模糊聚类分析方法在评价碘缺乏病防治监测结果中的应用

本文采用模糊聚类分析方法,探讨了如何对碘缺乏病县防治监测结果进行评价和分析,以指导防治工作。通过对江苏10个重点碘缺乏病区县患病率、7～14岁中小学生肿大率、健康成人尿碘和碘盐合格率4项指标监测结果进行模糊聚类分析,将10个县分为3类,其中6个县归为一类,各指标监测结果大致相仿;另有3个县归为一类,这些县碘盐合格率偏低;另有一县自成一类,该县健康成人尿碘水平偏低。     

基于多维标度法的聚类分析

本文将用于揭示事物间关系的多维标度法用于多指标聚类分析，并将此应用于小学生智力测试且得到较满意的效果。结果表明：多维标度法用于聚类分析直观具体，可以作为多指标聚类分析的一种有效工具。     

模糊模式识别法在有机毒物系统鉴别中的应用

首先获得常见有机毒物的标准红外光谱，然后用模糊聚类分析方法存贮标准光谱，建立起常见有机毒物标准红外光谱库。鉴定未知有机毒物时，用模式识别的直接方法寻找图谱。以２０１种常见有机毒物为实例进行检索，证明该方法可以用于有机毒物的快速筛选和定性鉴别。     

模糊模式识别法在有机毒物系统鉴别中的应用

首先获得常见有机毒物的标准红外光谱，然后用模糊聚类分析方法分类存贮标准光谱，建立起常见有机毒物标准红外光谱库。鉴定未知有机毒物时，用模式识别的直接方法寻找图谱。以201种常见有机毒物为实例进行检索，证明该方法可以用于有机毒物的快速筛选和定性鉴别。     

药品不良反应风险分级警戒模型设计

目的:建立药品不良反应风险分级警戒模型。方法:采用模糊聚类分析进行药品不良反应风险分级。结果:利用模糊聚类分析,从不良反应严重程度和发生率两方面出发,通过实例分析表明利用该模型进行的不良反应风险分级具有可行性。结论:本模型设计可以为加强药品安全监管、提供临床药物选择依据以及后期不良反应救济决策提供参考。     

用模式识别法对去痛片的质量进行再评价

用模糊聚类分析的原理和模式识别方法,对2002年全国抽验的"去痛片"质量进行进一步评价.     

溧水县卫生防疫工作质量的模糊数学评价

采用模糊数学原理，对溧水县１９９１年和１９９５年卫生防疫工作质量进行了模糊综合评判。通过对规范化门诊、疫苗接种率、疫情报告、传染病发病率、资料管理５项考评结果，进行模糊聚类分析，两个年份都在优的等级上，且最大隶属度比较和综合评判结果，１９９５年全县卫生防疫工作质量都较１９９１年有了明显的提高     

大叶相思立地类型的研究

本文根据大叶相思在广东不同引种区的标准地数据,用逐步回归方法筛选影响该树种生长的主要因子,再根据模糊聚类分析归纳为3个立地类型组及12个立地类型。其中,7个类型适于大叶相思生长;2个类型严重缺钾;2个类型要加强营造技术措施;1个类型不宜种植大叶相思。     

不同产地青蒿FTIR特征图谱的系统聚类分析和主成分分析

目的：建立不同产地青蒿药材FTIR特征图谱的系统聚类分析和主成分分析方法。方法：采用傅里叶变换红外光谱仪测定不同产地28个青蒿样品的光谱图，对所获光谱进行系统聚类分析和主成分分析。结果：系统聚类分析所得系统树图和主成分分析所得二维投影图均具有较好的聚类功能。结论：所建方法可用于青蒿药材的产地聚类分析。该法的建立为青蒿药材的质量控制提供了一种简便、有效的手段。     

伊贝母的HPLC指纹图谱研究

目的 建立伊贝母的HPLC-ELSD指纹图谱.方法 采用HPLC-ELSD法对伊贝母样品进行测定,并用SPSS 22.0软件对不同批次的样品进行主成分分析和聚类分析.结果 筛选出特征峰累计贡献率达81.436％的4个主成分,并对原始数据进行系统聚类分析,建立了伊贝母的特征指纹图谱.结论 聚类分析的结果与其植物学分类的一致,表明该法可用于伊贝母的质量控制.     

五味子与南五味子的化学模式识别与计算机辨识研究

目的用高效液相色谱法鉴别五味子与南五味子。方法采用RP—HPLC,以五味子甲素峰为参考峰,色谱柱：DIKMA DIAMONSIL C18柱（4．6mm×150mm,5μm）;流动相：甲醇-水（65：35）;检测波长：254nm。结果在选定的色谱条件下,对五味子与南五味子进行系统聚类与判别分析,提供了稳定可控的液相色谱图。结论能够满足鉴别五味子与南五味子的要求;采用系统聚类与判别分析和液相色谱技术鉴别五味予与南五味子是切实可行的。     

Identification of the most relevant factors that affect and reflect the quality of granules by application of canonical and cluster analysis.

