤（MPMT）的诊断与治疗,提高对MPMT的认识和诊疗水平。方法　采用回顾性分析方法,对2004年1月至2010年1月收治的妇科恶性肿瘤合并MPMT 10例临床资料进行综合分析。结果　同时性癌7 例,其中手术+放疗2例,单纯手术治疗2例,手术+化疗2例,手术+放、化疗1例。7例同时性癌2、5年生存率分别为71.4 %、28.6 %。异时性癌 3例,第一癌时手术+放疗1例,单纯手术治疗1例,手术+化疗1例;第二癌时手术+化疗1例,单纯手术2例。3例异时性癌2、5年生存率分别为66.7 %、33.3 %。其中子宫颈、子宫内膜、卵巢、胃肠道肿瘤的发病率明显高于其他器官。结论　如果对第二癌的治疗原则同第一癌,做到早发现、早诊断、早治疗,MPMT患者仍会有较好的预后。     

Carcinoembryonic antigen in primary carcinoid tumors of the lung

Antibody staining for carcinoembryonic antigen (CEA) was used in 31 cases of primary pulmonary carcinoids to assess the presence of this marker as a parameter of clinical behavior. Other parameters have also been studied (size, position, and histologic characteristics) in order to determine their value as determinants of eventual disease outcome. Tumor size and position did not influence the progression of disease. Atypical histology was a significant predictor (P = 0.05) of treatment failure. Positive CEA marking was the most strongly significant (P = less than 0.01) of all studied parameters for predicting treatment failure.     

肺癌与多原发癌

目的：探讨原发性肺癌合并多原发恶性肿瘤的发生率以及原发性肺癌与多原发癌之间的关系。方法：回顾性分析1964年至1992年间因原发性肺癌接受外科手术治疗的病例。结果：全组共1019例原发性肺癌，21例（2．1％），合并多原发性恶性肿瘤，其中71．4％，多发性肿瘤位于消化道，28．6％位于消化道以外的其它脏器。5例第一原发癌与第二原发癌为同时发生，16例异时发生。结论：原发性肺癌患者容易患者其它脏器恶性肿瘤，术后除监测肺癌复发外，应定期监测多原发癌。     

Stereotactic ablative radiation therapy for primary lung tumors

Stereotactic ablative radiotherapy, also known as stereotactic body radiation therapy, has been developed as an innovative therapy for stage I non-small cell lung cancer and has now emerged as a standard treatment option for medically inoperable patients through careful analysis utilizing prospective, multi-institutional trials. This article reviews and updates the evidence for use of stereotactic ablative radiotherapy in medically inoperable patients with stage I lung cancer, its extension of use to medically operable patients, and the toxicities associated with this emerging technique.     

Double primary malignant tumors involving a lung cancer

Patients with multiple primary malignant tumors involving a primary lung cancer have been analyzed at our department in the Gunma University hospital. With reference to the lung cancer, three quarters of these patients were clinically in stages III or IV. The lung cancers were histologically classified into 26 epidermoid cancers, 14 adenocarcinomas, one large cell carcinoma, and one small cell carcinoma. Other primary cancers were 13 gastric cancers, 7 laryngeal cancers, 6 cervical cancers, 3 colon cancers, and other such cancers. Cases manifesting simultaneous cancers showing less than a one-year interval were 15 whereas 27 cases had double primary cancers with intervals of over one-year. Eleven patients had been given radiation therapy for their initial malignant tumor, but only two cases were considered to have incurred a radiation-induced lung cancer with a latent period of 5 and 12 years respectively.     

Analysis of multiple primary malignant tumors including lung cancer

In our hospital, from 1984 to 1986, we have performed autopsies on 50 lung cancer cases. Ten (20%) cases were found to have multiple primary malignant tumors, ie. one quadruple, 2 triple, 7 double malignant tumors, and almost all cases with multiple primary malignancies were males more than 70 years old. A histological examination showed that seven of these had tumors of the squamous cell type. In six cases, lung cancer was the primary disease and in 5 cases both malignancies existed simultaneously. When we lysed 5 g of autopsied lung, we were able to detect more than 100 asbestos bodies in 9 cases out of ten. Further, we noticed that triple or quadruple cases showed more asbestos bodies. Thus, we suspect that nearly all cases had been affected by exposure to asbestos.     

