体检人群的体脂率与代谢指标的相关性分析

目的 观察并探讨体检人群的体脂率与代谢指标的相关性.方法 3410例于本院体检中心进行体检的人员为研究对象,通过数据分析探讨人群的体脂率与代谢指标的相关性.结果 男女体检者在年龄、体脂率、舒张压(SBP)、收缩压(DBP)、空腹血糖(Glu)、甘油三酯(TG)、高密度脂蛋白(HDL)、总胆固醇(TC)、糖化血红蛋白(H...     

脂联素、体质量指数与女性心脑血管病的关系

目的通过检测女性心脑血管病患者血清脂联素、体质量指数(body mass index,BMI),明确二者与与女性心脑血管病的关系。方法女性住院患者120例,其中心脑血管病患者60例,非心脑血管病患者60例。分别测量身高、体质量并获取体质量指数,同时抽取肘静脉血,以检测脂联素。结果女性心脑血管病患者的年龄、BMI要高于非心脑血管病患者,两组间有明显的统计学差异[年龄(66.83±10.59)VS(63.26±11.99),P<0.05;BMI(25.68±3.41)VS(23.30±8.47),P<0.001]。脂联素水平在心脑血管病组要低于非心脑血管病组,二组之间有明显的统计学差异[(7.59±2.44)VS(9.62±1.11),P<0.001]。脂联素是女性心脑血管病患者的独立危险因素(OR=1.84)。结论女性心脑血管病患者的年龄、BMI和脂联素与非心脑血管病患者相比具有显著差异,脂联素是女性心脑血管病患者的独立危险因素。     

生物电阻抗法测量2型糖尿病患者体脂率的可行性研究

目的研究应用生物电阻抗法测量糖尿病患者体脂含量并探讨其可行性。方法 92例2型糖尿病患者进行生物电阻抗法测量体脂率、测量皮褶厚度。将用生物电阻抗法测得的体脂率与应用皮褶厚度推导的体脂率进行相关分析。结果生物电阻抗分析法测量的体脂率与应用皮褶厚度推导的体脂率相关系数r=0.756,P<0.01。结论应用生物电阻抗法测量2型糖尿病患者体脂率具有较高的可行性。     

健康体检人群体脂率与代谢指标的相关性研究

目的探讨深圳地区健康体检人群的体脂率与血压、血脂、血糖、尿酸、骨代谢等临床指标的相关性。方法回顾性分析2016年8~12月我院体检中心305例成年人健康体检者的体检资料,利用Pearson相关分析观察体脂率与各代谢指标的相关性。结果男性人群的体脂率与BMI(r=0.295,P<0.05)、TC(r=0.508,P<0.05)、LDL(r=0.576,P<0.05)、Ins(r=0.342,P<0.05)指标存在正相关;女性人群的体脂率与BMI(r=0.337,P<0.05)、TC(r=0.301,P<0.05)、Ins(r=0.299,P<0.05)、UA(r=0311,P<0.05)、Hcy(r=0.249,P<0.05)、Vit D(r=0.341,P<0.05)、β-CTX(r=0.357,P<0.05)、OC(r=0.464,P<0.05)指标均存在正相关,与HDL存在负相关(r=-0.325,P<0.05)。结论深圳地区成人健康体检者体脂率超重率高,体脂率可预测高脂血症、胰岛素抵抗、高尿酸血症、骨质疏松等疾病的发病风险,其性别亦为影响体脂率的重要因素,但无论对于男性、女性,均需采取针对性的健康教育及生活干预,以此稳定体脂率,保证其正常代谢,提高生活质量。     

不同人群2型糖尿病患者体脂含量百分比、体质指数与骨密度相关性

目的分析不同人群2型糖尿病患者体脂含量百分比、体质指数与骨密度相关性。方法资料随机选自2013年7月至2014年7月本院收治的2型糖尿病患者150例,测量体质指数、体脂含量百分比、骨密度,分析各指标相关性。结果依据体质指数进行分组,肥胖组体脂含量百分比、体质指数高于正常组与超重组,对比差异有统计学意义(P<0.05)结论体脂含量百分比、体质指数和骨密度密切相关,相较于2型糖尿病男性患者,女性患者的骨密度下降较为明显,患者保持适当体质量可能利于骨质疏松的预防。     

脂联素及体质指数与女性冠状动脉粥样硬化性心脏病的关系

目的检测女性冠状动脉粥样硬化性心脏病（冠心病）患者血清脂联素及体质指数，并探讨其与冠心病的关系。方法初步诊断为冠心病的女性患者125例，其中确诊冠心病患者50例为冠心病组，非冠心病患者75例为非冠心病组。分别测量2组身高、体重获取体质指数，同时抽取肘静脉血检测脂联素。结果冠心病组患者的年龄、体质指数高于非冠心病组患者，2组相比有统计学意义。年龄（66．83±10．59）对比（63．26±11．99），（P〈0．05）；体质指数（25．68±3．41）对比（23．30±8．47），（P〈0．01）。冠心病组脂联素水平低于非冠心病组，（7．59±2．44）对比（9．62±1．11），2组之间有统计学意义（P〈0．01）。结论女性冠心病患者的年龄、体质指数和脂联素与非冠心病患者相比存在差异，脂联素是女性冠心病患者的独立危险因素。     

