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结直肠肿瘤在临床上具有极高的发病率及死亡率,预防与筛查结直肠腺瘤性息肉以及早期治疗是预防结直肠肿瘤的重要手段之一,中医药亦是结直肠肿瘤防治的重要手段之一。因此,运用中医药防治结直肠腺瘤性息肉,符合中医"治未病"的思想,对控制和降低结直肠癌发病率以及死亡率具有十分重要的现实意义。总结前人认识和现代临床经验,认为脾肾两虚是决定结直肠腺瘤性息肉、肿瘤复发的最主要因素,贯穿于结直肠肿瘤的始终。基于结直肠腺瘤性息肉的病因病机,选择以健脾扶正为主、燥湿化瘀为辅的中医治疗方案,尤其是对于先天不足、素体虚弱及术后元气亏虚、正虚邪恋而导致病情迁延、易复发的息肉等病症,可以起到明显的疗效,甚至预防其癌变。 相似文献
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《世界科学技术-中医药现代化》2011,(6):933
当前,我国结直肠癌发病率与死亡率均有较快增长,如何降低发病率、提高根治率、提高患者生存质量、减少转移复发已成为摆在我们面前的重要课题。目前,提高结直肠癌疗效的主要措施是多学科综合治疗,中医药在其中所发挥的作用愈来愈受到广泛重视。中西医结合是我国肿瘤治疗的特色和优势,但传统中医比较注重经验医学模式,缺乏标准化、信息化研究,为临床推广、疗效评价、创新发展带来困难。 相似文献
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结直肠癌( colorectal cancer, CRC)是我国常见的恶性肿瘤,2003—2007年结直肠癌在恶性肿瘤中发病率和死亡率分别为10.56%和7.8%,位居第3和第5位[1]。随着国人生活水平的不断提高和饮食习惯的变化,结直肠肿瘤的发病率和死亡率均呈上升趋势。结直肠癌初起时,临床表现隐匿,早期诊断率低,就诊时多为晚期,已失去手术治疗的机会,目前结直肠癌的治疗多为综合治疗为主,多采用中药联合化疗、放疗和手术。而中医药治疗恶性肿瘤,在稳定病灶,改善症状,提高生活质量,延长生存期及减轻放化疗毒副反应等方面独具特色[2]。兹将近年来中医药治疗晚期结直肠癌的进展综述如下。 相似文献
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结直肠癌(CRC)是世界范围内发病率和死亡率较高的的消化道恶性肿瘤,美国一项统计发现癌症死亡率2017年为止,总体下降29%,然而,在过去十年间(2008—2017年),结直肠癌的死亡率下降缓慢,发病率居第四位,死亡率居第三位。治疗上对于晚期结直肠癌,化疗已进入瓶颈,其毒副作用和耐药问题不能有效解决,基于此,如何有效防治结直肠癌细胞的侵袭、迁移是治疗结直肠癌的关键。文章通过论述肠道菌群在中医病因学中的作用机制,及中医中药改善肠道微生物菌群的构成比,肠道菌群参与宿主免疫调节等方面,探讨中医药通过调节肠道菌群直接或间接延缓结直肠癌的发生、发展,进而为中医学改善结直肠癌患者的预后提供思路。 相似文献
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结直肠癌(CRC)是常见的恶性肿瘤,是继肺癌和乳腺癌之后我国第三大常见恶性肿瘤。近年来,我国结直肠癌发病率和死亡率逐年增高,分别居于恶性肿瘤发病率及死亡率的第4位和第5位[1]。目前,早期CRC可通过手术治愈,术后总的5年生存率在50%左右[2]。但大部分结直肠癌患者就诊时已处于晚期,丧失手术机会,只能接受姑息治疗,以致其5年生存率明显下降。 相似文献
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结直肠癌(Colorectal cancer,CRC)作为一种常见癌症,在世界范围内都是导致患者死亡的重要原因之一,然而,其发病的分子机制仍很不清楚。尽管对CRC发病机理的研究逐渐深入并提供增强的筛查策略,但由于早期CRC的症状并不明显,难以诊断,使得许多患者错过最佳手术治疗的机会,因此目前患病率仍在上升。目前多数研究表明,CRC早期发病主要原因是由于机体所处环境、膳食、遗传和存在患者体内的其他因素等所作用造成。对于CRC的治疗大多是手术结合化疗药物进行治疗。在此,本文就CRC主要发病机制与临床中主要的治疗方法,包括筛查方法、药物靶向治疗、手术与放化疗的结合、中医药在CRC治疗中的应用等方面进行简要综述,旨在为临床对该类疾病的针对性防治及相关病理机理的阐明提供最新的见解。 相似文献
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目的 结直肠癌(Colorectal Cancer, CRC)是一种临床常见的恶性消化道肿瘤,随着结直肠癌发病率的不断升高,对于结直肠癌的临床治疗研究也越来越趋于多样化,目前对于结直肠癌公认的首选诊疗手段仍以西医治疗为主,主要包括手术治疗、化放疗以及靶向治疗等,然而手术后患者的并发症、复发率,以及放化疗后的不良反应严重影响着患者的生存质量;随着中国中医药事业的不断发展以及临床经验的不断积累,中医防治结直肠癌尤其是针对结直肠癌术后不良反应进行干预的临床优势不断凸显,此文将对近几年来中西医联合治疗结直肠癌术后的各种临床研究作综合阐述。 相似文献
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中医药在结直肠癌术后的治疗中能减轻放化疗不良反应,促进手术后患者康复,改善患者的生存质量,提高治愈率,减少肿瘤复发和转移,大量临床研究已经证实中医药能增强化疗的敏感性,可减轻化疗的不良反应,提高化疗的治疗效果,降低结直肠癌的的复发转移率。 相似文献
