血清脂蛋白（a）在慢性肺原性心脏病中的临床意义

目的观察血清脂蛋白（a）[Lp（a）]在慢性肺原性心脏病（下称肺心病）的临床意义。方法采用全自动生化分析仪分别检测50例慢性阻塞性肺病（COPD）、35例慢性肺心病及45例健康志愿者血清三酰甘油（TG）、总胆固醇（TCH）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）及Lp（a）水平。结果CPPD及肺心病组TG、TCH、HDL、Lp（a）、ApoB升高,LDL、ApoA1、ApoA1／ApoB降低,肺心病组Lp（a）水平较COPD组升高更为明显,各组间比较提示Lp（a）差异有统计学意义。结论脂蛋白（a）的异常更能反映慢性肺原性心脏病的脂质代谢异常,Lp（a）高低与慢性肺原性心脏病发病有相关性。     

Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men

So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ApoB) in subfractions of LDL and HDL in 265 healthy working men. Concentrations of cholesterol, phospholipids, and ApoB in small, dense atherogenic LDL particles (sdLDL) correlated negatively (p<0.001) with those of cholesterol, phospholipids, and ApoA1 in HDL2, respectively. Age correlated positively with sdLDL while increasing BMI correlated with an atherogenic shift of cholesterol, phospholipids, and ApoB from large, buoyant LDL (lbLDL) to sdLDL and decreasing concentrations of HDL2 constituents. Physical activity and alcohol intake correlated negatively with sdLDL constituents and positively with HDL2 components. Consumption of monounsaturated fatty acids (MUFA) correlated with a lower ratio of sdLDL to HDL2 cholesterol. A favorable lipoprotein subfraction profile linked to a reduced risk of cardiovascular disease in men was associated with physical activity, moderate alcohol consumption, and dietary intake of MUFA, which might be exploited in future interventions for prevention of age- and BMI-associated atherogenic shifts of lipoprotein subfractions.     

糖尿病患者尿GPDA与血清脂质变化的关系

目的　探讨糖尿病患者尿甘氨酰脯氨酸二肽氨基肽酶 (GPDA)与血清脂质变化的关系。方法　选择糖尿病患者 2 1 1例 ,正常对照组 98名 ,检测尿GPDA和血清脂质的水平 ,对其相互关系进行分析。结果　糖尿病患者组尿GPDA水平显著高于正常对照组 (t=4 .2 5 5 5 ,P <0 .0 0 1 ) ,血清胆固醇 (TC)、三酰甘油 (TG)、低密度脂蛋白胆固醇 (LDL C)、TC/高密度脂蛋白胆固醇比值 (TC/HDL C)、LDL C/HDL C比值、载脂蛋白B(ApoB)、脂蛋白 (a) [Lp(a) ]水平均高于正常对照组 (P <0 .0 0 1 ) ,而HDL C、载脂蛋白Al(ApoAl)、ApoAl/ApoB比值则明显低于正常对照组 (P <0 .0 1 )。糖尿病患者分组比较 ,血清TC、TG、LDL C、TC/HDL C、LDL C/HDL C、ApoB、Lp(a)随尿GPDA排泄量增多呈增高趋势 ,而HDL C、ApoAl、ApoAl/ApoB比值呈下降趋势。 结论　糖尿病患者伴有脂代谢紊乱 ,并与尿GPDA的升高、肾功能的损害相平行     

Concentrations of apolipoproteins B, C-I, C-II, C-III and E in sera from normal men and their relation to serum lipoprotein levels