脂蛋白脂酶基因Pvu Ⅱ酶切位点多态性与高脂血症的关系

目的探讨脂蛋白脂酶基因第6内含子PvuⅡ酶切位点多态性与高脂血症发生之间的关联性。方法采用聚合酶链反应及限制性片段长度多态性方法对辽宁大连地区144例高脂血症患者及173例血脂正常者脂蛋白脂酶基因PvuⅡ酶切位点多态性及其与血脂、载脂蛋白水平的关联进行对照研究。结果高脂血症组P 等位基因频率较对照组增加(0.79vs0.64,P<0.01);而P-等位基因频率则明显低于对照组(0.21vs0.36,P<0.01)。高脂血症组P P 基因型者血浆甘油三酯水平明显高于P P-和P-P-(P<0.01);血浆总胆固醇水平、LDL也高于P P-和P-P-(P<0.05),而HDL-C水平则降低。结论脂蛋白脂酶基因内含子PvuⅡ酶切位点多态性与高脂血症有一定关联。     

正常人血清瘦素水平及其与性别、体质量指数和腰臀比的关系

目的:研究正常人群血清瘦素水平及其与性别、体质量指数(BMI)和腰臀比(WHR)的关系。方法:以我市体检人群中的300例志愿者作为研究对象,并根据体质量分为正常组155例和肥胖组142例,测定血清瘦素(RIA法)、身高、体质量、腰围和臀围。结果:正常组的血清瘦素水平不服从正态分布,中位数6.66μg/L,正常组81例女性瘦素中位数为8.89μg/L,双侧90%瘦素浓度范围为5.43～15.39μg/L;74例男性瘦素中位数为3.15μg/L,双侧90%瘦素浓度范围为0.25～9.99μg/L。BMI与性别因素对血清瘦素水平均有显著影响,两者比较差别有统计学意义(P<0.001)。肥胖组的血清瘦素水平呈正态分布,男性血清瘦素为(9.14±4.77)μg/L;女性血清瘦素为(19.34±10.90)μg/L。女性和男性的BMI、WHR均与瘦素浓度呈线性相关。结论:血清瘦素浓度性别差异显著,与BMI及WHR显著相关,肥胖组血清瘦素浓度比正常组显著升高。     

体质指数、腰臀围比与高血压、糖尿病患病关系研究

分析了体质指数、腰臀围与血压、血糖的关系 ,提示 BMI、WHR与血压、血糖呈正相关关系 ,随着 BMI、WHR增加 ,高血压、糖尿病患病率呈上升趋势 ,腹型肥胖者高血压、糖尿病患病危险性明显增大     

Optimal body fat percentage cut-offs for obesity in Chinese adults

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2型糖尿病患者体脂指标与血压血脂的关系

目的：探讨2型糖尿病患者体质指数（BMI）、腰围（WC）、腰臀比（WHR）、腰围／身高比（WHtR）与血压、血脂的关系。方法调查191例2型糖尿病患者,测量身高、体重、腰围、臀围及血压,计算BMI、WHR、WHtR,测定总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）,分析上述四种体脂指标与2型糖尿病患者血压、血脂的关系。结果偏相关分析显示：BMI、WC、WHR、WHtR均与收缩压（SBP）独立正相关,其中WHtR相关性最强。BMI、WHtR均与舒张压（DBP）呈正相关。BMI、WC、WHR、WHtR异常组的SBP、DBP、TC、TG、LDL-C水平均较正常组偏高,HDL-C水平较正常组偏低。多元逐步线性回归表示WHtR为TG水平的影响因素。结论各体脂指标（BMI、WC、WHR、WHtR）与2型糖尿病患者的血压及血脂水平的改变有一定的相关性,对于减少2型糖尿病患者发生代谢综合征的风险而言,预防肥胖是至关重要的。     

Value of waist circumference, body mass index and hyperinsulinaemia in identifying metabolic syndrome

