Transient erythroblastopenia of childhood presenting with echovirus 11 infection

We report a case of transient erythroblastopenia in a three-year-old girl presenting with echovirus 11 infection. Viral infection was demonstrated by isolation of echovirus 11 in stool cultures and the presence of echovirus 11-specific IgM antibody in serum. We suggest that echovirus may have played a role in the pathogenesis of transient erythroblastopenia of childhood in this patient.     

Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis

All cases of transient erythroblastopenia in children less than 10 years of age, diagnosed in Sweden during the years 1987–89, were identified. Almost all (51/53) were less than 3 years of age. In this group, the incidence was 4.3/100000, which is the same as that of acute lymphatic leukaemia. No geographical, but a possible temporal, cluster was seen in 1989. The anaemia was severe in some cases; haemoglobin concentration was less than 40 g/1 in 8 oc53 children. Thrombocytosis and neutropenia were common and were attributed to high endogenous erythropoietin activity. Thirty-seven of 53 children were given a blood transfusion. All children recovered and no complications or relapses were seen. Transient erythroblastopenia of childhood is a benign disease, and it is important to make a correct diagnosis to prevent unnecessary anxiety for leukaemia or aplastic anaemia.     

Transient erythroblastopenia due to human parvovirus B19 infection: A case report of a boy suffering from purpura

Transient erythroblastopenia of childhood (TEC) was observed in a boy infected by human parvovirus B19 (B19) before the manifestation of the typical clinical picture of erythema infectiosum (EI). He did not have any apparent symptoms of anemia, and spontaneous resolution of erythroblastopenia was observed before the manifestation of the symptoms of EI. The difference between primary B19 infection and classical TEC is discussed.     

Transient erythroblastopenia of childhood

In the period 1975–1983 22 patients, aged 4–36 months were seen with severe transient normochromic, normocytic anaemia caused by a transient erythroblastotopenia.In 20 patients bone marrow aspirations were obtained; they showed erythroblastopenia.In ten cases we observed young lymphoid cells, suggesting a diagnosis of acute lymphoblastic leukaemia. One patient suspected of a leukaemia, was studied in more detail.All patients showed reticulocytopenia. MCV and HbF were within normal range. During recovery reticulocytosis and higher levels of HbF were found. Except for blood transfusion in most patients, therapy (e.g. corticosteroids) was not necesssary. Spontaneous recovery is a feature of this kind of erythroblastopenia, contrasting with congenital hypoplastic anaemia.Abbreviations CHA congenital hypoplastic anaemia - TEC transient erythroblastopenia of childhood - MCV mean corpuscular volume - HbF fetal haemoglobin - ALL acute lymphoblastic leukaemia - cALL common ALL - IgG immunoglobulin G     

Transient neurological disorder associated with transient erythroblastopenia of childhood

Three patients are described with transient erythroblastopenia of childhood (TEC) associated with a transient neurological disorder. This association may not be uncommon in view of the presentation of these three patients to one small pediatric center over a 2 year period, out of a total of four patients presenting with TEC.     

Transient erythroblastopenia of childhood in siblings: case report and review of the literature

Transient erythroblastopenia of childhood is characterized by anemia due to decreased production of red blood cell precursors. It is almost always self-resolving and requires clinical intervention only in severe cases. This article describes 2 cases in half-siblings diagnosed approximately 10 years apart. A review of the literature identifies 11 other sibling pairs. Our case suggests an autosomal dominant pattern of inheritance. To date, the gene involved in the development of transient erythroblastopenia of childhood has not been identified.     

Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: a new case of transient hyperphosphatasemia in early childhood

We report the case of a 20-month old boy with markedly elevated serum alkaline phosphatase (ALP) levels, documented during an episode of acute laryngotracheobronchitis. Biochemical investigations and imaging studies revealed no evidence of bone or liver disease. Transient hyperphosphatasemia (TH) was confirmed when serum ALP levels normalized within 2 months. Several theories were suggested for TH pathophysiology, viral infections among them; the exact causes, however, remain unclear. It is important to recognize TH and avoid misdiagnosis and unnecessary investigations.     

Transient red cell aplasia in siblings: a common environmental or a common hereditary factor?

