舌鳞状细胞癌临床病理学资料的回顾性研究

目的：通过病理学资料分析，了解舌鳞状细胞癌发病特点及变化趋势。方法：分析北京大学口腔医学院舌癌的病理资料并进行统计学处理。结果：1990－1997年舌病患者比例及40岁以下患者比例较1970－1977年均有显著性增加（P＜0．05），就诊舌癌患者在男女比例、发病年龄及好部位方面无明显变化，就诊患者的平均病程显著缩短（P＜0．01）Ⅱ级上以鳞癌患者所占比例显著增加。结论舌鳞状细胞癌的发病情况包括发病年龄、在口腔癌中的比例及恶性程度较以前有变化的趋势。     

湖北地区唇腭裂患者的ABO血型研究

目的 :研究湖北地区唇腭裂的发生与ABO血型有无相关性。方法 :统计湖北地区唇腭裂患者的A、B、O、AB血型的百分比 ,与湖北正常人群的A、B、O、AB血型的百分比相比较。分别统计A、B、AB、O血型患者中唇裂 ,腭裂 ,唇腭裂发病人数 ,并进行统计学处理。结果 :唇腭裂患者中A型血所占比例较正常人群低 (P 0 .0 5 ) ,O型血所占比例较正常人群高 (P 0 .0 5 ) ,B型及AB型血在唇腭裂患者与正常人群中无显著性差别。唇裂、腭裂、唇腭裂的发生与A、B、O、AB血型无明显相关性。结论 :湖北地区A型血胎儿不易患唇腭裂 ,O型血胎儿易患唇腭裂。唇腭裂的发生与血型无关     

1 267例南京及周边地区口腔恶性肿瘤统计分析

目的 分析了解南京及周边地区口腔恶性肿瘤的发病情况和构成特点,为口腔恶性肿瘤的防治提供参考数据。方法 对南京市口腔医院2010—2013年4年间住院治疗的口腔恶性肿瘤患者1 267例,作一回顾性统计分析。结果 1 267例口腔恶性肿瘤患者平均年龄60.94岁,男性发病率高于女性,男女性别比为1.3∶1.0,具有吸烟与饮酒史者亦为男性高于女性, 60~69岁及70岁以上为高发年龄组,男性于60~69岁患病比例最高,女性于70岁以上患病比例最高,男女各年龄组统计学分析（P<0.05） 差异有统计学意义;口腔恶性肿瘤以口腔癌多见,口腔癌中又以鳞状上皮癌多见,共818例,占总数64.56%;发病部位分布在前6位的依次为舌、颊、牙龈、软硬腭、颌骨、涎腺,其中以舌部为多,占27.55%,口腔溃疡、口腔黏膜病和牙齿病变者932例,占73.56%。结论 在南京市口腔医院住院治疗的口腔恶性肿瘤患者中男性高于女性,高发年龄在60岁以上,以口腔上皮鳞癌为多见,提示应加强老年人的口腔保健工作。     

Ⅰ期和Ⅱ期舌鳞癌患者预后较差

该文旨在比较舌鳞癌与其他部位口腔癌患者生存率的差别。对1988-2004年间诊断为口腔癌并处于T1-T2NOM0期的患者进行研究，资料来源SEER数据库。时序检验比较舌癌及其他部位口腔癌的总生存率（OS）和病因别生存率（CSS）。结果：6791患者纳入研究，40％为舌癌。患者平均年龄64岁，舌癌患者的5年OS和CSS分别为60．9％和83．5％，其他部位口腔癌患者为64．7％和94．1％。多因素分析显示，OS、CSS与肿瘤T分期、发病部位、患者年龄、性别有关。结论：舌鳞癌较口腔其他部位的鳞癌预后差，更应对之行综合治疗。     

