梭形细胞血管内皮瘤

报告1例梭形细胞血管内皮瘤.患者男,16岁.右跖部结节10余年,相继波及左足和双小腿下段,无自觉症状.皮损组织病理检查可见真皮中下层由海绵状血管腔隙和梭形细胞组成的团块.依据临床表现和组织病理学改变,诊断为梭形细胞血管内皮瘤.     

梭形细胞血管内皮瘤1例

临床资料 患者女，82岁，头顶、额部浸润性斑块、结节半年余。半年前无明显诱因额部出现鸡蛋大紫蓝色斑片，无疼痛及痛痒感，皮损进行性增大。患者未予重视。2个月前在其头顶、额部出现境界清楚的浸润性斑块。近2周出现轻微痒感，抓后易出血。遂于2005年8月1日来我科就诊。     

卡波西形血管内皮瘤一例

患者男,21岁,因左下肢肿胀、疼痛 4个月,伴结节、肿块2个月入院。4个月前患者出现左下肢肿胀,轻度疼痛。2个月前左下肢、腹股沟、会阴部出现蓝紫色及暗红色结节,逐渐增大。同时左下肢肿胀加剧,阴囊及阴茎出现水肿,左下肢活动受限。在外院病理检查怀疑卡波西肉瘤,为进一步诊治而收入院。家族中无类     

梭形细胞鳞状细胞癌一例

患者女,62岁.下唇斑块伴轻度瘙痒2年就诊.2年前无明显诱因下唇中部出现一硬化、增厚的黄豆大小斑疹,轻度瘙痒,少许片状脱屑,无糜烂、渗液及结痂.     

梭形细胞血管瘤

报告1例梭形细胞血管瘤。息者男,24岁。左手掌大鱼际、手腕屈侧多个结节2~3年来诊。皮损组织病理检查显示真皮中下层由海绵状血管腔隙和梭形细胞组成的团块。诊断梭形细胞血管瘤。     

梭形细胞血管瘤

报告1 例梭形细胞血管瘤.患者女,52 岁.左足外侧缘、外踝及左跖部结节伴疼痛15 年.皮损组织病理检查示真皮中下层由海绵状血管腔隙和梭形细胞组成的团块,诊断:梭形细胞血管瘤.     

复发性多发性梭形细胞血管瘤

报告1例复发性多发性梭形细胞血管瘤.患者女,20岁.因左手背反复出现红色结节6年就诊.患者曾3次行手术切除皮损,但多数结节均于术后在原位复发.皮损组织病理检查示真皮内大量增生的梭形血管内皮细胞,形成大小不一的血管腔及实性肿瘤团块.诊断:梭形细胞血管瘤.     

色素性梭形细胞痣

<正>患者女,34岁。主诉:右侧臀部黑色丘疹半年。现病史:患者半年前无明显诱因右侧臀部出现一直径约2 mm的黑色丘疹,无明显自觉症状,皮损增大明显,于2018年5月14日就诊于我科。既往史、个人史及家族史:无特殊。体格检查:一般情况好,系统检查正常。皮肤科检查:右侧臀部一直径约4 mm的黑色扁平丘疹,类圆形,境界清楚,颜色均匀,形态对称(图1)。     

皮肤梭形细胞鳞状细胞癌1例

患者男,70岁,阴茎增生物半年余。患者半年多前无明显诱因出现阴茎新生物,无明显疼痛、瘙痒等不适,自行外用抗生素药膏后无明显好转;曾因尿道梗阻行包皮环切术,否认冶游史。皮肤科情况：冠状沟左侧可见一增生物,表面凹凸不平,有湿润感,但无明显分泌物,触痛(-),双侧腹股沟淋巴结未触及。病理诊断为冠状沟皮肤梭形细胞鳞状细胞癌(HPV不相关型)。     

Cutaneous metastasis from anaplastic thyroid carcinoma exhibiting exclusively a spindle cell morphology. A case report and review of literature