During the years 1987-89, transient erythroblastopenia of childhood was diagnosed in 52 previously healthy Swedish children aged less than 4 y. Among these children there were four pairs of siblings, including one pair of identical female twins. This is a much higher familial occurrence than expected. The probability of finding 4 pairs of siblings with this disease in 50 families was estimated to be considerably less than 10-6. In the retrospectively analysed material, no environmental factor was implicated and no association with human leucocyte antigen could be proven. The twins demonstrated the disease simultaneously. Their anaemia was transient and did not recur, but showed certain features usually seen in congenital hypoplastic anaemia. The other pairs of siblings fulfilled the criteria for transient erythroblastopenia of childhood and several years elapsed between the development of the disease in siblings. Two of the fathers were reported to have had transient anaemia during their childhood. Our findings indicate that transient erythroblastopenia of childhood may involve hereditary factors, eventually demonstrating an autosomal dominant inheritance.     

Transient focal neurologic deficits associated with hypoglycaemia in children with insulin-dependent diabetes mellitus

We describe 54 transient focal neurologic deficits (TFND) episodes in 44 children under 18 y observed retrospectively during a 5-y period (1991–96). Mean age and duration of insulin-dependent diabetes mellitus (IDDM) were 8.4 and 3.4 y, respectively. None of the children had a history of seizure disorder and only one had a personal history of migraine. Twenty-nine episodes were characterized by right- and 25 by left-sided hemiparesis. Three of six patients who presented more than one event had alternate episodes of right- and left-sided hemiparesis. On 8 occasions the episode was preceded by a brief convulsion, in 39 it was not witnessed, and in 7 it was certainly absent. Hypoglycaemia (<2.77 mmol/l) was documented on 26 occasions. On 18 of these 26 occasions, the episodes did not resolve promptly after sugar administration. The clinical course was benign, all patients remained neurologically normal and none developed migraine at follow up. Episodes of TFND were associated with hypoglycaemia in the majority of our cases and we do not consider invasive investigations to be mandatory, since the long-term prognosis was invariably good.     

Transient erythroblastopenia of childhood. A retrospective study of 57 cases with a review of the literature

Anaemia, erythroblastopenia     

Primary intraspinal soft-tissue sarcoma in childhood: Report of two cases with a review of the literature

Two young children who presented with lower spinal cord dysfunction manifested by bilateral leg weakness and urinary retention were diagnosed with intraspinal soft-tissue sarcoma. Neither patient had a significant extradural mass. Both tumors had histochemical features of rhabdomyosarcoma. Temporary responses were noted after combination chemotherapy either with vincristine, actinomycin D, and cyclophosphamide or with ifosfamide/mesna and etoposide. However, both patients developed uncontrollable cerebrospinal fluid (CSF) dissemination of tumor and died within 6 months of diagnosis, despite intrathecal chemotherapy and irradiation for one and very high-dose intravenous methotrexate (33 g/m²) for the other. This rare tumor can respond to parenteral antisarcoma chemotherapy, but better strategies are needed to prevent CSF spread and ultimate demise. Early institution of intrathecal cytostatic agents may retard or prevent CSF dissemination and prolong survival. © 1994 Wiley-Liss, Inc.     

ZFP57基因相关新生儿暂时性糖尿病双胎报告并文献复习

目的 探讨ZFP57基因变异所致新生儿暂时性糖尿病(TNDM)的临床及基因变异特征.方法 回顾分析2019年12月收治的一对ZFP 57基因变异所致TNDM双胎患儿的临床资料和基因测序结果.同时检索建库至2020年2月的中国知网数据库、万方数据库及PubMed数据库,复习相关文献.结果 双胎均为女性,生后24小时内出现...     

Transient major hypothermia associated with acetaminophen: A pediatric case report and literature review

We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36 °C) after acetaminophen intake for post-vaccination fever. A recurrence of the hypothermia was observed after acetaminophen rechallenge for fever. We reviewed 14 other pediatric cases of hypothermia secondary to therapeutic doses of acetaminophen. Hypothermia after a therapeutic dose is a very rare side effect of acetaminophen. Several hypotheses have been made but the exact mechanism remains unknown.     

Secretory breast cancer in childhood and adolescence: Report of a case and review of the literature

A 17-year-old boy underwent a wide partial mastectomy with axillary dissection for secretory breast cancer, followed by low grade irradiation (30 Gy). There were no axillary lymph node metastases. Hormone receptor assay of the tumor was positive for progesterone and negative for estrogen. There was no local recurrence or sign of dissemination after nearly 5 years. Literature search revealed 21 cases of secretory breast cancer in childhood and adolescence; in only 2 cases was the hormonal status studied. We report an additional case and review the literature. © 1992 Wiley-Liss, Inc.