EDITORIAL BOARD OF 《ACTA ANATOMICASINICA》

Editor　ZHANGJing bo(InstituteofBasicMedicalSciences,CAMS ,Beijing)AssociateEditorsXUQun yuan (CapitalUniversityofMedicalSciences,Beijing)YUEn hua(PekingUniversityHealthScienceCenter,Beijing)XUZeng lu (InstituteofBasicMedicalSciences,CAMS ,Beijing)WUYan wan(NationalResearchInstituteforFamilyPlanning ,Beijing)LUOJian hong(ZhejiangUniversitySchoolofMedicine ,Hangzhou)NIUJian zhao(BeijingUniversityofTraditionalChineseMedicine ,Beijing)TANGJun min(PekingUniversityHe…     

EDITORIAL BOARD OF 《ACTA ANATOMICA SINICA》

Editor　ZHANGJing bo(InstituteofBasicMedicalSciences,CAMS ,Beijing)AssociateEditorsXUQun yuan (CapitalUniversityofMedicalSciences,Beijing)YUEn hua(PekingUniversityHealthScienceCenter,Beijing)XUZeng lu (InstituteofBasicMedicalSciences,CAMS ,Beijing)WUYan wan(NationalResearchInstituteforFamilyPlanning ,Beijing)LUOJian hong(ZhejiangUniversitySchoolofMedicine ,Hangzhou)NIUJian zhao(BeijingUniversityofTraditionalChineseMedicine ,Beijing)TANGJun min(PekingUniversityHe…     

简报

按照国际医学物理组织的建议，于2000年5月28日在北京国际会议中心召开了亚太地区医学物理联合会筹备会议，参加会议的代表有： Tony WONG Radiation Oncology Centre Austin  Repatriation Med． centre Australia HU Yi－min Cancer lnstitute （Hosp）， CAMS Beijing China HUANG Ye－cho Xian Diao Tong University China BAO Shanglian lnstitute of Heavy lon Physics Peking University China LIU Zhicheng CapitaI University of Medical Sciences China CHEUNG Kin Yin Department of Clinical Oncol…     

《医学分子生物学杂志》第一届编委会名单

主编:邓耀祖(武汉) Editor in Chief:DENG Yaozu(Wuhan) ’副主编:屈伸(武汉)许根簿(上海)沈诩排(北京)冯作化(武汉) AssodateC址ef Editors:QU Shen(Wuhan)XU Cenjun(Shanghai)SHEN Yufei(Beijing)兀NG Zuohua(Wuhan) 编委(以汉语拼音为序，*常务编委) Members of Editoriai Boards(*Standing Member): 陈侄(北京)陈惠鹏(北京)成军(北京)戴秀玉(北京) CHEN Quan(Beijing)CHEN Huipeng(Beijing)CHENG Jun(Beijing)DAI芜uyu(Beijing) 邓耀祖‘(武汉)冯友梅(武汉)冯作化.(武汉)耿运琪(天津) DENG Yaozu(Wuhan)FENG…     

《医学分子生物学杂志》第一届编委会名单

主编:邓耀祖(武汉) E曲or in Chief:DENG Yaozu(Wuhan) 副主编:屈伸(武汉)许根俊(上海) Ass喊ate Chief Editors:QU Shen(Wuhan) 编委(以汉语拼音为序，*常务编委) 沈诩洲卜(北京) 冯作化(武汉) XU Cenjun(Shanghai)SHEN Yufei(Beijing)兀NG Zuohua(Wuhan) Members of Editorial Boards(*Standing Member): 陈侄(北京)陈惠鹏(北京) CHEN Quan(Beijing)CHEN Huipeng(Beijing) 邓耀祖‘(武汉)冯友梅(武汉) DENG Yaozu(Wuhan)FENG Youmei(Wuhan) 龚非力(武汉)韩晓(南京) GONG Feili(Wuhan)HAN Xiao(Nanjing) 贾弘…     