The concentrations of apolipoproteins B, C-I, C-II, C-III and E (by enzyme immunoassay), and cholesterol, triglycerides and phospholipids both in while serum and in serum very low (VLDL), low (LDL) and high (HDL) density lipoproteins, HDL2 and HDL3, were determined in sera from 29 randomly selected normolipidemic men, age 40-60 years, in Stockholm, Mean values, +/- SD, were for, apolipoprotein B, 720 +/- 162; C-I, 63 +/- 14; C-II, 27 +/- 11; C-III, 125 +/- 57; and for E, 25 +/- 6 mg/l. A skewness to the right of the distributions was found for apolipoproteins B and C-II and for serum triglycerides and VLDL lipids. The relations between the different variables were studied by linear correlation analysis. Several significant correlations existed between the lipoprotein levels. Apolipoprotein C-I, C-II and C-III were significantly correlated with each other, whereas neither apolipoprotein B nor apolipoprotein E was correlated with any other apolipoprotein. The following significant, positive correlations existed between the apolipoproteins and total serum lipids and/or lipids of lipoprotein density classes: apolipoprotein B with serum cholesterol and LDL lipids, apolipoprotein C-I with HDL3 cholesterol, apolipoprotein C-II with serum triglycerides and VLDL lipids, apolipoprotein C-III with serum cholesterol and phospholipids. Apolipoprotein E showed no correlation with either serum lipids or lipoproteins.     

冠心病患者D二聚体的影响因素探讨

目的　探讨不同类型冠心病患者血浆D二聚体的水平及其影响因素。方法　对 12 4例不同类型的冠心病患者与 2 6例正常人分别采用酶联免疫吸附法测定血浆D二聚体和脂蛋白 (a)的水平 ;酶法测定甘油三酯、总胆固醇和高密度脂蛋白胆固醇的浓度 ,并计算出低密度脂蛋白胆固醇浓度 ;免疫散射比浊法测定载脂蛋白A1和载脂蛋白B浓度 ,同时检测其空腹血糖 ;测量其收缩压、舒张压、体重指数 ,并计算其吸烟指数。结果　D二聚体与甘油三酯、载脂蛋白B和脂蛋白 (a)呈明显正相关关系 (r =0 .393,0 .6 5 0和 0 .5 79,P <0 .0 0 1) ;与总胆固醇、收缩压、舒张压和空腹血糖亦呈正相关关系 (r =0 .2 35 ,0 .2 2 6 ,0 .195和 0 .198,P =0 .0 0 9,0 .0 12 ,0 .0 30和 0 .0 2 6 ) ;与载脂蛋白A1和高密度脂蛋白胆固醇呈负相关 (r =- 0 .4 96 ,- 0 .178,P <0 .0 0 1和P =0 .0 4 7)。结论　多种冠心病危险因子对冠心病患者的D二聚体水平有影响 ,其中载脂蛋白B和脂蛋白 (a)为独立影响D二聚体水平的危险因子。     

血脂、血糖与脑卒中的病因学关系分析

目的:探讨血脂、血糖与脑卒中的病因学关系。方法:选择100例脑卒中患者(脑梗死59例、脑出血41例)作为观察组,选择100例无影响血脂代谢及神经系统疾病健康体检者作为对照组。分别将脑卒中、脑梗死、脑出血患者的总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)水平与对照组患者进行比较。结果:脑卒中及脑出血患者TC、TG、HDL、LDL、ApoB与对照组比较差异有统计学意义(P<0.01),脑梗死患者TC、TG、HDL、LDL、ApoA、ApoB与对照组比较差异有统计学意义(P<0.01,P<0.05)。结论:血脂与脑血管病有一定关系,TG、HDL、LDL是预测脑卒中发病的重要易患因子;高血糖可能与严重脑卒中患者的预后有关。     

Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age

We quantified lipoprotein(a) [Lp(a)] immunochemically in young (less than 46 y) male survivors of myocardial infarction and in age-matched controls recruited from participants of the Prospective Cardiovascular Münster (PROCAM) study. We further determined apolipoprotein E polymorphism and measured triglycerides, total cholesterol, high- and low-density lipoprotein cholesterol (HDL and LDL), and apolipoproteins AI, AII, and B in the serum of these subjects. Lp(a) concentrations in serum were not correlated with other well-recognized risk factors for early myocardial infarction such as apolipoproteins AI and B, LDL cholesterol, and HDL cholesterol. Apolipoprotein E polymorphism did not affect Lp(a) concentrations, but had a major influence on apolipoprotein B concentration. Lp(a) concentrations were not influenced by age. Our data suggest that (a) an increased concentration of Lp(a) constitutes an independent risk factor for early myocardial infarction and (b) the concentrations of Lp(a) and LDL cholesterol (apolipoprotein B) in serum are under separate metabolic control.     

