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Piero Stratta Caterina Canavese Marco Quaglia Elisa Lazzarich Veronica Morellini Maddalena Brustia Beatrice Bardone Giorgio Bellomo 《Nephrology, dialysis, transplantation》2006,21(9):2664-2666
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Cihan Heybeli Andrew Bentall Jiqiu Wen Mariam Priya Alexander Francis K. Buadi Fernando G. Cosio Patrick G. Dean Angela Dispenzieri David Dingli Mireille El Ters Morie A. Gertz Hatem Amer Prashant Kapoor Hasan Khamash Taxiarchis Kourelis Shaji Kumar Elizabeth C. Lorenz Martin Mai Nelson Leung 《Kidney international》2021,99(3):707-715
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《Renal failure》2013,35(5):636-638
Background: Benign monoclonal gammopathy (MG) is an MG that is not accompanied by clinical manifestations of plasma cell dyscrasia, such as multiple myeloma, macroglobulinemia, amyloidosis, or other related disorders. Benign MG can progress to malignancy, but seldom causes organ damage. Case report: We presented a case denied any underlying disease who visited our hospital as acute uremia syndrome. Laboratory data indicated renal failure and abnormal paraprotein in the serum and urine. Renal biopsy indicated acute tubular necrosis and cast in the renal tubule. The plasma cell counts were normal in his bone marrow biopsy. The patient had received maintenance hemodialysis for the irreversible renal failure. Conclusion: Benign MG might progress to malignancy or other related disorders in a risk of 1% per year. It also might cause secondary organ impairment, such as kidney. 相似文献
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Monoclonal gammopathy after intense induction immunosuppression in renal transplant patients 总被引:1,自引:0,他引:1
OBJECTIVES.: Incidence and risk factors of post-transplant monoclonal gammopathywere studied in renal transplant patients who received theirgrafts between 1982 and 1992 (n=390 grafts). Immunoelectrophoresiswas performed at annual intervals after transplantation. RESULTS.: Forty-six cases of clonal gammopathy were detected: 35 monoclonal,11 bi- or triclonal, with a predominance of IgG and K light-chainsubtypes (IgG, 39; IgA, 3; IgM, 4; K, 35; , 19). Gammopathywas transient in 17 patients (37%). The 5-year cumulative incidenceof gammopathy was 10.7%, much higher than expected for a groupof similar age from the general population. Thirty of the 46gammopathies appeared within the first 2 years of transplantation.Gammopathy never progressed to multiple myeloma during follow-up(median 1 year; (range 010)); one patient subsequentlydeveloped Kaposi sarcoma. The 2-year incidence of gammopathywas much higher in patients transplanted in 19891991(23/142) than in 19821988 (7/248) (P<0.0001). Thiscoincided with the use of quadruple induction immunosuppression(cyclosporin A+azathioprine+prednisone plus either ATG-Fresenius(ATG-F) or OKT3) since 1989. The risk for acquiring gammopathywithin 2 years of transplantation was 14.7% (95% CI 9.2, 20.3%)in patients receiving quadruple induction therapy, but only3.0% (CI 1.2, 6.1%) without such therapy (P<0.0001). Therisk for patients receiving quadruple immunosuppression withOKT3 was 24.5%, significantly greater than with ATG-F (11.8%,P<0.05). Discriminant analysis revealed that the type ofimmunosuppression, but not age or year of transplantation, wereindependent risk factors for gammopathy. CONCLUSIONS.: Monoclonal gammopathy frequently occurs after renal transplantation.Risks are higher for patients receiving quadruple inductionimmunosuppression, particularly if it includes OKT3. Follow-upof these patients is warranted for the early detection of malignanttransformation. 相似文献
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Several renal pathologic entities have been reported in patientswith lymphoplasmacytic disorders with their typical excess immunoglobulinproduction. We report dense deposit disease in a patient whowas discovered to have an IgG kappa monoclonal protein withoutclinical evidence of underlying lymphoplasma cytic malignancyduring investigation for chronic renal failure with associatednephrotic range proteinuria. This case is unusual since densedeposit disease occurs only rarely in older patients and hasnot been reported in association with monoclonal gammopathyof unknown significance. Because of the diversity of renal lesionsassociated with lymphoplasmacytic disorders, renal biopsy isnecessary to assess the type of renal lesion in this patientpopulation. 相似文献
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Xin Zhang Xiao-Juan Yu Dan-yang Li Su-xia Wang Fu-de Zhou Ming-hui Zhao 《Renal failure》2021,43(1):1437
