血清铁蛋白测定对几种恶性肿瘤的诊断价值

铁蛋白（Ferritin）是一种分子量较大的含铁蛋白,主要存在于肝脏、脾脏和骨髓中,主要的生理功能是储存铁元素,同时在机体合成含铁物质时提供铁。血清中含有微量的铁蛋白,在正常条件下,含量稳定。近年来的研究表明,血清铁蛋白（Serum ferritin,SF）的增高可以作为恶性肿瘤的辅助实验诊断指标。因此,血清铁蛋白的测定在临床的应用越来越受到重视。     

血清铁在脓毒症诊断及预后评估中的临床价值

目的 探讨血清铁在脓毒症诊断及预后评估中的临床价值.方法 回顾性分析2018年9月－2019年9月入住大理大学第一附属医院重症监护室(ICU)的85例脓毒症患者的临床资料,选取同期入住ICU且性别、年龄匹配的非脓毒症患者50例为对照组.根据28 d生存情况将脓毒症患者分为生存组(n=51)与死亡组(n=34),比较两组...     

Effects of iron supplementation in female athletes with low serum ferritin concentration.

Low serum ferritin concentrations are commonly found in female athletes. By studying the effects of an 8-week iron or placebo supplementation in 31 female athletes (aged 17-31 years), with an initial serum ferritin concentration less than or equal to 25 micrograms/l and blood hemoglobin 120 g/l, we investigated whether low serum ferritin values hinder aerobic performance. Serum ferritin concentration increased from 14 (25th and 75th percentile: 11, 21) to 26 (18, 36) micrograms/l in the iron-supplemented group, but remained at a low 11 (9, 17) micrograms/l in the placebo group (group difference after supplementation: p = 0.001). Before supplementation, blood hemoglobin concentration was not different in the two groups. After supplementation, however, the concentration in the iron group was 139 (135, 144) g/l and 128 (126, 134) g/l in the placebo group (group difference: p = 0.001). Iron supplementation did not affect blood lactate concentration or VO2max during an incremental ergometer test. Hence, aerobic performance was not impaired in nonanemic female athletes with serum ferritin 25 micrograms/l.     

The effect of intramuscular iron injections on serum ferritin levels and physical performance in elite netballers

The purpose of this study was to determine the effect of iron supplementation by intramuscular injection on both serum ferritin (SF) levels and exercise performance in iron depleted, non-anaemic elite female netballers. Fifteen iron depleted (Serum Ferritin <40 ug x L(-1). Haemoglobin >125 g x L(-1)) subjects (19+/-3 y) first performed their routine test battery: a vertical jump test, a 10s power and 5x6s repeat sprint test on a cycle ergometer and a 20m multi-stage shuttle run. Subjects were matched on the basis of height, mass, and playing position and then assigned to either a Ferritin Group (FG) or Placebo Group (PG) (single blind design). Subjects then underwent a course of 5x2ml intramuscular injections of either Ferrum H (FG) or normal saline (PG) over a period of 8-10 days before repeating the blood and physical performance tests. Five and 10 days following supplementation, SF levels in the FG increased significantly from baseline levels (P<0.05) and were also significantly greater than levels measured in the PG (P<0.01). Haemoglobin levels remained unchanged in both groups. All test scores remained unchanged from baseline values and were not different between the two groups. These results demonstrate that a course of 5x2ml intramuscular iron injections significantly increased SF concentration within 2 weeks without increasing Hb levels, but this rapid elevation did not enhance the physical performance in selected tests of iron depleted, non-anaemic athletes.     

Changes in serum ferritin and other factors associated with iron metabolism during chronic hyperbaric exposure.

Factors related to iron metabolism were determined in 20 United States Navy divers during 8 d of air saturation-excursion hyperbaric exposures. During these simulated dives progressive and correlated increases in serum ferritin and iron occurred. No significant changes were observed in bilirubin, hemoglobin, ceruloplasmin, transferrin, copper, or total iron binding capacity. The significance of the increased serum ferritin is discussed in relation to bone marrow damage and early detection of aseptic bone necrosis.     

脑脊液白蛋白/血清白蛋白比值在中枢神经系统疾病中的诊断价值

脑脊液 (ＣＳＦ)蛋白质检查在中枢神经系统疾病中具有重要参考价值。传统的脑脊液总蛋白 (ＣＴＰ)、Ｐａｎｄｙ试验等测定结果多能判断ＣＳＦ蛋白浓度。ＣＳＦ蛋白质含量受血清蛋白质含量变动而影响 ,因此对疾病的诊断还存在不足之处。有鉴于此 ,不少学者提出在测定ＣＴＰ、脑脊液白蛋白 (ＣＡｌｂ)基础上 ,强调测定ＣＡｌｂ与血清白蛋白 (ＳＡｌｂ)的比值 (ＣＡｌｂ ＳＡｌｂ)。本文测定了 80例中枢神经系统疾病患者和 31例对照组的 (ＣＡｌｂ ＳＡｌｂ)的比值 ,探讨其比值的改变对判断血脑屏障损伤程度、异常蛋白质来源的临床价值 ,现报告…     