Anaplastic thyroid carcinoma is a highly aggressive cancer accounting for 1–2% of thyroid malignancies. Cutaneous metastases from anaplastic thyroid carcinoma are exceedingly rare. We report a 65‐year‐old woman with anaplastic thyroid carcinoma (BRAF V600E mutation) who had lymph node metastases (pT4 N1b) treated by total thyroidectomy, postoperative radiotherapy, adjuvant chemotherapy (paclitaxel and pazopanib) and targeted therapy (vemurafenib). Nine months after initial diagnosis, radiographic studies revealed multiple pulmonary metastases. A dermatologic examination showed a solitary 1.2‐cm chest nodule. Skin biopsy from this nodule revealed infiltrative dermal spindle cells arranged in poorly formed fascicles. Immunohistochemical studies demonstrated the tumor cells to be PAX‐8 (+), pancytokeratin (+, focally), TTF‐1 (?) and SOX‐10 (?). Comparison with the patient's primary anaplastic thyroid carcinoma revealed focal areas of poorly differentiated spindle cells morphologically similar to the malignant spindle cells in the skin biopsy. Together, these findings confirmed the diagnosis of anaplastic thyroid carcinoma metastatic to skin. Cutaneous metastasis of anaplastic thyroid carcinoma composed exclusively of spindle cells broadens the histologic differential diagnosis of cutaneous spindle cell malignancies and presents further diagnostic challenges. PAX‐8 may be useful in discerning the spindle cell component of anaplastic thyroid carcinoma from other spindle cell malignancies in the skin.     

A case of combined nevus: compound nevus and spindle cell Spitz nevus

Combined nevi consisting of a Spitz nevus and an acquired nevus are unusual, and, to our knowledge, the combination of a spindle cell Spitz nevus and an overlying compound nevus has not been previously reported. We report a 17-year-old girl with a nodule on the left anterior lower extremity. The nodule was asymptomatic, firm, brown, symmetrical, dome-shaped, 8 mm in diameter, and not found with ulceration. Histological findings showed proliferation of spindle-shaped cells with an overlying compound nevus. The spindle-shaped cells were large, non-pigmented, uniform in size and shape, with rare mitoses and without nuclear atypia, and arranged in a storiform pattern in thick collagen bundles. They stained positively for S-100 and negatively for HMB-45. The lesion was considered to be a new type of combined nevus consisting of a spindle cell Spitz nevus and an overlying compound nevus.     

Coexistence of spindle cell lipoma and ordinary lipoma

We report a patient with a spindle cell lipoma on the nape and three ordinary lipomas on the abdomen and extremities. The coexistence of spindle cell lipoma and ordinary lipoma in a single patient is rare. Abundant CD34-positive spindle cells and mast cells were found in the spindle cell lipoma, but in the ordinary lipomas, only a small number of CD34-positive spindle cells were found in the interstitial connective tissue and no mast cells were seen. Because mast cells are known to stimulate mesenchymal cell proliferation and collagen production, mast cell infiltration may be a trigger for the proliferation of CD34-positive spindle cells, leading to the conversion of ordinary lipoma into spindle cell lipoma.     

梭形细胞血管肉瘤一例

患者男,95岁,因双上肢出现红色结节1年余,于2016年8月23日来广州医科大学附属第二医院皮肤科就诊。患者于1年前双上肢无明显诱因出现红色结节,皮损进行性增大且数量增多,无疼痛、瘙痒,未予治疗。既往体健,否认高血压、冠心病等慢性病史,否认外伤史及手术史。家族成员中无类似病史……     

Spindle cell hemangioendothelioma: report of three cases

Three cases of spindle cell hemangioendothelioma were studied. Two had multiple nodules and the third had a single, recurrent lesion in the dermis or subcutis of the distal extremities. The tumor initiated at the age of 3 months in one patient and at the ages of 11 or 12 years in the remaining two. Local recurrence after surgical excision was observed in all cases. Microscopically the tumors were composed of two components; cavernous blood spaces and a proliferation of spindle cells. Among these spindle cells, there were occasional epithelioid endothelial cells with intracytoplasmic lumina. Phleboliths were observed in two cases. Most of the endothelial cells lining the cavernous spaces were positive for factor VIII-associated antigen in all cases; the intracytoplasmic lumina were also positive in two cases. The spindle cells were negative for that antigen in all cases. However, they were positive for desmin in one case. Electronmicroscopically, the spindle cells resembled primitive mesenchymal cells.     

卡波西样血管内皮细胞瘤1例

报告1例卡波西样血管内皮细胞瘤。患儿男,13个月。右下腹红斑,硬结伴疼痛9个月,皮诊进行性扩大。皮肤科检查见右下腹大片浸润壮斑块。组织病理检查示真皮及皮下组织内长梭形细胞及椭圆形细胞聚集成团块,伴管腔形成,免疫组化示CD31及CD34阳性,诊断为卡波西样血管内皮细胞瘤。