第十届全球华人生命科学家大会即将召开

第十届全球华人生命科学家大会 (10thSCBAInternationalSymposium)将于 2 0 0 3年 8月 16日～ 2 0日在北京国际会议中心召开。大会主题 :科学为高质量人生服务 (ScienceforABetterLife)。目的 :促进基因组学 蛋白质组学的发展 ,加强生命科学领域中全球华人和国际生命科学家的合作与交流。主办单位 :美洲华人生命科学家协会 (SCBA)、中国科学院 (CAS)、北京大学 (PKU)、中国医学科学院 (CAMS)。协办单位 :中国科协、中国科技部、中国教育部、中国卫生部、中国工程院。我国大陆多位院士和科学家都将参与相关领域报告的组织领导工作…     

体外研究整合素αv、α4、β1、β3在小鼠胚泡着床中的作用

整合素(Integrin)是一类存在于细胞表面的跨膜糖蛋白，属于细胞粘附分子(cell adhesion molecules，CAMS)的一大家族，是细胞外基质(ECM)的受体，以受体一配体相对应的形式调节细胞与细胞、细胞与细胞外基质的相互作用，介导细胞的增殖、分化、粘附、迁移等过程。胚泡着床是个复杂的生理过程，包括胚泡孵出、胚泡与子宫内膜的识别、粘附及滋养层细胞向子宫内膜侵入等，     

《医学分子生物学杂志》第二届编委会名单

主编:邓耀祖(武汉)Editor in Chief:DENG Yaozhu(Wuhan)副主编:屈伸(武汉)曾溢滔(上海)沈(北京)冯作化(武汉)Associate Chief Editors:QU Shen(Wuhan)ZENG Yitao(Shanghai)SHEN Yufei(Beijing)FENG Zuohua(Wuhan)编委(以汉语拼音为序,*常务编委)Members of Editorial Board     

《医学分子生物学杂志》第一届编委会名单

主编:邓耀祖(武汉)Editor in Chief:DENG Yaozhu(Wuhan)副主编:屈伸(武汉)许根俊(上海)沈(北京)冯作化(武汉)Associate Chief Editors:QU Shen(Wuhan)XU Genjun(Shanghai)SHEN Yufei(Beijing)FENG Zuohua(Wuhan)编委(以汉语拼音为序,*常务编委)Members of Editorial Boards     

2nd Far Eastern Conference on Medical and Biological Engineering,1993

ForewordIt is our honor and pleasure to welcome you to the 2nd Far Eastern Conference on Medicaland Biological Engineering (2nd FECMBE) in Beijing,China,1993.In 1987,Far Eastern Society of Biomedical Engineering(China,Japan,Korea and Taipei,China) affiliated to International     

《医学分子生物学杂志》第二届编委会名单

主编:邓耀祖(武汉) E山tor in Chief:DENC YaozhL，(Wuhan) .lJ主编:屈伸(武汉)曾溢滔(上海)沈瑚排(北京)冯作化(武汉) ASS0ciate Chief Editors:QU Shen(Wuhan)ZENG Yitao(Shanghai)SHEN Yufei(Beijing)编委《以汉语拼音为序，*常务编委) Members of Editorial Boards(*Standi     

北京市性传播HIV-1感染者流行毒株gag基因序列测定和亚型分析

目的 了解北京市性传播HIV-1感染者流行毒株亚型特点和流行规律.方法 随机采集北京市2008年新确证性传播HIV感染者的抗凝全血标本100份,分离血浆,提取病毒RNA,用套式聚合酶链反应扩增病毒gag基因,并进行序列测定和亚型分析.结果 系统进化分析确定北京市性传播HIV-1感染者流行毒株存在8个亚型或流行重组型,分别为B亚型22份,B'亚型8份,C亚型1份,CRF01_AE 38份,CRF02_AG 2份,CRF07 BC 9份,CRF08_BC 3份,疑似C/CRF01_AE重组型1份.结论 CRF01_AE和B亚型分别占45.2%和26.2%,为性传播感染者主要的亚型,应该加强我市HIV-1亚型流行情况的监测.

