鄂西北地区汉族人群CD40基因单核苷酸多态性分析

目的研究CD40-E1SNP和E4SNP单核苷酸多态性在鄂西北部地区汉族人群中的分布,并探讨CD40基因单核苷酸多态性与血浆可溶性CD40水平的关系。方法 318例汉族人,其中男性187例,女性131例;平均年龄31.2岁。应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)及测序的方法,CD40-E1SNP和E4SNP并计算其基因型频率及等位基因频率,酶联免疫吸附分析检测血浆可溶性CD40浓度,并与文献报道不同种族人群比较。结果鄂西北地区汉族人群CD40-E1SNP基因型频率:CC型29.2%,CT型54.1%,TT型16.7%,C、T等位基因频率分别为56.3%、43.7%,这种多态性分布在男女间差异无统计学意义(P>0.05),与英国、波兰比较,发现不同种族间CD40-E1SNP基因型分布及等位基因频率差异均存在统计学意义(P<0.01);CD40-E1SNP各基因表型之间可溶性CD40含量分别为:CC(57.3±6.6)pg/mL,CT(34.2±4.5)pg/mL,TT(28.8±4.2)pg/mL,差异存在统计学意义(P<0.01)。在实验中未检测到CD40-E4SNP单核苷酸多态性。结论鄂西北地区汉族人群中存在CD40-E1SNP单核苷酸多态性,其基因型在不同种族间存在较大的差异,并且可能影响CD40的表达,而不存在CD40-E4SNP单核苷酸多态性。     

青海省妊娠高血压综合征患者瘦素基因启动子区G-2548 A单核苷酸的多态性

目的探讨青海省妊娠高血压综合征(PIH)与瘦素基因启动子区单核苷酸多态性的关系。方法选择青海省PIH患者130例,正常妊娠对照组135例,应用聚合酶链反应-限制性内切酶片段长度多态性(PCRRFLP)方法,分析PIH患者和对照组瘦素基因G-2548 A多态性分型并测序验证。结果 PIH组基因型频率GG型、GA型和AA型分别为53.1%、40%和6.9%,对照组分别为60%、34.1%和5.9%。PIH组和对照组瘦素基因G-2548 A位点等位基因A和G频率分布具有差异性(P0.05),妊娠高血压综合征组G等位基因频率高于对照组(χ2=4.21,P0.05,OR=0.66,95%CI=0.45~0.99)。结论青海省瘦素基因G2548位点G/A基因多态性与其妊娠高血压的易感性有关。G等位基因可能为妊娠高血压综合征的易感基因,A等位基因可能为妊娠高血压综合征的保护基因。     

中国汉族人群LDL受体基因NcoⅠ多态性及其与血清高胆固醇的相关性研究

目的研究低密度脂蛋白(LDL)受体基因外显子18中NcoⅠ限制性片段多态性在中国正常人群及血清高胆固醇患者中的频率分布,分析基因型与血清高胆固醇之间的相关性.方法应用多聚酶链反应结合限制性酶切方法,对50名健康体检者和50例血清高胆固醇患者进行LDL受体基因多态性检测.PCR后直接用限制性内切酶酶切检测基因多态性.结果在正常对照组中,A1等位基因的频率为0.66,A2等位基因的频率是0.34;在血清高胆醇组中,A1等位基因出现的频率是0.49,A2等位基因的频率是0.51.两组基因频率差异具有显著性(P＜0.05).结论中国南方汉族人群LDL受体基因中存在着NcoⅠ多态性位点,NcoⅠ多态性位点与血清高胆固醇相关联.     

红细胞补体受体1(CR1)数量基因多态性与反复呼吸道感染易感性的研究

目的通过研究红细胞补体受体1(CR1)数量基因多态性与反复呼吸道感染的相关性,探讨反复呼吸道感染(RRTI)患儿的遗传易感因素.方法利用限制性内切酶HindⅢ,聚合酶链反应限制性片段长度多态性(PCR-RFLP)分析,基因测序等技术测定58例RRTI患儿(病例组)和56例正常儿童(对照组)的红细胞CR1数量基因多态性,并进行比较.结果病例组中CR1基因HH、HL和LL基因型分布频率分别为34.2%、55.3%和10.5%,而对照组中HH、HL和LL基因型分布频率分别为75%、21.4%和3.6%.两组CR1基因型的分布频率差异有显著性(P＜0.001).病例组中HL和LL基因型占优势(OR=5.77).两组CR1基因等位基因的分布频率差异也有显著性(P＜0.01),病例组中L等位基因分布频率高于对照组.结论红细胞补体受体1(CR1)数量基因多态性与反复呼吸道感染有相关性,提示CR1基因HindⅢ酶切位点多态性可能在决定个体反复呼吸道感染遗传易感性方面有重要作用.     