维生素E修饰的透析膜对血液透析患者血脂的影响

目的观察VitE修饰的透析膜对血液透析患者血脂的影响.方法 40名稳定血液透析患者随机分为2组.A组(n=20)用VitE修饰的透析膜透析;B组(n=20)用纤维素透析膜透析,观察4周.分别于第1次和第13次透析前抽血,测定血浆和红细胞中丙二醛(MDA)、VitE及血浆中的甘油三酯(TG)、总胆固醇(TCH)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、脂蛋白A[Lp(a)]、载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)浓度.结果 A组实验结束比实验前血浆VitE(P=0.003)和红细胞中VitE(P=0.032)明显升高,血浆MDA(P=0.043)和红细胞内MDA(P=0.033)明显下降.TC、TG、LDL、HDL无明显变化,但Lp(8)(P=0.049)、ApoB(P=0.040)明显下降,ApoA1(P=0.027)较前明显升高.B组实验前后观察指标无明显变化.结论使用VitE修饰的透析膜透析有抗氧化作用,改善脂质代谢,有助于防止动脉粥样硬化.     

高血压病患者血清瘦素及可溶性瘦素受体水平检测分析

目的　研究血清瘦素和可溶性瘦素受体水平与高血压病的关系。方法　应用放射免疫分析法(RIA)及 酶联免疫吸附分析法(ELISA)检测45例高血压病患者及33例健康对照组血清瘦素(Lp)、可溶性瘦素受体(sLR),同 时检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL C)、低密度脂蛋白胆固醇(LDL C)、载脂蛋白 ApoA、ApoB、ApoA/B、胰岛素(Ins)、C肽(C P)、胰岛素抵抗指数(HOMA IR)、体质量指数(BMI)、腰围、臀围等指 标,分析Lp、sLR与高血压、血脂异常、体形改变、BMI及胰岛素抵抗(IR)的关系。结果　高血压病组血清Lp、TC、 LDL C、ApoB明显高于对照组(P<0.05),sLR、ApoA/B明显低于对照组(P<0.01),TG、HDL C及BMI差异无 统计学意义。Lp与Ins、C P、HOMA IR、BMI、腰围及臀围呈正相关,与sLR呈负相关(P<0.05);sLR与Lp、C P、 BMI、腰围及臀围呈负相关(P<0.05),与Ins及HOMA IR无显著相关。结论　高血压病与Lp及sLR异常有关,其 与血脂异常、体形改变、BMI、IR密切相关,共同参与高血压病的形成。     

不同年龄脑梗死与血脂水平的相关性研究

AIM: To investigate the relationship between the patients with cerebral infarction(CI) in different ages and blood lipid levels.METHODS:The serum concentration of blood lipid levels were measured in 211 patients with CI and 144 control cases.RESULTS: The level of lipoprotein(a)[Lp(a)] in the young adults with CI and the levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL C), apolipoproteinB100(ApoB100) and Lp(a) in the subgroup of mid adults with CI were much higher than corresponding controls. The levels of TC, LDL C ApoB100 and Lp(a) in the subgroup of olds were significantly higher when compared with the corresponding controls, while the high density lipoprotein cholesterol(HDL C) level was lower. Multiple linear regression showed that age had positive correlation to TC and ApoB100 and negative correlation to HDL C. CONCLUSION: There are different disturbances of blood lipid metabolism in the patients with CI in different ages.The serum Lp(a) levels may be an independent risk factor for CI.     

