Mixed Mullerian tumors of the uterine corpus: a review

The literature relating to mixed Mullerian tumors of the uterine corpus has been reviewed. A critical account of the clinico-pathologic features of these tumors, their prognosis and treatment is presented.     

Adenosarcoma of the uterine cervix with heterologous elements: a case report and review of literature

Introduction  

Adenosarcoma of the uterus is a rare tumor composed of benign epithelial and malignant stromal components, usually encountered in young women. Till date, more than 100 cases of mullerian adenosarcoma of the cervix with homologous elements have been reported. However, only 15 cases of mullerian adenosarcoma of the cervix with heterologous elements are reported.     

Primary osteosarcoma of the uterine corpus. Report of a case and critical review of the literature

Uterine osteosarcoma represents an extremely rare pure heterologous sarcoma of the uterus. In the present case osteosarcoma occurred primarily in the uterine cavity of a 56-year-old woman. The tumor was anaplastic and the presence of different proliferative patterns caused differential diagnostic problems with various malignant tumor types. The osteoid features of extracellular matrix were demonstrated by electron microscopy. Clinical and pathological features of previously reported cases of uterine osteosarcoma are critically reviewed.     

Pregnancy after uterine rupture: a report of 5 cases and a review of the literature

Management and outcome of 5 cases of pregnancy after uterine rupture are discussed. All women in these cases were delivered by cesarean delivery and no repeat ruptures occurred. After reviewing the literature, it is concluded that women with a previous uterine rupture have a favorable outcome in a subsequent pregnancy. With a rupture in a lower segment scar, an elective cesarean delivery should be performed before labor starts after assessing fetal lung maturity or administration of corticosteroids. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader should be able to describe the risk associated with a subsequent pregnancy after a previous uterine rupture, summarize the complications of uterine rupture during a subsequent pregnancy, and to list the treatment plans for a patient in a subsequent pregnancy after uterine rupture.     

Primary non-Hodgkin lymphoma of the uterine corpus. Case report and review of the literature

We report a case of primary nonHodgkin lymphoma (NHL) of the uterine corpus, diagnosed by endometrial biopsy, in a 60-year-old patient suffering from uterine bleeding. Pathological analysis had concluded to diffuse large B-cell lymphoma. Further staging had not revealed other nodal or extranodal localization (Ann Arbor stage IE) and there were no signs of recurrence during follow-up. Therefore, the diagnostic criteria for true primary NHL of the uterine corpus were met. This localization is extremely rare since only six cases have previously been published. The patient was successfully treated by an immunochemotherapy combining rituximab-CHOP and rituximab-VCAP. After 28 months of follow-up, she is free from the disease. A review of the literature regarding these exceptional tumors is undertaken.     

Primary precursor B cell lymphoblastic lymphoma of uterine corpus: case report and review of the literature

Introduction  

Primary lymphomas of the female genital tract are rare. Most involve the cervix rather than the uterine corpus. Many cases of primary endometrial lymphoma are diagnosed as diffuse large B cell type, whereas the precursor B cell lymphoblastic type is extremely rare.     

Primary uterine lymphoma: report of 2 cases and review of literature

Primary uterine non-Hodgkin's lymphoma is a rare malignancy. We here describe 2 patients who presented with cervical growth, stage IE, diffuse large B cell histology. Both were treated with chemotherapy followed by involved field radiotherapy in 1 patient. They achieved complete clinical and radiological response. Data of 101 patients collected from the literature are reviewed.     

卵巢上皮性癌脑转移10例临床分析

目的 探讨卵巢上皮性癌脑转移的发生率、诊断、治疗及预后等相关因素。方法 回顾性分析1996—2001年,收治的卵巢上皮性癌478例中发生脑转移10例患者的临床资料。结果 卵巢上皮性癌脑转移的发生率为2．1％;脑转移常见的首发症状为头痛、呕吐、肢体乏力;常见的转移部位为脑顶部及枕部。10例患者中,8例行颅脑放射治疗及全身化学药物治疗,其中7例完成了治疗,颅脑照射剂量,单发病灶为30—38Gy／4周,多发病灶为40—45Gy／5周。10例患者总体中位生存时间为6．3个月,其中7例完成治疗者为8．3个月,3例放弃治疗及末完成治疗者为1．4个月。结论 脑转移的诊断主要依据临床症状、体征及影像学检查;联合应用颅脑放射治疗及全身化学药物治疗,大部分患者的病情可获得明显缓解。     

