Successful Treatment of Steroid-Dependent Eosinophilic Cellulitis With Cyclosporine

Eosinophilic cellulitis (EC) is a rare idiopathic disorder, first described as a "recurrent granulomatous dermatitis with eosinophilia", that mimics cellulitis of infectious origin. We describe here a previously healthy 11-year-old girl who experienced fever and tender erythematous patch lesions after trauma to her knees. Because of the relapsing cellulitis-like skin lesions, skin biopsies were taken, resulting in a diagnosis of EC. The patient responded well to oral prednisolone but experienced side effects and relapse during dose tapering. She was switched from prednisolone to cyclosporine. Her EC remained under control, and she showed no evidence of relapse after discontinuation of cyclosporine.     

音乐疗法治疗慢性精神分裂症疗效分析

目的 观察音乐疗法对慢性精神分裂症的治疗效果。方法 住院慢性精神分裂症患者64例，随机分为实验组和对照组，各32例，观察8周，以BPRS、SANS量表评定疗效。结果 两组患者BPRS、SANS评分差异均有显著性意义。结论 音乐疗法对慢性精神分裂症病人的康复治疗有一定疗效。     

改良式森田疗法应用于慢性精神分裂症的对照研究

改良式森田疗法用于慢性精神分裂症的康复治疗。方法30例患者为森田疗法组,匹配18例为常规治疗对照组。改良式森田疗法包括轻作业期、重作业期和社会回归期,每期大约10个月。两组均用抗精神病药物维持治疗。治疗前后进行BPRS、SDSS、ADL、MMPI和骨矿物质含量、EEG、脑CT检查与评价。结果森田,疗法组的BPRS、SDSS、ADL评分和骨矿物质含量结果明显优于对照组。MMPI疗前为6／8图形,疗后1．5年和3年无变化。EEG和脑CT结果无异常。结论森田疗法对慢性精神分裂症的阴性症状、社会功能、个人生活能力有明显的改善作用。     

主、被动音乐治疗对慢性精神分裂症疗效分析

目的　观察主、被动音乐治疗对慢性精神分裂症治疗效果。方法　慢性精神分裂症 72例 ,随机分为主、被动音乐治疗组 ,各 3 6例 ,观察 8周。以 BPRS、SANS量表评定疗效。结果　两组患者 BPRS、SANS量表评分差异均有显著性意义。结论　对慢性精神分裂症的康复治疗主动性音乐治疗优于被动性音乐治疗。     

认知干预结合中药灌肠对慢性前列腺炎疗效的影响

目的 探讨中药灌肠治疗慢性前列腺炎(CP)的过程中认知干预的作用.方法 64例慢性前列腺炎的患者随机分为两组,对照组仅采用中药灌肠治疗,研究组的患者中药灌肠治疗同时运用心理认知疗法 ,连续治疗10天后,用NIH-CPSI、SCL-90进行疗效评定,观察认知干预对CP患者心理症状和躯体症状的影响.结果 与对照组比,①干预组患者心理不适明显减少;②干预组患者躯体症状也有一定程度缓解.结论 认知干预能起到减轻CP患者心理不适、缓解躯体症状的作用.     

小剂量肝素辅助治疗慢性乙型肝炎的临床观察

目的探讨肝素治疗慢性乙型肝炎的临床疗效与安全性。方法将132例慢性乙型肝炎患者随机分成二组，治疗组、对照组各66例。对照组给予常规护肝治疗(甘利欣、门冬氨酸钾镁、维生素C、B6等)，治疗组在对照组治疗的基础上加用肝素钠注射液6250u加入5％葡萄糖注射液100ml中静脉滴注，每天一次，疗程14d。治疗前后进行血常规、肝功能、凝血功能检查。结果治疗组ALT、TBiL、PT、APTT等指标改善均优于对照组。结论肝素治疗慢性乙型肝炎安全有效。     

中西医结合治疗慢性乙肝的临床观察

目的 探究应用中西医结合疗法对慢性乙肝患者进行治疗的临床效果。方法 选取2016年10月~2017年11月于我院进行诊治的慢性乙肝患者86例,随机分为常规组与观察组,每组43例。常规组患者采用拉米夫定和肌苷片进行治疗;观察组患者在常规组的治疗基础上添加自拟疏肝健脾方剂进行治疗。对比两组患者治疗后的谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）等肝功能指数及治疗效果。结果 观察组TP为（67.62±3.17）g/L,高于常规组的（61.57±3.29）g/L,观察组AST（47.88±18.97）U/L、ALT（61.29±27.77）U/L和TBIL（27.33±9.28）μmol/L分别低于常规组的（47.88±18.97）U/L、（53.57±26.64）U/L、（38.59±9.77）μmol/L,差异均有统计学意义（P＜0.05）。观察组治疗的总有效率为86.05%,高于常规组的65.12%,差异有统计学意义（P＜0.05）。结论 中西医结合治疗慢性乙肝疗效显著,可有效促进患者肝功能的恢复,提高疗效,值得临床借鉴。     