中国北方汉族人细胞色素P4501 A1基因MspⅠ多态性的研究

目的　探讨中国北方汉族人细胞色素P(cytochromeP ,CYP) 4 5 0 1A1基因MspⅠ多态性。方法　用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)技术 ,分析了 172名北方汉族正常健康成人CYP1A1基因 3′端限制性内切酶MspⅠ位点的3种基因型 (A、B、C)的分布频率。结果　MspⅠ等位基因m1、m2分别占 6 0 8%、39 2 %。MspⅠ基因型A占 34 9% ,基因型B占 5 1 7% ,基因型C占 13 4 %。结论　本研究结果提示中国北方汉族人解毒酶CYP1A1基因存在MspⅠ多态性。     

E-选择素基因第2外显子G98T单核苷酸多态性的调查

目的 :研究湖北地区汉族人群E 选择素 (E selectin)基因第 2外显子 98位点的单核苷酸多态性 (SNP) ,比较种族间单核苷酸的基因频率分布差异。方法 :应用聚合酶链反应 限制性片段长度多态性(PCR RFLP)的分析方法 ,检测了 2 40名健康者E selectin第 2外显子 98位点单核苷酸的基因型。结果 :E selectin各基因型频率GG型91.3 % ,GT型 8.7% ;G ,T各等位基因频率分别为 95 .6% ,4.4% ,这种基因多态性分布在男女间均无显著性差异 (P >0 .0 5 )。与其它种族比较 ,发现不同种族间E selectin基因型分布及等位基因频率均存在显著差异 (P <0 .0 5 )。结论 :在湖北地区汉族人群中存在E se lectin基因第 2外显子 98位点的单核苷酸多态性 ,这种多态性在种族间可能存在着较大的差异     

青海省汉族妊娠期高血压疾病与维生素D受体基因FokⅠ多态性的关系

目的 探讨维生素D受体(VDR)基因单核苷酸多态性(SNP)FokⅠ(rs2228570/rs10735810)位点多态性与青海省汉族妇女妊娠期高血压疾病(HDCP)的相关性。方法 选择青海省汉族HDCP患者137例(HDCP组),正常汉族孕妇146例(对照组),使用聚合酶链式反应-限制性核酸内切酶片段长度多态性(PCR-RFLP)方法检测HDCP组和对照组FokⅠ位点的基因分型并测序验证,使用SPSS 19.0统计学软件检验两组一般临床资料、基因型及等位基因频率分布差异是否具有统计学意义。结果 HDCP组和对照组FokⅠ位点FF、Ff、ff基因型频率分别为51.82%、37.96%、10.22%和34.93%、43.15%和21.92%(χ²=11.099,P<0.05),HDCP组FF基因型(OR=2.004,95%CI=1.243～3.231)频率高于对照组;HDCP组和对照组FokⅠ位点F和f等位基因频率分布差异有统计学意义(χ²=12.454,P<0.001),HDCP组F等位基因(OR=1.253,95%CI=1.10...     

脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性

目的 研究脂联素基因单核苷酸多态性(SNP)45(T/G)位点与宁夏汉族人群2型糖尿病之间的关系.方法 100例2型糖尿病患者和101例正常对照者,采用聚合酶链式反应--限制性内切酶长度多态性(PCR-RFLP)技术,对脂联素基因SNP45多态性位点进行基因分型,同时测定代谢参数.结果 2型糖尿病组SNP45位点GG基因型频率和G等位基因频率均高于正常对照组(P＜0.05).结论 脂联素基因的SNP45多态性位点与宁夏汉族人群中2型糖尿病相关;GG基因型者具有2型糖尿病高易感性.     