Laparoscopic excision of uterine adenomatoid tumour: two cases and literature review

Introduction  

Adenomatoid tumours are rare, benign neoplasms of the genital tract, occurring most commonly during the reproductive years. In females, the uterus is the most common site. These tumours can be associated with fibroids and tend to mimic them clinically and radiologically, making pre-operative diagnosis very difficult. We report two cases of uterine adenomatoid tumours that were excised laparoscopically. Intraoperatively, there was no clear line of demarcation between the uterus and the tumours and laparoscopic manipulation of the tumours was difficult due to their friable nature. Simple excision with uterine conservation is the treatment of choice, especially in women who desire future fertility, as degeneration, recurrence, malignant transformation or metastasis has not been reported.     

Primary signet ring cell carcinoma of the uterine cervix: A clinicopathologic study of two cases with review of the literature

Haswani P, Arseneau J, Ferenczy A. Primary signet ring cell carcinoma of the uterine cervix: A clinicopathologic study of two cases with review of the literature. Int J Gynecol Cancer 1998; 8 : 374–379.
Signet ring cell carcinoma of the endocervix is most commonly considered to be metastatic in origin. We describe two cases of apparently primary cervical signet ring cell adenocarcinoma occurring in patients aged 33 and 38 years, respectively. Both patients had been treated previously for cervical "condylomas". The lesions, occupying the posterior lip of the cervix, were formed predominantly of malignant neoplastic signet ring cells. One case was positive for HPV type 18 and coexisted with adenocarcinoma in situ and a high grade squamous intraepithelial lesion (HSIL). One patient died 18 months after the diagnosis of carcinoma with massive intra-abdominal metastasis; autopsy was not performed. The second patient is alive and well nine months postsurgery and undergoing pelvic radiotherapy for FIGO stage IB1 adenocarcinoma with one of the pelvic nodes containing a metastasis. Although in neither of the two cases was absolute proof obtained of the absence of a gastrointestinal tract tumor, the clinical presentation of the tumors, the history of previous HPV infection of the cervix, the coexistent in situ adenocarcinoma and HSIL and the detection of HPV type 18 in one case lent support for a primary cervical origin of this rare form of adenocarcinoma.     

Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature

Objective

To assess the clinicopathological characteristics and clinical management of patients diagnosed with mullerian adenosarcoma of the uterine cervix.

Hypercalcemia associated with a uterine leiomyoma: a case report and review of the literature

BACKGROUND: Humoral hypercalcemia is known to be an important cause of hypercalcemia associated with malignancy. Humoral hypercalcemia due to benign conditions has been rarely reported. CASE: We report on a 45-year-old woman with humoral hypercalcemia secondary to uterine leiomyoma. Following the surgical removal of leiomyoma by hysterectomy, serum calcium, suppressed parathyroid hormone (PTH) and elevated parathyroid hormone-related protein (PTH-rP) levels were normalized. CONCLUSIONS: To our knowledge, this is the second reported case of humoral hypercalcemia associated with uterine leiomyoma. We suggest that for women with hypercalcemia who had suppressed PTH and elevated PTH-rP levels, uterine leiomyoma should be included in the differential diagnosis.     

Ivemark syndrome with agenesis of the corpus callosum: a case report with a review of the literature

Asplenia associated with situs ambiguus, symmetric liver, bilateral trilobulated lungs, and a complex heart defect was diagnosed on autopsy in a 14-day-old infant. Furthermore, examination of the brain displayed agenesis of the corpus callosum (ACC) with pachygyria and hydrocephalus. The characteristic association of asplenia with visceroatrial heterotaxia is traditionally named after the Swedish pediatrician, Ivemark. Although exceptional, association of Ivemark syndrome with callosal agenesis has been reported recently. The concept of 'developmental fields' describes morphogenetically reactive units of the embryo determining and controlling the development of complex structures in a hierarchical manner. Lateralization defects such as situs inversus, asplenia or polysplenia due to defective left-right axis development, as well as decussation defects such as ACC, are considered as defects of the primary developmental field. Therefore, additional callosal agenesis in Ivemark syndrome may be a coherent and synchronic defect in the primary developmental field rather than a causally independent malformation.