To investigate the significance of waist circumference (WC), body mass index (BMI) and hyperinsulinaemia A (HIns) in evaluating metabolic syndrome (MS). Clinical data from middle-aged and senile individuals (middle-senile group) who received glucose tolerance test after diabetes mellitus screening and a group of subjects who received annual oral glucose tolerance test (OGTT) for diabetes mellitus screening (adult group) were collected. Data were collected by use of special messengers, input into a computer data base and analyzed using SAS 5.0 software by expert staff. Abnormal WC and BMI were determined according to International Diabetes Federation (IDF) and Chinese Diabetes Society (CDS) criteria. HIns was ascertained if fasting insulin (FIns) ⩾ 15 mU/L, and/or 2-hour insulin after a glucose challenge was (2hPIns) ⩾ 80 mU/L. Abnormalities in WC, BMI and HIns were all found to be risk factors for abnormal glucose metabolism, hypertension and dyslipidemia. In the middle-senile group, the abnormality rate of WC and HIns as well as the overall insulin level were significantly higher than those in the adult group. The abnormality rate of BMI was higher in the adult group, and HIns was mostly seen in impaired glucose test (IGT) and normal glucose test (NGT). The concordance rate of WC and BMI diagnostic criteria for evaluating obesity in the middle-senile and adult groups were 77.5% and 74.3%, respectively. When only the WC criterion was used for evaluating the existence of insulin resistance, there was a 28.2%missed diagnosis rate for MS patients. WC, BMI and HIns were all risk factors for abnormal glucose metabolism, hypertension and dyslipidemia. There was differing prevalence in the different populations. The combination of WC, BMI and HIns might be more helpful in identifying MS at early stage. __________ Translated from Medical Journal of Chinese People’s Liberation Army, 2007, 32(10): 1001–1004 [译自: 解放军医学杂志]     

低血糖指数膳食对代谢综合征患者体重指数、腰臀比值及内脏脂肪的影响

目的研究低血糖指数（GI）膳食对代谢综合征（MS）患者体重指数（BMI）、腰臀围比值（W/H）和内脏脂肪的影响。方法选取BMI≥25 kg/m2的MS患者296例,进行为期8周的低GI膳食的标准化的营养干预,观察干预前后BMI、W/H、VFA及非酒精性脂肪肝（NAFLD）的变化情况,采用SPSS 15.0软件包进行统计分析。结果干预后BMI、W/H下降,VFA减少,NAFLD的严重程度改善,与干预前对比,P均〈0.01,有统计学意义。结论在控制总能量的基础上,采用低GI膳食的标准化营养干预能有效改善MS患者的BMI、W/H、内脏脂肪积聚及NAFLD。     

2型糖尿病患者肥胖不同指标与尿微量白蛋白关系的探讨

目的:探讨2型糖尿病(T2DM)患者尿微量白蛋白(UMA)的发生与腰臀比(WHR)、腰围身高比(WHtR)及体质量指数(BMI)等之间的关系.方法:292例T2DM患者根据BMI分为正常组(88例)、超重组(121例)和肥胖组(83例),分析各组24 h UMA变化及其影响因素.结果:随着BMI的增加,WHR、WHtR、24 h UMA、舒张压(DBP)呈上升趋势,差异有统计学意义(P＜ 0.05或P＜0.01);UMA与病程、WHtR、WHR、BMI、SBP、DBP呈显著正相关(r分别为0.119、0.603、0.426、0.509、0.210和0.205,P＜0.05或P＜0.01);多元逐步回归分析结果表明WHtR、SBP是UMA的危险因素(P＜ 0.05或P＜0.01).结论:WHtR较大的T2DM患者微量白蛋白尿发生的可能性较大,腹型肥胖是微量白蛋白尿的危险因素.     

腰围身高比值与2型糖尿病关系的随访研究

目的探讨和评价腰围／身高比值（WHtR）作为腹型肥胖的指标与2型糖尿病发病危险的关系。方法以2000年参加石家庄市社区健康检查的35～55岁城市居民中筛选出无高血压、血脂异常、糖尿病或糖耐量异常及其他疾病的单纯肥胖者558例作为研究对象,2007年对上述人群进行随访,随访到520例,分析评价WHtR与2型糖尿病发病风险的关系,应用logistic回归进一步分WHtR、腰围（WC）、体质指数（BMI）、腰臀比（WHR）对2型糖尿病的预测作用。结果WHtR≥0．5组2型糖尿病的发病率26．7％（86／322）明显高于WHtR〈0．5组10．6％（21／198）,2组差异有统计学意义（x2=19．40,P〈0．01）;WHtR≥0．5组的血压、TC、TG、LDL-C、HOMA-IR明显高于WHtR〈0．5组,HDL-C明显低于WHtR〈0．5组;Logistic逐步回归分析显示,WHtR、WC、BMI、WHR均进入回归方程,但WHtR成为2型糖尿病的主要危险因素,比数比分别为4．68、3．72、2．49、2．28。结论WHtR与WC高度相关,可成为腹型肥胖的有效参考指标,同时WHtR可作为预测单纯肥胖人群发生2型糖尿病的指标。     