纤支镜灌洗治疗肺炎合并脓毒症的疗效分析

目的 探讨纤支镜灌洗应用于肺炎合并脓毒症治疗对血清C反应蛋白水平的影响.方法 选取我院收治的90例重症肺炎合并脓毒症患者,将其随机分为观察组以及对照组,每组45例,其中对照组给予常规治疗,观察组在常规治疗的基础上给予纤支镜灌洗,比较两组治疗前后的体温、呼吸及白细胞计数变化,治疗前以及治疗后1、2周的CRP水平,比较两组退热时间、机械通气时间、住院时间.结果 治疗后两组患者的体温、呼吸及白细胞计数均较治疗前明显改善,且组间比较差异具有统计学意义(P＜0.05);治疗后1、2周两组CRP均明显优于治疗前,且相同时间点组间比较差异具有统计学意义(P＜0.05);观察组患者的退热、机械通气以及住院时间相比于对照组均明显缩短,组间比较差异具有统计学意义(P＜0.05).结论 纤支镜肺泡灌洗治疗能明显降低脓毒症患者的CRP水平,减轻炎症反应,促进重症肺炎患者的疗效,改善炎症症状,值得推广应用.     

黄芪注射液治疗儿童肺炎的Meta分析

目的 运用Meta分析方法评价黄芪注射液治疗儿童肺炎的临床疗效。方法 计算机检索中国期刊全文数据库（CNKI）、中文科技期刊全文数据库维普（VIP）、中国生物医学文献数据库（CBM）、万方数字化期刊全文库、美国医学文摘数据库（Medline）等数据库,对纳入的随机对照试验文献进行质量评价,并采用Rev Man 5.3软件进行Meta分析。结局指标为治愈率、显效率、有效率、总有效率、影像消失时间。结果 共检索到黄芪注射液治疗儿童肺炎的临床研究75篇,合格文献20篇,共纳入患者1988例,Meta分析结     

Effect in Man of Anti-Allergic Drugs on the Immediate and Late Phase Cutaneous Allergic Reactions Induced by Anti-IgE

Wheal and flare reactions as well as a late cutaneous allergic reaction (LCAR) were induced by anti-human IgE in healthy subjects. The effect of the β₂-adrenoceptor stimulant terbutaline, the histamine-1 (H₁) receptor blocking agent mepyramine and the synthetic glucocorticoid betamethasone on these reactions was studied. All administrations were given intradermally (i.d.)
The immediate reaction to anti-IgE was inhibited by 3 μg terbutaline and 30 μg mepyramine ( P < 0.01) whereas 50 μg betamethasone had no effect. Terbutaline had no effect on the flare response induced by i.d. injected histamine but a slight effect on whealing. Terbutaline and mepyramine weakly reduced the LCAR throughout the observation period of 24 h ( P < 0.01). In contrast, betamethasone almost completely abolished the LCAR. It is concluded that the two phases of the skin reaction to anti-IgE are interrelated since an inhibition of the early phase was followed by an attenuation of the LCAR. The mechanism of action of steroids seems to differ fundamentally from that of other anti-allergic drugs since inhibition of the early step in the reaction is not essential to the action on the late step. It is further suggested that terbutaline inhibits anti-IgE-mediated cutaneous reactions by inhibition of the mast cell release reaction.     

Granulomatous Arteritis with Massive Eosinophilic Leukocyte Infiltration and Transient Peripheral Eosinophilia Subsequent to Transarterial Embolization Therapy with a Gelatin Sponge

A 38-year old man presented with a cavernous hemangioma in the liver. Transarterial embolization (TAE) using a gelatin sponge was carried out 14 days prior to surgical resection of the tumor. Granulomatous arteritis with massive infiltration by eosinophilic leukocytes and histiocytes was present at the periphery of the hemangioma, and transient eosinophilia in the peripheral blood occurred six days after resection. Granulomatous arteritis was evident in medium-sized arteries and there was narrowing or occlusion of the vascular lumen. In the granulomatous cellular infiltrates in the arteries, giant cells of the foreign body type were numerous. An eosinophilic substance differing from fibrin was present in some of the vascular lumina. As this showed staining for collagen, it was considered likely to be fragments of the gelatin sponge. The patient had no symptoms of fever, chills or general fatigue. The clinical course and pathologic findings suggest a causative role of the gelatin sponge in this case of granulomatous arteritis. Vascular change, a rare complication of TAE therapy, may be induced by a hypersensitivity reaction against the intraarterial gelatin sponge. Acta Pathol Jpn 41: 618-622, 1991.     