The production of granules by wet granulation in a fluidized bed was assessed according to two statistical techniques to identify the most relevant factors that affect the quality of the granules. The statistics used include Canonical Analysis and Cluster Analysis. The factors studied, according to a center of gravity design, included the solubility of a model drug, different grades of polyvinylpirrolidone (PVP), the polarity and the rate of administration of the granulation solution, the atomizing air pressure, the inlet air pressure and rate. The properties of the granules considered were the yield, the assay of the drug, the size, the densities (true, bulk and tapped), the friability, the flowability and one compressibility index. Statistical analysis of the factors evaluated has shown that the solubility of the materials and the pressure of the atomizing air in the nozzle were the most critical parameters affecting the quality of the granules. Less relevant were the granulation solution and the grade of PVP. The properties of the granules that best described their quality were the yield and the densities. From the Cluster Analysis it was possible to divide the granules in two clusters, where cluster 1 was identifiable by the yield, the assay, the flowability, and the friability, whereas cluster 2 was better identified by the size of the granules.     

活血化淤药的模糊聚类分析

目的:对活血化淤药进行分类。方法:对33种具有活血化淤作用的常用中药,通过SPSS10.0统计软件包建立数据库,收录药物的性、味归经及功效,将之作为能反映分类特征的变量,并将药物名称作为测量的变量,进行分层聚类中的Q型聚类。结果:当分为4类时,第1类应当为活血调经药,第2类为活血止痛消症药,第3类为活血化淤止痛药,第4类为破血逐淤药;当分为5类时,第5类为活血疗伤药;当分为6类时,第3类为活血祛风药,第6类为活血止血药。结论:运用聚类分析法,能较好地将不同类别却有相同功效的药物归类,并根据这一类药物作用趋势的不同分类。     

Fuzzy pharmacology: theory and applications

Fuzzy pharmacology is a term coined to represent the application of fuzzy logic and fuzzy set theory to pharmacological problems. Fuzzy logic is the science of reasoning, thinking and inference that recognizes and uses the real world phenomenon that everything is a matter of degree. It is an extension of binary logic that is able to deal with complex systems because it does not require crisp definitions and distinctions for the system components. In pharmacology, fuzzy modeling has been used for the mechanical control of drug delivery in surgical settings, and work has begun evaluating its use in other pharmacokinetic and pharmacodynamic applications. Fuzzy pharmacology is an emerging field that, based on these initial explorations, warrants further investigation.     

聚类分析法在术类药材分类中的应用

对9种不同品种术类药材挥发油的主要成分进行色谱扫描,从薄层色谱扫描中测得主要成份相对含量的差异,用聚类分析的数学方法进行处理,准确地区分了术类的品种。     

Ionization, lipophilicity and solubility properties of repaglinide

Potentiometric and spectrophotometric titrations were used for the determination of ionization behaviour, lipophilicity and solubility profile of repaglinide. Acid-base equilibria were characterized by means of protonation macro- and microconstants using Target Factor Analysis of spectrophotometric data. Lipophilicity profiles were evaluated by determination of partition coefficients of neutral and ionized forms of repaglinide in biphasic octanol/water system. The intrinsic solubilities of repaglinide were determined from the solubility data and temperature dependence of intrinsic solubilities were evaluated using van't Hoff equation. Repaglinide possesses two protonation sites and in aqueous solutions exhibits ampholitic properties. At isoelectric pH the zwitterionic form of the molecule predominates over the uncharged form with the tautomeric ratio, logKz=1.9. The difference between calculated and measured logP values, as well as the difference between logP values of uncharged form of repaglinide, HR0, and either one of mono-charged forms indicated the significant partition of zwitterion into octanol. Temperature dependence of solubility data revealed exothermic dissolution process with DeltasolH=-36 kJmol-1 and negative entropy of solution of DeltasolS=-0.19 kJK-1mol-1.     

基于因子分析的茵栀黄注射液质量评价

目的：分析茵栀黄注射液的评价性抽验结果,对该品种进行总体质量评价。方法：采用因子分析方法对110批茵栀黄注射液的评价性抽验定量检测结果进行统计分析,并将公共因子得分做聚类分析。结果：12个原始变量通过因子分析提取出4个公共因子,分别解释为主药成分因子、杂质和残留物因子以及辅料因子。4个公共因子的得分大小反映各批号产品的主药成分、杂质残留和辅料等方面的质量情况。因子得分的聚类结果表明,茵栀黄注射液的质量与原材料来源和工艺相关。结论：因子分析作为一种降维统计方法,适用于以大量定量数据为基础的药品质量综合评价分析。     

Partition behavior of anilines in bulk-phase and high-performance liquid chromatographic systems: influence on correlation with biological constants.

The partition behavior of a mixed series of ring-substituted anilines in reversed-phase high-performance liquid chromatographic systems is substantially different from that observed in a classical bulk-phase partition system with n-heptane as the aprotic reference solvent. On the basis of the equivalence of each ring substituent in the p-straight-chain methylene groups (v value) as a function of the fraction of organic solvent (acetonitrile or methanol) in the mobile phase, the biased partition behavior for imperfect homologues and heterologues is verified relative to that of perfect homologues. This behavior was tentatively attributed, mainly, to differences in the hydrogen bonding capacity of the compounds, which is associated with the electronic character of the working solvent. These differences cannot be normalized through the use of extrapolated initial partition coefficient (K'o) values because of carryover effects of the solvent. When the chromatographic partition constants (K') and K'o are used, correlations with previously determined intestinal absorption rate constants are definitely worse than the correlations with the reference n-heptane partition coefficients. Possible implications of these observations on lipophilicity-biological activity correlations are briefly discussed.