CSF/plasma ratio of 10-hydroxynortriptyline is influenced by sex and body height

The CSF/plasma ratios of nortriptyline (NT) and its major metabolite 10-hydroxy-NT (10-OH-NT) were investigated retrospectively in 25 depressed patients. For 10-OH-NT (but not NT), a significant influence of sex and body height was found, most conspicuously in males, in whom the ratio related to body height curvilinearly (N=8;R=0.93;P<0.01). In males, the NT/10-OH-NT ratio in plasma correlated with body height (N=8;r=0.80;P<0.05). Hypothetically, CSF circulation is partly influenced by body height, which accounts for a steeper gradient of 10-OH-NT across the blood-brain barrier in taller persons. From the lumbar site, the more polar 10-OH-NT is assumed to be eliminated by bulk flow via the villi, while the less polar NT exits by diffusion in the choroid plexus. Prospective studies are urgently needed to further evaluate the distribution of antidepressants in the CSF.     

Role of heart rate in the relation between regional body fat and subendocardial viability ratio in women

Subendocardial viability ratio (SEVR) is a measure of left ventricular function, specifically; it is an index of myocardial perfusion relative to left ventricular workload. Women have lower SEVR than men, partly due to a faster resting heart rate that reduces diastolic time (i.e., time for myocardial perfusion). It is unclear if body fat relates to SEVR, thus the purpose of this study was to examine the relation between body fat and SEVR in women. Twenty‐eight middle‐aged (31–45 years) and 31 older (60–80 years) women were examined. Radial artery applanation tonometry was used to calculate SEVR from a synthesized central aortic pressure wave. Dual‐energy X‐ray absorptiometry was used to assess body composition including fat in the trunk, legs, android and gynoid regions. Body fat was not related (P>.05) with SEVR in older women. In middle‐aged women, all measures of regional fat were correlated with heart rate (range, r=.49–.59, P≤.01) and SEVR (range, r=.43–.53, P≤.01). Android‐to‐gynoid ratio was identified as the strongest predictor (r²=?.26, P<.01) of SEVR among measures of regional fat. Middle‐aged women with lower android‐to‐gynoid fat ratio had higher SEVR (1.96±0.33 vs 1.66±0.20, P=.009) than women with higher fat ratio, even after adjusting for age, height, daily physical activity, and aortic mean pressure (P=.02). Adjusting for heart rate or diastolic time abolished the difference in SEVR between groups (1.80±0.09 vs 1.82±0.09, P=.56). These results suggest that middle‐aged women with a greater distribution of fat in the abdomen have poorer left ventricular function that is dependent on the negative influence of heart rate on diastolic time.     

某社区507名65岁以上老人体检资料分析

目的：分析社区65岁以上老年人健康状况。方法：统计分析体重指数、血压、血糖、血脂、丙氨酸转氨酶、尿酸、尿素、肌酐指标在不同年龄和性别患者间的差异。结果：体重指数异常率为40%,甘油三酯总异常率为48%,总胆固醇总异常率为24%,血糖总异常率为25%,不同年龄段异常率比较差异无统计学意义（P＞0.05）,男女比较差异有统计学意义（P＜0.05）。血压控制良好。结论：需重视老年人健康教育,定期进行体检。     

Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjects

1. Obesity appears to influence vascular stiffness, an important cardiovascular risk factor. An accurate picture of arterial stiffness may be obtained when a combination of various techniques is used. 2. The purpose of the present study was to assess whether the body mass index (BMI) and body fat content obtained by bioimpedance were of equal value in estimating the influence of body fatness on various indices of vascular stiffness and wave reflection. 3. A total of 175 healthy subjects was studied. Anthropometric measurements and total body bio-impedance analysis were performed to assess fat mass as a proportion of total body composition. Arterial stiffness and wave reflection were assessed using digital volume pulse analysis and tonometric measurement of the wave reflection indices and central haemodynamics. 4. Significant differences in the stiffness index (SI(DVP); P < 0.0001), peripheral augmentation index (pAI(x); P < 0.0001), central augmentation index (cAI(x); P < 0.0001), peripheral pulse pressure (pPP; P = 0.026) and central pulse pressure (cPP; P < 0.0001) were found when the population examined was divided accordingly to tertile of body fat content. However, subdividing various indices of arterial stiffness according to the tertile of BMI did not reveal any significant differences between groups, except for pPP and cPP. 5. Body fat content was significantly correlated with SI(DVP), pAI(x), cAI(x), pPP and cPP. The BMI correlated weakly with SI(DVP), pPP and cPP. 6. In conclusion, the BMI is not very useful in predicting changes in arterial stiffness and wave reflection due to obesity. However, stiffness and wave reflection indices derived from digital volume pulse analysis, the characteristics of radial and aortic pressure waveforms and peripheral and aortic pulse pressure are all related to body fat content, as estimated by bioimpedance.