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目的:运用Meta分析研究的方法系统的评价中医药联合化疗治疗结直肠癌患者的临床有效性和安全性,为临床治疗结直肠癌患者提供新思路、新方法。方法:运用中国知网、万方数据库、维普、PubMed等相关数据库进行相关数据分析和检索,搜集关于中医药联合化疗治疗结直肠癌患者的随机对照研究,并运用Jadad量表对纳入文献评分采用Review Manager5.3软件进行Meta分析。结果:本次研究共纳入11项随机对照试验,试验中共涉及728例患者。Meta分析结果显示,在临床有效性方面,中医药联合西医治疗CRC试验组与单纯西医治疗对照组相比较,联合治疗可以有效改善患者的临床症状,在中医症候疗效、不良反应、降低化疗对患者的毒副反应及试验室检查等相关方面的结局指标,差异有显著性。结论:临床上中医药联合西医治疗CRC患者是安全和有效的,对于改善CRC患者的临床症状有显著疗效,值得临床推广。 相似文献
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随着现代医疗体系不断完善,癌症治愈率与生存率明显提高,但癌症治疗占据大量医疗资源,治疗过程严重损伤患者的机体,并且治疗费用昂贵。癌症治疗重在"早预防、早发现、早治疗"。本文积极推进中医癌症预防措施,以中医预防大数据平台为手段,实现与地方其他部门的深度融合,构建地区中医预防癌症大数据体系,推动中医资源预防癌症的实效性,努力发挥中医治疗领域大数据作用,为降低居民恶性癌症发病率奠定坚实的基础。 相似文献
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Traditional Chinese Medicine Syndromes Distribution in
Colorectal Cancer and its Association with Western Medicine
Treatment and Clinical Laboratory Indicators
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Meng-Die Yang Xiao-Le Chen Xue-Qing Hu Xiao-Zheng Xie Wen-Jun Zhou Chun-Gen Zhou Bin Jiang Qing Ji Qi Li Peng Wang Zhi-Qiang Meng Wen-Hai Wang Yuan-Jia Hu Shi-Bing Su 《World Journal of Traditional Chinese Medicine》2019,(2)
Objective: The objective of the study is to explore the traditional Chinese medicine (TCM) syndrome distribution in colorectal cancer (CRC)
and its correlation with treatment methods and clinical laboratory indicators. Materials and Methods: Using the CRC cases report form of
TCM, 760 CRC patients with TCM four diagnosis information, western medicine treatment information and clinical laboratory indicators were
collected, and TCM syndromes distribution in CRC were summarized. The correlation between TCM syndrome type and western medicine
treatments, clinical laboratory indicators such as liver and kidney function, immune function, and tumor biomarkers was analyzed. Results: In
760 cases of CRC, Spleen deficiency syndrome (SDS, 25%), liver and kidney Yin deficiency syndrome (LKYDS, 13%), LKYDS?SDS,
12%, spleen deficient Qi stagnation syndrome (SDQSS, 10%), and damp heat syndrome (DHS, 9%) were more common TCM syndrome
types. LKYDS, SDS, LKYDS?SDS, and SDQSS were significantly distributed under different treatment methods (P < 0.001). There was
no statistically significant difference in the distribution of immune function and cytokine among the five TCM syndromes (P > 0.05), but
there was statistically significant difference in the distribution of blood routine, liver and kidney function, and tumor biomarkers (P < 0.05).
Conclusion: LKYDS, SDS, LKYDS?SDS, SDQSS, and DHS were the first five TCM syndromes in CRC. There were the significant