ABCA1基因启动子区—14bp和ZNF位点多态性与血脂水平及冠心病易感性的关联分析

目的 检测三磷酸腺苷结合盒转运子A1(ATP-binding cassette transporter A1,ABCA1)基因启动子区-14 bp及-220 bp锌指蛋白可变数目串联重复序列(variable number of tandem repeats-zinc finger protein,VNTR-ZNF)多态性与天津市汉族人群冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)易感性及血脂水平的关联.方法 采用病例对照研究,用聚合酶链反应-限制性片段长度多态性方法对260例经冠状动脉造影确诊的CHD患者和220名健康对照进行ABCA1基因-14 bp C/T以及VNTR-ZNF位点ACCCC插入和缺失检测,探讨不同基因型与血脂水平及CHD易感性的关联.结果 ABCA1基因-14 bp位点多态性检测显示,全部检测人群中CC基因型占42.7％,CT型占51.5％,TT型占5.8％.CHD组与对照组的基因型频率及等位基因频率差异均无统计学意义(P＞0.05);T等位基因携带者高密度脂蛋白胆固醇水平低于非携带者(P＜0.05).ABCA1基因VNTR-ZNF位点全部检测人群中基因型分别为插入型6.2％,缺失型43.8％,插入及缺失型50.0％.两组间基因型频率及等位基因频率比较差异无统计学意义(P＞0.05).血浆高密度脂蛋白胆固醇水平在各基因型间差异亦无统计学意义(P＞0.05).结论 ABCA1基因-14 bp及VNTR-ZNF位点多态性与CHD发生无相关性.-14 bp位点T等位基因携带者血浆高密度脂蛋白胆固醇水平低下.     

APOA5基因单核苷酸多态性与冠心病相关性研究

目的　探讨APOA5基因多态性与冠状动脉粥样硬化性心脏病 (coronaryheartdisease ,CHD)的相关性、与血脂关系及其在中国汉族人群中的分布。方法　用聚合酶链反应 限制性片段长度多态性分析APOA5与APOA4交界区域的T/C单核苷酸多态。结果　T/C单核苷酸多态位点等位基因T、C频率在CHD组和正常对照组分别为 0 .43 5、0 .5 65和 0 .3 74、0 .62 6。等位基因频率和基因型频率分布均符合Hardy Weinberg平衡定律。T/C基因多态性基因型频率 ,等位基因T、C频率在两组间差异有显著性(P <0 .0 5 ) ,且基因型CC的冠心病患者其血浆高密度脂蛋白水平显著高于其他基因型患者 (P <0 .0 1)。中国人T/C单核苷酸多态位点T、C等位基因频率与欧洲白人比较 ,差异存在非常显著性 ( 0 .3 74vs 0 .663、0 62 6vs 0 .3 3 7;P <0 .0 0 1)。结论　T/C单核苷酸多态性与CHD存在相关性 (P <0 .0 5 ) ,患者组CC基因型与血浆高密度脂蛋白水平密切相关 (P <0 .0 1)。     

Polymorphisms of the lipoprotein lipase gene are associated with atherosclerotic cerebral infarction in the Chinese

BACKGROUND: Lipoprotein lipase (LPL), which plays an essential role in plasma lipoprotein metabolism and transportation, appears to be a risk factor for ischemic vascular diseases. Several studies have recently reported the presence of relationship between HindIII, PvuII, Ser447Ter (C-->G) polymorphisms of LPL and ischemic vascular diseases. PURPOSE: We first studied the relationship between LPL polymorphisms and the risk of atherosclerotic cerebral infarction (CI) by detecting the frequencies of LPL HindIII, PvuII and Ser447Ter genotypes and combined genotypes in the Chinese. METHODS: We recruited 185 CI patients, confirmed by cranial computed tomography or magnetic resonance imaging/angiography, or both, and 186 control subjects. Polymerase chain reaction-restriction fragment length polymorphisms technique was used to detect HindIII, PvuII and Ser447Ter polymorphisms of the LPL gene. RESULTS: The frequencies of the H+H+ genotype and H+ allele did not differ between CI and control groups. The frequencies of the P+P+ genotype and P+ allele gene were significantly higher in the CI group (P=0.040, P=0.015). The frequencies of CG+GG genotype and G allele were lower in the CI group (P<0.001, P<0.001). In the CI group, the individuals with P+P+ genotype had a significantly higher level of plasma triglyceride (TG) and a lower level of plasma high density lipoprotein cholesterol (HDL-c). CG+GG genotypes were correlated with significantly higher levels of plasma total cholesterol (TC), HDL-c and low density lipoprotein cholesterol (LDL-c) in the CI group. The frequencies of H+/C and P+/C combined genotypes were higher in the CI group than in controls (P<0.001, P<0.001). The frequency of H+/P+/C combined genotype was significantly higher in the CI group than in controls (P<0.001). CONCLUSIONS: Our study suggests that PvuII and Ser447Ter polymorphisms are associated with lipid profile and CI.     