幽门螺杆菌感染对冠心病患者血脂水平的影响

目的 探讨幽门螺杆菌(Hp)感染对冠心病患者血脂水平的影响.方法 应用醇联免疫吸附试验法测定冠心病患者(242例)和非冠心病患者(88例)血清Hp抗体(Hp IgG),比较两组Hp IgG阳性率;检测冠心痛患者血TC、TG、HDL-C、LDL-C、载脂蛋白A(APOA)、载脂蛋白B(APOB)等指标,并对HpIgG阳性组和Hp IgG阴性组进行对比分析.结果 冠心病组血清Hp IgG阳性率明显高于非冠心病组(53.3%与38.6%,P<0.05);冠心病患者Hp IgG阳性组HDL-C、APOA均明显低于Hp IgG阴性组(均P<0.05),而两组血清TC、TG、LDL-C、ApoB差异均无统计学意义(均P>0.05).结论 Hp感染与冠心病发病有关,可能通过降低HDL-C水平促进冠心痛的发生和发展. 冠心痛患者血TC、TG、HDL-C、LDL-C、载脂蛋白A(APOA)、载脂蛋白B(APOB)等指标,并对HpIgG阳性组和Hp IgG阴性组进行对比分析.结果 冠心病组血清Hp IgG阳性率明显高于非冠心病组(53.3%与38.6%,P<0.05);冠心病患者Hp IgG阳性组HDL-C、APOA均明显低于H IgG阴性组(均P<0.05),而两组血清TC、TG、LDL-C     

Correlation research between the patients with cerebral infaction in different ages and blood lipid levels

INTRODUCTIONInthepaper,wehopetoinvestigatetherelationshipbetweencerebralinfarctionindifferentagesandbloodlipidlevelsbythedeterminationsandcomparisonsofbloodlipidlevelsatthepatientswithcerebralin-farctionindifferentages.MATERIALSANDMETHODSMaterialsAccordingtothecriteriainstitutedbytheFourthNationalMeetingofCerebralVesselDisease,211patients(agedfrom19to80,mean58±13,124maleand87female)withcerebralinfarction(CI)inourhospitalfromJanuary1998toJuly2000wereselect-ed.Allcasesweredeterm…     

常用血脂检测指标及临床意义

血脂可反映体内脂类代谢的情况,是临床上重要的检测指标,广泛应用于动脉粥样硬化性心血管疾病（ASCVD）的防治中。临床上把血浆中总胆固醇（TC）和（或）甘油三酯（TG）过高或高密度脂蛋白胆固醇（HDL C）过低称为脂质异常。血脂分类中的TG、HDL C、低密度脂蛋白胆固醇（LDL C）、脂蛋白（a）［Lp（a）］、ApoA1、ApoB等对评估ASCVD的发生、发展具有重要意义。本文就血脂种类、水平划分、脂质异常分类及相关临床意义进行综述。     

Lipids, lipoproteins and apolipoproteins in the elderly

The lipoprotein components were studied in connection with a population study concerning the state of health and living habits of the elderly people in Turku, Finland. Serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, apolipoprotein A1 (apo A1) and apolipoprotein B (apo B) of the 347 elderly people (aged 65 years or over) were measured and those of low density lipoprotein (LDL) cholesterol were calculated. The levels of total cholesterol, LDL cholesterol and apo B were significantly higher in females than in males, and the concentrations decreased with advancing age. The concentrations of HDL cholesterol and apo A1 were significantly higher in females than in males but age had no effect. Serum triglycerides behaved differently in males and females; in females age had a significant increasing effect whereas in males no age effect was observed. The apo A1/apo B ratio did not differ between males and females. Reference values of serum lipids, lipoproteins and apolipoproteins of the elderly are suggested.     

应用ROC曲线评价同型半胱氨酸及血脂水平对脑梗死的诊断价值

目的评价同型半胱氨酸（homocysteine,Hcy）及血脂水平在脑梗死（cerebralinfarction,CI）中的诊断价值。方法选择73例CI住院患者和30例健康体检者,使用奥林巴斯AU400全自动生化分析仪测定Hcy,脂蛋白a[1ipoprotein（a）,Lp（a）]及其他脂类指标,采用t检验对两组间的数据进行比较,并绘制受试者工作特征（receiveroperatingcharacteristic,ROC）曲线对各指标的临床诊断性能进行评价。结果Hcy、Lp（a）、载脂蛋白B（apolipoproteinB,ApoB）、低密度脂蛋白胆固醇（10wdensitylipoproteincholesterol,LDL-C）及甘油三酯（triglyeride,TG）的水平在两组间差异均有统计学意义（P均〈0．01）,两组间胆固醇（cholesterol,CHO）、载脂蛋白A（apolipoproteinA,ApoA）、高密度脂蛋白胆固醇（highdensitylipoproteincholesterol,HDL-C）水平差异均无统计学意义（P均〉0．05）;Hcy、Lp（a）、ApoB、LDL-C的ROC曲线下面积（areaundercurve,AUC）分别为0．767、0．745、0．734、0．715．对CI的最佳诊断cutoff值分别为15．250μmol／L,162．000mg／L,1．030g／L,2．495mmol／L。TG、HDL-C、ApoA、CH0的AUC^ROC分别为0．640、0．613、0．593、0．515。结论Hcy、Lp（a）、ApoB、LDL-C对CI具有较好的诊断价值,TG、HDL-C、ApoA、CH0的诊断价值较差。     