correlations between the distribution of TCM syndrome and the clinical laboratory indicators, and the distribution of TCM syndromes was
affected by surgery, radiotherapy, and chemotherapy 相似文献
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杨宇飞 《世界科学技术-中医药现代化》2022,24(11):362-366
近三十年来,我团队致力于结直肠癌研究,初步建立防治保康中西并重模式,并付诸实践。应用中医之道:从建立多学科肿瘤治疗团队向建立多学科肿瘤康复团队的转变;用中医理论指导下生活方式的改变,以推进肠镜检查为结局,最终找出高危人群进行二级预防为目标;应用中医之术:以健脾补肾解毒为大法的结直肠癌全程治疗策略和多学科合作模式,为结直肠癌患者提供全程康复治疗,为单病种中西并重防治保康做出示范。借助于北京市中医肿瘤防治办公室和大数据创新实验室进行实践,在预防上积极探索以慢病管理APP为抓手,乡村干部、镇卫生院、区中医院为三级联动的结直肠癌中西医并重预防模式并向其他慢病扩展。在治疗方面,与北京肿瘤医院合作,在结直肠癌中西并重全程管理治疗模式中取得进展。在我院开展的中西医结合肿瘤康复多学科门诊模式标志着我国肿瘤康复事业前进了一大步。而在大数据分析上:团队对北京市三甲中西医医院住院病历的探讨,则能够从侧面看到目前的现状和存在的问题。本系列组稿将从多方面展现上述命题。 相似文献
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《结合医学学报(英文版)》2020,18(5):369-384
Worldwide, colorectal cancer (CRC) is one of the most common malignant tumors, leading to immense social and economic burdens. Currently, the main treatments for CRC include surgery, chemotherapy, radiotherapy and immunotherapy. Despite advances in the diagnosis and treatment of CRC, the prognosis for CRC patients remains poor. Furthermore, the occurrence of side effects and toxicities severely limits the clinical use of these therapies. Therefore, alternative medications with high efficacy but few side effects are needed. An increasing number of modern pharmacological studies and clinical trials have supported the effectiveness of Chinese herbal medicines (CHMs) for the prevention and treatment of CRC. CHMs may be able to effectively reduce the risk of CRC, alleviate the adverse reactions caused by chemotherapy, and prolong the survival time of patients with advanced CRC. Studies of molecular mechanisms have provided deeper insight into the roles of molecules from CHMs in treating CRC. This paper summarizes the current understanding of the use of CHMs for the prevention and treatment of CRC, the main molecular mechanisms involved in these processes, the role of CHMs in modulating chemotherapy-induced adverse reactions, and CHM’s potential role in epigenetic regulation of CRC. The current study provides beneficial information on the use of CHMs for the prevention and treatment of CRC in the clinic, and suggests novel directions for new drug discovery against CRC. 相似文献
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大肠癌是全球第三大恶性肿瘤,与中医脾虚、湿热、毒聚等因素相关.中医在降低大肠癌化疗毒副反应,改善临床证侯,提高生存质量,以及预防复发、转移等方面显示出了一定的优势.但治疗大肠癌的中医理论、辩证分型,以及治疗模式研究明显滞后.本文从大肠癌辨证分型研究、中医临床治疗研究、中药对大肠癌作用机制研究等方面进行全面深入地分析,提出了抗癌中药与化疗、靶向治疗等药物治疗存在共同生物学基础,如细胞凋亡、细胞衰老、细胞自噬等,为进一步提高中医大肠癌治疗提供了新的线索与基础. 相似文献