ObjectiveTo investigate the demographic and clinicopathological features and renal outcomes of Chinese patients with C3 glomerulonephritis in the setting of monoclonal gammopathy.MethodsPatients with renal biopsy-proven C3 glomerulonephritis and detectable serum and/or urine monoclonal immunoglobulin from 2006 to 2018 in Peking University First Hospital were included, their clinical data, renal pathology type, treatment, and prognosis were collected and analyzed.ResultsNineteen patients were enrolled, accounting for 24% of C3GN patients in the study period. The mean age of onset was 55 years old and the gender ratio was 4/15 (female/male). The mean eGFR at biopsy was 49.55 ± 29.81 ml/min/1.73m2. The prominent clinical manifestations included nephrotic syndrome (58%), anemia (68%), microscopic hematuria and leukocyturia (58%), and hypocomplementemia (13, 68%). The IgG was the most common isotype of monoclonal Ig on immunofixation electrophoresis. Kidney biopsies revealed a relatively prominent MPGN pattern. Only two patients had direct evidence of monocle immunoglobulins acting as C3GN pathogenic factors. Two patients had concurrent TMA-like renal injuries. The median renal survival was 12 and 15 months, respectively in patients receiving conservative therapy and immunosuppressant therapy, without statistical significance. The efficacy of clone-targeted therapy needed further investigation. Plasma exchange therapy only improved one patient’s renal outcome.ConclusionsThis is the first case series report of C3GN combined with monoclonal Ig in northern China. The renal prognosis of these patients is poor, and immunosuppressant therapies show no advantage over supportive therapy in renal prognosis, while the benefit of clone-targeted chemotherapy is still requiring investigation. 相似文献
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(Received for publication on Dec. 14, 1998; accepted on July 13, 1999) 相似文献
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The causes of renal failure are diverse. Among them, monoclonal gammopathy is one important but easily-missed cause in aged people. Monoclonal gammopathy may produce a large number of abnormal immunoglobulins and/or fragments and produce different kinds of deposition in tissues, including cast, crystal, fibril and granules. Cast nephropathy is considered the hallmark of the renal disease in patients with multiple myeloma. Crystaglobulinemia syndrome and crystal nephropathy, on the other hand, have been rarely reported. Herein, we report a case of multiple myeloma presented with irreversible renal failure. The biopsy showed massive crystal deposition in bone marrow and kidneys. 相似文献
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Samih H. Nasr Satoru S. Kudose Samar M. Said Dominick Santoriello Mary E. Fidler Sean R. Williamson Sibel Erdogan Damgard Sanjeev Sethi Nelson Leung Vivette D. D’Agati Glen S. Markowitz 《Kidney international》2021,99(2):410-420
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《Kidney international》2023,103(3):616-626
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Galioto A Morando F Rosi S Schipilliti M Fasolato S Magrin M Frigo AC Adami F Cavallin M Zanus G Plebani M Romano A Sticca A Cillo U Gatta A Angeli P 《Transplant international》2012,25(1):25-33
The aims of the study were to evaluate (i) the prevalence of MGUS in patients after liver transplantation (LT), (ii) the role of MGUS as a risk factor for malignancy and other medical complications after LT. One hundred and fifty consecutive patients were included in the study and followed prospectively after LT for more than 18 months. Eighteen patients had MGUS before LT, whereas 49 patients developed MGUS after LT ('de novo' MGUS). Thirty-six of these patients showed a MGUS along all the follow up after LT ('permanent' MGUS). In 31 patients, MGUS disappeared after LT ('transient' MGUS). No patient with MGUS developed B-malignant lymphoproliferative disorder and only one patient developed a myeloma after LT. Comparing patients with 'permanent' MGUS to patients with 'transient' MGUS or without MGUS after LT, the former group showed a higher rate of serious infections (30% versus 13%, P = 0.01), chronic kidney disease (CKD) (75% versus 44%, P = 0.001) and mortality (33% versus 17%, P = 0.04). Permanent MGUS was confirmed as an independent risk factor for serious infections and CKD by multivariate analysis. Permanent MGUS after LT does not entail a significant risk of malignancy, but it is associated with a higher risk of serious infections and CKD. 相似文献