北京市居民原发口腔鳞状细胞癌发病情况及相关资料分析——单中心5年连续研究

目的:分析北京市居民原发口腔癌发病、治疗及资源消耗情况.方法:连续抽取2009 ～ 2013年于北京大学口腔医院住院的北京市居民原发口腔癌患者的病历资料,采集年龄、性别、部位、分期、烟酒史、术式、住院日、费用等信息进行回顾性分析.结果:共有415例患者入组,男女性别比为1.2∶1.舌癌最多见(41.0％),男女口腔癌的部位分布有统计学差异(P＜0.01).40岁以上患者占96.6％,中位诊断年龄64岁,男女口腔癌的年龄分布有统计学差异(P＜0.01).晚期口腔癌占54.9％.中位治疗费、手术费、住院日随肿瘤T分期进展而递增.结论:从单中心角度看,北京市晚期口腔癌占半数,晚期口腔癌医疗资源消耗明显升高,应当进一步加强预防措施.     

576例口腔癌患者的流行病危险因素研究

目的:研究口腔癌发病危险因素。方法:利用第四军医大学口腔医院临床数据库中口腔癌患者的基本信息,针对性别、年龄、吸烟嗜好、生活环境、病理和早晚期等因素进行统计分析。结果:在2007～2009年来口腔医院就诊的576例患者中,发现农村患者的平均年龄明显小于城市患者;鳞癌患者的吸烟比例远高于腺癌患者;晚期患者的吸烟比例高于早期患者。结论:吸烟嗜好和老年是口腔鳞癌发病的风险因素。     

先天性唇、腭裂的发生率取决于血型

作者调查600例先天性唇、腭裂患者的血型,男397例,女203例。对照组为10177例健康人。调查结果:健康人血型,AB 型占9.9%,A 型26%,O 型31.2%,B 型32.9%。唇、腭裂患者的血型,AB 型占10.7%;A 型25.2%;O 型26.8%,低于对照组(P<0.05);B 型37.3%,高于对照组(P<0.05)。表明B 血型发生先天性唇、腭裂的机率较高,而O 血型则发     

口腔内癌肿396例临床病理分析

本文通过我院收集的近７年口腔内癌肿３９６例与日本癌学会１９９０年发表的３５０例口腔癌材料对比分析,可以明确看出来源于口腔粘膜被覆上皮的癌瘤占９６％以上,其中以鳞状细胞癌为绝大多数．在来自小涎腺导管上皮的癌瘤中以腺样囊性癌和粘液表皮样癌居多．口腔癌的好发部位以舌占首位,日本的材料中显得更为突出,占５９．４％．在其他部位上,两国材料有较大差异,我们的资料中牙龈癌占第二位,口底癌相对少见,与西方某些国家的统计相近,日本资料中口底癌的发病仅次于舌癌．其发病年龄段均以５０～６９岁间为高发,平均年龄分别为５４．９岁和５９．２岁．在性别方面,资料均显示以男性为多,且所占比例也较接近．本组３９６例中,非上皮源性恶性肿瘤共有８例约占２％,其中口腔粘膜恶性黑色素瘤占半数。     

舌鳞癌组织细胞外基质金属蛋白酶诱导因子的表达及其与预后的关系

目的：研究舌鳞癌组织中细胞外基质金属蛋白酶诱导因子（EMMPRIN）的表达及其与舌癌患者临床病理特征和生存期之间的相关性。方法：应用SP免疫组织化学法,检测68例舌鳞癌组织及相应的癌旁组织中EMMPRIN的表达情况,并对68例舌鳞癌患者进行随访观察。应用非参数秩和检验检测两个独立样本的EMMPRIN的表达差异,应用SPSS 13.0软件包进行生存分析;应用Cox比例风险模型分析预后。结果：EMMPRIN在舌鳞癌组织中的表达阳性率高于相应的癌旁组织（P〈0.05）。舌鳞癌组织中EMMPRIN的表达与肿瘤大小和临床分期密切相关,与性别、年龄、淋巴结转移和肿瘤病理分化程度不相关。Cox比例风险模型多因素预后分析显示,EMMPRIN表达是影响舌鳞癌患者预后的独立因素。结论：EMMPRIN可以作为舌鳞癌预后判断的参考指标,并有望成为口腔癌生物治疗的潜在靶点。     