Eosinophilic Granuloma of Lymph Node

Eosinophilic granuloma confined to the lymph node of a 25-year-old Japanese woman is reported. She presented with a low-grade fever and pain in the left cervical region. A finger-tip-sized cervical lymph node was excised for histological study. Microscopically, the normal architecture of the lymph node was distorted, and histiocytoid cells had proliferated mainly in the sinus. Numerous eosinophils and an appreciable number of large multinucleated cells were also observed. Ultrastructurally, Birbeck granules were found in the cytoplasm of the histiocytoid cells. Immunohistochemically, the proliferating cells and multinucleated cells were found to be positive for S 100 protein but negative for lysozyme in the cytoplasm. The patient has been well without recurrence for 10 months after the lymph node biopsy. Acta Pathol Jpn 40: 851-855, 1990.     

慢性阻塞性肺炎重症患者行综合护理干预的价值分析

目的 探讨慢性阻塞性肺炎重症患者行综合护理干预的临床应用效果。方法 选取我院2017年1月~2018年6月收治的60例慢性阻塞性肺炎重症患者,按照随机数字法分为对照组和研究组,各30例。对照组采用常规护理干预,研究组进行综合护理干预,比较两组患者氧分压（PO2）、二氧化碳分压（PCO2）、呼吸频率、心率、pH值、突发抢救情况、死亡情况及护理满意。结果 研究组PO2、pH值均高于对照组,PCO2、呼吸频率、心率均低于对照组,差异有统计学意义（P＜0.05）;研究组死亡率（33.33%）较对照组（63.33%）低,突发抢救次数（7次）较对照组（18次）少,差异有统计学意义（P＜0.05）;研究组护理态度及护理效果得分[（90.25±3.46）分、（92.25±3.41）分]均较对照组高[（80.26±3.49）分、（79.69±3.58）分] ,差异有统计学意义（P＜0.05）。结论 慢性阻塞性肺炎重症患者行综合护理干预可减少突发抢救次数,避免病情被延误,降低死亡率,患者具有较高的满意度。     

碳青霉烯类治疗铜绿假单胞菌肺炎的临床效果分析

目的 探究碳青霉烯类治疗铜绿假单胞菌肺炎的效果。方法 选取2017年1月~2018年1月收治的86例PA肺炎患者临床资料进行分析,随机分为对照组和研究组,每组43例。对照组行头孢哌酮钠舒巴坦钠治疗,研究组行碳青霉烯类双联法治疗,比较两组肺功能（FEV1/FVC、FEV1）、实验室指标（CRP、PCT、WBC）及生活质量（SGRQ评分）。结果 两组患者治疗后FEV1/FVC、FEV1水平均优于治疗前,且研究组改善幅度大于对照组,统计学意义显著（P＜0.01）。研究组治疗后实验室各指标水平均优于治疗前,且优于对照组,统计学意义显著（P＜0.01）。治疗后,研究组SGRQ评分为（30.87±3.55）分,低于对照组的（40.54±4.36）分,统计学意义显著（P＜0.01）。结论 碳青霉烯类治疗铜绿假单胞菌肺炎,可有效改善患者肺功能,减轻炎症反应,提高生活质量。     

Eosinophilic angiocentric fibrosis of the sinonasal tract

Eosinophilic angiocentric fibrosis (EAF) is an uncommon inflammatory fibrosing lesion of the upper respiratory tract and orbit that occurs mainly in young to middle-aged women. The etiology of EAF is unknown. To our knowledge, approximately 28 cases have been previously reported in the English literature. We report here 3 additional cases of EAF of the sinonasal tract; 2 in women aged 19 and 31 years, and 1 in a man aged 49 years. The 19-year-old woman is the youngest patient with EAF ever described. The patients presented with a nasal cavity mass, face pain, or nasal obstructive symptoms of long duration.     

穴位注射配合自血疗法治疗慢性风疹59例

目的：研究穴位注射配合自血疗法在临床上治疗慢性风疹的疗效。方法对符合标准的59例患者采用本法治疗,共计3个疗程后观察疗效。结果痊愈28例、显效16例、有效10例,无效5例,总有效率达91.5豫。结论穴位注射配合自血疗法治疗慢性风疹,临床有效率较高,且无任何毒副作用,值得在临床推广。     

揿针疗法在骨科常见慢性疼痛性疾病治疗中的应用

目的 观察揿针疗法在骨科常见慢性疼痛疾病中的临床疗效。方法 选取2018年2月~2019年1月在我院骨科慢性疼痛性疾病患者160例,行腧穴埋针法治疗,观察临床治疗总有效率及随访6个月复发率。结果 揿针疗法治疗骨科常见慢性疼痛性疾病总有效率为92.50%,其中治愈88例,好转60例,无效12例。随访6个月总复发率为4.38%,其中颈型颈椎病、肱骨内上髁炎未见复发病例,肱骨外上髁炎、桡骨茎突狭窄性腱鞘炎各复发1例,膝关节骨性关节炎内侧关节间隙疼痛复发5例。结论 揿针疗法治疗骨科常见慢性疼痛性疾病,操作简单、安全有效,不良反应少,复发率低,值得临床应用。