Cholesterol ester transfer protein,apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease in the Turkish population

The aim of this study was to compare patients with coronary artery disease (CAD) to healthy objects, in order to explore a possible association between CAD and the variants in the gene encoding cholesterol ester transfer protein (CETP), apolipoprotein E (Apo E) and lipoprotein lipase (LPL). The relationship between CETP MspI, apo E and LPL PvuII gene polymorphisms and serum lipids were investigated in 173 patients with CAD and 111 healthy controls. The frequency of Apo epsilon4 (p < 0.05) and CETP M1 (p < 0.01) alleles were higher in the CAD group than in the control group. In the CAD group, those with the Msp M1 allele had higher levels of total cholesterol (TC) (p = 0026) and low-density lipoprotein cholesterol (LDL-C) than those with the Msp M2 allele. Subjects with an epsilon2 allele had the lowest levels of TC and LDL-C, while subjects with the epsilon4 allele had the highest. In the control group, CETP, the Msp M2 allele was associated with a higher level of high-density lipoprotein cholesterol (HDL-C) (p = 0.012) than the Msp M1 allele. The distributions of LPL genotype and allele did not differ between the CAD and control groups. The present study demonstrates that the CETP Msp1 and Apo E gene polymorphisms are associated with variations in lipids in patients with CAD and healthy controls in Turkish population.     

Genetics of the lipoprotein lipase gene and hypertriglyceridaemia

The aim of this study is to assess whether genetic variation at the lipoprotein lipase (LPL) gene is related to fasting triglyceride levels or to the presence of vascular disease. Hypertriglyceridaemic patients are genotyped for the N291S, G188E, and P207L variants and the HindIII and PvuII restriction fragment length polymorphisms of the LPL gene. Sequence analysis is carried out on exons 1-9 of the LPL gene for patients with severe hypertriglyceridaemia, to search for new gene variants. No differences were found between the patient and control group for the N291S, G188E and P207L variants. The HindIII and PvuII allelic frequencies were found to be similar for patients and controls; however, the frequency of the PvuII P2 allele was higher in patients with vascular disease (allele frequency: 0.56) than patients with no vascular disease (allele frequency, 0.42) (P=0.03). Sequence analysis revealed no exon sequence variants in the LPL gene but two intron sequence variants were found in intron 5 in two patients.     

Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity

Cholesteryl ester transfer protein (CETP) is one of the key proteins in reverse cholesterol transport (RCT). The role of CETP in atherosclerosis remains controversial. In this study we investigated the associations between polymorphisms of CETP (mutations in intron 14 and exon 15, and Taq1B), hepatic lipase (C-514T), lipoprotein lipase ( PvuII and HindIII), and ATP-binding cassette transporter 1 (R219K) loci and longevity in 256 centenarians and 190 healthy younger controls. Although heterozygous CETP deficiency and the B2 allele of the Taq1B polymorphism was consistently associated with higher HDL-C concentrations both in centenarians and controls, the allelic frequencies of those polymorphisms did not differ between the two groups. The allelic frequencies of other gene polymorphisms in RCT were not different between the two groups. Centenarians with lipoprotein lipase P(-/-) genotype had significantly higher HDL-C concentration than those with P(-/+) or with P(+/+), in contrast, there was no such a relationship among controls. In stepwise multiple regression analysis, serum albumin, CETP deficiency and lipoprotein lipase PvuII genotype were independently associated with HDL-C in centenarians. Sex, CETP deficiency, and the Taq1B genotype were also independently associated with HDL-C; however, lipoprotein lipase PvuII genotype had no significant effect on their HDL-C in controls. In conclusion, we observed that CETP deficiency and other gene polymorphisms in RCT have no impact on longevity for Japanese centenarians.     