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《结合医学学报(英文版)》2014,(3)
Introduction: Colorectal cancer(CRC) is the third most commonly diagnosed cancer in all racial and ethnic groups.Although there is an increasing use of traditional healing methods, like acupuncture, in integrative medical practice in the US, there is very limited research on the use of traditional healers in communitybased public health outreach.Given the high use of traditional Chinese medicine(TCM) among Chinese Americans, this study was conducted to explore the potentially useful approach of incorporating TCM providers(including both acupuncturists and herbalists) in a culturally relevant public health education program for the Chinese American community.Methods: This study was conducted in three phases during 2011-2013 in San Francisco, California.Phase 1 explored the suitability of TCM providers in CRC prevention.Phase 2 developed and tested a 38-page integrative educational flipchart.Phase 3recruited and trained four TCM providers to conduct CRC prevention intervention using small group education sessions and the culturally relevant CRC prevention materials developed in Phase 2.Focus groups, observations, and interviews were conducted with TCM providers and their clients as well as Chinese American community members.Results: In Phase 1, the role of TCM providers as CRC educators was deemed acceptable by both providers and community members, although some providers had reservations about engaging in CRC outreach activities due to lack of expertise.In Phase 2, the integrative CRC education flipchart was perceived as culturally appropriate based on stakeholder input and feedback.In Phase 3, both TCM providers and their participants showed increased understanding of integrative methods in CRC prevention.Conclusion: This study indicates that TCM providers are a valuable and culturally appropriate community resource for providing information on CRC prevention.It suggests a potential role for traditional healers as change agents in the community health network. 相似文献
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目的 建立中医药干预治疗晚期结直肠癌的疗效预测模型进行疗效预测。方法 纳入120例晚期结直肠癌患者的人口学诊断、信息、治疗信息等深入观察随访,以生存时间为因变量,其他与生存时间相关的变量作为自变量建立Cox模型。通过Cox模型进行预后因素筛选,选取有显著统计学差异(P < 0.05)的变量包括发病部位、转移部位、基因分型、KPS评分、症状总评分、主症评分、生活质量评分,结合临床经验和描述分析的结果,加入中医证型作为自变量,把前期制定的中医优势、劣势、中间人群划分标准作为因变量进行判别分析,建立4种判别函数,根据模型预测结果选择预测效果最好的二次判别分析(QDA)模型作为最终晚期结直肠癌中医干预治疗疗效预测模型。结果 经验证,模型总的疗效预测准确率为84.2%,在中医劣势人群中的预测准确率为100%。结论 该模型可作为临床预测模型应用于晚期结直肠癌患者的中医药治疗,为进一步探求中医临床决策支持系统奠定相关基础。 相似文献