430例复发性口疮临床特征及分析

目的:对430例复发性口疮(RAU)的临床特征及发病机理进行分析。方法:采用回顾性研究方法,430例RAU的临床特征中分别记录病例的性别、年龄、部位、类型、中医分型,伴随全身症状,并对病例资料进行统计学分析。结果:在430例RAU患者中,50.3%为女性,49.7%为男性。轻型RAU占69.8%、重型RAU占17.9%、疱疹型占12.3%,口疮累及的部位依次为唇部、舌部、颊部、口底;中医分型心脾积热型占73.0%,阴虚火旺型占14.9%,脾肾阳虚型占12.1%;RAU患者体液免疫检查IgM,IgA,IgG,补体C3多在正常范围内。结论:RAU的发病与全身因素有关。     

Oral cancer in Myanmar: a preliminary survey based on hospital‐based cancer registries

J Oral Pathol Med (2011) 40 : 20–26 The occurrence of oral cancer is not clearly known in Myanmar, where betel quid chewing habits are widely spread. Since betel quid chewing has been considered to be one of the important causative factors for oral cancer, the circumstantial situation for oral cancer should be investigated in this country. We surveyed oral cancer cases as well as whole body cancers from two cancer registries from Yangon and Mandalay cities, both of which have representative referral hospitals in Myanmar, and we showed that oral cancer stood at the 6th position in males and 10th in females, contributing to 3.5% of whole body cancers. There was a male predominance with a ratio of 2.1:1. Their most frequent site was the tongue, followed by the palate, which was different from that in other countries with betel quid chewing habits. About 90% of male and 44% of female patients had habitual backgrounds of chewing and smoking for more than 15 years. The results revealed for the first time reliable oral cancer frequencies in Myanmar, suggesting that longstanding chewing and smoking habits are etiological backgrounds for oral cancer patients.     

Oral cancer in young non-habituè females: a report of four cases and review of the literature

Background: The aim of this study is to highlight the growing incidence of oral cancer in young females without apparent traditional risk factors. Methods: We present a case series of young female patients with histopathologically diagnosed squamous cell carcinoma of the tongue and no known exposure to major risk factors, reporting to our institution over one year. A review of the literature was carried out to find documented studies on oral cancer in young females. Results: We found an increase in the number of young female patients presenting with squamous cell carcinomas on the lateral border of the tongue who did not have any of the traditional risk factors associated with the disease, which is in contrast with the number of male patients presenting with the same disease. Conclusions: Our study highlights the increasing incidence of oral cancer in young females without apparent traditional risk factors, an area of growing concern. Published studies in this particular group are limited. Nevertheless, the situation is alarming owing to the seriousness this problem poses for the community. More research is required to determine the aetiological and risk factors associated with this outcome.     

我国东南地区口腔黏膜鳞癌发病状况的描述性分析

目的:分析我国东南地区口腔黏膜鳞癌近年来的发病特点。方法:对791例我国东南地区的口腔黏膜鳞癌病例进行描述性统计分析。采用SPSS19.0软件包对数据进行整理,成组资料t检验和χ2检验比较组间差异。结合国内外文献报道,分析疾病发病的时间和地区变化。结果:本组资料的男女性别比为1.94∶1;男女病例的平均年龄分别为56.9岁和57.5岁。男性发病部位前3位的是舌(49.8%)、口底(15.1%)和牙龈(14.6%);女性发病部位前3位的是舌(60.2%)、颊(21.9%)和牙龈(13.4%)。结论:与20世纪的统计资料相比,我国东南地区口腔黏膜鳞癌的高发年龄后移近10年;男女性别比的地区差异明显,年代变化不大。舌是目前口腔黏膜鳞癌最主要的发病部位;口底和颊分别位男女口腔黏膜鳞癌的第2位;牙龈癌的占比有所下降。     