Abstract：

Objective To investigate the subtype distribution and sequence characteristics of HIV-1 strains prevalent among sexual infectors in Beijing. Methods We collected the blood samples from 100HIV sexual infectors in Beijing during 2008 and separated plasma specimens. RNA was extracted from the plasma and the gag gene was amplified by RT-PCR and nest-PCR. The PCR products were sequenced directly and phylogenetic analyses of gag gene was performed using the MEGA4 software. Results Among 100 HIV-1 plasma samples,84 gag gene fragments were amplified and analyzed. Eight HIV subtypes including B(22 strains), B'(8 strains),C( 1 strain) ,CRF01_AE (38 strains) ,CRF02_AG (2 strains) ,CRF07_BC(9 strains) ,CRF08_BC(3 strains) and C/CRF01_AE recombinant like strain( 1 strain) were identified circulating in Beijing. Conclusion CRF01 _AE and subtype B were predominant in Beijing account for 45.2% and 26.2% and the surveillance of HIV gene variation should be paid more attention.     

北京市2007-2010年风疹病原学监测

目的 对北京地区风疹病原学进行监测.方法 收集风疹疑似病例血清标本和尿液和(或)咽拭子,用于血清学检测和病毒分离.病毒分离物和临床标本中的核酸利用real-time PCR方法进行检测.结果 2007-2010年,共收集99个风疹疑似病例血清标本和临床标本,血清学确诊55个病例(56%),病毒分离确诊51个病例(52%).回顾性检测疑似风疹病例及尿液和(或)咽拭子核酸,共确诊72个风疹病例(73%).分离的风疹病毒基因型主要为1E基因型.结论 北京地区主要流行的风疹病毒为1E基因型别.

Abstract：

Objective To clarify the pathogen for rubella in Beijing from 2007 to 2010. Methods Beijing Center for Disease Preventipn and Control ( CDC ) collected the specimens (including blood, urine and throat swab specimens) frqm clinically diagnosed rubella cases for serological test and virus isolation. The nucleic acid of rubella virus in clinical specimens and isolations was detected by real-time PCR. Results Fifty-five out of 99 blood specimens were positive for anti- rubella IgM. Fifty-one out of 99 clinically diagnosed rubella cases were confirmed as rubella cases by virus isolation. Seventy-two were confirmed as rubella virus infections with real-time PCR method for detecting the nucleic acid of rubella virus in clinical specimens. Compared with the sequences of reference strains of rubella virus, all of detected rubella virus belonged the IE gene type. Conclusion This study indicates that IE gene type virus was the predominant endemic rubella virus in Beijing.     

甲型H1N1流感病毒样颗粒疫苗的初步研究

目的对甲型H1N1病毒样颗粒的免疫原性和保护效果进行初步研究,为研发不依赖鸡胚生产工艺的流感疫苗提供新的思路。方法使用昆虫-杆状病毒表达系统表达并纯化甲型H1N1流感病毒A/California/07/2009(H1N1)的病毒样颗粒;通过Western blot、血凝、单向免疫扩散,透射电镜等方法鉴定病毒样颗粒;使用A/California/07/2009(H1N1)裂解疫苗作为对照,腹腔注射免疫Balb/c小鼠,并使用A/Beijing/501/2009(H1N1)进行攻毒,评价病毒样颗粒疫苗的免疫原性及保护效果。结果经鉴定,纯化后的病毒样颗粒血凝滴度为1:512,HA含量为92.9μg/ml,颗粒大小在100 nm左右,二免10 d后IgG抗体效价7.9×103,血凝抑制实验测得血抑(Hemagglutination Inhibition,HI)效价384,对50LD50的A/Beijing/501/2009(H1N1)病毒的保护率达到100%。结论甲型H1N1流感病毒样颗粒的免疫原性显著高于裂解疫苗,为发展不依赖鸡胚生产的流感亚单位疫苗提供了技术保证。     

奥林巴斯（北京）销售服务有限公司宣告成立

为了在持续扩大的中国市场上增加内窥镜和生物显微镜的销售,奥林巴斯株式会社合并了中国本地销售代理商,在北京设立了奥林巴斯(北京)销售服务有限公司[Olympus(Beijing)Sales＆Service co.,Ltd.],并已于2004年7月1日正式开始营业。 奥林巴斯进入中国市场已有40年的历史。过去,内窥镜和生物显微镜一直是通过在中国的代理店进行销售和服务。此次将中国代理店纳入旗下,实现了奥林巴斯向直接进行销售、服务、市场开拓的经营体制的转变。奥林巴斯(北     