肾性贫血患者血清铁蛋白与叶酸检测的临床意义

目的探求肾性贫血患者血清铁蛋白及叶酸检测的临床诊疗价值。方法采用Beckman-Coulter Access 2化学发光免疫分析仪,检测156例肾性贫血患者和48例正常对照组的血清铁蛋白（SF）和叶酸（FA）含量,对检测结果进行比较分析。结果肾性贫血患者的SF和FA含量明显低于正常对照组（P〈0.01）。结论检测的SF和FA含量可了解患者铁代谢的状况以及叶酸的缺乏程度,对纠正肾功能不全引起的贫血有重要的临床意义。     

血清胱抑素C在肿瘤化疗患者肾功能评价中的临床应用

目的:探讨血清胱抑素C(cystatin C,Cys C)在肿瘤化疗患者肾脏功能评价中的临床应用. 方法:随机取37例肿瘤化疗患者和30例正常对照血清,同时测定血清中的Cys C、肌酐(Scr),Cys C检测采用增强透射免疫比浊法;Scr采用苦味酸法测定,并测定患者24 h尿肌酐(Ucr),计算出内生肌酐清除率(Ccr).结果:肿瘤化疗患者Cys C水平(1.16±0.43)mg/L显著高于正常对照组(0.61±0.06)mg/L;化疗前、后(1个疗程)Cys C、Scr和Ccr水平存在显著性差异(P＜0.05);患者化疗前后Cys C的异常检出率均显著高于Scr、Ccr (P＜0.05).结论:Cys C是评价肿瘤患者化疗期间肾功能损伤的一项灵敏、可靠的指标,在反映肿瘤化疗患者肾功能早期损害中有很好的临床参考价值.     

子宫内膜异位症患者血清CA125表达研究

 目的 探讨子宫内膜异位症患者血清CAl25的表达特点及相关影响因素.方法 分析104例子宫内膜异位症患者血清CAl25的表达.根据修正的美国生育学会标准分期,统计不同分期、不同类型、不同生育史、不同盆腔状态患者术前血清CAl25水平,评估术前血清CA125与子宫内膜异位症之间的相关性,用卡方检验及线性相关对数据进行分析.结果 (1)子宫内膜异位症患者血清CA125水平与患者生育次数及流产次数无相关性;(2)血清CA125水平随rAFS分期的增高而升高,I期与Ⅳ期、Ⅲ期与Ⅳ期、Ⅱ期与Ⅳ期之间差异有统计学意义,具有相关性;(3)单纯卵巢型内异症与合并多部位内异症的血清CA125水平差异有统计学意义;(4)血清CA125水平随子宫直肠窝是否封闭及封闭程度的逐渐加重而升高,存在相关性;与盆腔粘连范围无相关性,但随粘连程度的加重而升高,且具有相关性;(5)CA125水平随痛经程度的加重而升高,两者之间存在相关性.结论 血清CA125在异位症患者中明显升高,尤其是重度者,可作为评判内异症严重程度的辅助指标.CA125可作为术前评价内异症盆腔粘连严重程度的一个指标.     

Alphafetoprotein in patients with malignant diseases

The serum level of AFP was determined in 227 patients: 75 with gastric carcinoma, 81 with colon cancer and 71 with breast carcinoma. AFP in the serum was measured by a radioimmunoassay method before and after operation. In patients with stomach and colon cancer, the serum level of AFP was statistically decreased after operation. In patients with breast cancer there was no significant change after operation. In patients with stomach cancer, the level of AFP was 22.70 +/- 6.89 ng ml-1 before operation, and 5.94 +/- 0.81 ng ml-1 after operation; in patients with colon cancer, 14.36 +/- 2.84 and after operation 5.80 +/- 0.82; and in patients with breast cancer, 8.96 +/- 0.97 and after operation 8.50 +/- 0.95.     

铁蛋白对多发性骨髓瘤诊断中的临床意义

  目的 探讨血清铁蛋白(serum ferritin, SF)水平对多发性骨髓瘤(multiple myeloma, MM)诊断的临床意义。方法 选择2016-01至2018-06在同济大学附属第十人民医院血液科初治的32例MM患者和39例健康志愿者(对照组)作为研究对象,MM组患者已排除引起铁蛋白升高的其他因素。比较MM组与对照组SF表达水平。通过ROC曲线检测SF在MM患者中的诊断价值,随访32例MM组患者每次化疗前的SF水平以及相应的β₂-微球蛋白(β₂-microglobulin,β₂-MG)水平及乳酸脱氢酶(lactic dehydrogenase, LDH)水平共计169人次,并对检测结果进行统计分析。结果 MM组SF(546.60±427.66)ng/ml明显高于对照组(231.20±111.70)ng/ml,差异有统计学意义(t=4.06,P=0.000)。ROC曲线分析中,SF水平曲线下面积为0.75(P=0.000),具有一定的诊断意义。随访32例MM患者共169人次,定期化疗前SF与β₂-MG有正相关关系(r=0.714,P<0.01),而与LDH水平无明显相关关系(r=0.059, P>0.01)。Ⅲ期MM患者中SF水平明显高于Ⅰ期和Ⅱ期,差异具有统计学意义(P<0.05)。结论 SF对MM有辅助诊断价值,能反映一定程度的肿瘤负荷,SF结合β₂-MG对MM患者分期和预后判断有重要价值。