Carcinoma of the tongue: a case series analysis of clinical presentation, risk factors, staging, and outcome

OBJECTIVE: Oral cancer is primarily a disease of epithelial origin. The tongue is the most common site of oral cancer. Oropharyngeal cancer accounts for approximately 2% of all cancer deaths. The purpose of this study was to analyze a case series of patients with tongue cancer. STUDY DESIGN: The medical records of 322 consecutive patients diagnosed with squamous cell carcinoma (SCC) of the tongue treated from 1979-1994 were reviewed. RESULTS: Patients had a mean age of 61.1 years and a 1.5:1 male to female ratio. Approximately, half of the cancers were diagnosed at an advanced stage and most involved the base of the tongue. The majority of oral tongue tumors were diagnosed at an early stage and had more well-differentiated cell types than those of the base of the tongue. Localized discomfort was the most common complaint (66.5%), present for up to 6 months in patients prior to diagnosis and were related to the oral tongue in 90% of cases. Symptoms associated with base of tongue lesions included neck masses, dysphagia, ear pain, and weight loss. Seventy-nine percent of the patients smoked, 58% consumed alcohol on a daily basis, and 43% consumed more than 4 alcoholic drinks daily. Primary radiotherapy was the treatment of 49.6% lesions, of which 57% were at an early stage at diagnosis. The mean overall survival was 3 years and 5 months, with a 5-year overall survival of 40%. Patients with stage 1 tumors had a disease-specific survival of over 80%. The 5-year survival of patients with cancer of the oral tongue was 43% and cancer of the base of the tongue was 27%. CONCLUSION: The prognosis is poorer for patients presenting with advanced stage and with tumors involving the base of the tongue. Symptoms were more common in tumors of the oral tongue, which likely results in earlier diagnosis. Patients with SCC of the base of the tongue presented with advanced stage of disease and were typically poorly differentiated lesions.     

Epidemiologic study of oral cancer in Fars Province, Iran

Abstract From January 1962 to December 1978, 381 consecutive cases of oral cancer in Fars Province were analyzed and studied. The incidence of oral cancer was found to be 1.13/100000. The male/female ratio was 5:1, the median age of oral cancer was 55 years. 97 % of the oral cancel-was squamous cell carcinoma. The most commonly affected oral site was the lower lip, next was the tongue. Tobacco smoking and opium addiction were more common among the affected compared with the control group. Dental sepsis and poor oral hygiene were common in both groups. Malnutrition, anemia and liver dysfunction were common in the examined sample and are thought to be possible causative factors especially in those with no smoking habits. The role of general dental practitioners was limited, they suspected and referred only 13 advanced cases.     

Oral and maxillofacial cancer: A 35-year retrospective analysis at a referral dental hospital in Saudi Arabia

ObjectivesAs rates of oral and maxillofacial cancer (OMFC) continue to rise, the role of dentists in early detection and prevention has become increasingly important. The present study examined the frequency and pattern of OMFC cases diagnosed at a referral dental hospital.MethodsA retrospective analysis of all primary malignant neoplasms of the oral and maxillofacial area diagnosed at the Histopathology Laboratory of the Dental University Hospital, Medical City, King Saud University, Saudi Arabia from 1984 to 2020 was performed.ResultsA total of 242 patients had histologically diagnosed primary malignant neoplasms of the oral and maxillofacial area, accounting approximately 3.7% of the archives. The mean age of patients was 48.87 years, and the male-to-female ratio was 1.5:1. The most prevalent malignant neoplasm was squamous cell carcinoma (SCC) (58.3%), followed by mucoepidermoid carcinoma (11.6%). The tongue and gingiva were the most prevalent malignancy sites, accounting for 19.8% and 18.2% of the cases, respectively. The prevalence of SCC in patients over 50 years old (68.4%) was highly significantly greater than that in younger subjects (31.5%) (P < 0.0005). SCC was also more common in males (66.7%) than in females (33.3%) (P = 0.026).ConclusionOMFC primarily affecting the tongue and gingiva was the predominant in older male patients. SCC was the most frequent type of OMFC and was significantly associated with age older than 50 years. This study provides baseline data on the frequency of OMFC cases diagnosed for the first time by dental practitioners and warrants the need for increasing OMFC awareness among these clinicians.     