Lipoprotein lipase locus and progression of atherosclerosis in coronary-artery bypass grafts.

PURPOSE: Our aim was to test whether polymorphisms in the lipoprotein lipase (LPL) gene were associated with the progression of atherosclerosis in grafts examined in the Post-Coronary Artery Bypass Graft Trial (Post-CABG Trial). METHODS: 843 subjects in the post-CABG trial were genotyped for the LPL-D9N, N291S, PvuII, (TTTA)n, and HindIII polymorphisms. Associations between genotype and angiographically measured progression of atherosclerosis in grafts, medical history, and family history were examined. RESULTS: Greater progression of atherosclerosis was observed in subjects with LPL-HindIII 2/2 (56% versus 42% of those with other LPL HindIII genotypes, P = 0.025) and with LPL (TTTA)n 4/4 (63% versus 43% of those with other (TTTA)n genotypes, P = 0.020). Mantel-Haenszel analysis yielded an odds ratio of 1.84 for the effect of LPL HindIII 2/2 genotype on the progression of atherosclerosis in grafts (P = 0.015) and demonstrated that the effect of genotype on progression was of the same magnitude as, but independent of, the effect of drug treatment. CONCLUSION: The LPL-HindIII 2/2 genotype is a marker for genetic variation in the 3'-end of LPL that acts as an independent risk factor for the progression of atherosclerosis in grafts examined in the Post-CABG Trial.     

Association of CETP and CRP gene polymorphisms with non-valvular atrial fibrillation in Chinese Han population

OBJECTIVE: To study whether the polymorphisms of TaqIB of cholesteryl transfer protein (CETP) gene and 1444C/T of C reactive protein (CRP) gene are associated with non-valvular atrial fibrillation in the Chinese Han population. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used to detect the distribution of genotypes of CETP TaqIB and CRP 1444C/T in 147 patients with non-valvular atrial fibrillation and 147 control subjects in Chinese Han population. RESULTS: (1) The distribution of CETP TaqIB and CRP 1444C/T genotypes was in Hardy-Weinberg equilibrium. (2) A statistically significant difference between patients and controls for CETP TaqIB (P= 0.005, OR= 0.614, beta = -0.488) and CRP 1444C/T (P= 0.003, OR= 2.428, beta = 0.887) was observed. (3) In female group, significant difference was observed in smoking, CETP TaqIB and CRP 1444C/T polymorphisms. And in male group, significant difference was observed in body mass index and CETP TaqIB polymorphisms. CONCLUSION: (1) These results suggest that CETP TaqIB (B2 allele as protective factor) and CRP1444C/T (T allele as risk factor) genetic polymorphisms may be associated with the non-valvular atrial fibrillation in the Chinese Han population. (2) Smoking and CRP1444T single nucleotide polymorphism may induce hereditary susceptibility to non-valvular atrial fibrillation in female. Obesity may induce hereditary susceptibility to non-valvular atrial fibrillation in male.     

Frequencies of five genetic polymorphisms in coronarographed patients and effects on lipid levels in a supposedly healthy population

Allele frequencies of genetic polymorphisms were compared between supposedly healthy subjects and angiographically proven coronary artery disease patients. The polymorphic candidate loci investigated were the apolipoprotein (apo) B signal peptide and Xba I polymorphisms, the apo E polymorphism and two polymorphisms of lipoprotein lipase (LPL) gene: Hind/ III and PvuII. Apo B signal peptide and Hind III/LPL polymorphisms showed significant differences in allele partition between cases and controls; the rare alleles of both polymorphisms were less frequent (p<0.05) in cases. We looked for associations between the polymorphisms and lipid concentration variability in a supposedly healthy population (145 men and 144 women). Apo B signal peptide, apo E and Pvul II/LPL polymorphisms seem to influence some lipid metabolism parameters significantly. Apo AI and LpCIII levels were significantly different among apo B signal peptide genotypes: Del homozygotes had the highest concentrations of both variables. The e4 allele of apo E polymorphism was associated with increased concentrations of total cholesterol, LDL cholesterol and apo B. Increased LpAI:AII levels observed in E3 homozygotes (p<0.01) have not previously been reported. LpAI:AII concentration was also influenced by Pvu II/LPL polymorphisms.     