会讯

第 4次亚洲立体定向与功能神经外科学术会议2 9/10 - 3/11/2 0 0 0 Beijing,China中国北京海军总医院神经外科中心Tel/电话 :( 86) 10 685860 56,669584 0 4 Fax/(传真 ) :( 86) 10 685860 56,68530 645E- mail:tianzm@public.sti.ac.cnMEDEXPO CHINA 2 0 0 04 4 th China National Medical Equipment Fair第 4 4届全国医疗器械秋季博览会 ( 2 0 0 0成都 )30 /10 - 3/11/2 0 0 0 Chengdu,China中国成都China National Corp.of Medical Equipment In-dustry中国医疗器械工业公司Tel/电话 :( 86) 10 644 48666- 815- 8Fax/传真 :…     

《ACTA ANATOMICA SINICA》INDEX(1979～1988)

Beijing Medical College.Adrenorgie Nerve Fibers一the Chief Faetor Affeeting th七Changes of Electrie Resistanee of the Rabbit Pinna in ExPerimental PePtie Uleer 1980;(1):45Bai Huiying.Age Changes of the Mandibular Angle in Chinese 1979,10:13Bai Huiyin名.The sagittal and Transverse Diameters of Chinese SPinal Canal 1983,(3):261Bai}luiying.Tlle Measurement and observarion of tlie Transverse Foramina of the Cervieal Verte一 brae and the Calibre of the Vertebral Artery 1983,(3):225…     

血红蛋白北京〔α_(16)(β_(14))Lys→Asn〕:一种新型快速异常血红蛋白

我们用醋纤薄膜电泳法在北京友谊医院献血员中发现一种快速异常血红蛋白(Hb),其电泳位置相当于Hb J组,经化学结构分析证明为α-链第16位赖氨酸被门冬酰胺取代,是迄今文献中未见报道的一种新型异常血红蛋白,兹根据其发现地点,命名为血红蛋白北京,(Hb Beijing),用α_(16)(β_(14))Lys→Asn表示。     

Current understanding and therapy of asthma workshop summary

The prevalence of asthma has increased globally in the past 2 decades.To address this critical issue,a workshopon “Current Understanding and Therapy of Asthma”was recently held in Beijing,as a part of the 10thInternational Conference of the Society of Chinese Bioscientists in America(SCBA).Several pertinent topicswere addressed by leading experts from China,Taiwan,Japan and the US,which include epidemiology,themolecular genetic mechanism,pathogenesis,treatment and prevention of asthma.This article highlights theissues presented and discussed in this ground-breaking symposium emphasizing this important public healthproblem in the Chinese population.Cellular & Molecular Immunology.2004;1(6):436-439.     

ABSTRACTS OF ORIGINAL ARTICLES

Page 1/Reliability of Skin Flap Survival Area Results Obtained with Laser Doppler Imaging/Wang Youbin, Wu Huanwen, Xiao Yiding, Gao Chunjin, Liu Xuehua, Zhao Ling, Liu Yunqi, Wang Xiaojun, Ma Xuernei/1 Peking Union Medical College Hospital, Beijing 100730, China; ZDepartment of Hyperbaric Oxygenic, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; 3Beijing University of Technol- ogy, Beijing 100083, China Objective： To determine the reliability of skin flap survival area re- sults obtained with laser Doppler imaging （LDI） by comparing the results obtained with laser Doppler imaging or transparent paper and analyzing the pathologic results. Method： 12 male SD rats were used in this experi- ment. An extended epigastric adipocutaneous flap was raised, based on the right superficial epigastric artery and vein. 3-hours flap isehemia was induced by clamping the pedicle vessels with microvaseular clamp. On the fifth postoperative day, the survival area of the flap was recorded with LDI and transparent sheet. Then the rats were sacrificed and skin flap tissue was sampled at the edge of the survival area. The tissue was ana- lyzed with HE and CD34 staining. Results： The survival area obtained with LDI was （10.19-＋-3.27）cm2. This area was（10.21~3.15）emz if the flap was calculated with transparent sheet. The difference was not obvi- ous （P〉0. 05）. Skin tissue kept normal in survival area. Obvious in- flammatory was observed in necrosis area of the flap. Micro-vessels in this area was dilated and jammed. Conclusion： Skin flap survival can be analyzed with LDI. Survival area results obtained with LDI are reliable. Key words： Skin flap;Laser Doppler imaging;Transparent paper; Survival area ; Rat