维持性血透患者营养不良、炎症与脂质代谢紊乱的相关性分析

目的:探讨尿毒症维持性血透(MHD)患者营养不良、炎症与脂质代谢紊乱三者间的相关关系,以及对心血管并发症的预测。方法:测51例尿毒症维持性血透患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白(Apo)A1、ApoB、脂蛋白(a)LP(a)、白蛋白(ALB)、C反应蛋白(CRP)、血清铁蛋白(SF),与30例正常人进行对照研究。结果:MHD患者TG、LDL、ApoB、LP(a)、CRP、SF显著增高,HDL、ApoA1、ALB显著降低(P<0.05);随着透析时间的延长,各项检测指标变化进一步加重;且心血管事件发生者血清CRP和LP(a)明显增高,ALB明显降低,血脂紊乱更显著。相关性分析:ALB与HDL、ApoA1正相关,与CRP、LP(a)、TC、TG、ApoB负相关;CRP与LP(a)、TC、TG、ApoB、LDL、SF正相关,与HDL、ApoA1负相关,P均<0.05。结论:MHD患者存在明显的脂质代谢紊乱、炎症和营养不良,三者的相互促进和影响可能是心血管事件发生的危险因素。     

缺血性脑卒中患者载脂蛋白及血浆脂蛋白相关磷脂酶A2与TOAST病因分型的研究

目的 探讨载脂蛋白（Apo）及血浆脂蛋白相关磷脂酶A2（Lp PLA2）与缺血性脑卒中TOAST病因分型的关系。方法 将388例缺血性脑卒中患者按照经典的TOAST病因分型进行分组,分别为心源性脑栓塞(CE)、大动脉粥样硬化性卒中(LAA)、小动脉卒中/腔隙性脑梗死(SAO)、其他原因引发的缺血性卒中(SOE) 、原因不明的缺血性卒中(SUE),所有患者次日晨抽取静脉血检测ApoA1、ApoB、ApoH及血浆Lp PLA2。比较各组年龄、高血压、糖尿病、吸烟、饮酒、血脂异常的暴露率; 分析LAA及SAO发病的危险性因素。结果 5组高血压、糖尿病和血脂异常暴露率比较差异有统计学意义(P<0.01);LAA组及SAO组的Lp PLA2、ApoB水平均高于CE、SOE及SUE组(P<0.05);LAA组及SAO组的ApoA1水平低于CE、SOE及SUE组(P<0.05);Lp PLA2、ApoB水平是LAA及SAO患者的危险因素,ApoA1是保护性因素。结论 Lp PLA2及ApoB水平升高是LAA及SAO患者的危险因素,而ApoA1水平升高是保护性因素,血浆Lp PLA2、ApoB及ApoA1水平检测有助于明确缺血性脑卒中的TOAST病因分型。     

Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome

Objective: Dyslipidaemia is very common in patients with polycystic ovary syndrome (PCOS) but, beyond plasma lipids, atherogenic lipoprotein (Lp) and apolipoprotein (apo) alterations are still ill defined. Design: We measured concentrations of apoB, Lp(a) and small, dense low‐density lipoprotein (LDL) in 42 patients with PCOS [age: 28 ± 7 years, body mass index (BMI): 27 ± 5 kg/m²] vs. 37 age‐ and BMI‐matched healthy controls. Methods: Elevated Lp(a) levels considered were those > 30 mg/dl while elevated apoB concentrations were those > 100 g/l. Results: Polycystic ovary syndrome showed increased triglycerides levels (p = 0.0011) and lower high‐density lipoprotein (HDL)‐cholesterol concentrations (p = 0.0131) while total‐ and LDL cholesterol were similar. PCOS also showed smaller LDL size (p = 0.0005), higher levels of total small, dense LDL (p < 0.0001), higher concentrations of Lp(a), as considered as absolute values (p = 0.0143) and log‐transformed (p = 0.0014), while no differences were found in apoB levels. Elevated Lp(a) concentrations were found in 24% of PCOS, while elevated apoB levels were relatively uncommon (14%). Spearman correlation analysis revealed that Lp(a) concentrations were weakly correlated only with HDL‐cholesterol levels (r = ?0.378, p = 0.0431). In addition, 36% of patients with PCOS with normal plasma lipid profile showed elevated levels of Lp(a), apoB or small, dense LDL. Conclusions: Atherogenic Lp abnormalities may be found in one‐third of women with PCOS who have a normal lipid pattern. Future prospective studies are needed to test to which extent such atherogenic forms of dyslipidaemia may contribute to the increased cardiovascular risk in young women with PCOS.     

Lipoproteins and apolipoproteins in human pleural effusions.

We investigated the lipoproteins and apoproteins in human serum and pleural effusions of different origin: transudates, inflammatory exudates, and malignant exudates. Transudates had a low cholesterol content of 35 +/- 12 mg/dl (mean +/- SD) because of low levels of low-density lipoprotein (LDL) cholesterol--representing 16% of serum levels--whereas inflammatory exudates (cholesterol 92 +/- 26 mg/dl) and malignant exudates (cholesterol 86 +/- 6 mg/dl) exhibited high levels of LDL, with 67% and 69% of serum levels. Apolipoprotein (apo) B level corresponded with LDL and presented with multiple split-products in sodium dodecyl sulfate-polyacrylamide gel electrophoresis in exudative effusions. LDL levels in effusions correlated with serum levels in exudates but did not correlate with those in transudates. In contrast, lipoprotein(a) appeared in all effusions from patients with detectable serum levels. The isoforms were similar as demonstrated by immunoblotting. Differences were found in the composition of the high-density lipoprotein (HDL) fraction: transudates had cholesterol-rich HDL when compared with serum. HDL particles of malignant exudates were poor in cholesterol, and isoelectric focusing demonstrated more sialized apolipoprotein E. A strongly abnormal HDL level with accumulation of cholesterol was found in a long-standing tuberculous effusion. In conclusion, cholesterol in acute effusions is bound to lipoproteins and derived from the blood. The difference in total cholesterol levels between transudates and exudates is based on the lack of LDL in transudates. Transudates show the lipoprotein characteristics of interstitial fluid. Alterations of lipoproteins occur in chronic inflammation and in malignancy with possible de novo synthesis of apolipoprotein E by tumor cells. Lipoprotein(a) accumulates independently from LDL in the pleural space, a finding that supports the view that the physiologic function of lipoprotein(a) is located in the interstitial space.     

血脂与动脉粥样硬化发展阶段的相关性

目的通过检测动脉粥样硬化(As)不同发展阶段的各种血脂相关指标,来探讨各种检测值与As各个发展阶段的相关性。方法随机选择健康体检者60例[As(-)组]、脑As无并发症患者24例[As(+)组]、As性脑梗死患者67例[As(++)组],酶化学法测定血清三酰甘油(TG)、总胆固醇(TC),直接法测定低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC),免疫透射比浊法测定载脂蛋白A1(ApoA1)、载脂蛋白B100(ApoB100)、脂蛋白(a)[LP(a)],并对三组的检测值进行统计分析。结果As(+)组与As(-)组比较,TG、TC、LDLC、ApoB100、LP(a)、ApoB100/ApoA1增高(P<0.05),HDLC、ApoA1降低(P<0.05)。As(++)组与As(+)组比较,ApoB100、LP(a)、ApoB100/ApoA1增高(P<0.05)。As(++)组与As(-)组比较,ApoB100、LP(a)、ApoB100/ApoA1显著增高(P<0.01)。结论TG、TC、LDLC、HDLC、ApoA1、ApoB100、LP(a)、ApoB100/ApoA1水平与As的早期发展阶段相关,而且ApoB100、LP(a)、ApoB100/ApoA1水平与As的晚期发展阶段相关。