汉族人群胆固醇酯转运蛋白基因和C反应蛋白基因多态性与非瓣膜性房颠的关联

目的 研究胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)基因TaqIB、C反应蛋白(C reactive protein,CRP)基因1444C/T单核苷酸多态性(single nonucleotide polymorphism,SNP)与汉族非瓣膜性房颤的相关.方法 选取非瓣膜性房颤患者147例、病例对照147例,应用聚合酶链反应-限制性内切酶片段长度多态性鉴定基因型.结果 CETP TaqIB(P=0.005,OR=0.614,B=-0.488)和CRP 1444C/T(P=0.003,OR=2.428,β=0.887)遗传多态性在病例组和对照组间差异有统计学意义.根据性别分组:女性组,吸烟、CETP TaqIB、CRP 1444C/T病例对照间差异有统计学意义;男性组,体重指数和CETP Taq IB病例对照间差异有统计学意义.结论 中国汉族CETP TaqIB (B2等位基因为保护性因子)和CRP1444C/T(T等位基因为危险因子)多态性可能与非瓣膜性房颤相关.吸烟、CRP 1444C/T多态性可能增加女性非瓣膜性房颤遗传易感性;肥胖可能增加男性非瓣膜性房颤遗传易感性.     

江苏汉族人群XRCC1基因的遗传多态性研究

目的探讨江苏省汉族正常人群中X线修复交叉互补基因1（XRCC1）常见的两个单核苷酸多态（SNPs）C26304T和G27466A的遗传分布特点。方法采用聚合酶链反应（PCR）及限制性片段长度多态（RFLP）方法分析江苏省扬中地区511名健康汉族人的XRCC1基因C26304T和G27466A的基因多态性。结果511名江苏汉族人的XRCC1 C26304T基因型CC、CT、TT的频率分别为45．8％、42．7％和11．5％,等位基因C、T的频率分别为67．1％和32．9％。G27466A基因型GG、GA、AA的频率分别为68．9％、29．0％和2．1％,等位基因G、A的频率分别为83．4％和16．6％。江苏人群的C26304T基因型频率和等位基因频率分布与浙江、台湾人群均无明显差异（P〉0．05）,但与意大利人、美国白人、美国黑人的差异具有显著性（P〈0．05）。江苏人群的G27466A基因型频率和等位基因频率分布与浙江人、台湾人、意大利人、美国白人、美国黑人的差异均具有显著性（P〈0．05）。结论本研究揭示了江苏汉族人群XRCC1基因C26304T和G27466A的等位基因频率和基因型频率分布特点;证实了C26304T和G27466A位点的等位基因和基因型频率存在种族、地区差异。     

中国人内源性高甘油三酯血症与脂蛋白脂酶基因PvuⅡ多态性关联的研究

目的：探讨中国人内源性高甘油三酯血症（hypertriglyceridemics,HTG)与脂蛋白脂酶基因PvuⅡ多态性是否关联。方法：采用聚合酶链反应和限制性片段长度多态性方法,对成都地区135例内源性高甘油三酯血症患者和193名血脂正常者脂蛋白脂酶基因内含子6PvuⅡ多态性及其对血脂及载脂蛋白（apo)水平的影响进行了研究。结果：HTG患者和正常人均以P＋等位基因为主,HTG组以P＋P＋基因型为主,而正常对照组P＋P－基因型为主。HTG组的P＋P＋基因型分布频率及P＋等位基因分布频率则显著高于正常对照组（0.460vs0.337,P＜0.05;0.689vs0.565,P＜0.01)。P＋P＋基因型者的血清甘油三酯（TG）、apoCⅡ、apoCⅢ、apoE水平及TG／HDL－C比值较P－P－基因型者显著增高（P＜0．05）。结论：脂蛋白酯酶基因P＋P＋基因型与中国人内源性高甘油三酯血症的遗传易感性有一定关联。