口腔癌及口咽癌术后伴舌缺损患者吞咽功能的相关因素分析

目的　探讨口腔癌及口咽癌术后伴舌缺损患者吞咽功能与舌动度及舌压的相关性,筛选吞咽功能最佳预测指标。方法　选取2017年7月至2018年3月于中山大学附属口腔医院口腔颌面头颈肿瘤外科门诊复诊的口腔癌及口咽癌术后伴舌缺损患者36例,通过洼田饮水试验对其吞咽功能进行评级,应用舌运动范围法对其舌动度进行测量评分,同时利用爱荷华口腔行为仪测量其舌压。采用Spearman秩相关分析方法计算洼田饮水试验等级与舌动度评分及舌压之间的秩相关系数（rs）及相应的P值。结果　舌动度评分及舌压与洼田饮水试验等级的rs分别为-0.575和-0.613（均P＜0.05）;其中舌压与洼田饮水试验等级的rs值较舌动度评分的rs大。 结论　舌压与舌动度均可影响口腔癌及口咽癌术后伴舌缺损患者的吞咽功能,其中舌压是评估患者吞咽功能的最佳预测指标。     

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??Objective??To select the best predictor of swallowing functions by exploring the correlation between the swallowing function and tongue mobility and tongue pressure of the patients with tongue defects after oral cancer surgery or oropharyngeal cancer surgery. Methods??From July 2017 to March 2018??in Hospital of Stomatology??Sun Yat-sen University??thirty-six cases of patients with tongue defects after oral cancer surgery or oropharyngeal cancer surgery were collected during return visits in the outpatient clinics of our hospital. The swallowing functions were graded by their water swallowing test??WST??results. The tongue mobility scores were evaluated by using the lingual range of motion??LROM??method??while the tongue pressure was measured by using the Iowa oral performance instrument??IOPI??. Spearman rank correlation analysis was applied to calculate the rank correlation coefficient??rs?? between the tongue mobility scores or tongue pressure and WST results??and the corresponding P value. Results??The rs value between WST results and tongue mobility scores or tongue pressure was -0.575 and -0.613 respectively??P??0.05??. The rs value of tongue pressure was larger than that of tongue mobility scores. Conclusion??Both the tongue mobility scores and tongue pressure have a great impact on the swallowing functions of patients with tongue defects after oral cancer surgery or oropharyngeal cancer surgery??and tongue pressure is the best predictor.     

异常吞咽与口周力相关性的研究

目的：定量分析异常吞咽口周力的分布特征。方法：用微力传感器和计算机辅助口周力测量系统对12名异常吞咽患者和12名正常吞咽错He患者上下颌中切牙、尖牙、第一磨牙颊、舌侧进行口周力的测量，对测量数据进行了统计学分析。结果：正常吞咽时男女之间各牙位的口周边值无显著性差异；异常吞咽时男性口周力大于女性，口周力与性别有相关性；异常吞咽组口周力大于正常吞咽组，其间差异有显著性。无论正常吞咽组还是异常吞咽组同侧上下颌同名牙位唇、颊侧与舌侧压力相比有显著性差异，下颌唇舌侧压力大于上颌唇舌侧压力。结论：异常吞咽时口周力与性别有相关性；异常吞咽组口周力大于正常吞咽组；舌的功能运动影响口周力，口周力会因吞咽方式的改变而发生适应性的变化。