Vitamin-K-dependent proteins in microsomes of primary Lewis lung tumors

Microsomes isolated from Lewis lung (LL) primary tumors raised in C57BL/6 mice have been shown to (i) contain a 4-hydroxycoumarin (warfarin)-sensitive cycle of vitamin K metabolism which is at least qualitatively similar to that of liver, and (ii) catalyze the incorporation of NaH14 CO3 into endogenous protein in a vitamin-K hydroquinone-dependent reaction to produce gamma-carboxyglutamate. As in liver microsomes, LL microsomal reduction of vitamin K 2,3-epoxide to vitamin K was greatly enhanced by exogenous dithiols such as dithiothreitol, but under identical conditions the former was 10-fold faster. The R(+) and S(-) warfarin enantiomers were highly and equally effective inhibitors of both the liver and tumor vitamin K 2,3-epoxide reductases-the average I50 against the tumor enzyme was 0.25 microM. Partially purified reductases isolated by centrifugation of sodium-cholate-treated liver and LL tumor microsomes over a discontinuous sucrose gradient were also inhibited by the sulfhydryl reagent N-ethylmaleimide following their reduction by dithiothreitol. Like the activity of the epoxide reductase, that of the gamma-carboxylase was much lower in tumor than in liver microsomes and was only detectable in microsomes isolated from tumor-bearing mice previously administered S(-) warfarin. In view of the reported inhibition of LL tumor metastasis by warfarin and diet-induced vitamin-K deficiency, vitamin-K-dependent proteins may play a role in the spread and/or subsequent growth of LL cells.     

儿童肺部原发性肿瘤56例临床分析

目的探讨儿童肺部原发性肿瘤的临床特征、治疗方案及预后。方法 2009—2019年间广州市妇女儿童医疗中心共收治儿童肺部原发性肿瘤患儿56例, 收集其一般资料、影像学资料、病理资料及手术记录等, 进行回顾性分析。结果 56例患儿中, 胸膜肺母细胞瘤28例, 炎性肌纤维母细胞瘤20例, 黏液表皮样癌6例, 血管瘤1例, 硬化性肺细胞瘤1例。临床表现以呼吸道症状为主, 咳嗽26例, 气促17例, 咳血3例。另外, 发热15例, 胸痛3例, 上腹部疼痛2例。肿瘤位于左肺下叶18例, 右肺下叶11例, 左肺上叶10例, 右肺上叶7例, 右肺中叶6例, 肺门4例。56例患儿均行手术治疗, 其中行开胸手术41例, 胸腔镜手术13例, 纤维支气管镜下手术2例。5例Ⅰ型胸膜肺母细胞瘤患儿术后未行化疗, 至随访结束仍存活。5例Ⅱ型胸膜肺母细胞瘤患儿中, 2例术后未化疗, 复发后死亡;3例术后化疗, 至随访结束仍存活。18例Ⅲ型胸膜肺母细胞瘤患儿术后均予IVADo方案化疗, 出现肿瘤复发6例, 远处转移3例, 肿瘤相关死亡8例。20例炎性肌纤维母细胞瘤患儿中, 行楔形切除术13例, 复发5例;行肺叶切除术6例, 复发1例;行纤维支气管镜手术1例, 术后复发。6例黏液表皮样癌患儿中, 行肺叶切除术5例, 行肺楔形切除术1例, 至随访结束均存活。1例血管瘤患儿行支气管镜下肿物切除术, 1例硬化性肺细胞瘤患儿行肺楔形切除术, 至随访结束均存活。结论儿童肺部原发性肿瘤缺乏特异性临床表现, 手术完整切除有利于取得良好预后。对于Ⅱ、Ⅲ型胸膜肺母细胞瘤, 化疗是必要的辅助治疗。